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| 1 | Quantitative diffusion-weighted magnetic resonance enterography in ileal Crohn’s disease: A systematic analysis of intra and interobserver reproducibility显示文摘BACKGROUND Magnetic resonance enterography(MRE) is increasingly attractive as a noninvasive and radiation-free tool for assessing Crohn’s disease(CD). Diffusionweighted imaging(DWI) is recommended as an optional MRE sequence for CD by the European Society of Gastrointestinal and Abdominal Radiology, and has shown a superb potential as a quantitative modality for bowel inflammation evaluation. However, the measurement reproducibility of quantitative DWI analysis in MRE has not been ascertained so far. To facilitate the application of quantitative diffusion-weighted MRE in the clinical routine, systematic investigations of the intra and interobserver reproducibility of DWI quantitative parameters should be performed.AIM To evaluate the intra and interobserver reproducibility of quantitative analysis for diffusion-weighted MRE(DW-MRE) in ileal CD.METHODS Forty-four subjects(21 with CD and 23 control subjects) who underwent ileocolonoscopy and DW-MRE(b = 800 s/mm2) within one week were included.Two radiologists independently measured apparent diffusion coefficients(ADC)of the terminal ileum and signal intensity ratio(SR) of the terminal ileum to ipsilateral psoas muscle on DWI images(b = 800 s/mm2). Between-and withinreader agreements were assessed using intraclass correlation coefficients(ICC),coefficients of variation(CoV), and 95% limits of agreement of Bland-Altman plots(BA-LA LoA). Diagnostic performances of ADC and SR for identifying inflamed terminal ileum from the normal were evaluated by receiver operating characteristic(ROC) curve analysis.RESULTS There were no significant differences in ADC or SR values between the two sessions or between the two radiologists either in the CD or control group(paired t-test, P > 0.05). The intra and interobserver reproducibility of ADC(ICC: 0.952-0.984;CoV: 3.73-6.28%;BA-LA LoA: ±11.27% to ±15.88%) and SR(ICC: 0.969-0.989;CoV: 3.51%-4.64%;BA-LA LoA: ±10.62% to ±15.45%) was excellent for CD.Agreement of ADC measurements was slightly less in control subjects(ICC:0.641-0.736;CoV: 10.47%-11.43%;BA-LA LoA: ± 26.59% to ± 30.83%). SR of normal terminal ileum demonstrated high intra and interobserver reproducibility(ICC: 0.944-0.974;CoV: 3.73%-6.28%;BA-LA LoA: ± 18.58% to ± 24.43%). ADC and SR of two readers had outstanding diagnostic efficiencies(area under the ROC curve: 0.923-0.988).CONCLUSION Quantitative parameters derived from DW-MRE have good to excellent intra and interobserver agreements with high diagnostic accuracy, and can serve as robust and efficient quantitative biomarkers for CD evaluation. | Hao Yu Ya-Qi Shen Fang-Qin Tan Zi-Ling Zhou Zhen Li Dao-Yu Hu John N Morelli | 2019 | World Journal of Gastroenterology2019，25，27： | 7 |
| 2 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 3 | Human infections with Rickettsia raoultii, China显示文摘 | Jia N Zhen$ YC Ma L | 2014 | Emerg Infect Dis2014，20，5： | 1 |
| 4 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non--sta- tionary time series analysis 显示文摘 | HUANG N E ZHEN Shen LONG SR etal | 1998 | Proc R Soc Lond A1998，454，： | 1 |
| 5 | Battery performance and photocatalytic activity of mesoporous anatase TiO2 nanospheres/graphene composites by template-free self-assembly 显示文摘 | Li N Liu G Zhen C Li F Zhang L L Cheng H M | 2011 | Advanced Functional Materials2011，21，9： | 1 |
| 6 | A review of algorithms for medical image segmentation and their applications to the female pelvic cavity 显示文摘 | Ma Zhen Tavares J M R S Jorge R N | 2010 | Computer Methods in Biomechanies and Biomedical Engineering2010，13，2： | 1 |
| 7 | Neighborhood discriminant analysis for face recognition显示文摘 | YOU Q ZHEN N DU S | 2007 | Pattern Recognition Letters2007，40，8： | 1 |
| 8 | The evaluation of anti-angiogenic treatment effects for implanted rabbit VX2 breast tumors using functional multi-slice spiral computed tomography (f-MSCT) 显示文摘 | Zhen L Ma H Xu N | 2011 | Eur J Radiol2011，78，2： | 1 |
| 9 | A functional MRI study of sensation and movement integrate deficits in patients with early parkinson's disease 显示文摘 | ZHAO Y L ZHEN X N ZHANG M M | 2008 | Proceedings of RSNA2008，，： | 1 |
| 10 | Correlation of l-methyl-11C-methionine(MET)uptake with l-type amino acid transporter 1 in human gliomas显示文摘 | OKUBO S ZHEN H N KAWAI N | 2010 | J Neurooncol2010，99，2： | 1 |
| 11 | Resveratrol inhibits cell growth and induces apoptosis of rat C6 glioma cells显示文摘 | ZHANG W FEI Z ZHEN H N | 2007 | Neuroon- col2007，81，3： | 1 |
| 12 | The empirical mode decomposition and Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | Huang N E Zhen S Long S R eta | 1998 | Proceedings of the Royal Society of London1998，454，： | 1 |
| 13 | Definition of the Anterior Choroidal Artery Territory in Rats Using Intraluminal Occluding Technique 显示文摘 | Zhen He Shao- Hua Yang Hiroaki N | 2000 | Journal of the Neurological Sciences2000，182，： | 1 |
| 14 | PrestigeRank: a new evalu- ation method for papers and journals 显示文摘 | Su C Pan Y T Zhen Y N | 2011 | Journal of Informet- rics2011，5，1： | 1 |
| 15 | A new view of nonlinear water waves: the Hilbert spectrum 显示文摘 | Huang N E Zhen S Long S R | 1999 | Annum Review of Fluid Mechanics1999，31，： | 1 |
| 16 | Epidermal growth factor receptor and tumor response to radiation:in vivo preclin- ieal studies显示文摘 | Milas L Fan Zhen Andratschke N H | 2004 | Int J Radiat Oneol Biol Phys2004，58，3： | 1 |
| 17 | Modification of regenerated cellulose ultrafiltration membranes by surface-ini- tiated atom transfer radical polymerization显示文摘 | SINGH N ZHEN C TOMER N | 2008 | Journal of Membrane Science2008，311，12： | 1 |
| 18 | Survivin expression and itsrelation with proliferation, apoptosis, and angiogenesis in brain gliomas显示文摘 | Zhen H N Zhang X Hu P Z | 2005 | Cancer2005，104，12： | 1 |
| 19 | GaN Heteroepitaxial Growth Techniques显示文摘 | NASSER N M YE ZHI ZHEN LI JIA WEI | 2001 | Journal of Microwaves and Optoelectronics2001，2，3： | 1 |
| 20 | Factors influencing the dechlorination of 2,4-dichlorophenol by Ni-Fe nanoparticles in the presence of humic acid显示文摘 | ZHANG Zhen CISSOKO N WO Jingjing | | 0，，1： | 1 |
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