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| 1 | Develop a 3D neurological disease model of human cortical glutamatergic neurons using micropillar-based scaffolds显示文摘Establishing an effective three-dimensional(3D) in vitro culture system to better model human neurological diseases is desirable, since the human brain is a 3D structure. Here, we demonstrated the development of a polydimethylsiloxane(PDMS) pillar-based 3D scaffold that mimicked the 3D microenvironment of the brain. We utilized this scaffold for the growth of human cortical glutamatergic neurons that were differentiated from human pluripotent stem cells. In comparison with the 2D culture, we demonstrated that the developed 3D culture promoted the maturation of human cortical glutamatergic neurons by showing significantly more MAP2 and less Ki67 expression. Based on this 3D culture system,we further developed an in vitro disease-like model of traumatic brain injury(TBI), which showed a robust increase of glutamate-release from the neurons, in response to mechanical impacts, recapitulating the critical pathology of TBI. The increased glutamate-release from our 3D culture model was attenuated by the treatment of neural protective drugs, memantine or nimodipine. The established 3D in vitro human neural culture system and TBI-like model may be used to facilitate mechanistic studies and drug screening for neurotrauma or other neurological diseases. | Cheng Chen Xin Dong Kai-Heng Fang Fang Yuan Yao Hu Min Xu Yu Huang Xixiang Zhang Danjun Fang Yan Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 2 | In-situ anion exchange based Bi_(2)S_(3)/OV-Bi_(2)MoO_(6)heterostructure for efficient ammonia production:A synchronized approach to strengthen NRR and OER reactions显示文摘Photocatalytic ammonia generation via nitrogen reduction reaction(NRR)is a green and prospective nitrogen fixation technique.However,NRR is often hampered by the high N_(2) adsorption/activation energies and is accompanied by a slow kinetics oxygen evolution reaction(OER).Herein,a robust Bi_(2)S_(3)/OVBi_(2)MoO_(6)S-scheme heterojunction is constructed using a simple in-situ anion exchange process,which enables oxygen vacancy(OVs)abundant Bi_(2)Mo O_(6) microspheres with surface deposited Bi_(2)S_(3).The asfabricated Bi_(2)S_(3)/OVBi_(2)MoO_(6) functioned as an effective photocatalyst to convert N_(2)-to-NH_(3) under mild conditions.The photocatalytic NH_(3)/NH_(4)^(+) production rate reached 126μmol g_(cat)^(-1)under visible light for2.5 h with 2%of Bi_(2)S_(3)/OVBi_(2)MoO_(6)photocatalyst,which was 8-fold higher than pristine Bi_(2)MoO_(6).Furthermore,the as-fabricated Bi_(2)S_(3)/Bi_(2)MoO_(6)heterojunction exhibited good selectivity,high stability and reproducibility.The excellent photocatalytic NRR performance was ascribed to the Bi_(2)S_(3)/Bi_(2)MoO_(6)heterojunction formed subsequent to the strong interaction between Bi_(2)S_(3)and Bi_(2)MoO_(6).The OVs facilitated the chemical adsorption process allowing activation of N_(2)molecule on the Bi_(2)S_(3)/Bi_(2)MoO_(6).Simultaneously,the S-scheme heterojunction prolonged the lifetime of photogenerated carriers,accelerated the electrons/holes spatial separation and accumulation on the Bi_(2)S_(3)(reduction)and Bi_(2)MoO_(6)side(oxidation),respectively,thus strengthening both OER and NRR half-reactions.This simple in-situ anion exchange method offers a novel technique for strengthening OER and NRR half-reactions in Bi-based photocatalysts for effective photocatalytic ammonia generation. | Yuanyuan Zhang Li Guo Yingxian Wang Tianyu Wang Taoxia Ma Zhuangzhuang Zhang Danjun Wang Bin Xu Feng Fu | 2022 | Journal of Materials Science & Technology2022，，15： | 0 |
| 3 | Impact of Water Molecules on the Isomerization of CH3S(OH)CH2 to CH3S(O)CH3: A Computational Investigation显示文摘CH3S 的异构化(哦) 到在水的缺席和存在的 CH3S (O) CH3 的 CH2 在 G3XMP2//B3LYP/6-311+G 被调查了(2df, p ) 水平。裸体异构化,没有水的反应,给高障碍高度(21.56 | Cao Jia Wenliang Wang Tianlei Zhang Loujun Gao Feng Fu Danjun Wang | 2013 | Chinese Journal of Chemistry2013，31，10： | 0 |
| 4 | Diagnosis and Prevention of Colibacillosis in Chickens显示文摘The characteristics of chicken colibacillosis are introduced from the aspects of pathogen,epidemiology,clinical symptoms and necropsy,and clinical comprehensive diagnosis and laboratory diagnosis methods are given.The disease is distinguished from diseases with similar symptoms such as chicken chlamydia,chicken streptococcus,chicken necrotic enteritis,broiler ascites syndrome and chicken paratyphoid infections.Eventually,the preventive and therapeutic measures against the disease are put forward. | Shen Xuehuai Zhang Danjun Zhao Ruihong Pan Xiaocheng Yin Lei Hu Xiaomiao | 2019 | Animal Husbandry and Feed Science2019，11，5： | 0 |
| 5 | Diagnosis and Prevention of Duck Virus Enteritis显示文摘The characteristics of duck virus enteritis(DVE)are introduced from the aspects of pathogen,epidemiology,clinical symptoms,autopsy pathological changes,etc.,and clinical comprehensive diagnosis and laboratory diagnosis methods are given.The disease is distinguished from similar diseases including duck necrotic enteritis,duck candidiasis,duck hemorrhage,duck coccidiosis and duck vitamin A deficiency.Eventually,the prevention and treatment measures of the disease are put forward. | Pan Xiaocheng Zhao Ruihong Shen Xuehuai Yin Lei Zhang Danjun Da Yin | 2019 | Animal Husbandry and Feed Science2019，11，5： | 0 |
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