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您的检索式：作者名="Zhangyuan Lin"
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| 1 | miR-23a/b regulates the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells显示文摘Age-related osteoporosis is associated with the reduced capacity of bone marrow mesenchymal stem cells(BMSCs) to differentiate into osteoblasts instead of adipocytes. However, the molecular mechanisms that decide the fate of BMSCs remain unclear. In our study, micro RNA-23 a, and micro RNA-23b(mi R-23a/b) were found to be markedly downregulated in BMSCs of aged mice and humans. The overexpression of mi R-23a/b in BMSCs promoted osteogenic differentiation, whereas the inhibition of mi R-23a/b increased adipogenic differentiation. Transmembrane protein 64(Tmem64), which has expression levels inversely related to those of mi R-23a/b in aged and young mice, was identified as a major target of mi R-23a/b during BMSC differentiation. In conclusion, our study suggests that mi R-23a/b has a critical role in the regulation of mesenchymal lineage differentiation through the suppression of Tmem64. | Qi Guo Yusi Chen Lijuan Guo Tiejian Jiang Zhangyuan Lin | 2016 | Bone Research2016，4，2： | 12 |
| 2 | Causal associations of brain structure with bone mineral density:a large-scale genetic correlation study显示文摘In this study,we aimed to investigate the causal associations of brain structure with bone mineral density(BMD).Based on the genome-wide association study(GWAS)summary statistics of 1325 brain imaging-derived phenotypes(BIDPs)of brain structure from the UK Biobank and GWAS summary datasets of 5 BMD locations,including the total body,femoral neck,lumbar spine,forearm,and heel from the GEFOS Consortium,linkage disequilibrium score regression(LDSC)was conducted to determine the genetic correlations,and Mendelian randomization(MR)was then performed to explore the causal relationship between the BIDPs and BMD.Several sensitivity analyses were performed to verify the strength and stability of the present MR outcomes.To increase confidence in our findings,we also performed confirmatory MR between BIDPs and osteoporosis.LDSC revealed that 1.93%of BIDPs,with a false discovery rate(FDR)<0.01,were genetically correlated with BMD.Additionally,we observed that 1.31%of BIDPs exhibited a significant causal relationship with BMD(FDR<0.01)through MR.Both the LDSC and MR results demonstrated that the BIDPs“Volume of normalized brain,”“Volume of gray matter in Left Inferior Frontal Gyrus,pars opercularis,”“Volume of Estimated Total Intra Cranial”and“Volume-ratio of brain segmentation/estimated total intracranial”had strong associations with BMD.Interestingly,our results showed that more left BIDPs were causally associated with BMD,especially within and around the left frontal region.In conclusion,a part of the brain structure causally influences BMD,which may provide important perspectives for the prevention of osteoporosis and offer valuable insights for further research on the brain-bone axis. | Bin Guo Chao Wang Yong Zhu Zhi Liu Haitao Long Zhe Ruan Zhangyuan Lin Zhihua Fan Yusheng Li Shushan Zhao | 2023 | Bone Research2023，11，3： | 0 |
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