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| 1 | The Y.D.and climate abrupt events in the early and middle Holocene:Stalagmite oxygen isotope record from Maolan,Guizhou,China显示文摘The isotope records which range from 3.9 kaBP to 15.7 kaBP with an average resolution of 90 a have been obtained from 45 cm to 193.6 cm of the upper part of D4 stalagmite from Dongguo Cave in Libo, Guizhou, by using system TIMS U-series dating and carbon and oxygen stable isotope analyses.The study indicates that the last cold event, the YD (Younger Dryas) event, of the last glacial period was apparently shown in D4 record, which started from 12.80 kaBP and ended in 11.58 kaBP, with a great range of drop in temperature. The end of the last glacial period was consistent with the termination I in oceanic isotope records and was with time limit of 11.3 kaBP. The three most distinct cold events in the early and middle Holocene occurred respectively in 10.91 kaBP, 8.27 kaBP and 4.75 kaBP, with a range of drop in tem- perature reaching 2—5℃. The climate abrupt events in thousand and hundred years scale re- corded in stalagmite δ O can be compared to those in GISP2 ice cores from Greenland in their 18 happening time and the range of their lasting time. The cold events in 8.27 kaBP and 4.75 kaBP can also be compared to CC3 stalagmite records in Ireland, which indicate that climate changes of short range in China monsoon areas, western Europe and polar regions, have the same driv- ing factor. This has a global significance. In addition, the trend of record curves in some time- stages is apparently different, which reflects probably the difference between environment in monsoon climate areas and in polar regions. | QIN Jiaming1, YUAN Daoxian1, CHENG Hai2, LIN Yushi1, ZHANG Meiliang1, WANG Fuxing1, R. L. Edwards2, WANG Hua1 & RAN Jingcheng3 1. The Karst Dynamic Laboratory, IKG, CAGS, Guilin 541004, China 2. Geology and Geophysics Department, Minnesota University, MN55455, USA 3. The Management of Maolan National Nature Reserve, Libo 558400, China | 2005 | Science China Earth Sciences2005，48，4： | 23 |
| 2 | Diagenesis and Its Effect on Reservoir Quality of Silurian Sandstones,Tabei Area,Tarim Basin,China显示文摘The diagenetic processes of the Tabei sandstones in the Tarim Basin include compaction, cementation (quartz overgrowths, calcite, clay minerals and a minor amount of pyrite), and dissolution of the feldspar and calcite cement. Porosity was reduced by compaction from an assumed original 40% to about 22.1%. Cementation reduced porosity to 26.6%. The Tabei sandstones lost a little more porosity by compaction than by cementation. Quartz cementation, especially syntaxial quartz overgrowth, is a major cause of porosity-loss in many reservoirs in moderately to deeply buried sandstone. Calcite cementation played a key role in the porosity evolution of sandstones. At the early stage of burial, the early calcite cement occupied most of the pore spaces resulting in significant porosity. On the other hand, some primary porosity has been preserved due to incomplete filling or the presence of scattered patches of calcite cement. In addition to calcite, several clay minerals, including illite and chlorite occurred as pore-filling and pore-lining cements. The pore-lining chlorite may have helped in retaining the porosity by preventing the precipitation of syntaxial quartz overgrowths. Illite, which largely occurred as hair-like rims around the grains and bridges on the pore throats, caused a substantial deterioration of penetrability of the reservoir. Calcite cement dissolution was extensive and contributed significantly to the development of secondary porosity. | Zhang Jinliang Jia Ying Du Guilin | 2007 | Petroleum Science2007，4，3： | 21 |
| 3 | Clinical significance of serum intercellular adhesion molecule-1 detection in patients with hepatocellular carcinoma显示文摘INTRODUCTION Since the late 1980s,studies on the expression ofintercellular adhesion molecule-1(ICAM-1)inpatients with malignancies have demonstrated thatICAM-1 may strongly express in two forms in suchdiseases:membranous one on the surface of tumorcells(membrane-bound ICAM-1)and soluble one incirculation(soluble ICAM-1,sICAM-1). | Ming Hui Mei Jing Xu Qin Fen Shi Jing Hong Yang Qian CHen Li Ling Qin Department of Hepatobiliary Surgery, Institute of Hepatobiliary Surgery,Guilin Medical College,Guilin 541001,Guangxi Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 20 |
| 4 | Atmospheric lead pollution in fine particulate matter in Shanghai, China显示文摘The Pb-monitoring program was extended for 6 years from 2002 to 2007 at 17 representative urban sites (6 traffic, 5 industrial, and 6 residential sites), and 3 suburban sites to assess the lead pollution in fine particulate matter (PM2.5) after phasing out leaded gasoline in Shanghai. Compared with Pb levels reported in other places, the Pb pollution in Shanghai is still serious after phasing out leaded gasoline, which remains at high concentration range (213–176 ng/m3) in PM2.5 in winter. Significant spatial variation of Pb concentrations and strong seasonal variation of higher Pb concentration in winter than that in summer were detected. The size distribution of Pb in particulate matter has a unimodal mode that peaks at approximately 0.154–1.59 μm particle diameter, indicating that Pb is mainly concentrated in fine fraction. Lead in the fine fraction is enriched by a factor of 103–104 relative to Pb abundance in crust. Eight categories of Pb pollution sources were identified in the PM2.5 in the winter of 2007 in Shanghai. The important emission sources among them are vehicle exhaust derived from combustion of unleaded gasoline, metallurgic industry emission, and coal combustion emission. | LI Xiaolin ZHANG Yuanxun TAN Mingguang LIU Jiangfeng BAO Liangman ZHANG Guilin LI Yan IIDA Atsuo | 2009 | Journal of Environmental Sciences2009，21，8： | 20 |
| 5 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 6 | Evolution of Sedimentation and Tectonics of the Youjiang Composite Basin, South China显示文摘Located at the southern margin of the South China plate, the Youjiang basin is a closely related to the NW- and NE-trending syndepositional faults in respect to the configuration and structure of the basin. The evolution of the Youjiang basin progressed through two stages. In the Hercynian period, the opening of the Ailaoshan-Honghe ocean basin gave rise to a number of NW-trending rift belts in the Youjiang area. During this period, deep-water sediments were dominant and the basin was possesed of the characteristics of the rift system of passive continental margins. In the early Indosinian after the Dongwu movement, the circum - Pacific tectonism led to a major change in the configuration and structure of the basin. In the meantime, the Ailaoshan ocean basin began to be subducted towards the northeast, thus causing the basin to be split and expand again, and then the basin developed into the stage of the back -arc basin. At the end of the Indosinian period, the basin gradually closed from east to west, | Zeng Yunfu, Liu Wenjun, Cheng Hongde, Zheng Rongcai, Zhang Jinquan Chengdu Institute of Technology, Chengdu, SichuanLi Xiaoquan and Jiang Tingcao Regional Geological Survey Party of Guangxi,Guilin,Guangxi Jiang M inxi | 1995 | Acta Geologica Sinica(English Edition)1995，69，4： | 18 |
| 7 | The δ^(18)O variation of a stalagmite from Qixing Cave,Guizhou Province and indi-cated climate change during the Holocene显示文摘A stalagmite from Qixing Cave, Guizhou Province was dated with the TIMS U-series method and its oxygen isotope composition was analyzed. On the basis of the ages and the variations of the δ18O of the stalagmite, the climate change of the last 7.7 ka has been reconstructed in this area: 7.7-5.8 ka, summer monsoon maximum period; 5.8-3.8 ka summer monsoon weakening period; 3.8-0.15 ka, weakened summer monsoon and high amplitude climate fluctuations period. We put forward that the increasing trend of δ18O of the stalagmite reflected not only the weakening of the summer monsoon, which was caused by the decreasing of solar radiation in the Northern Hemisphere, but also the possibly decreasing contribution of the southwest monsoon to the rainfall of this area. These results are consistent with the output of the numerical climate-model modeling. The high amplitude fluctuation of the δ18O may imply the quick shift of the contributions of different moisture sources to the precipitation in this area. | CAI Yanjun, ZHANG Meiliang, PENG Zicheng, LIN Yushi, AN Zhisheng, ZHANG Zhaofeng & CAO YunningState Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710054, China Karst Dynamics Laboratory, Ministry of Land and Resources, Guilin 541003, China Department of Earth and Space Science, University of Science & Technology of China, Hefei 230023, China | 2001 | Chinese Science Bulletin2001，46，22： | 18 |
| 8 | A Review on Graphene-Based Gas/Vapor Sensors with Unique Properties and Potential Applications显示文摘Graphene-based gas/vapor sensors have attracted much attention in recent years due to their variety of structures, unique sensing performances, room-temperature working conditions, and tremendous application prospects, etc.Herein, we summarize recent advantages in graphene preparation, sensor construction, and sensing properties of various graphene-based gas/vapor sensors, such as NH_3, NO_2, H_2, CO, SO_2, H_2S, as well as vapor of volatile organic compounds.The detection mechanisms pertaining to various gases are also discussed. In conclusion part, some existing problems which may hinder the sensor applications are presented. Several possible methods to solve these problems are proposed, for example, conceived solutions, hybrid nanostructures, multiple sensor arrays, and new recognition algorithm. | Tao Wang Da Huang Zhi Yang Shusheng Xu Guili He Xiaolin Li Nantao Hu Guilin Yin Dannong He Liying Zhang | 2016 | Nano-Micro Letters2016，8，2： | 18 |
| 9 | High-resolution climate variability of southwest China during 57―70 ka reflected in a stalagmite δ^(18)O record from Xinya Cave显示文摘A 26-cm-long stalagmite (XY2) from Xinya Cave in northeastern Chongqing of China has been ICP-MS 230Th/U dated, showing a depositional hiatus at 2.3 cm depth from the top. The growth of the 2.3―26 cm interval determined by four dates was between 57 ka and 70 ka, with a linear growth rate of 0.023 mm/a. We have analyzed 190 samples for δ 18O and δ 13C, mostly in the 2.3―26 cm part. The δ 18O and δ 13C values between 57 ka and 70 ka reveal decadal-to-centennial climatic variability during the glacial in-terval of Marine Isotope Stage 4 (MIS4), exhibiting much higher resolution than that of the published Hulu and Dongge records during this interval. Speleothem δ 18O in eastern China, including our study area can be used as a proxy of summer monsoon strength, with lighter values pointing to stronger summer monsoon and higher precipitation, and vice versa. Two decreases in the δ 18O signature of XY2 record around 59.5 and 64.5 Ka are argued to correspond to the Dansgaard-Oeschger (D-O) events 17 and 18 respectively. The Heinrich event 6 (H6) can be identified in the record as a heavy δ 18O peak around 60 ka, indicating significant weakening of the monsoon in Chongqing during the cold period. The XY2 δ 18O record shows very rapid change toward to the interstadial condition of the D-O event, but more gradual change toward to the cold stadial condition. This phenomenon found in the Greenland ice core records is rarely observed so clearly in previously published speleothem records. According to SPECMAP δ 18O record, the glacial maximum of MIS 4 was around 64.5 ka with the boundary of MIS 3/4 around 60 ka. Unlike the marine record, the speleothem record of XY2, China, exhibits much high fre-quency variations without an apparent glacial maximum during MIS 4. However, the timing of MIS 3/4 boundary seems to be around 60 ka when the H6 terminated, in agreement with the marine chronology. The growth period of sample XY2 during glacial times probably reflects a local karstic routing of water, rather than having climatic significance. | LI TingYong1, YUAN DaoXian1,2, LI HongChun1,3 ,YANG Yan2, WANG JianLi1, WANG XinYa1, LI JunYun1, QIN JiaMing2, ZHANG MeiLiang2 & LIN YuShi2 1 College of Geographical Science, Southwest University, Chongqing 400715, China 2 Karst Dynamics Laboratory, Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004, China 3 Department of Earth Sciences, Cheng-Kung University, Tainan 70101, Taiwan, China | 2007 | Science China Earth Sciences2007，50，8： | 14 |
| 10 | Expressions of ICAM-1 and its mRNA in sera and tissues of patients with hepatocellular carcinoma显示文摘INTRODUCTIONThe increased expression of ICAM-1 on a widerange of cells and in the sera of patients withmalignancies, chronic liver diseases andinflammation diseases has been described since thelate 1980s[1-22]. Recently rapid progress in studieson expression of ICAM-1 in patients withhepatocellular carcinoma ( HCC ) have beenachieved, including clinical and experimentalresearches[23-31]. | Jing Xu1 Ming Hui Mei1 Si En Zeng2 Qing Fen Shi3 Yong Ming Liu4 Li Ling Qin3 1Department of Hepatobiliary Surgery2Department of Pathology3Institute of Hepatobiliary Surgery4Department of Biochemistry, Guilin 541001, Guangxi Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 14 |
| 11 | Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element显示文摘杀死肿瘤的基因的 Glioma 特定的抄写作为有希望的基因被利用了在 glioma 病人的治疗学的形式。Musashi1 (Msi1 ) 和 GFAP 基因倡导者两个都是癌症特定的倡导者。优化 HIF 有约束力的地点(optHBS ) 顺序最新象在癌症基因治疗用作 enhancer 的 EPO HRE 一样被发现有效。我们构造了 4optHBS-Msi1/GFAP 倡导者并且测试了他们的能力调停在 glioma 房间导致 apoptosis 的 BAX 表示排队。我们的结果证明 4optHBS-Msi1/GFAP 倡导者是有在指向的 glioma 基因治疗的潜在的申请的显然强壮、 glioma 选择的倡导者,并且 4optHBS-Msi1/GFAP-BAX 是为 glioma 基因治疗的珍贵工具。 | Jiwei Huang Jun Gao Xiang Lv Guilin Li Delong Hao Xiaoying Yao Liquan Zhou Depei Liu Renzhi Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 11 |
| 12 | Reform of Carbonate Rock Subsurface by Crustose Lichens and Its Environmental Significance显示文摘Crustose lichens are distributed extensively in karst areas in Southern China. They can be found on the surface of carbonate rocks. Through biophysical and biochemical processes, crustose lichens reform the subsurface of carbonate rocks and in the meanwhile change their physical and chemical properties: (1) the mechanical strength decreases by 17.04° on average (up to 33.2° ); (2) the chemical solution surface area increases from 28.26% to 75.36% (lichen microholes considered only); and (3) the water-holding capacity is greatly improved. Comparative field experiments between biokarst samples underneath crustose lichens and fresh rock samples with the same composition and texture show that the corrosional rate of carbonate rocks of the former is 1.264-1.643 times higher than that of the latter. Crustose lichens are considered as an activator of the surface corrosion of carbonate rocks. | CAO Jianhua and WANG FuxingInstitute of Karst Geology, Chinese Academy of Geological Sciences, Guilin, Guanxi 541004 Xiao Pinfang Liu Xinzhu | 1998 | Acta Geologica Sinica(English Edition)1998，72，1： | 10 |
| 13 | Equilibrium dialysis study on the interaction between Cu(Ⅱ) and HSA or BSA显示文摘The interaction of Cu(Ⅱ) and human serum albumin (HSA) or bovine serum albumin (BSA) at physiological pH is studied by equilibrium dialysis. The successive stability constants are obtained by non-linear least square methods fitting Bjerrum formula. For both the Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA systems, the order of magnitude of K 1 and K 2 was found to be ≈10 4 mol -1·dm 3. There are about twenty stoichiometry binding sites found in one HSA or BSA molecule. They can be divided into two or three sets. Results of equilibrium dialysis experiments suggest that there exists one strong metal binding site in both Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA. It is the imidazol group nitrogen atoms of His 3 that are primarily concerned with copper binding site. After reaching dialysis equilibrium, there is the interaction among the different binding sites, the values of K all deviate from the simple statistical effect except for K-1 and K-2 in both Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA systems, and the positive cooperative effect is found. | LIANG Hong 1, XIN Bengang 1, WANG Xiujian 1, YUAN Yuzhou 1, ZHOU Yongqia 2 and SHEN Panwen 2 1. Department of Chemistry, Guangxi Normal University, Guilin 541004, China 2. Department of Chemistry, Nankai University, Tianjin 300071, China | 1998 | Chinese Science Bulletin1998，43，5： | 10 |
| 14 | The record of paleoclimatic change from stalagmites and the determination of termination II in the south of Guizhou Province, China显示文摘A high-resolution climate record from 163.00 kaBP to 113.80 kaBP has been obtained through TIMS-U series dating and carbon and oxygen isotope analysis of the three large stalagmites from two caves in the south of Guizhou Province, China. The record of the oxygen isotopes from the stalagmites reveals that the undulation characteristics between the cooling event of the glacial period and the warming event of the interglacial period in the research area can compare well to those of ice cores, lake sediments, loess and deep sea sediments on the scale of ten-thousand years or millennium time scale. The climate undulation provided by the record of the stalagmites has a coherence with the global changes and a tele-connection to the paleoclimate changes in the north polar region. Our results suggest that the direct dynamics of paleo-monsoon circulation changes reflected in the record of the stalagmites might be caused by changes of the global ice volume, and in turn related to various factors, including the solar radiation strength at the mid-latitudes in the Northern Hemisphere, the southern extension of the ice-rafted event in the North Atlantic, and changes of the equatorial Pacific sea surface temperature at the low-latitudes. Using δ18O values, we have calculated the temperatures and the results show that the temperature difference between the penultimate glacial period (with an average temperature of 8.1℃, and a minimum temperature range from 0.65℃ to -1.43℃ at stage 6 ) and the last interglacial period (with an average temperature of 18.24℃ at sub-stage 5e ) was about 10℃. This temperature difference from the record of the stalagmites corresponds in general to the record temperature variation (about 10℃) of measured ice cores. The climate records from the three stalagmites in the two caves have shown that the circulation strength of the Asian summer monsoon and the winter monsoon in the penultimate glacial period and the last interglacial period had a clear change. With the TIMS-U series method, termination II of the penultimate glacial period has been precisely dated at an age of (129.28±1.10) kaBP for the three stalagmites in the south of Guizhou Province, China. This borderline age represents the beginning of the last interglacial period or the boundary between the Middle Pleistocene and the Late Pleistocene, and corresponds to the beginning age of the last interglacial period shown by the ice cores and in the SPECMAP curve of the marine oxygen isotopes. The chronology determination of termination II is not only of stratigraphic and chronological significance, but also lays an important foundation for discussing the short time scales of climate oscillation and rapidly changing events of paleoclimate in the circulation region of the East Asian monsoon. | ZHANG Meiliang, YUAN Daoxian1, LIN Yushi, CHENG Hai, QIN Jiaming &ZHANG HuilingKarst Dynamics Laboratory, Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004, China Geography Department, Minnesota University, MN 55455, USA Correspondence should be addressed to Zhang Meiliang | 2004 | Science China Earth Sciences2004，47，1： | 9 |
| 15 | Sulfur speciation and bioaccumulation in camphor tree leaves as atmospheric sulfur indicator analyzed by synchrotron radiation XRF and XANES显示文摘Analyzing and understanding the effects of ambient pollution on plants is getting more and more attention as a topic of environmental biology.A method based on synchrotron radiation X-ray fluorescence and X-ray absorption near edge structure spectroscopy was established to analyze the sulfur concentration and speciation in mature camphor tree leaves (CTLs),which were sampled from 5 local fields in Shanghai,China.Annual SO2 concentration,SO42-concentration in atmospheric particulate,SO42-and sulfur concentration in soil were also analyzed to explore the relationship between ambient sulfur sources and the sulfur nutrient cycling in CTLs.Total sulfur concentration in mature camphor tree leaves was 766-1704 mg/kg.The mainly detected sulfur states and their corresponding compounds were +6 (sulfate,include inorganic sulfate and organic sulfate),+5.2 (sulfonate),+2.2 (suloxides),+0.6 (thiols and thiothers),+0.2 (organic sulfides).Total sulfur concentration was strongly correlated with sulfate proportion with a linear correlation coefficient up to 0.977,which suggested that sulfur accumulated in CTLs as sulfate form.Reduced sulfur compounds (organic sulfides,thiols,thioethers,sulfoxide and sulfonate) assimilation was sufficed to meet the nutrient requirement for growth at a balanced level around 526 mg/kg.The sulfate accumulation mainly caused by atmospheric sulfur pollution such as SO2 and airborne sulfate particulate instead of soil contamination.From urban to suburb place,sulfate in mature CTLs decreased as the atmospheric sulfur pollution reduced,but a dramatic increase presented near the seashore,where the marine sulfate emission and maritime activity pollution were significant.The sulfur concentration and speciation in mature CTLs effectively represented the long-term biological accumulation of atmospheric sulfur pollution in local environment. | Jianrong Zeng Guilin Zhang Liangman Bao Shilei Long Mingguang Tan Yan Li Chenyan Ma Yidong Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 16 | A new grid-associated algorithm in the distributed hydrological model simulations显示文摘This paper presents a new grid-associated algorithm to improve the performance of a D8 algorithm based distributed hydrological model computation.The algorithm is based on the well known single-flow D8 algorithm of grid flow.This algorithm allocates calculation priorities according to the distance between the units and the outlet,then carries out the ergodic computations of the hydrological units according to the priority division.For the parallelized algorithm,a standard thread-level shared memory system for parallel programming(OpenMP-Open specifications for Multi Processing) was introduced,and the parallel coding was implemented in C lan-guage.A case study showed that the absolute speed-up ratio of the grid-associated algorithm is 1.64 over the original D8 algorithm,and the linear speed-up ratio of the parallel associated algorithm is 2.42 under 4 cores.The parallel grid-associated algorithm can be applied to a variety of research fields that use the grid method. | XU Rui1,2,HUANG XiaoXue1,LUO Lin1 & LI ShaoCai3 1 State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and Environment,Sichuan University,Chengdu 610065,China 2 College of Electronic Engineering,Guilin University of Electronic Technology,Guilin 541004,China 3 College of Life Sciences,Sichuan University,Chengdu 610065,China | 2010 | Science China(Technological Sciences)2010，53，1： | 8 |
| 17 | FAST RECURSIVE LEAST SQUARES LEARNING ALGORITHM FOR PRINCIPAL COMPONENT ANALYSIS显示文摘Based on the least-square minimization a computationally efficient learning algorithm for the Principal Component Analysis(PCA) is derived. The dual learning rate parameters are adaptively introduced to make the proposed algorithm providing the capability of the fast convergence and high accuracy for extracting all the principal components. It is shown that all the information needed for PCA can be completely represented by the unnormalized weight vector which is updated based only on the corresponding neuron input-output product. The convergence performance of the proposed algorithm is briefly analyzed.The relation between Oja’s rule and the least squares learning rule is also established. Finally, a simulation example is given to illustrate the effectiveness of this algorithm for PCA. | Ouyang Shan Bao Zheng Liao Guisheng(Guilin Institute of Electronic Technology, Guilin 541004)(Key Laboratory of Radar Signal Processing, Xidian Univ., Xi’an 710071) | 2000 | Journal of Electronics(China)2000，17，3： | 8 |
| 18 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 19 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 20 | Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses显示文摘IntroductionLung cancer is the most common cancer worldwide.In the United States,it causes more cancer-related deaths than the next four causes(breast cancer,prostate cancer,colon cancer,and pancreatic cancer)of cancer-related mortality combined(1).About 30% of people have already | Wenlong Shao Wei Wang Weiqiang Yin Zhihua Guo Guilin Peng Ying Chen Jianxing He | 2013 | Chinese Journal of Cancer Research2013，25，1： | 7 |
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