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| 1 | Zircon U-Pb age and Hf isotope of Quanyishang A-type granite in Yichang: Signification for the Yangtze continental cratonization in Paleoproterozoic显示文摘Zircon U-Pb age and Hf isotope, and major and trace element compositions were reported for granite at Quanyishang, which intruded into the Kongling complex in Yichang, Hubei Province. The results show that the Quanyishang granite is rich in silicon and alkalis but poor in calcium and magnesium, and displays enrichment in Ga, Y, Zr, Nb but depletion in Sr and Ba, exhibiting the post-orogenic A-type affinity. 90% zircons from the granite are concordant, and give a middle Paleoproterozoic magmatic crystallization age (mean 1854 Ma). Initial Hf isotope ratios (176Hf/177Hf)i of the middle Paleoproterozoic zircons range from 0.280863 to 0.281134 and they have negative εHf(t) values with a minimum of -26.3. These zircons give the depleted mantle model ages (TDM) of 2.9―3.3 Ga (mean 3.0 Ga), and the average crustal model ages (Tcrust) of 3.6―4.2 Ga (mean 3.8 Ga). A Mesoarchean grain with 207Pb/206Pb age of 2859 Ma has a slightly high TDM (3.4 Ga) but similar Tcrust (3.8 Ga) to the Paleoproterozoic zircons. All these data suggest that the source materials of the Quanyishang A-type granite are unusually old, at least ≥2.9 Ga (even Eoarchean). The event of crustal remelting, which resulted in the formation of the Quanyishang granite in the middle Paleoproterozoic, recorded the cratonization of the Yangtze conti- nent. The process may have relation to the extension and collapse of the deep crust with Archean ages, in response to the transition stage of the assembly and breakup of the Columbia supercontinent. | XIONG Qing HENG JianPing YU ChunMei SU YuPing TANG HuaYun ZHANG ZhiHai | 2009 | Chinese Science Bulletin2009，54，3： | 46 |
| 2 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 3 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 4 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 5 | Fluxes of CH4 and N_2O from soil under a tropical seasonal rain forest in Xishuangbanna, Southwest China显示文摘从在在 Xishuangbanna 的热带季节的雨林下面的土壤的 CH4 和 N2O 流动,西南中国用关上的静态的房间技术和气体色层法方法被测量一年。三个处理被放在学习的地里:(A) 没有崽,有垃圾的(B) ,和有垃圾和幼苗的(C) 。结果证明在我们的学习的土壤是大气的 CH4 的一个水池和大气的 N2O 的来源。从处理 A, B,和 C 的观察吝啬的 CH4 流动是 50.0 ± 4.0, 35.9 ± 2.8, 31.6 ± 2.8 μ g C/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动是 2.8, 2.6,和 3.7 kgN/hm 2 分别地。在 CH4 和 N2O 流动的季节变化在所有三个处理之中是重要的。垃圾的存在减少了 CH4 举起在湿季节期间(P < 0.05 ) ,然而并非在干旱期期间。调停幼苗的 N2O 排出物有类似的增加在期间湿并且干旱期,显示幼苗在两个季节增加了 N2O 排放。一种强壮的积极关系为处理 B 和处理 C 为所有三个处理,和在 CH4 流动和土壤温度之间的弱关系在 CH4 流动和土壤潮湿之间存在。N2O 流动为所有三个处理与土壤温度相关。 | YAN Yuping SHA Liqing CAO Min ZHENG Zheng TANG Jianwei WANG Yinghong ZHANG Yiping WANG Rui LIU Guangren WANG Yuesi SUN Yang | 2008 | Journal of Environmental Sciences2008，20，2： | 18 |
| 6 | Improving water-use efficiency by decreasing stomatal conductance and transpiration rate to maintain higher ear photosynthetic rate in drought-resistant wheat显示文摘In wheat, the ear is one of the main photosynthetic contributors to grain filling under drought stress conditions. In order to determine the relationship between stomatal characteristics and plant drought resistance, photosynthetic and stomatal characteristics and water use efficiency(WUE) were studied in two wheat cultivars: the drought-resistant cultivar ‘Changhan 58' and the drought-sensitive cultivar ‘Xinong 9871'. Plants of both cultivars were grown in pot conditions under well-watered(WW) and water-stressed(WS) conditions. In both water regimes,‘Changhan 58' showed a significantly higher ear photosynthetic rate with a lower rate of variation and a significantly higher percentage variation of transpiration compared to control plants at the heading stage under WS conditions than did ‘Xinong 9871' plants. Moreover,‘Changhan 58' showed lower stomatal density(SD) and higher stomatal area per unit organ area(A) under both water conditions. Water stress decreased SD, A, and stomatal width(SW), and increased stomatal length in flag leaves(upper and lower surfaces) and ear organs(awn, glume,lemma, and palea), with the changes more pronounced in ear organs than in flag leaves.Instantaneous WUE increased slightly, while integral WUE improved significantly in both cultivars. Integral WUE was higher in ‘Changhan 58', and increased by a greater amount, than in‘Xinong 9871'. These results suggest that drought resistance in ‘Changhan 58' is regulated by stomatal characteristics through a decrease in transpiration rate in order to improve integral WUE and photosynthetic performance, and through sustaining a higher ear photosynthetic rate, therefore enhancing overall drought-resistance. | Yuping Li Hongbing Li Yuanyuan Li Suiqi Zhang | 2017 | The Crop Journal2017，5，3： | 18 |
| 7 | Heterogeneous Fenton-like degradation of 4-chlorophenol using iron/ordered mesoporous carbon catalyst显示文摘Ordered mesoporous carbon supported iron catalysts(Fe/OMC) were prepared by the incipient wetness impregnation method and investigated in Fenton-like degradation of 4-chlorophenol(4CP) in this work. XRD and TEM characterization showed that the iron oxides were well dispersed on the OMC support and grew bigger with the increasing calcination temperature. The catalyst prepared with a lower calcination temperature showed higher decomposition efficiency towards 4CP and H2O2, but more metals were leached. The effect of different operational parameters such as initial pH, H2O2 dosage, and reaction temperature on the catalytic activity was evaluated. The results showed that 96.1% of 4CP and 47.4% of TOC was removed after 270 min at 30°C, initial pH of 3 and 6.6 mmol/L H2O2. 88% of 4CP removal efficiency was retained after three successive runs, indicating Fe/OMC a stable catalyst for Fenton reaction. 4CP was degraded predominately by the attack of hydroxyl radical formed on the catalyst surface and in the bulk solution due to iron leaching. Based on the degradation intermediates detected by high performance liquid chromatography, possible oxidation pathways were proposed during the 4CP degradation. | Feng Duan Yuezhu Yang Yuping Li Hongbin Cao Yi Wang Yi Zhang | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 8 | Theoretical Progress and Key Technologies of Onshore Ultra-Deep Oil/Gas Exploration显示文摘Oil/gas exploration around the world has extended into deep and ultra-deep strata because it is increasingly difficult to find new large-scale oil/gas reservoirs in shallow–middle buried strata. In recent years, China has made remarkable achievements in oil/gas exploration in ultra-deep areas including carbonate and clastic reservoirs. Some (ultra) large-scale oil and gas fields have been discovered. The oil/gas accumulation mechanisms and key technologies of oil/gas reservoir exploration and development are summarized in this study in order to share China’s experiences. Ultra-deep oil/gas originates from numerous sources of hydrocarbons and multiphase charging. Liquid hydrocarbons can form in ultradeep layers due to low geothermal gradients or overpressures, and the natural gas composition in ultra-deep areas is complicated by the reactions between deep hydrocarbons, water, and rock or by the addition of mantle- or crust-sourced gases. These oils/gases are mainly stored in the original highenergy reef/shoal complexes or in sand body sediments. They usually have high original porosity. Secondary pores are often developed by dissolution, dolomitization, and fracturing in the late stage. The early pores have been preserved by retentive diageneses such as the early charging of hydrocarbons. Oil/gas accumulation in ultra-deep areas generally has the characteristics of near-source accumulation and sustained preservation. The effective exploration and development of ultra-deep oil/gas reservoirs depend on the support of key technologies. Use of the latest technologies such as seismic signal acquisition and processing, low porosity and permeability zone prediction, and gas–water identification has enabled the discovery of ultra-deep oil/gas resources. In addition, advanced technologies for drilling, completion, and oil/gas testing have ensured the effective development of these fields. | Xusheng Guo Dongfeng Hu Yuping Li Jinbao Duan Xuefeng Zhang Xiaojun Fan Hua Duan Wencheng Li | 2019 | Engineering2019，5，3： | 15 |
| 9 | Research Progress on Heat Stress of Rice at Flowering Stage显示文摘Global warming has caused frequent occurrence of heat stress at the flowering stage of single-season rice in the Yangtze River region of China, which results in declines of spikelet fertility and yield in rice. Rice flowering stage is the most sensitive period to high temperatures, and therefore, the key for heat stress happening is the flowering stage coinciding with high temperature, which causes spikelet fertility decreasing in heat-sensitive varieties, and is the major factor for heat injury differences among various rice planting regions. With the development of rice breeding, temperature indexes for heat stress has been converted from daily maximum temperature of 35 oC to 38 oC with the stress duration of more than 3 d. During the flowering stage, anther dehiscence inhibition and low pollen shedding onto the stigma are two main reasons for spikelet fertility reduction under high temperatures. At panicle initiation stage, high temperatures aggravate spikelet degeneration, and destroy floral organ development. Various types of rice varieties coexist in production, and indica-japonica hybrid rice demonstrates the highest heat resistance in general, followed by indica and japonica rice varieties. In production, avoiding high temperature is the main strategy of preventing heat stress, and planting suitable cultivars and adjustment of sowing date are the most effective measures. Irrigation is an effective real-time cultivation measure to decline the canopy temperature during the rice flowering stage. We suggested that further study should be focused on exploring heat injury differences among different rice variety types, and innovating rice-planting methods according to planting system changes in rice planting regions with extreme heat stress. Meanwhile, high temperature monitor and warning systems should be improved to achieve optimal heat stress management efficiencies. | WANG Yaliang WANG Lei ZHOU Jianxia HU Shengbo CHEN Huizhe XIANG Jing ZHANG Yikai ZENG Yongjun SHI Qinghua ZHU Defeng ZHANG Yuping | 2019 | Rice science2019，26，1： | 13 |
| 10 | Prediction of Primary Climate Variability Modes at the Beijing Climate Center显示文摘Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing the research and development carried out, and the recent progress made, at the Beijing Climate Center(BCC) in predicting some primary climate variability modes. These include the El Ni?o–Southern Oscillation(ENSO), Madden–Julian Oscillation(MJO), and Arctic Oscillation(AO), on global scales, as well as the sea surface temperature(SST) modes in the Indian Ocean and North Atlantic, western Pacific subtropical high(WPSH), and the East Asian winter and summer monsoons(EAWM and EASM, respectively), on regional scales. Based on its latest climate and statistical models, the BCC has established a climate phenomenon prediction system(CPPS) and completed a hindcast experiment for the period 1991–2014. The performance of the CPPS in predicting such climate variability modes is systematically evaluated. The results show that skillful predictions have been made for ENSO, MJO, the Indian Ocean basin mode, the WPSH, and partly for the EASM, whereas less skillful predictions were made for the Indian Ocean Dipole(IOD) and North Atlantic SST Tripole, and no clear skill at all for the AO, subtropical IOD, and EAWM. Improvements in the prediction of these climate variability modes with low skill need to be achieved by improving the BCC's climate models, developing physically based statistical models as well as correction methods for model predictions.Some of the monitoring/prediction products of the BCC-CPPS are also introduced in this paper. | Hong-Li REN Fei-Fei JIN Lianchun SONG Bo LU Ben TIAN Jinqing ZUO Ying LIU Jie WU Chongbo ZHAO Yu NIE Peiqun ZHANG Jin BA Yujie WU Jianghua WAN Yuping YAN Fang ZHOU | 2017 | Journal of Meteorological Research2017，31，1： | 13 |
| 11 | Three dimensional velocity structure and accurate earthquake location in Changning–Gongxian area of southeast Sichuan显示文摘In order to understand the crustal structure and tectonic background of the Changning–Gongxiang area, southeastern Sichuan Province, where a series of moderate-to-strong earthquakes occurred in recent years, we utilized the seismic phase data both from a local dense array and from the regional seismic networks;we used the tomoDD program to invert for the high-resolution three-dimensional velocity structure within the depth range of 0–10 km and for accurate hypocentral locations in this area. We analyzed the seismogenic structures for the events of Xingwen M5.7 in 2018 and Gongxian M5.3 and Changning M6.0 in 2019. The results show that:(1) widespread lateral inhomogeneity exists in the velocity structure of the study area, and the location of the velocity anomaly is largely consistent with known structures. In the range of distinguishable depth, the inhomogeneity decreases with increasing depth, and the velocity structure anomalies in some areas are continuous in depth;(2) earthquakes occurred in clusters, showing the characteristics of zonal folding trends in the NW-SE and NE-SW directions;the focal depth in the area is generally shallow in both the sedimentary cap and the crystalline basement. The seismogenic structures of small earthquake clusters are different in size and occurrence in different sections, and the clusters occurred mostly in regions with high P-or S-wave velocities;(3) synthesis of a variety of data suggests that the seismogenic structures of the Xingwen M5.7 and Changning M6.0 earthquakes are associated with slip faults that trend NW-SE in, respectively, the south wing and the axis of the Changning–Shuanghe anticline, while that of the Gongxian M5.3 earthquake is associated with thrust faults that trend N-S in the Jianwu syncline region. The dynamic sources of the three earthquakes are all from the SE pushing of the Qinghai–Tibet block on the Sichuan basin;(4) the risk of future strong earthquakes in this area must be reevaluated in light of the facts(a)that in recent years, moderate-to-strong earthquake swarms have occurred frequently in southeast Sichuan;(b) that the complex structural area exhibits the easy-to-trigger characteristic, and(c) that the small-scale faults in this area are characterized by the phenomenon of stress 'lock and release'. | Feng Long ZhiWei Zhang YuPing Qi MingJian Liang Xiang Ruan WeiWei Wu GuoMao Jiang LongQuan Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 13 |
| 12 | Mapping Heterotic Loci for Yield and Agronomic Traits Using Chromosome Segment Introgression Lines in Cotton显示文摘在现在的学习,一套染色体片断基因渗入排队(CSIL ) 使用 Gossypium hirsutum L。TM-1 作为接受者父母和 G。施主父母被用来为种间的混血儿探索杂种优势的基因基础的 barbadense Hai7124。个别地从与两个父母一起交叉的 CSIL 导出的 F1 人口的二个集合被设置调查 heterotic loci (HL ) 和替换效果 loci (SL ) 。58 HL 和 39 SL 的一个总数在 3 年里被识别。一稳定的 HL, hLP-A4-3,能在所有 3 年里被检测。三 HL, hBS-A8-1, hLP-D6-1,和 hSI-D7-11,能在 2 年里被检测。四 SL, sBS-D7-1, sLP-A8-1, sLP-D7-1,和 sLP-D12-1,能在 2 年里被检测。HL 和 SL 趋于在有靠近的位置的一些 HL 富有的染色体片断分布式。与在以前的研究检测的 QTL 相比, HL 与 QTL 显示出很少重叠,显示特点显型和杂种优势可能被 loci 的不同集合控制。基因效果的所有三种形式(部分 -- ,完整 -- ,在主导上) 被识别,当在主导上的效果做了主要贡献到杂种优势时。这些结果可以帮助为在棉花澄清杂种优势的遗传机制打了基础。 | Xian Guo Yuping Guo Jun Ma Fang Wang Mizhen Sun Lijuan Gui Jiajia Zhou Xianliang Song Xuezhen Sun Tianzhen Zhang | 2013 | Journal of Integrative Plant Biology2013，55，8： | 13 |
| 13 | Climate change in Mt. Qomolangma region since 1971显示文摘Using monthly average, maximum, minimum air temperature and monthly precipitation data from 5 weather stations in Mt. Qomolangma region in China from 1971 to 2004, climatic linear trend, moving average, low-pass filter and accumulated variance analysis methods, the spatial and temporal patterns of the climatic change in this region were analyzed. The main findings can be summarized as follows: (1) There is obvious ascending tendency for the interannual change of air temperature in Mt. Qomolangma region and the ascending tendency of Tingri, the highest station, is the most significant. The rate of increasing air temperature is 0.234 oC/decade in Mt. Qomolangma region, 0.302 oC/decade in Tingri. The air temperature increases more strongly in non-growing season. (2) Compared with China and the global average, the warming of Mt. Qomolangma region occurred early. The linear rates of temperature increase in Mt. Qomolangma region exceed those for China and the global average in the same period. This is attributed to the sensitivity of mountainous regions to climate change. (3) The southern and northern parts of Mt. Qomolangma region are quite different in precipitation changes. Stations in the northern part show increasing trends but are not statistically significant. Nyalam in the southern part shows a decreasing trend and the sudden decreasing of precipitation occurred in the early 1990s. (4) Compared with the previous studies, we find that the warming of Mt. Qomolangma high-elevation region is most significant in China in the same period. The highest automatic meteorological comprehensive observation station in the world set up at the base camp of Mt. Qomolangma with a height of 5032 m a.s.l will play an important role in monitoring the global climate change. | YANG Xuchao ZHANG Yili ZHANG Wei YAN Yuping WANG Zhaofeng DING Mingjun CHU Duo | 2006 | Journal of Geographical Sciences2006，16，3： | 12 |
| 14 | The SLC transporter in nutrient and metabolic sensing, regulation, and drug development显示文摘The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic diseases. Consistent with metabolic characteristics, the top five organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as Metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. Gene-modified animal models have demonstrated that SLC transporters participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, tissue development, oxidative stress, host defense, and neurological regulation. Furthermore, the human genomic studies have identified that SLC transporters are susceptible or causative genes in various diseases like cancer, metabolic disease, cardiovascular disease, immunological disorders, and neurological dysfunction? Importantly, a number of SLC transporters have been successfully targeted for drug developments。 This review will focus on the current understanding of SLCs in regulating physiology, nutrient sensing and uptake, and risk of diseases. | Yong Zhang Yuping Zhang Kun Sun Ziyi Meng Ligong Chen | 2019 | Journal of Molecular Cell Biology2019，11，1： | 11 |
| 15 | Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies显示文摘As compared to permanent orthopedic implants for load-bearing applications, biodegradable orthopedic implants have the advantage of no need for removing after healing, but they suffer from the 'trilemma' problem of compromising among sufficiently high mechanical properties, good biocompatibility and proper degradation rate conforming to the growth rate of new bones. In the present work, in vitro and in vivo studies of a Zn-0.05 wt%Mg alloy(namely, Zn-0.05 Mg alloy) were conducted with pure Zn as a control. The Zn-0.05 Mg alloy is composed of a small amount of Mg_2 Zn11 phase embedded in the refined Zn matrix with an average grain size of ~20 μm. The addition of 0.05 wt% Mg into Zn significantly increases the ultimate tensile strength up to 225 MPa and the elongation to fracture to 26%, but has little influence on the in vitro degradation rate. Both Zn and Zn-0.05 Mg alloy exhibit homogeneous in vitro degradation with a rate of about 0.15 mm/year. Based on the cytotoxicity evaluation, Zn and Zn-0.05 Mg alloy do not induce toxicity to L-929 cells, indicating that they have little toxicity to the general functions of the animal. An in vivo biocompatibility study of Zn and Zn-0.05 Mg alloy samples by placing them in a rabbit model for 4.12 and 24 weeks, respectively did not show any inflammatory cells, and demonstrated that new bone tissue formed at the bone/implant interface, suggesting that Zn and Zn-0.05 Mg alloy promote the formation of new bone tissue. The in vivo degradation of Zn and Zn-0.05 Mg alloy does not bring harm to the important organs and their cell structures. More interestingly, Zn and Zn-0.05 Mg alloy exhibit strong antibacterial activity against Escherichia coli and Staphylococcus aureus. The above results clearly demonstrate that the Zn-0.05 Mg alloy could be a potential biodegradable orthopedic implant material. | Chi Xiao Liqing Wang Yuping Ren Shineng Sun Erlin Zhang Chongnan Yan Qi Liu Xiaogang Sun Fenyong Shou Jingzhu Duan Huang Wang Gaowu Qin | 2018 | Journal of Materials Science & Technology2018，34，9： | 11 |
| 16 | Dynamics of total culturable bacteria and its relationship with methylmercury in the soils of the water level fluctuation zone of the Three Gorges Reservoir显示文摘Field investigations were conducted to study the temporal and spatial distribution characteristics of total culturable bacteria(TCB)and its relationship with methylmercury(MeHg)in the soils of the water level fluctuation zone of the Three Gorges Reservoir.Different altitudes(170–180,170–175,165–170 and 160–165 m)in Zhenxi(Site 1),Shibaozhai(Site 2)and Tujing(Site 3),Chongqing,China were chosen as sampling sites.Results indicated that TCB did not have significant difference in the top(0–10 cm)and sub(10–20 cm)soil of the non-inundated area(175–180 m),but showing a significant difference in the water level fluctuation zone(\175 m,suggesting that water level fluctuation had an important effect on TCB.Moreover,TCB in soils of various altitudes of Site 1 and 2had significant difference,while for Site 3,this difference was not significant.And the difference of TCB in Site 2was much greater than that in Site 1.These results suggested that there were significant differences for TCB in soils of mainstream and tributaries.In addition,TCB in soils of 10–20 cm had significant or highly significant positive correlations with MeHg level(r C 0.762,P B 0.048),thus we assumed that there may be some aerobic microorganisms playing dominant roles in mercury methylation. | Yuping Xiang Hongxia Du Hong Shen Cheng Zhang Dingyong Wang | 2014 | Chinese Science Bulletin2014，59，24： | 10 |
| 17 | Electrospun Nanofibrous Materials for Wound Healing显示文摘Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired.Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area,better mimicry of native extracellular matrix,adjustable waterproofness and breathability,and programmable drug delivery process.In this review article,we begin with a discussion of wound healing process and current commercial wound dressing materials.Then,we emphasize on electrospun nanofibrous materials for wound dressing,covering the efforts for controlling fiber alignment and morphology,constructing 3D scaffolds,developing waterproof-breathable membrane,governing drug delivery performance,and regulating stem cell behavior.Finally,we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings. | Yuping Dong Yuqi Zheng Keyan Zhang Yueming Yao Lihuan Wang Xiaoran Li Jianyong Yu Bin Ding | 2020 | Advanced Fiber Materials2020，2，4： | 10 |
| 18 | Effect of extrusion speed on microstructure and mechanical properties of the Mg-Ca binary alloy显示文摘This work reported the effect of extrusion speeds on the microstructures and mechanical properties of Mg-Ca binary alloy.The results showed that yield strength of the as-extruded Mg-1.2wt.%Ca alloys decrease from∼360MPa to∼258MPa as the ram speed increases from 0.4mm/s to 2.4 mm/s,and the elongation increases from∼3.9%to∼12.2%.The microstructure changes from bimodal grain feature to the complete dynamical recrystallization(DRX)with increase of the extrusion speed.The ultrafine DRXed grains in size of∼0.85μm,the numerous nano-Mg_(2)Ca particles dispersing along the grain boundaries and interiors,as well as the high density of residual dislocations,should account for the high strength.It is believed that the high degree of dynamic recrystallization and the resulting texture randomization play the critical roles in the ductility enhancement of the high-speed extruded Mg alloys. | Jingren Li Aiyue Zhang Hucheng Pan Yuping Ren Zhuoran Zeng Qiuyan Huang Changlin Yang Lifeng Ma Gaowu Qin | 2021 | Journal of Magnesium and Alloys2021，9，4： | 9 |
| 19 | Crop Classification Using MODIS NDVI Data Denoised by Wavelet: A Case Study in Hebei Plain, China显示文摘Time-series Moderate Resolution Imaging Spectroradiometer (MODIS) Normalized Difference Vegetation Index (NDVI) data have been widely used for large area crop mapping.However,the temporal crop signatures generated from these data were always accompanied by noise.In this study,a denoising method combined with Time series Inverse Distance Weighted (T-IDW) interpolating and Discrete Wavelet Transform (DWT) was presented.The detail crop planting patterns in Hebei Plain,China were classified using denoised time-series MODIS NDVI data at 250 m resolution.The denoising approach improved original MODIS NDVI product significantly in several periods,which may affect the accuracy of classification.The MODIS NDVI-derived crop map of the Hebei Plain achieved satisfactory classification accuracies through validation with field observation,statistical data and high resolution image.The field investigation accuracy was 85% at pixel level.At county-level,for winter wheat,there is relatively more significant correlation between the estimated area derived from satellite data with noise reduction and the statistical area (R2 = 0.814,p < 0.01).Moreover,the MODIS-derived crop patterns were highly consistent with the map generated by high resolution Landsat image in the same period.The overall accuracy achieved 91.01%.The results indicate that the method combining T-IDW and DWT can provide a gain in time-series MODIS NDVI data noise reduction and crop classification. | ZHANG Shengwei LEI Yuping WANG Liping LI Hongjun ZHAO Hongbin | 2011 | Chinese Geographical Science2011，21，3： | 9 |
| 20 | Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride显示文摘Using the high-resolution Terahertz Time-domain spectroscopy (THz-TDS) and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride (CH), a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77-295 K. Between 0.2 and 3.6 THz (6.6-120.0 cm-1 ), seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control. | YANG YuPing LEI XiangYun YUE Ai ZHANG ZhenWei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，4： | 9 |
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