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| 1 | Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers显示文摘Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler(LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency. | Tongtong Zhang Yanming Chen Yuanyuan Ge Yuzhen Hu Miao Li Yiguang Jin | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 12 |
| 2 | Postmarketing safety evaluation: depside salt injection made from Danshen(Radix Salviae Miltiorrhizae)显示文摘OBJECTIVE: To systematically examine the postmarketing safety of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),identifythe potential risk factors, and ensure its clinical safety.METHODS: We examined a comprehensive series of studies on the production process, quality standards, pharmacology, population pharmacokinetics, and safety evaluation of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae). Data from Ⅰ-Ⅳ clinical drug trials, hospital information systems(HIS), and spontaneous reporting systems(SRS) were also analyzed.RESULTS: The effective components of salvianolic acid salt content reached almost 100%, and the magnesium lithospermate B content reached morethan 80%. The median lethal dose(LD50) calculated by the Bliss method was 1.49 g/kg, with 95%confidence intervals of 1.29-1.72 g/kg. Long-term tests on Beagle dogs indicated that doses of less than 80 mg/kg were safe and doses of 320 mg/kg were toxic. Adverse drug reactions(ADRs) included digestive disorders; drug-induced erythrocyte deformation in lung, liver, spleen, kidney, bone marrow, intestinal mucosa, lymph nodes, and other tissues; megakaryocytes in lung, liver, and spleen resulting from mild hemolysis; and mild hyperplasia in bone marrow hematopoietic tissue. Other studies indicated no irritative effect of the injection on local tissues and blood vessels, and no allergic reactions, erythrocyte coagulation, or hemolysis. SRS data showed that the most common ADRs were headache, head distention, dizziness, facial flushing, skin itching, thrombocytopenia, and the reversibility of elevated Aspartate transaminase. HIS data indicated no damage to renal function from using depside salt injection made from Danshen(Radix Salviae Miltiorrhizae) at a dosage higher than the recommended dose.CONCLUSION: This study analyzes the clinical characteristics of ADRs from depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),and discusses the factors influencing such reactions. It provides scientific reference and recommendations for clinically safe medication of the Danshen injection. | Yanpeng Chang Wen Zhang Yanming Xie Xiangyang Xu Rendi Sun Zheng Wang Ruihua Yan | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 8 |
| 3 | Invited review:Remediation strategies for mycotoxin control in feed显示文摘Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cause adverse effects on the health and performance of animals.Therefore,physical,chemical,biological and nutritional regulation approaches have been developed as primary strategies for the decontamination and detoxification of these mycotoxins in the feed industry.Meanwhile,each of these techniques has its drawbacks,including inefficient,costly,or impractically applied on large scale.This review summarized the advantages and disadvantages of the different remediation strategies,as well as updates of the research progress of these strategies for AFB1,DON,ZEN and FB1 control in the feed industry. | Meng Liu Ling Zhao Guoxin Gong Lei Zhang Lei Shi Jiefan Dai Yanming Han Yuanyuan Wu Mahmoud Mohamed Khalil Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 8 |
| 4 | Promoted effect of zinc–nickel bimetallic oxides supported on HZSM-5 catalysts in aromatization of methanol显示文摘Zn/ZSM-5(NZ2) and Zn/Ni/ZSM-5(NZ3) as the catalysts for methanol to aromatics(MTA) were synthesized by a simple ultrasonic impregnation. The textural and acid properties of all catalysts were characterized using XRD, HRTEM, NH_3-TPD, Py-IR, XPS, XRF and TG techniques. The XRD and HRTEM results showed that the basic zeolite structures were not affected much with the incorporation of Zn and Ni species. However, great changes have taken place in acid properties. The Py-IR and XPS results indicated that the Zn-Lewis acid sites(ZnOH^+ species), which have stronger interaction with the zeolite framework compared with ZnO species, were generated at the expense of B acid sites with the incorporation of zinc species. Moreover, the product analysis results showed that the incorporation of zinc species promoted the primary aromatization by enhancing the dehydroaromatization and suppressing the cracking and subsequent H-transfer reaction. Furthermore, the addition of Ni species well inhibited the loss of zinc species by converting partial ZnO species to ZnOH^+ species, and thus improved the aromatization activity and catalyst stability. The catalytic performance results showed that the NZ3 possess higher conversion of methanol in a longer time and lower average rate of coke formation compared with NZ2. In addition,the NZ3 also exhibited the highest yield of BTX as the reaction proceeds. | Yanming Jia Junwen Wang Kan Zhang Wei Feng Shibin Liu Chuanmin Ding Ping Liu | 2017 | Journal of Energy Chemistry2017，26，3： | 7 |
| 5 | Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during human erythroid differentiation显示文摘在 erythroid 开发期间编码基因, miRNAs,和 lncRNAs 上的研究在最近的年里被执行了。然而,集中于三种 RNA 类型的集成的分析还得被做。在现在的学习,我们比较了编码基因, miRNA,和 lncRNA 表示侧面的动力学。为了在在 transcriptome 控制这些变化的红血球生成和潜在的机制探索动态变化,铺平,我们利用了定序技术从绳索血获得 transcriptome 数据的高产量造血的干细胞和下列四个 erythroid 区别阶段,以及从成熟的红血房间。结果显示 lncRNAs 为 erythroid 区别正在答应房间标记候选人。聚类分析分类差别表示基因进在 stemness 维护期间对应于动态变化的四种子类型,中间区别,并且成熟。综合分析揭示了 RNA 潜在地参予了控制血细胞成熟的那 noncoding,并且特别与到氧种类和 DNA 损坏的 heme 新陈代谢和回答联系了。这些规章的相互作用在一个全面网络,在 RNA 之间的从而推断的关联和他们的联系功能被显示。这些数据为正常红血球生成的学习提供了一个大量的资源,它将允许 erythroid 开发的进一步的调查和理解并且获得 erythroid 混乱。 | Nan Ding Jiafei Xi Yanming Li Xiaoyan Xie Jian Shi Zhaojun Zhang Yanhua Li Fang Fang Sihan Wang Wen Yue Xuetao Pei Xiangdong Fang | 2016 | Frontiers of Medicine2016，10，3： | 6 |
| 6 | Carbon Storage and Vertical Distribution in Three Shrubland Communities in Gurbantünggüt Desert,Uygur AutonomousRegion of Xinjiang,Northwest China显示文摘This study was carried out in the Gurbantünggüt Desert,Uygur Autonomous Region of Xinjiang,Northwest China in August,2009.To quantify the storage,contribution and vertical distribution patterns of plant biomass carbon (PBC)and soil organic carbon(SOC)in the study area,we investigated the carbon concentrations and its vertical distribution in three different desert shrubland communities dominated by Reaumuria soongorica,Haloxylon ammodendron+R.soongorica and Tamarix ramosissima+R.soongorica,respectively.We analyzed vertical distribution of root biomass carbon and soil carbon contents by excavating soil profiles for each dominated community.The results show that SOC is considerably the larger carbon pool in the soil layers of 1.0-3.0 m(the mean value of three shrubland communities is 38.46%)and 3.0-5.0 m(the mean value is 40.24%).In contrast,70.74%of belowground biomass carbon storage in 0-1.0 m layer,and its content decrease with increasing soil depth.The Haloxylon ammodendron+R. soongorica shrubland community has the highest belowground biomass carbon among three selected communities. This study highlights the importance of SOC stored in deep soil layers(lower than 3.0 m from the surface)in arid shrubland communities in the global carbon balance.In addition,it provides the data support for revealing deep soil solid carbon potential,and offers scientific basis for the further research in the carbon cycle of terrestrial ecosystem. | GONG Yanming HU Yukun FANG Fei LIU Yanyan LI Kaihui ZHANG Guangming | 2012 | Chinese Geographical Science2012，22，5： | 6 |
| 7 | Illite Crystallinity Mapping of Very Low Grade Metamorphism of Triassic Metapelites in the Zoigê Area,Western China显示文摘X-ray diffraction methods for estimating the metamorphic grade of diagenetic,anchizone and epizone in metapelites are reviewed and applied to samples from a 7000m+ borehole in western China and surface samples from the surrounding Zoigê area.Kübler's illite crystallinity(IC) measurements provide more consistent results than calculated values of percentage of illite in the I/S mixed layers and percentage of I/S mixed layers.Down-borehole IC values display a typical burial metamorphic relationship between stratigraphic level and IC.A method for preparing very low grade metamorphic maps is described,and isograds plotted on a regional geological map at selected values of IC,delineating a high temperature diagenetic zone,an anchizone,and an epizone.The map shows that IC values are controlled by stratigraphic level in the north of the study area(i.e.burial metamorphism),and proximity to an igneous intrusive body in the south(i.e.contact metamorphism). | TANG Yan SANG Longkang YUAN Yanming YU Jishun ZHANG Yunpeng QI Xianmao YANG Yunlong | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 6 |
| 8 | Post-marketing safety monitoring of Shenqifuzheng injection: a solution made of Dangshen(Radix Codonopsis)and Huangqi(Radix Astragali Mongolici)显示文摘OBJECTIVE:Toidentify the potential risk factors associated with Shenqifuzheng injection(SFI), a solution made of Dangshen(Radix Codonopsis) and Huangqi(Radix Astragali Mongolici), for the timely provision of information to regulatory authorities.METHODS: A comprehensive analysis of the production process, quality standards, pharmacology,post-marketing clinical studies, and safety evaluation using the primary literature of adverse reactions(ADR), case analyses, and systematic reviews,intensive hospital safety monitoring of post-marketing drugs, and data provided by the hospital in-formationsystem(HIS).RESULTS: Sub-acute toxicity tests suggesting that a dose of 15 mL/kg(concentrated solution) had specific biological effects, whereas a smaller dose engendered no observable effects. Long-term toxicity testing in domestic rabbits showed that after SFI was administered for 90 days, the animals in each dosing group showed no chronic toxic reactions. Among 20 100 cases observed, the incidence of an ADR was 1.85‰. From March to November 2013,of the leading institutions and 22 sub-centers involved in the post-marketing clinical safety intensive hospital monitoring, 21 units completed 8484 cases of monitoring, and reported 23 cases of adverse reactions. No damage to renal function was found using SFI ata dosageanda treatment course larger and longer than that recommended for the adjuvant treatment of tumors. This could reduce the mortality rate of admitted patients based on the analysis of the data provided by the HIS. A total of 16 clinical case reports of adverse reactions related to SFI in 1999-2012 were obtained through literature retrieval. These reports contained information concerning 17 cases, with adverse reaction symptoms including thrombocytopenia, rash,chills,feeling cold,palpitation,dyspnea,edemaofa lower extremity, palpebral edema, and superficial vein in flammation,among others.CONCLUSION: This study introduces 'get full access' to the flow of information on medicines regarding their ADR incidence rate and characteristics and factors.It supports the safety of SFI for clinical, research, and production uses based on objec-tive, reliable, and scientific information to provide safe medication. | Qinghua Ai Wen Zhang Yanming Xie Wenhua Huang Hong Liang Hui Cao | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 5 |
| 9 | Numerical analysis on water exchange and its response to the coastal engineering in the Yueqing Bay in China显示文摘On the basis of a numerical model of tidal current using Delft3D, the distribution of the semi - exchange time of water was simula- ted in the Yueqing Bay here. The result showed that the semi - exchange time was about more than 6 d in the bay end, and about 1~2 d in the bay mouth. Besides, based on the calculation of the semi - exchange time before and after the Xuanmen Dam pro- ject, a comparison between them was further carried out. And the same work was also done with the recent reclamation projects in the Yueqing Bay as well. The results showed that the change in semi - exchange time caused by the Xuanmen Dam project was a- bout 6 d increase near the dam and 4.5 d increase at the bay end. And it was about 5 d increase at the bay end and 1 d increase at the mouth of the bay caused by the recent reclamation projects. | LI Jia YAO Yanming LI Xiaoyan ZHANG Hongwei | 2008 | Acta Oceanologica Sinica2008，27，z1： | 5 |
| 10 | Influence of liquid water on coalbed methane adsorption:An experimental research on coal reservoirs in the south of Qinshui Basin显示文摘Using Isothermal Adsorption/Desorption System Model IS-100 and Electrohydraulic Servo Rock System Model MTS815 as the main apparatuses and collecting samples from the major coal reservoirs in the south of Qinshui Basin, a hot point region of coalbed methane exploration, the paper carries out systematical comparisons of the isothermal adsorption experimental data for injection water coal samples, equilibrium moisture samples and dry coal samples, probes and establishes an experimental method of injection water coal sample preparation and isothermal experiment to simulate real reservoir conditions, and then summaries the experimental regulations and discusses the mechanism of liquid water influencing coal methane adsorption. Results of the experiment indicate that: The Langmuir volume of injection water coal samples is notably larger than that of equilibrium moisture samples, as well as larger than or equivalent to that of dry coal samples; the Langmuir pressure of injection water coal samples is the highest, the next is equilibrium moisture samples, while the dry samples is the lowest, of which the experimental results of injection water samples to simulate real reservoir conditions are more close to the fact. Under the conditions of in-position reservoirs, liquid water in coals has evident influence on methane adsorption ability of coal matrix, which can increase the adsorbability of coal and make the adsorption regulation fit to Langmuir model better. Its major reason is the increase of wetting coal matrix adsorbability. The above experimental results overthrow the conventional cognition that liquid water has no influence on coalbed methane adsorption, which may lead to an improvement of the coalbed methane isothermal adsorption experimental method and of the reliability of coalbed methane resource evaluation and prediction. | Shuxun Sang Yanming Zhu Jing Zhang Xiaodong Zhang Shiyin Zhang | 2005 | Chinese Science Bulletin2005，50，S1： | 4 |
| 11 | A Modified Enrichment Method to Construct Microsatellite Library from Plateau Pika Genome(Ochotona curzoniae)显示文摘A microsatellite-enriched library of plateau pika(Ochotona curzoniae) was constructed according to the strong affinity between biotin and streptavidin.Firstly,genomic DNA was fragmented by ultrasonication,which is a major improvement over traditional methods.Linker-ligated DNA fragments were hybridized with biotinylated microsatellite probes,and then were subjected to streptavidin-coated magnetic beads.PCR amplification was performed to obtain double-stranded DNA fragments containing microsatellites.Ligation and transformation were carried out by using the pGEM-T Vector System I and Escherichia coli DH10B competent cells.Sequencing results showed that 80.2% of clones contained microsatellite repeat motif.Several modifications make this protocol time-efficient and technically easier than the traditional ones;particularly,composition and relative abundance of microsatellite repeats in plateau pika genome were truly represented through the optimized PCR conditions.This method has also been successfully applied to construct microsatellite-enriched genomic libraries of Chinese hamster(Cricetulus griseus) and small abalone [Haliotis diversicolor(Reeve)] with high rates of positive clones,demonstrating its feasibility and stability. | Jianing Geng Kexin Li Yanming Zhang Songnian Hu | 2010 | Genomics, Proteomics & Bioinformatics2010，8，1： | 4 |
| 12 | cDNA cloning and expression of erythropoietin in the plateau zokor(Myospalax baileyi) from the Qinghai-Tibet Plateau显示文摘All organisms respond to variation in their environments and manage environmental stress through metabolic adjustments.The plateau zokor(Myospalax baileyi) is an endemic and keystone subterranean rodent species that inhabits the Qinghai-Tibet Plateau between 2800 and 4200 m above sea level.It is a hypoxic-tolerant mammal with a high ratio of oxygen utilization that enables it to cope with its harsh surroundings.To explore the molecular mechanism of altitude acclimatization of the plateau zokor,we cloned the zokor erythropoietin(Epo) gene and used real-time PCR to compare Epo mRNA levels in zokors inhabiting 16 different altitudes.The full-length zokor Epo open reading frame was 579 bp that encoded a precursor peptide of 192 amino acids with a signal peptide of 26 residues.The Epo gene of the plateau zokor was 81%-95% homologous to that of human,mouse,rat,root vole and the Golan Heights blind mole rat,with the highest homology(95%) to species of the genus Spalax.Epo mRNA was detected mainly in the zokor kidney and spleen among 8 selected tissues.The level of Epo mRNA increased in the liver and kidney with increases in altitude.The increase in the kidney was 5 times that in the liver.Remarkably,expression of Epo mRNA in the kidney of zokors living at the highest altitude(4268 m) was 12-fold higher than that of zokors living at the lowest(2492 m) altitude.These findings provide essential information for understanding the possible role of Epo in adaptation to hypoxia in the plateau zokor. | WANG ZhenLong CHEN Yan YANG Jie CHEN WeiJun ZHANG YanMing ZHAO XinQuan | 2012 | Chinese Science Bulletin2012，57，9： | 4 |
| 13 | Feasibility study on application of volume acid fracturing technology to tight gas carbonate reservoir development显示文摘How to effectively develop tight-gas carbonate reservoir and achieve high recovery is always a problem for the oil and gas industry.To solve this problem,domestic petroleum engineers use the combination of the successful experiences of North American shale gas pools development by stimulated reservoir volume(SRV)fracturing with the research achievements of Chinese tight gas development by acid fracturing to propose volume acid fracturing technology for fractured tightgas carbonate reservoir,which has achieved a good stimulation effect in the pilot tests.To determine what reservoir conditions are suitable to carry out volume acid fracturing,this paper firstly introduces volume acid fracturing technology by giving the stimulation mechanism and technical ideas,and initially analyzes the feasibility by the comparison of reservoir characteristics of shale gas with tight-gas carbonate.Then,this paper analyzes the validity and limitation of the volume acid fracturing technology via the analyses of control conditions for volume acid fracturing in reservoir fracturing performance,natural fracture,horizontal principal stress difference,orientation of insitu stress and natural fracture,and gives the solution for the limitation.The study results show that the volume acid fracturing process can be used to greatly improve the flow environment of tight-gas carbonate reservoir and increase production;the incremental or stimulation response is closely related with reservoir fracturing performance,the degree of development of natural fracture,the small intersection angle between hydraulic fracture and natural fracture,the large horizontal principal stress difference is easy to form a narrow fracture zone,and it is disadvantageous to create fracture network,but the degradable fiber diversion technology may largely weaken the disadvantage.The practices indicate that the application of volume acid fracturing process to the tight-gas carbonate reservoir development is feasible in the Ordovician Majiagou Formation of lower Paleozoic,which is of great significance and practical value for domestic tight-gas carbonate reservoir development and studies in the future. | Nianyin Li Jinxin Dai Chao Liu Pingli Liu Yanming Zhang Zhifeng Luo Liqiang Zhao | 2015 | Petroleum2015，1，3： | 4 |
| 14 | Mechanism of keyhole pore formation in metal additive manufacturing显示文摘During metal additive manufacturing,the porosity of the as-built part deteriorates the mechanical property and even hinders the further application of metal additive manufacturing.Particularly,the mechanisms of keyhole pores associated with the keyhole fluctuation are not fully understood.To reveal the mechanisms of the keyhole pores formation,we adopt a multiphysics thermal-fluid flow model incorporating heat transfer,liquid flow,metal evaporation,Marangoni effect,and Darcy’s law to simulate the keyhole pore formation process,and the results are validated with the in situ X-ray images.The simulation results present the instant bubble formation due to the keyhole instability and motion of the instant bubble pinning on the solidification front.Furthermore,comparing the keyhole pore formation under different laser scanning speeds shows that the keyhole pore is sensitive to the manufacturing parameters.Additionally,the simulation under a low ambient pressure shows the feasibility of improving the keyhole stability to reduce and even avoid the formation of keyhole pores. | Lu Wang Yanming Zhang Hou Yi Chia Wentao Yan | 2022 | npj Computational Materials2022，，1： | 3 |
| 15 | Postmarketing studies on safety of Dengfeng~ shenmai injection显示文摘OBJECTIVE: To systematically research the postmarketing safety of Dengfeng shenmai injection, identify potential risk factors, and ensure its clinical safety. METHODS: We investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction(ADR) case analysis and systematic review. Data from the hospital information system(HIS) and spontaneous reporting system(SRS) were also analyzed. RESULTS: The approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain. CONCLUSION: This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection. | Lianxin Wang Wen Zhang Yanming Xie Yang Bai Mulan Wang Qinghua Ai | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 3 |
| 16 | Using big data to track marine oil transportation along the 21st-century Maritime Silk Road显示文摘China's designation of the '21 st-century Maritime Silk Road'(MSR) region is of extraordinary significance to its maritime rights, transportation security, and socio-economic development. We developed a technical framework allowing the use of 'big data' derived from the Automatic Identification System(AIS, an automatic ship-tracking network) for two purposes: the accurate mapping of oil tanker trajectories and the creation of heat maps showing the relative use of oil tanker routes and marine shipping chokepoints. We then applied these methods to 1.5 billion AIS records collected within the MSR in 2014 to statistically identify and analyze busy routes, areas, and chokepoints in this strategic region. Our results demonstrate that the proposed framework can provide an effective analysis of oil movements based on large-scale AIS datasets, helping researchers and policy makers better understand the footprint and strategic implications of maritime oil transportation in the MSR region. | CHENG Liang YAN ZhaoJin XIAO YiJia CHEN YanMing ZHANG FangLi LI ManChun | 2019 | Science China(Technological Sciences)2019，62，4： | 3 |
| 17 | Geochemistry of Late Triassic pelitic rocks in the NE part of Songpan-Ganzi Basin,western China:Implications for source weathering,provenance and tectonic setting显示文摘从在 NE 的 Hongcan 井 1 的近来三叠纪的沉积(有细密纹理的沙岩和 mudstones ) Songpan-Ganzi 盆分开的专业,踪迹和稀土元素元素(REE ) 集中,西方的中国,被用来表明捱过,起源和推断的来源区域的构造背景。改变(中央情报局) 的化学索引思考一对在凉爽、有点干燥的气候,和一个 A-CN-K 阴谋的化学捱过的中等的度低建议 felsic 统治到平均 tonalite 作文的中间的火的岩石的更旧的上面的大陆人外壳起源。把构造背景辨别图基于各种各样的 geochemical,晚三叠纪的沉积被推断在在活跃大陆人边缘(Kunlun-Qinling 褶层带) 和一条大陆人岛弧(Yidun 岛弧) 之间位于的背弧盆被扔了。在学习区域的三叠纪的沉积由 petrographic 数据在近似斜坡盆环境经历了快速的侵蚀和埋葬,当在 Aba-Zoige 区域的三叠纪的 turbidites 的出版流动方向没被支持时 Yidun 暴烈的弧来源。因此,我们建议 Kunlun-Qinling 岩层是最可能的供应了原始资料到 Songpan-Ganzi 盆的东北部分在期间晚三叠纪。 | Yah Tang Longkang Sang Yanming Yuan Yunpeng Zhang Yunlong Yang | 2012 | Geoscience Frontiers2012，3，5： | 3 |
| 18 | Establishment of safety evidence for Xingxue~ Shuxuening injection显示文摘OBJECTIVE: To systematically investigate the safety of Xingxue~ Shuxuening injection(SXN) in preand post-marketing, and to ensure clinical drug safety.METHODS: Strict quality control in raw herb selection and production processes was adopted and pharmacology research on SXN was performed by the drug manufacturing company, Heilongjiang ZBD Pharmaceutical Co., Ltd. We systematically reviewed the safety literature of Xingxue~ SXN. Adverse drug reaction(ADR) data of the drug, extracted from Spontaneous Reporting System(SRS), and clinical characters based on 20 hospital information systems(HIS) in China, were analyzed. Large-scale prospective safety monitoring and Risk Minimization Action Plans(Risk MAPs) of Xingxue~SXN were carried out.RESULTS: The quality of SXN was stable and controllable when it was produced. Drug toxicology studies found no effect on rabbits with hemolytic or condensed, local stimulation and muscle stimulation, and no allergic reactions in guinea pigs. The ADRs of Xingxue~ SXN were dizziness, phlebitis,and vomiting based on SRS data. The injection did not conform to instructions in clinical practice when we analyzed HIS database, and patient’s abnormal blood urea nitrogen levels may be related to the drug, when analyzed using the propensity score method. A nested case-control study was designed and performed to analyze the influencing factors of suspected allergic reactions to SXN. The study showed that patients with an allergy history were more prone to allergic reactions(P<0.001),and some medicine combinations could cause allergic reactions.CONCLUSION: These studies have established a body of evidence on Xingxue~ SXN safety, and provide a good model for Chinese medicine injection for clinical safety. The Xingxue~ SXN production process and toxicology research indicate the safety of the injection. However, the use of the injection is not consistent with instructed clinical practice.Xingxue~ SXN causes ADRs perhaps from inappropriate usage or its pharmacological action. This injection needs better Risk MAPs to ensure its clinical safety. | Wei Yang Wen Zhang Yanming Xie Bing Han | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 3 |
| 19 | The Combined Effect of Plastic Particles Size and Concentration on Rotifers’ (Brachionus plicatilis) Performance显示文摘The presence of microplastics in aquatic ecosystems is of increasing global concern.Nano-sized plastics,in particular,can penetrate the cell membrane and cause biological death.Our study evaluated the combined impacts of several polystyrene mi-crospheres’sizes and nominal concentrations on the overall performance changes of Brachionus plicatilis.Experimental animals were exposed to three microplastic sizes(0.08,0.5 and 6μm)and five nominal concentrations(0,0.5,2,8,32μg mL−1)for 20 d.Our results showed that the toxicological effect of particle size on rotifers did not significantly depend on the nominal concentration.The interaction between the nominal concentration and size occurred only for body length and lorica width.Specifically,high nominal concentrations of microplastics that were close to nanometer size significantly impaired the overall vitality of rotifers,embodied in shortage of body type,delay in the arrival of maturity,reduction in the cumulative number of neonates,and the advance of the death process.In comparison,fair-sized size(0.5 and 6μm)displayed non-significant damage except for individual groups.Most notably,the net reproductive yield was only a third of what it was in the original environment,implying that there was not much fertility left.Besides,with the development of rotifers,the adverse effects of polystyrene microsphere drive had become more and more serious. | SUI Yanming WANG Senyang MOHSEN Mohamed ZHANG Longsheng SHEN Mengyan LIU Zhiquan NGUYEN Haidang ZHANG Shengmao LI Kaixing LV Linlan DONG Xuexing | 2022 | Journal of Ocean University of China2022，21，2： | 3 |
| 20 | Comparison of aerosol characteristics during haze periods over two urban agglomerations in China using CALIPSO observations显示文摘 | Qiong Liu Xiaojun Ma Yanrong Yu Yan Qin Yonghang Chen Yanming Kang Hua Zhang Tiantao Cheng Yan Ling Yujie Tang | 2017 | Particuology2017，15，4： | 2 |
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