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| 1 | γ⁃Fe2O3@carboxymethyl Cellulose as Potential Oral Nanomedicine for Iron Deficiency Anemia Treatment on Rats显示文摘Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal adverse impact caused by Fe2+stimulus and low bioavailability severely impedes its therapeutic effects.In recent years,it has been found that nano iron⁃based nanoparticles with high surface⁃to⁃volume ratio and low iron ion leakage can alleviate the toxic effect and improve the gastrointestinal absorbance.For further clinical development,nano materials need to meet the pharmaceutical quality demand.Carboxymethyl cellulose(CMC)is a significant pharmaceutical ingredient applied in approved drug formulations,and polyglucosorbitol carboxymethylether(PSC)has been utilized in iron⁃based nanomedicine ferumoxytol synthesis,both of which can be firmly anchored on iron oxide by carboxyl chelation.In this work,iron oxide nanoparticles(NPs)modified with CMC were designed and synthesized,and the structure composition and physicochemical properties were distinctly characterized.Oral supplement effects on rat IDA were investigated and compared with other recently reported iron supplements including NPs modified with PSC.Results show that the oral nano iron supplement achieved the recovery of hemoglobin and serum iron level in only two weeks with high safety.The nano iron oxide modified with pharmaceutical excipients provides new potential approach for oral iron supplement available in clinics. | Bo Chen Peng Zhao Qiwei Wang Zhanhang Guo Xin Liu Yan Li Yue Zhang Min Ji Ning Gu | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，3： | 2 |
| 2 | Recovery of injured corticospinal tracts after late recanalisation of basilar artery occlusion显示文摘In this study,we performed emergency stent angioplasty in a patient with basilar artery occlusion(BAO)at 21 hours after onset.Serial diffusion tensor tract imaging revealed that the ischaemic corticospinal tracts(CSTs),which passed through pontine infarct,rapidly recovered to normal level even after delayed reperfusion.This case provided in vivo evidences that ischaemic white matter was still salvageable even after prolonged ischaemia.It also provided a new method(diffusion tensor tract imaging)and a novel therapeutic target(white matter)in the evaluation and treatment of acute BAO. | Xiaodi Li Yuzhou Wang Zhanhang Wang Peiming Wang Chuanxing Shao Jinlong Ye | 2018 | Stroke & Vascular Neurology2018，3，4： | 2 |
| 3 | Experimental study of interactions between multi-directional focused wave and vertical circular cylinder, Part I: Wave run-up显示文摘 | Jinxuan Li Zhanhang Wang Shuxue Liu | 2012 | Coastal Engineering2012，，： | 1 |
| 4 | PRELIMINARY RESULTS OF VALIDATION OF A NEW PATIENT-REPORTED OUTCOME INSTRUMENT FOR ADVANCED CHRONIC KIDNEY DISEASE显示文摘The uremic symptoms of advanced chronic kidney disease(CKD)can severely impair physical function,psychological health and social life.Some patients,especially for the older,chose conservative kidney management(CKM)and Traditional Chinese medicine(TCM)but not dialysis in this stage.To measure the patients-reported outcome(PRO)from these people,Advanced Chronic Kidney | Li Chuang Qu Zhanhang Mao Wei Xu Peng Wu Yifan Liu Sujun Liu Xusheng | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
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