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| 1 | Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress,protecting mitochondrial function,and regulating metabolic pathways显示文摘The development of acute liver injury can result in liver cirrhosis,liver failure,and even liver cancer,yet there is currently no effective therapy for it.The purpose of this study was to investigate the protective effect and therapeutic mechanism of Lycium barbarum polysaccharides(LBPs)on acute liver injury induced by carbon tetrachloride(CCl_(4)).To create a model of acute liver injury,experimental canines received an intraperitoneal injection of 1 mL/kg of CCl_(4)solution.The experimental canines in the therapy group were then fed LBPs(20 mg/kg).CCl_(4)-induced liver structural damage,excessive fibrosis,and reduced mitochondrial density were all improved by LBPs,according to microstructure data.By suppressing Kelch-like epichlorohydrin(ECH)-associated protein 1(Keap1),promoting the production of sequestosome 1(SQSTM1)/p62,nuclear factor erythroid 2-related factor 2(Nrf2),and phaseⅡdetoxification genes and proteins downstream of Nrf2,and restoring the activity of anti-oxidant enzymes like catalase(CAT),LBPs can restore and increase the antioxidant capacity of liver.To lessen mitochondrial damage,LBPs can also enhance mitochondrial respiration,raise tissue adenosine triphosphate(ATP)levels,and reactivate the respiratory chain complexes I–V.According to serum metabolomics,the therapeutic impact of LBPs on acute liver damage is accomplished mostly by controlling the pathways to lipid metabolism.9-Hydroxyoctadecadienoic acid(9-HODE),lysophosphatidylcholine(Lyso PC/LPC),and phosphatidylethanolamine(PE)may be potential indicators of acute liver injury.This study confirmed that LBPs,an effective hepatoprotective drug,may cure acute liver injury by lowering oxidative stress,repairing mitochondrial damage,and regulating metabolic pathways. | JIANJIA HUANG YUMAN BAI WENTING XIE RONGMEI WANG WENYUE QIU SHUILIAN ZHOU ZHAOXIN TANG JIANZHAO LIAO RONGSHENG SU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 2 |
| 2 | Cloning, sequence analysis and expression of bacterial lipasecoding DNA fragments from environment in Escherichia coli显示文摘 | Zhaoxin Fan Changwu Yue Yang Tang | 2009 | Mol Biol Rep2009，36，： | 1 |
| 3 | Cloning, sequence analysis and expression of bacterial lipase -coding DNA fragments from environment in Escherichia coli显示文摘 | Zhaoxin Fan Changwu Yue Yang Tang | 2009 | Mol Biol Rep2009，36，： | 1 |
| 4 | Blockchain Security Threats and Collaborative Defense:A Literature Review显示文摘As a distributed database,the system security of the blockchain is of great significance to prevent tampering,protect privacy,prevent double spending,and improve credibility.Due to the decentralized and trustless nature of blockchain,the security defense of the blockchain system has become one of the most important measures.This paper comprehensively reviews the research progress of blockchain security threats and collaborative defense,and we first introduce the overview,classification,and threat assessment process of blockchain security threats.Then,we investigate the research status of single-node defense technology and multi-node collaborative defense technology and summarize the blockchain security evaluation indicators and evaluation methods.Finally,we discuss the challenges of blockchain security and future research directions,such as parallel detection and federated learning.This paper aims to stimulate further research and discussion on blockchain security,providing more reliable security guarantees for the use and development of blockchain technology to face changing threats and challenges through continuous updating and improvement of defense technologies. | Xiulai Li Jieren Cheng Zhaoxin Shi Jingxin Liu Bin Zhang Xinbing Xu Xiangyan Tang Victor S.Sheng | 2023 | Computers, Materials & Continua2023，76，9： | 1 |
| 5 | Antioxidant Activity of Extract and Its Major Constituents from Okra Seed on Rat Hepatocytes Injured by Carbon Tetrachloride显示文摘 | Lianmei Hu Wenlan Yu Ying Li Nagendra Prasad Zhaoxin Tang José Carlos Tavares Carvalho | 2014 | BioMed Research International2014，，： | 1 |
| 6 | Microbiome analysis reveals soil microbial community alteration with the effect of animal excretion contamination and altitude in Tibetan Plateau of China显示文摘The fertile forages in the Tibetan Plateau provide natural conditions for animal husbandry,whereas it is still unclear that whether animal excretion can result in the alteration of soil microbial community.Therefore,this study was performed to investigate the impact of animal excretion contamination and land altitude on the soil microbial community in different grazing areas of Tibetan Plateau.A total of 1160,190 high-quality valid sequences and 25,478 operational taxonomic units were achieved from 18 samples at three different altitude sites(Linzhi,Rikaze and Shannan).Here,we found excremental contamination did not alter the richness and diversity of soil microbial community,but it resulted in a significant alteration in the proportion of some bacteria.Specifically,the proportion of Proteobacteria in the LZa was obviously increased,whereas Gemmatimonadetes was significantly decreased as compared to LZe.Moreover,significant difference can also be observed in Verrucomicrobia between RKZe and RKZa.Remarkably,we also found that excremental contamination significantly decreased the abundance of some bacterial genera,such as Sphingopyxis,Polycyclovorans,Singulisphaera Cohnella,Polycyclovorans,Defluviicoccus,and Arthrobacter,which were closely related to soil health,pollutant degradation,and nutrient metabolism.Importantly,excremental contamination increased the proportion of harmful and beneficial bacteria in soil,such as the percentage of Acidibacter,Gemmatimonadaceae and Pajaroellobacter increased,while the ratio of Pontibacter,Flavisolibacter,Parasegetibacter,and Niastella decreased.Remarkably,soil samples collected from different altitude sites also displayed different soil microbial community structures.Our results demonstrated that excremental contamination could alter the soil microbial community structure and affect the normal function of the soil by affecting the proportion of harmful bacteria to beneficial bacteria.Moreover,this study can also provide a theoretical basis for the establishment of a supervision system for soil quality in Tibet. | Aoyun Li Yaping Wang Yajing Wang Hailong Dong Qingxia Wu Khalid Mehmood Zhenyu Chang Ying Li Yung-Fu Chang Lijun Shi Zhaoxin Tang Hui Zhang | 2021 | International Soil and Water Conservation Research2021，9，4： | 1 |
| 7 | An Analysis of China's Money Supply and Its Changes in 2008-2010显示文摘China divides the money supply into three levels:cash in circulation M0,cash that fl ows outside the banking system;the second is the narrow money supply M1,that is,M0 plus the deposit of enterprises and institutions;Money supply M2,that is,M1 plus enterprises and institutions of time deposits,household savings deposits and other deposits.In September 2008,China's monetary policy moderates easing in response to the serious impact of the international fi nancial crisis.At the beginning of 2009,the State Council put forward an annual growth of about 17%M2,more than 5 trillion yuan of new loans,relative to the expected 8%GDP growth rate and 4%of the CPI index is still a moderately easy monetary policy.China's monetary policy this shift is correct,strong with the government's active fi scal policy,the role of economic stabilization and recovery is more obvious. | Zhaoxin Wang Tingting Tang Xuebin Xia Xiaohong Yan | 2018 | Insight-Statistics2018，1，1： | 0 |
| 8 | Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice显示文摘Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease(NAFLD).This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism,and suppressed microbial dysbiosis in high-fat diet(HFD)-fed mice.Results showed that oral administration of L.plantarum Q16 improved serum and hepatic lipid profile.Protein analysis showed that L.plantarum Q16 could reduce hepatic lipid content by reducing the expression of FAS,ACC,SCD-1,Srebp-lc and ATGL,but increasing expression levels of CPT-1α,PPAR-αand ATGL.Meanwhile,L.plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1αsignaling pathway.Metagenomic analysis also discovered that L.plantarum Q16 increased species diversity and richness of intestinal microbiota,promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice.Overall,L.plantarum Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition. | Chao Tang Weiwei Zhou Mengyuan Shan Zhaoxin Lu Yingjian Lu | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
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