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| 1 | Li-richening strategy in Li_(2)ZrCl_(6) lattice towards enhanced ionic conductivity显示文摘All-solid-state Li batteries(ASSLBs) with solid-state electrolytes(SSEs) are exciting candidates for nextgeneration energy storage and receive considerable attention owing to their reliability. Halide SSEs are promising candidates due to their excellent stability against 4 V-class layered cathodes. Compared with Li3InCl6or Li_(3)ScCl_(6), the low ionic conductivity of Li_(2)ZrCl_(6)(LZC) is a challenge despite its low raw-material cost. Herein, we report a family of Li-Richened chloride, Li_(2+2x)Zr_(1–x)MxCl_(6), which can be used in highperformance ASSLBs owing to its high ionic conductivity(up to 0.62 mS cm^(-1)). The theoretical(ab initio molecular dynamics simulations) and experimental results prove that the strategy of aliovalent substitution with divalent metals to obtain Li-Richened LZC is effective in improving Li^(+)conductivity in SSEs. By combining Li_(2.1)Zr_(0.95)Mg_(0.05)Cl_(6)(Mg5-LZC) with a Li–In anode and a LiCoO_(2)cathode, a room-temperature ASSLBs with excellent long-term cycling stability(88% capacity retention at 0.3C for 100 cycles) and highrate capability(121 m A h g^(-1)at 1C) is reported. This exploratory work sheds light on improving the Li^(+)conductivity of low-cost LZC-family SSEs for constructing high performance ASSLBs. | Haochang Zhang Zhaozhe Yu Hannan Chen Yongjian Zhou Xiao Huang Bingbing Tian | 2023 | Journal of Energy Chemistry2023，，4： | 1 |
| 2 | Constructing stable Li-solid electrolyte interphase to achieve dendrites-free solid-state battery:A nano-interlayer/Li prereduction strategy显示文摘Solid-state batteries based on Li and nonflammable solid-state electrolytes(SSEs)have aroused the attention of numerous researchers because of their absolute safety and potentially high energy density.Most SSEs after coming into contact with Li are reduced,which leads to high interfacial charge-transfer impedance and dendrites formation.In this study,an“interlayer-Li pre-reduction strategy”was proposed to solve the above problem of reduction.An intermediate layer was introduced between solid electrolyte and Li,and it reacted with Li to produce a stable and ion-conductive interphase.Cubic garnet-type Nb-doped Li_(7)La_(3)Zr_(2)O_(12)(Nb-LLZO)was selected as an example solid electrolyte since it is characterized by high ionic conductivity,feasible preparation under ambient conditions,as well as low cost.The high impedance arising from the reduction at the Nb-LLZO|Li interface has limited its application.In this paper,a nano-scale Li phosphorus oxynitride(LiPON)layer was deposited on the Nb-LLZO pellets through radio frequency(RF)magnetron sputtering,which pre-reacted with Li in-situ to produce a lithiophilic,electronically insulating,and ionic conductive interphase.The produced interphase significantly inhibited the reduction of Nb5+against Li and the formation and propagation of Li dendrites.It is noteworthy that Li|LiPON|Nb-LLZO|LiPON|Li cells stably cycled for over 2,000 h without any short circuit.This study emphasizes and demonstrates the significance of the pre-conversion of modification layer between unstable SSE and Li metal to improve interfacial stability. | Yajun Niu Zhaozhe Yu Yongjian Zhou Jiawen Tang Maoxin Li Zechao Zhuang Yan Yang Xiao Huang Bingbing Tian | 2022 | Nano Research2022，15，8： | 0 |
| 3 | Halide/sulfide composite solid-state electrolyte for Li-anode based all-solid-state batteries显示文摘Li_(2)ZrCl_(6)(LZC) solid-state electrolytes(SSEs) have been recognized as a candidate halide SSEs for allsolid-state Li batteries(ASSLBs) with high energy density and safety due to its great compatibility with4V-class cathodes and low bill-of-material(BOM) cost.However,despite the benefits,the poor chemical/electrochemical stability of LZC against Li metal causes the deterioration of Li/LZC interface,which has a detrimental inhibition on Li^(+) transport in ASSLBs.Herein,we report a composite SSE combining by LZC and argyrodite buffer layer(Li_(6)PS_(5)Cl,LPSC) that prevent the unfavorable interaction between LZC and Li metal.The Li/LPSC-LZC-LPSC/Li symmetric cell stably cycles for over 1000 h at 0.3 mA/cm^(2)(0.15mAh/cm^(2)) and has a high critical current density(CCD) value of 2.1 mA/cm^(2)at 25 ℃,Under high temperature(60℃) which promotes the reaction between Li and LZC,symmetric cell fabricated with composite SSE also display stable cycling performance over 1200h at 0.3 mAh/cm^(2).Especially,the Li/NCM ASSLBs fabricated with composite SSE exhibit a high initial coulombic efficiency,as well as superior cycling and rate performance.This simple and efficient strategy will be instrumental in the development of halidebased high-performance ASSLBs. | Haochang Zhang Zhaozhe Yu Jinyin Cheng Hannan Chen Xiao Huang Bingbing Tian | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 4 | The efficacy of Kanglaite injection during treatment with tyrosine kinase inhibitor in elderly patients with non-small cell lung cancer显示文摘Objective Epidermal growth factor receptor–tyrosine kinase inhibitors(EGFR–TKIs) are widely used in the treatment of EGFR mutation-positive non-small cell lung cancer(NSCLC) patients. The Kanglaite injection(KLT) is a novel broad-spectrum anti-cancer injection produced from traditional Chinese medicinal herbs(coix seed). After its approval in 1995, KLT has become the most popular anti-cancer drug in China. As of this writing, no standard treatment guideline is available for elder patients with NSCLC, and the role of traditional Chinese medicinal herbs, including KLT, combined with TKI treatment remains unknown. This retrospective study evaluated the efficacy and safety of KLT in elderly NSCLC patients during TKI treatment.Methods Thirty elderly patients aged 71-79 years with histopathologically confirmed NSCLC attending the General Hospital of the Shenyang Military Region were enrolled in the study and received EGFR-TKI treatment. All participants received 200 m L KLT injections at the same time on days 1–21. Erlotinib(150 mg) or gefitinib(250 mg) was administered daily from days 1 to 21, and the cycle was repeated every 21 days. The endpoint of the primary study was the disease control rate.Results Thirty elderly patients were enrolled in this study. The objective response rate was 21.3% [95% confidence interval(CI): 8.6% to 35.2%], whereas the disease control rate was 80.4%(95% CI: 71.8% to 97.0%). The grade 3 or 4 adverse effects included leucopenia(13.7%), neutropenia(13.4%), anemia(2.9%), and nausea or vomiting(2.7%). Conclusion The administration of KLT combined with erlotinib or gefitinib showed high efficacy in elderly NSCLC patients. The adverse effects of the drug combination were well tolerated by the patients. KLT combined with TKI treatment might provide a satisfactory therapeutic strategy for elderly NSCLC patients. | Wei Zhou Tao Han Zhaozhe Liu Xiaodan Yang Yu Liu Wei Wang Benqiang Yang Xiaodong Xie | 2017 | Oncology and Translational Medicine2017，3，3： | 0 |
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