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| 1 | Gain-of-function mutant p53 in cancer progression and therapy显示文摘p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human cancers.Most of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 protein.In addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its GOF.Given the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great interest.Further understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing mutp53.In this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers. | Cen Zhang Juan Liu Dandan Xu Tianliang Zhang Wenwei Hu Zhaohui Feng | 2020 | Journal of Molecular Cell Biology2020，12，9： | 18 |
| 2 | Tumor suppressor p53 and its gain-of-function mutants in cancer显示文摘肿瘤 suppressor p53 在肿瘤抑制起一个枢轴的作用。p53 是在癌症的最经常变异的基因。作为 transcriptionfactor, p53 主要通过它的下游的目标 genes.Thus, p53 和它的目标基因形式的 transcriptional 规定在肿瘤抑制施加它的角色表明小径调整许多生物过程 toprevent tumorigenesis 的复杂 p53。最近的研究除了 apoptosis ,房间周期拘捕和老朽揭示了那,在新陈代谢和抗氧化剂防卫进一步在肿瘤 suppression.Studies 显著地贡献到它的角色的精力的规定的 p53'sfunctions 表演许多联系肿瘤的变异的 p53 蛋白质不仅失去肿瘤 wild-typep53 的镇压功能,而且获得独立于野类型的 p53 的新 oncogenic 活动包括支持肿瘤房间增长,幸存,新陈代谢的变化,野类型的 p53 功能的 frequentloss 和在肿瘤使 p53 成为的人的变异的 p53 的 gain-of-function 极其吸引人的 targetfor 癌症治疗。不同策略和许多小分子的药为基于 p53 的肿瘤 therapy.Here 正在被开发,我们在肿瘤开发在肿瘤抑制和 gain-of-function 异种 p53 考察 p53 的机制,也 asthe 在基于 p53 的肿瘤治疗的发展的最近的进展。 | Juan Liu Cen Zhang Zhaohui Feng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 15 |
| 3 | Tumor suppressor p53 cross-talks with TRIM family proteins显示文摘p53 is a key tumor suppressor.As a transcription factor,p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor suppression.In addition to tumor suppression,p53 is also involved in many other physiological and pathological processes,e.g.anti-infection,immune response,development,reproduction,neurodegeneration and aging.To maintain its proper function,p53 is under tight and delicate regulation through different mechanisms,particularly the posttranslational modifications.The tripartite motif(TRIM)family proteins are a large group of proteins characterized by the RING,B-Box and coiled-coil(RBCC)domains at the N-terminus.TRIM proteins play important roles in regulation of many fundamental biological processes,including cell proliferation and death,DNA repair,transcription,and immune response.Alterations of TRIM proteins have been linked to many diseases including cancer,infectious diseases,developmental disorders,and neurodegenera-tion.Interestingly,recent studies have revealed that many TRIM proteins are involved in the regulation of p53,and at the same time,many TRIM proteins are also regulated by p53.Here,we review the cross-talk between p53 and TRIM proteins,and its impact upon cellular biological processes as well as cancer and other diseases. | Juan Liu Cen Zhang Xue Wang Wenwei Hu Zhaohui Feng | 2021 | Genes & Diseases2021，8，4： | 5 |
| 4 | Tumor suppressor p53 and metabolism显示文摘p53 plays a key role in tumor suppression. The tumor suppressive function of p53 has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence in cells. However, recent studies suggest that other functions of p53 also contribute to its role as a tumor suppressor, such as its function in metabolic regulation. p53 regulates various metabolic pathways to maintain the metabolic homeostasis of cells and adapt cells to stress. In addition, recent studies have also shown that gain-offunction (GOF) mutant p53 proteins drive metabolic reprogramming in cancer cells, contributing to cancer progression. Further understanding of p53 and its GOF mutants in metabolism will provide new opportunities for cancer therapy. | Juan Liu Cen Zhang Wenwei Hu Zhaohui Feng | 2019 | Journal of Molecular Cell Biology2019，11，4： | 5 |
| 5 | Tumor suppressor p53 meets microRNAs显示文摘Tumor suppressor p53 plays a central role in tumor prevention.As a transcription factor,p53 mainly exerts its function through transcription regulation of its target genes to initiate various cellular responses.To maintain its proper function,p53 is tightly regulated by a wide variety of regulators in cells.Thus,p53,its regulators and regulated genes form a complex p53 network which is composed of hundreds of genes and their products.microRNAs(miRNAs)are a class of endogenously expressed,small non-coding RNA molecules which play a key role in regulation of gene expression at the post-transcriptional level.Recent studies have demonstrated that miRNAs interact with p53 and its network at multiple levels.p53 regulates the transcription expression and the maturation of a group of miRNAs.On the other hand,miRNAs can regulate the activity and function of p53 through direct repression of p53 or its regulators in cells.These findings have demonstrated that miRNAs are important components in the p53 network,and also added another layer of complexity to the p53 network. | Zhaohui Feng Cen Zhang Rui Wu Wenwei Hu | 2011 | Journal of Molecular Cell Biology2011，3，1： | 2 |
| 6 | Parkinson’s disease-associated protein Parkin: an unusual player in cancer显示文摘The mutation of the Parkin gene is a cause of familial Parkinson’s disease.A growing body of evidence suggests that Parkin also functions as a tumor suppressor.Parkin is an ubiquitin E3 ligase,and plays important roles in a variety of cellular processes implicated in tumorigenesis,including cell cycle,cell proliferation,apoptosis,metastasis,mitophagy and metabolic reprogramming.Here we review the role and mechanism of Parkin in cancer. | Juan Liu Cen Zhang Wenwei Hu Zhaohui Feng | 2018 | Cancer Communications2018，38，1： | 2 |
| 7 | Sensor fault-tolerant observer applied in satellite attitude control显示文摘The observing failure and feedback instability might happen when the partial sensors of a satellite attitude control sys- tem (SACS) go wrong. A fault diagnosis and isolation (FDI) method based on a fault observer is introduced to detect and isolate the fault sensor at first. Based on the FDI result, the object system state-space equation is transformed and divided into a corresponsive triangular canonical form to decouple the normal subsystem from the fault subsystem. And then the KX fault-tolerant observers of the system in different modes are designed and embedded into online monitoring. The outputs of all KX fault-tolerant observers are selected by the control switch process. That can make sense that the SACS is part-observed and in stable when the partial sensors break down. Simulation results demonstrate the effectiveness and superiority of the proposed method. | Jiaolong Wei Zhaohui Cen Rui Jiang | 2012 | Journal of Systems Engineering and Electronics2012，23，1： | 2 |
| 8 | Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504显示文摘 | Wenwei Hu Chang S. Chan Rui Wu Cen Zhang Yvonne Sun Jun S. Song Laura H. Tang Arnold J. Levine Zhaohui Feng | 2010 | Molecular Cell2010，，： | 1 |
| 9 | 帕金森病相关蛋白Parkin:癌症中一个不同寻常的角色显示文摘Parkin基因的突变可引起家族性帕金森病。越来越多的证据表明,Parkin也可作为肿瘤抑制因子来发挥功能。Parkin是一种E3泛素连接酶,在与肿瘤发生相关的各种细胞过程中起到重要的作用,包括细胞周期、细胞增殖、凋亡、转移、线粒体自噬和代谢重编程。在此,我们对Parkin在癌症中的作用和机制进行综述。 | Juan Liu Cen Zhang Wenwei Hu Zhaohui Feng | 2018 | 癌症2018，37，4： | 0 |
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