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| 1 | Analy- sis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China显示文摘 | Ma Zhenmei Kang Shaozhong Zhang Lu | 2008 | Journal of Hydrology2008，352，3： | 1 |
| 2 | Analysis of Impacts of Climate Variability and Human Activity on Stre- amflow for a River Basin in Arid Region of Northwest China显示文摘 | MA Zhenmei KANG Shaozhong ZHANG Lu | 2008 | Journal of Hydrology2008，，352： | 1 |
| 3 | Analysis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China显示文摘 | Zhenmei Ma Shaozhong Kang Lu Zhang Ling Tong Xiaoling Su | 2007 | Journal of Hydrology2007，，3： | 1 |
| 4 | Analysis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China显示文摘 | Zhenmei Ma Shaozhong Kang Lu Zhang Ling Tong Xiaoling Su | 2007 | Journal of Hydrology2007，，3： | 1 |
| 5 | Analysis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China 显示文摘 | MA Zhenmei KANG Shaozhong ZHANG Lu | 2008 | Journal of Hydrology2008，352，： | 1 |
| 6 | Analysis of Impacts of Climate Variability and Human Activity on Streamflow for a River Basin in Arid Region of Northwest China显示文摘 | Ma Zhenmei Kang Shaozhong Zhang Lu | 2008 | Journal of Hydrology2008，352，34： | 1 |
| 7 | Analysis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China显示文摘 | Ma Zhenmei Kang Shaozhong Zhang Lu | 2008 | Journal of Hydrology2008，352，34： | 1 |
| 8 | Analysis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China显示文摘 | MA Zhenmei KANG Shaozhong ZHANG Lu | 2008 | Journal of Hydrology2008，352，： | 1 |
| 9 | Analysis of Impacts of Climate Variability and Human Activity on Streamflow for a River Basin in Arid Region of Northwest China 显示文摘 | Zhenmei Ma Shaozhong Kang Lu Zhang | 2008 | Journal of Hydrology2008，352，4： | 1 |
| 10 | Analy- sis of impacts of climate variability and human activity on streamflow for a river basin in arid region of northwest China 显示文摘 | Ma Zhenmei Kang Shaozhong Zhang Lu | 2009 | Journal of Hydrology2009，352，314： | 1 |
| 11 | The effect oftetrahydrofuran on the enzymatic activity and microbial community in activated sludge from a sequencing batehreaetor显示文摘 | Yanlai Yao Zhenmei Lu Hang Min | 2012 | Eeotoxicology2012，21，1： | 1 |
| 12 | Crystal structure of heliorhodopsin 48C12显示文摘Dear Editor,Heliorhodopsins(HeRs)are a new class of Microbial rhodopsins(MRs),with a low homology(<15%)to all other MRs and a unique membrane topology in which their N-termini face the intracellular side and C-termini face the extracellular side.1 To explore the photoactivation mechanism of HeRs,we sought to solve the structure of HeR 48C12(hereafter referred to as HeR).HeR protein was expressed in insect cells and purified by standard membrane purification methods(Supplementary information,Fig.S1a and Data S1).The purified HeR shows a monodispersed peak and exhibits a high thermostability(Tm=74°C,Supplementary information,Fig.S1b,c). | Yang Lu X.Edward Zhou Xiang Gao Na Wang Ruixue Xia Zhenmei Xu Yu Leng Yuying Shi Guangfu Wang Karsten Melcher H.Eric Xu Yuanzheng He | 2020 | Cell Research2020，30，1： | 0 |
| 13 | SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway显示文摘Lenvatinib has become the first-line therapy in advanced hepatocellular carcinoma(HCC),but its efficacy is still limited because of the inevitable development of resistance.It has been reported that cellular cholesterol levels are associated with tyrosine kinase inhibitor(TKI)efficacy.Here,we show that betulin,a sterol regulatory elementbinding protein 2(SREBP2)inhibitor,markedly enhances the anti-tumor effect of lenvatinib in HCC both in vitro and in vivo.Our results also show that the combination treatment of lenvatinib and betulin synergistically inhibits the proliferation and clonogenicity of HCC cells.The mRNA and protein expressions of IL-1βare markedly decreased in HCC cells treated with betulin,while the sensitivity of HCC cells to lenvatinib is enhanced.Moreover,we find that the knockdown of IL-1βalso enhances the efficacy of lenvatinib,and recombinant IL-1βprotein rescues cell viability,which is reduced by lenvatinib in HCC cells.Further mechanistic studies indicate that betulin decreases the level of IL-1βin HCC cells by inhibiting the mTOR signaling pathway.Finally,the growth of the tumors in xenograft mouse models subjected to combination treatment is significantly suppressed.In summary,our study reveals that the SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway,which may be a promising therapeutic strategy for patients with HCC. | Minghao Fan Zhenmei Chen Weiqing Shao Yiran Chen Zhifei Lin Chenhe Yi Yitong Li Lu Lu Yu Zhou Jing Lin | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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