|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer显示文摘In previous research, chimerical BPI23-Fcγ1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcγ1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed within a recombinant adeno-associated virus serotype 2 (rAAV2) vector as rAAV2-BPI23-Fcγ1. Here, to evaluate the potentiality of applying gene therapy to gram negative bacterial (GNB) infection in high-risk patients, we investigated protection of immuno-compromised mice and immunocompetent mice from challenge with minimal lethal dose (MLD) Klebsiella pneumonia infection after rAAV2-BPI23-Fcγ1 gene transferred. The results showed that the survival rate of rAAV2-BPI23-Fcγ1 transferred immunocompetent mice as well as immuno-compromised mice (40.0% and 44.4%, respectively) were significantly higher than that of corresponding control mice (6.7% and 4.4%, respectively); the bacteria counting, level of endotoxin and proinflammatory cytokines in the rAAV2-BPI23- Fcγ1 transferred immuno-compromised mice were markedly lower than that of rAAV2-EGFP and rAAV2-Null transferred immuno-compromised mice. Our data suggest that rAAV2-BPI23-Fcγ1 gene transferring offered immuno-compromised mice with resistance against GNB infection, so it is quite potential in preventing GNB infection of clinical high-risk patients. | Jing Li Qingli Kong Zhe Lv Yuanzhi Guan Yong Qiu Chen Li Mingjie Sun Zhenlong Liu Yunqing An | 2008 | Cellular & Molecular Immunology2008，5，6： | 2 |
| 2 | Multi-Span and Multiple Relevant Time Series Prediction Based on Neighborhood Rough Set显示文摘Rough set theory has been widely researched for time series prediction problems such as rainfall runoff.Accurate forecasting of rainfall runoff is a long standing but still mostly signicant problem for water resource planning and management,reservoir and river regulation.Most research is focused on constructing the better model for improving prediction accuracy.In this paper,a rainfall runoff forecast model based on the variable-precision fuzzy neighborhood rough set(VPFNRS)is constructed to predict Watershed runoff value.Fuzzy neighborhood rough set dene the fuzzy decision of a sample by using the concept of fuzzy neighborhood.The fuzzy neighborhood rough set model with variable-precision can reduce the redundant attributes,and the essential equivalent data can improve the predictive capabilities of model.Meanwhile VFPFNRS can handle the numerical data,while it also deals well with the noise data.In the discussed approach,VPFNRS is used to reduce superuous attributes of the original data,the compact data are employed for predicting the rainfall runoff.The proposed method is examined utilizing data in the Luo River Basin located in Guangdong,China.The prediction accuracy is compared with that of support vector machines and long shortterm memory(LSTM).The experiments show that the method put forward achieves a higher predictive performance. | Xiaoli Li Shuailing Zhou Zixu An Zhenlong Du | 2021 | Computers, Materials & Continua2021，，6： | 1 |
| 3 | Element migration and phase distribution characteristics during crystallization of rare earth phase in rare earth slag显示文摘The crystallization experiment of molten rare earth(RE)slag under different cooling rates was carried out.The characteristics of element migration and phase distribution during RE phase crystallization were studied by using different equipment.The experimental results show that there are two RE phases in the RE slag,namely(Ca,Ce,La)_(5)(SiO_(4))6F and(Ca,Ce,La,Mg)_(3)(Ti,Al,Nb)_(2)O_(7).During the cooling crystallization process of molten RE slag,Ca and P elements in the RE phase of(Ca,Ce,La)_(5)(SiO_(4))_(6)F migrate from inside to outside,and finally gather at the outer edge of the phase to form phase Ca_(3)(PO4)2.The RE phase(Ca,Ce,La)_(5)(SiO_(4))_(6)F is distributed inside the furnace-cooled slag,and the RE phase(Ca,Ce,-La,Mg)_(3)(Ti,AI,Nb)_(2)O_(7)is distributed in the surface layer of the furnace-cooled slag.And based on the phase distribution characteristics,the central hollowing method is proposed to realize the preliminary enrichment of valuable elements Ti,Nb and RE in RE slag. | Wanli Yi Xuefeng She Huai Zhang Zhenlong An Jingsong Wang Qingguo Xue | 2023 | Journal of Rare Earths2023，41，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员