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| 1 | μ-and m-calpain expression and activity changes following diethylstilbestrol injection in the rat anterior pituitary显示文摘Little is known about changes in calpain activity in the pituitary gland.In the present study,μ-and m-calpain activity changes were detected in the rat anterior pituitary following intraperitoneal injection of diethylstilbestrol.Double-immunofluorescence labeling confirmed colocalization of μ-and m-calpain in prolactin-secreting cells(lactotrophs).Western blot analysis revealed significantly increased expression of both calpains,which accompanied upregulated cytosol and membrane zymographic activities at 12 weeks following diethylstilbestrol injection,compared with rats injected with sunflower oil.Moreover,following estrogen injection,pituitary gland pathological damage gradually worsened with increasing time.Results demonstrated that estrogen regulated calpain expression and activity,and both calpains participated in the pathophysiological processes of the pituitary gland.Ubiquitous calpain expression could serve as an effective target for anti-estrogen drugs. | Weijiang Zhao Zhongfang Shi Fang Yuan Guilin Li Yazhuo Zhang Zhongcheng Wang | 2011 | Neural Regeneration Research2011，6，1： | 7 |
| 2 | Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions显示文摘In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions.The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of time.Moreover,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse microradiography.In conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time. | Qian Ren Zhongcheng Li Longjiang Ding Xiuqing Wang Yumei Niu Xi Qin Xuedong Zhou Linglin Zhang | 2018 | Regenerative Biomaterials2018，5，2： | 5 |
| 3 | Electrochemical Properties and Microstructure of Al/Pb–Ag and Al/Pb–Ag–Co Anodes for Zinc Electrowinning显示文摘The Al/Pb–0.8%Ag and Al/Pb–0.75%Ag–0.03%Co(in mass fraction) anodes used in zinc electrowinning are prepared through the electrodeposition of lead methanesulfonate electrolyte onto an aluminum matrix.The results of anode polarization curves,Tafel curves,and EIS characterizations indicated that the Al/Pb–0.75%Ag–0.03%Co anode has higher electrocatalytic activity and corrosion resistance than the Al/Pb–0.8%Ag anode.SEM observations on the fruit surfaces demonstrated the crystals on the Al/Pb–0.8%Ag anode are larger than on the Al/Pb–0.75%Ag–0.03%Co anode.After 24 h of anodic polarization,SEM observations and XRD analysis showed that the MnO2–PbO2layer on the Al/Pb–0.75%Ag–0.03%Co anode surface is characterized by dendritic crystals,and the PbSO4–PbO2layer under the MnO2–PbO2layer is characterized by uniform and chaotic orientation tetragonal symmetry crystallites of PbSO4.However,the MnO2–PbO2layer on the Al/Pb–0.8%Ag anode surface is characterized by granular crystals,and the PbSO4–PbO2layer under the MnO2–PbO2layer is characterized by well-organized orientation crystallites of PbSO4,which are concentrated in certain zones. | Yongchun Zhang Buming Chen Zhongcheng Guo | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 5 |
| 4 | An Aptamer-based Colorimetric Sensor for Streptomycin and Its Application in Food Inspection显示文摘 | LIU Zhongcheng ZHANG Yanfen XIE Yao SUN Ying BI Kewei CUI Zhe ZHAO Lijian FAN Wufang | 2017 | Chemical Research in Chinese Universities2017，33，5： | 2 |
| 5 | Prediction Model of Coal Reservoir Pressure and its Implication for the Law of Coal Reservoir Depressurization显示文摘The main methods of coalbed methane(CBM)development are drainage and depressurization,and a precise prediction of coal reservoir pressure is thus crucial for the evaluation of reservoir potentials and the formulation of reasonable development plans.This work established a new reservoir pressure prediction model based on the material balance equation(MBE)of coal reservoir,which considers the self-regulating effects of coal reservoirs and the dynamic change of equivalent drainage area(EDA).According to the proposed model,the reservoir pressure can be predicted based on reservoir condition data and the actual production data of a single well.Compared with traditional reservoir pressure prediction models which regard EDA as a fixed value,the proposed model can better predict the average pressure of reservoirs.Moreover,orthogonal experiments were designed to evaluate the sensitivity of reservoir parameters on the reservoir pressure prediction results of this proposed model.The results show that the saturation of irreducible water is the most sensitive parameter,followed by Langmuir volume and reservoir porosity,and Langmuir pressure is the least sensitive parameter.In addition,the pressure drop of reservoirs is negatively correlated with the saturation of irreducible water and the Langmuir volume,while it is positively correlated with porosity.This work analyzed the reservoir pressure drop characteristics of the CBM wells in the Shizhuangnan Block of the Qinshui Basin,and the results show that the CBM reservoir depressurization can be divided into three types,i.e.,rapidly drop type,medium-term stability type,and slowly drop type.The drainage features of wells were reasonably interpreted based on the comprehensive analysis of the reservoir depressurization type;the latter was coupled to the corresponding permeability dynamic change characteristics,eventually proving the applicability of the proposed model. | YAN Xinlu ZHANG Songhang TANG Shuheng LI Zhongcheng WANG Kaifeng YI Yongxiang DANG Feng HU Qiuping | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 2 |
| 6 | Design and Characteristic Analysis on Direct Drive Permanent Magnet Synchronous显示文摘 | Bingyi Zhang Zhongcheng Huang Guihong Feng | 2011 | Proceeding of 2011 International Conference on ElectricalMachinesandSystems(ICEMS)2011，，8： | 1 |
| 7 | Melatonin modulates the effects of diethylstilbestrol (DES) on the anterior pituitary of the female Wistar rat显示文摘 | Zhao Weijiang Shi Zhongfang Yuan Fang Li Guilin Sun Yilin Zhang Yazhuo Wang Zhongcheng | 2010 | Folia Histochemica et Cytobiologica2010，，2： | 1 |
| 8 | De- sign and Characteristic Analysis on Direct Drive Permanent Magnet Synchronous 显示文摘 | Bingyi Zhang Zhongcheng Huang Guihong Feng | 2011 | Proceeding of 2011 International Conference on Electrical Machines and Systems (ICEMS)2011，，8： | 1 |
| 9 | Electrochemical study of the additive - effect on Sn electrodeposition in a methansulfonate acid electrolyte 显示文摘 | JinMing Long Zhu Zhang ZhongCheng Guo | 2012 | Advanced Materials Research2012，，460： | 1 |
| 10 | Additive- effects on the morphological and structural characteristics of matt tin electrode- posits from a methansulfonate acid bath 显示文摘 | JinMing Long Zhu Zhang ZhongCheng Guo | 2012 | Advanced Materials Research2012，，460： | 1 |
| 11 | Overexpression of Hdac6 extends reproductive lifespan in mice显示文摘 | Xiaoxi Zhang Jiao Yang Haiying Wang Renpeng Guo Yu Yin Dongdong Zhang Qian Zhang Hua Wang Zhongcheng Zhou Lingyi Chen Jun Zhou Lin Liu | 2017 | Protein & Cell2017，8，5： | 1 |
| 12 | Endoscopic transsphenoidal treatment of pituitary adenomas显示文摘 | Zhang Yazhou Wang Zhongcheng Liu Yejian | 2008 | Neurological Research2008，30，6： | 1 |
| 13 | Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant,CAL.20C显示文摘Dear Editor,New variants of SARS-CoV-2 have been emerging since the initial outbreak in 2019;1 one of the latest ones was identified in Southern California in October 2020 and was subsequently detected in 26 other states in the United States as well as other countries as of January 2021. | Zhongcheng Zhou Peng Du Meixing Yu Daniel T.Baptista-Hon Man Miao Andy P.Xiang Johnson Yiu-Nam Lau COVID-Immunity Investigation Group Gen Li Kang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 14 | An investigation on mass loss of ogival projectiles penetrating concrete tar- gets 显示文摘 | MU Zhongcheng ZHANG Wei | 2011 | International Journal of Impact Engineering2011，38，6： | 1 |
| 15 | In vitro selection of salinity tolerant variants from triploid bermudagrass (Cynodon transvaalensis?×?C. dactylon) and their physiological responses to salt and drought stress显示文摘 | Shaoyun Lu Xinxiang Peng Zhenfei Guo Gengyun Zhang Zhongcheng Wang Congying Wang Chaoshu Pang Zhen Fan Jihua Wang | 2007 | Plant Cell Reports2007，，8： | 1 |
| 16 | Neuroprotective effects of subthalamic nucleus high-frequency stimulation on substantia nigra neurons in a Parkinson's disease rat model显示文摘BACKGROUND:Deep-brain stimulation has proven to be beneficial in the treatment of Parkinson's disease(PD) patients.OBJECTIVE:To investigate the effects of high-frequency stimulation(HFS) to the subthalamic nucleus(STN) on neuronal apoptosis and apoptosis-related gene expression in the substantia nigra pars compacta,and to analyze the neuroprotective effect of HFS-STN.DESIGN,TIME AND SETTING:Neuronal morphology experiments were performed in the Beijing Neurosurgical Institute from May to December in 2005.MATERIALS:Forty healthy,adult,Sprague Dawley rats were used to establish a PD model with a unilateral microinjection of 6-hydroxydopamine into two target areas of the right medial forebrain bundle.6-hydroxydopamine was purchased from Sigma(USA);high-frequency electrical stimulator was produced by World Precision Instruments(USA);Terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL) kit was a product of Nanjing Jiancheng Technology Co.,Ltd.(China);and Bcl-2 and Bax protein assay kit were purchased from Wuhan Boster Bioengineering Co.,Ltd.(China).METHODS:Forty rats were randomly divided into three groups.The stimulation group(n = 15) received HFS-STN on the day of PD modeling.The PD model group(n = 15) was used to establish the PD model.The control group(n = 10) was injected with normal saline containing 0.2 g/L ascorbic acid into two areas of the right medial forebrain bundle.MAIN OUTCOME MEASURES:Survival of dopaminergic neurons in the substantia nigra pars compacta was determined using Nissl staining.Apoptosis of dopaminergic neurons was detected using TUNEL techniques.Expression of anti-apoptotic protein,Bcl-2,and pro-apoptotic protein,Bax,were assayed by immunohistochemistry.RESULTS:Following 6-hydroxydopamine injection,the number of substantia nigra pars compacta neurons was reduced in the stimulation and PD model groups,compared to the control group.At 2 and 4 weeks post-surgery,the grey value of Nissl stained images was significantly less in the PD model and stimulation groups(P < 0.05),and the stimulation group exhibited greater grey values compared to the model group(P < 0.05).At 2 and 4 weeks post-surgery,the number of apoptotic neurons was significantly less in the stimulation group compared to the model group(P < 0.05).In addition,Bcl-2 and Bax expression,as well as the Bcl-2/Bax ratio,was much higher in the stimulation group compared to the model group(P < 0.05).CONCLUSION:HFS-STN has a neuroprotective effect on dopaminergic neurons in the substantia nigra pars compacta of PD rats by promoting Bcl-2 expression,inhibiting Bax expression,and reducing the number of apoptotic dopaminergic neurons. | Yu Ma Zhongcheng Wang Jianguo Zhang Huanguang Liu Ying Zhang | 2008 | Neural Regeneration Research2008，3，9： | 1 |
| 17 | Predominant expression of β-chain variable region genes of T-cell receptor in TILs from human renal cell carcinoma显示文摘THE repertoire of T-cell antigen receptor(TcR)can be effectively analysed by an approachwith quantitative polymerase chain reaction(qPCR),which allows to characterize the ex-panding T-cell clones by the patterns of restricted usage of TcR V and J region genes. | LI Xueyi, WANG Ying, ZHENG Zhongcheng, ZHANG Dongqing, FUSaili, LING Jianyu and ZHOU Guangyan (CHOU Kuangyen)1. Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China 2. Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China 3. Shanghai Ruijin Hospital, Shanghai 200025, China | 1997 | Chinese Science Bulletin1997，42，8： | 0 |
| 18 | Uncertainty Analysis in CFD for Resistance显示文摘基于数字在 CFD (计算液体动力学) 作为无常的三个主要因素被拿的统计,第一边界层的厚度,骚乱模型和房间的拉丁方形的设计。壳的全部的抵抗被计算,在壳附近的流动地被 CFD 方法模仿。然后,壳抵抗上的无常因素的影响被回归分析与整修网孔讨论并且搅乱网孔。通过一系列计算和分析,最佳的计算方法被提出,并且计算的相关参数是坚定的。第三,不同速度的全部的抵抗被使用这些二种格子计算,它在对试验性的结果的好同意。最后,根据 ITTC 推荐了过程,在 CFD 的无常分析被格子的三个集合与一致精炼比率 rG = 与全部的抵抗的数字结果执行 2。当时,修改抵抗与试验性的结果相比,它改进了抵抗预言的精确性。 | WANG Zhongcheng LIU Xiaoyu ZHANG Shenglong XU Leping ZHOU Peilin | 2017 | Journal of Shipping and Ocean Engineering2017，7，5： | 0 |
| 19 | Cross-layer optimization in ultra wideband networks显示文摘Ultra wideband (UWB) network brings both chance and challenge to personal area wireless communications. Compared with other IEEE 802 small range wireless protocols (such as WLAN and Bluetooth), UWB has both extremely high bandwidth (up to 480 Mbps) and low radiation. Moreover, the structured MAC layer of UWB is the fundamental difference to WLAN. The top one is that only when two UWB de-vices belong to the same piconet can they communicate with each other directly, which means that we must jointly consider topology formation and routing when deploying UWB networks because the interaction between routing and topology formation makes separate optimization ineffective. This paper tries to optimize UWB network from a cross-layer point of view. Specifically, given device spatial distribution and traffic requirement, we want to form piconets and determine rout-ing jointly, to maximize the overall throughput. We formulate the problem of joint optimization to mixed-integer programming and give a practical lower bound that is very close to the theoretical upper bound in our simulation. Furthermore, our lower bound is much better than an algorithm that only considers topology formation in UWB networks. | WU Qi BI JingPing GUO ZiHua XIONG YongQiang ZHANG Qian LI ZhongCheng | 2007 | Science in China(Series F)2007，50，5： | 0 |
| 20 | The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera显示文摘To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA assay.Pseudotyped virus carrying a L452R-E484Q variant showed a comparable infectivity compared with D614G.However,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA vaccine.In addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman primates.These results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of SARS-CoV-2.Reduced neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development. | Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu Chengbin Guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
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