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| 1 | Kiwifruit Genome Database(KGD):a comprehensive resource for kiwifruit genomics显示文摘Kiwifruit(Actinidia spp.)plants produce economically important fruits containing abundant,balanced phytonutrients with extraordinarily high vitamin C contents.Since the release of the first kiwifruit reference genome sequence in 2013,large volumes of genome and transcriptome data have been rapidly accumulated for a handful of kiwifruit species.To efficiently store,analyze,integrate,and disseminate these large-scale datasets to the research community,we constructed the Kiwifruit Genome Database(KGD;http://gffzz6fc08c45f9754a68hvwvpp5cwqqfn6wou.ffgz.tsg.suse.edu.cn/).The database currently contains all publicly available genome and gene sequences,gene annotations,biochemical pathways,transcriptome profiles derived from public RNA-Seq datasets,and comparative genomic analysis results such as syntenic blocks and homologous gene pairs between different kiwifruit genome assemblies.A set of user-friendly query interfaces,analysis tools and visualization modules have been implemented in KGD to facilitate translational and applied research in kiwifruit,which include JBrowse,a popular genome browser,and the NCBI BLAST sequence search tool.Other notable tools developed within KGD include a genome synteny viewer and tools for differential gene expression analysis as well as gene ontology(GO)term and pathway enrichment analysis. | Junyang Yue Jiacheng Liu Wei Tang Ya Qing Wu Xiaofeng Tang Wei Li Ying Yang Lihuan Wang Shengxiong Huang Congbing Fang Kun Zhao Zhangjun Fei Yongsheng Liu Yi Zheng | 2020 | Horticulture Research2020，7，1： | 6 |
| 2 | Young's modulus for laminated machine structures with particular reference to switched reluctance motor vibrations显示文摘 | Tang Zhangjun Pillay P Omekanda A M | 2004 | IEEE Transactions on Industry Applications2004，40，3： | 1 |
| 3 | Prediction of Electromagnetic Forces and Vibrations in SRMs Operating at Steady-state and Transient Speeds 显示文摘 | Tang Zhangjun Pragasen Pillay Chen Yicheng | 2005 | Electric Industry Applica- tion2005，41，4： | 1 |
| 4 | Young' s modu- lus for laminated machine structures with particular reference to switched reluctance motor vibrations 显示文摘 | TANG Zhangjun PILLAY P OMEKANDA A M | 2004 | IEEE Transactions on In- dustry Applications2004，40，3： | 1 |
| 5 | Impact of stator windings and end-bells on resonant frequencies and modal shapes of switched reluctance motors显示文摘 | Cai Wei Pragasen Pillay Tang Zhangjun | 2002 | IEEE Transactions on Industry Applications2002，38，4： | 1 |
| 6 | Impact of stator windings and end bells on resonant frequencies and mode shapes of switched reluctance motors 显示文摘 | CAI Wei PILLAY P TANG Zhangjun | 2002 | IEEE Transactions on Industry Applica- tions2002，38，4： | 1 |
| 7 | Young’s modulus for laminated machine structures with particular reference to switched reluctance motor vibrations显示文摘 | Tang Zhangjun Pragasen Pillay Avoki M Omekanda | 2004 | IEEE Transactions on Industry Applica- tions2004，40，3： | 1 |
| 8 | Vibration Prediction in Switched Reluctance Motors With Transfer Function Identification from Shaker and Force Hammer Tests 显示文摘 | Zhangjun Tang Pillay P Omekanda A M | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 9 | Impact of stator windings and end -bells on resonant frequencies and mode shapes of switched reluc- tance motors 显示文摘 | Cai W Pillay P Tang Zhangjun | 2002 | IEEE Transactions on Industry Applications2002，38，4： | 1 |
| 10 | Impact of stator windings and end-bells on resonant frequencies and mode shapes of switched reluctancemotors显示文摘 | Wei Cai Pillay P Zhangjun Tang | 2002 | Industry Applications IEEE Transactions on2002，38，4： | 1 |
| 11 | Young's modulus for laminated machine structures with particular reference to switched reluctance motor vibrations显示文摘 | Tang Zhangjun Pillay P Omekanda A M | 2004 | Industry Applications IEEETransactions on2004，40，3： | 1 |
| 12 | Low - Vibration Design of Switched Reluctance Motors for Automotive Applications Using Modal Analysis 显示文摘 | Cai Wei Pragasen Pillay Tang Zhangjun | 2003 | IEEE Transactions on Industryl Applications2003，27，4： | 1 |
| 13 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 14 | 靶向eIF4AI的N-末端抑制其催化循环显示文摘文章简介蛋白翻译是中心法则的最后一环,是控制细胞内蛋白质稳态的关键生命过程。蛋白翻译起始是整个翻译过程中最关键的限速步骤,翻译过程的失调与神经发育类疾病以及恶性肿瘤等多种疾病密切相关。真核蛋白翻译起始因子eIF4A是最早被发现的DEAD盒(DEAD-box)RNA解旋酶超家族成员。 | 蒋晨晓 汤叶根 丁露露 Renke Tan Xiaojing Li Junyan Lu Jing Jiang Zhaomeng Cui Zhewei Tang Wei Li Zhangjun Cao Tilman Schneider-Poetsch Wei Jiang Cheng Luo 丁滪 刘建伟 党永军 | 2020 | 科学新闻2020，，2： | 0 |
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