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| 1 | Scorpion toxin BmKI directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats显示文摘在主要感觉神经原的电压门钠隧道(VGSC ) 在把疼痛信号传给中央神经系统起一个关键作用。BmK 我, site-3 钠从蝎子 Buthus martensi Karsch 的隧道特定的毒素,在老鼠导致疼痛行为。然而,我不是的 BmK 指向的 VGSC 的子类型完全变清。我们因此调查了 BmK 的效果我在当前的振幅, gating 和 Na 在 DRG 神经原与 neuronal hyperexcitability 被联系的 v 1.8, 。它被发现我 dose-dependently 增加了的那 BmK Na v 1.8 电流在小型(< 25 ? m ) 尖锐地分裂的 DRG 神经原,它在快、慢的 inactivation 上与它的抑制相关。而且,电压依赖者激活和不变的 inactivation Na v 1.8 在一个 hyperpolarized 方向被转移。因此, BmK 我减少了 neuronal 易兴奋性的阀值并且增加了在 DRG 神经原开火的行动潜力。在结论,我们的数据清楚地表明了我调制了的那 BmK Na v 1.8 显著地,建议我为学习 Na v 1.8。并且 Nav1.8 是与 BmK 我唤起疼痛有关的一个重要目标。 | Pin Ye Yunlu Jiao Zhenwei Li Liming Hua Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2015 | Protein & Cell2015，6，6： | 10 |
| 2 | Fabrication of three-dimensional porous La-doped SrTiO3 microspheres with enhanced visible light catalytic activity for Cr(VI) reduction显示文摘 | Dong Yang Xiaoyan Zou Yuanyuan Sun Zhenwei Tong Zhongyi Jiang | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 3 |
| 3 | Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain显示文摘BmK 我,从蝎子 Buthus martensi Karsch (BmK ) 的毒液净化了,是电压门钠隧道(VGSC ) 的一个受体 site-3-specific 调节的人并且能在老鼠导致疼痛相关的行为。tetrodotoxin 抵抗(TTX-R ) 钠隧道 Nav1.8 贡献大多数在背面的根 ganglia (DRG ) 位于行动潜力向上的一击下面的钠水流神经原并且可以用作 BmK 指向的一条批评离子隧道我。此处,使用 electrophysiological,分子、行为的途径,我们调查了在 DRG 的 Nav1.8 的异常表示是否贡献 BmK 导致的疼痛的产生我。Nav1.8 的表示被发现显著地在跟随 BmK 的 intraplantar 注射的 mRNA 和蛋白质层次被增加我在老鼠。另外, TTX-R Nav1.8 钠隧道的当前的密度显著地被增加, Nav1.8 的 gating 动力学也从 BmK 我对待老鼠在 DRG 神经原被改变。而且,自发的疼痛和机械 allodynia,然而并非热痛觉过敏由 BmK 导致了我,被它的选择 blocker A-803467 显著地通过 Nav1.8 钠隧道的任何一个封锁减轻或在由在老鼠指向 Nav1.8 的 antisense oligodeoxynucleotide (AS-ODN ) 的 DRG 的 Nav1.8 表示击倒。最后,我被给看导致的 BmK 提高了疼痛行为在里面完全的 freund 的助手(CFA ) 在 DRG 由于 Nav1.8 的在表示上部分煽动了老鼠,它是。我们的结果建议 DRG 神经原上的 Nav1.8 隧道的功能的起来规定在老鼠贡献 BmK 我导致疼痛的发展。 | Pin Ye Liming Hua Yunlu Jiao Zhenwei Li Shichao Qin Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 3 |
| 4 | Transient ischemic attack and stroke can be differentiated by analyzing the diffusion tensor imaging 显示文摘 | Tong T Zhenwei Y Xiaoyuan F | 2011 | Korean J Radial2011，12，： | 1 |
| 5 | 1H - MR spectroscopy changes in transient isehemic attack patients and their correlation with per fushion-weighted imaging显示文摘 | Tong T Zhenwei Y Xiaoyuan F | 2010 | Int J Neurosci2010，120，： | 1 |
| 6 | 1H-MRS spectroscopy changes in transient ischemic attack patients and their correlation with perfusion-weighted imaging显示文摘 | Tong T Zhenwei Y Xiaoyuan F | | 0，，： | 1 |
| 7 | Transient ischemic attack and stroke can be differentiated by analyzing the diffusion tensor imaging 显示文摘 | Tong T Zhenwei Y Feng XY | 2011 | Korean J Radiol2011，12，： | 1 |
| 8 | Transient ischemic attackand stroke can be differentiated by analyzing the diffusiontensor imaging显示文摘 | Tong T Zhenwei Y Xiaoyuan F | 2011 | Korean J Radiol2011，12，3： | 1 |
| 9 | Transient ischemic attack and stroke can be differentiated by analyzing the diffusion tensor imaging 显示文摘 | Tong T Zhenwei Y Xiaoyuan F | 2011 | Korean J Radiol2011，12，3： | 1 |
| 10 | MRI and 1H-MRS on diagnosis of pineal region tumors显示文摘 | Tong T Zhenwei Y Xiaoyuan F | 2012 | Clin Imaging2012，36，6： | 1 |
| 11 | Silencing of lncRNA LBX2-AS1 suppresses glioma cell proliferation and metastasis through the Akt/GSK3β pathway in vitro显示文摘Long non-coding RNAs(lncRNAs)have been proposed to play pivotal roles in the tumorigenesis of various malignant tumors.Previous studies have found that lncRNA LBX2-AS1 is involved in the progression of various tumors.However,currently,the expression and exact mechanism of LBX2-AS1 in glioma remain unclear.In this study,using online-available datasets combined with clinical glioma tissues collected,we found that LBX2-AS1 was significantly increased and negatively correlated with prognosis in glioma.In vitro functional assays such as CCK-8,Annexin V,transwell assay,and western blot analysis showed that silencing of LBX2-AS1 suppressed the proliferation,migration,and invasion of glioma cells and increased apoptosis.RNA sequencing and western blot analysis confirmed that LBX2-AS1 regulates the Akt/GSK3βpathway.In conclusion,this study showed that lncRNA LBX2-AS1 depletion inhibits the proliferation,migration,and invasion of glioma cells and increases apoptosis through the Akt/GSK3βpathway.lncRNA LBX2-AS1 is expected to become a new target for glioma therapy. | Haitao Wen Zhenwei Li Sirong Song Lixia Xu Xiaoguang Tong Hua Yan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 12 | Design and experiment of the components for soil flow direction control of hilling machine based on EDEM显示文摘Cultivation and hilling are important steps in crop field management and provide an important guarantee of crop quality and quantity.With the aim of addressing how the soil flow direction of a traditional cultivation and hilling machine is difficult to control,and because it is difficult to achieve high ridge soil cultivation,among other issues,the components of the soil flow direction control of a hilling machine was designed.The components of the soil flow direction control consisted of a soil-feeding plough device,spiral knives and guide cover devices,etc.The design and analysis of the guiding parts for the two tools of the soil-feeding plough device and the spiral knife were performed to obtain an appropriate guide wall and helix angle.The guiding principle in the flow direction control components was analyzed.The design of the guide wall adopts the torsional columnar plough surface,and the elementary line angle changes from stable to increasing.The analysis of spiral milling showed that when the spiral angle is large,the milling effect is better.According to the discrete element method,the working part of the machine-soil interaction model was established.EDEM software was used to simulate the control components for the soil flow direction of the hilling machine for compound cutting.The design method with a two-factor comprehensive test was used to study the linear velocity along the outer part of the spiral knife and the influence of the forward velocity of machine of the implement on the soil cultivation effect.The results of the discrete element simulation showed that both the linear velocity along the outer part of the spiral knife and the forward velocity of the machine have extremely significant effects on the transportation of particles to the ridge top and the hilling thickness.Following multiple comparisons of the average hilling thickness with different linear velocities along with the outer spiral knife and different forward velocities of the machine,it is concluded that the performance of the machine is better when the linear velocity along the outer spiral knife is 3.01 m/s and the forward velocity of the machine is 0.7 m/s.The research conclusion had great theoretical value and practical significance for the design of the machine,which worked for cultivation and hilling. | Zhenwei Tong Lianhao Li Xiuli Zhang Yong Chen Xiaochan Liu Peilin Zhou Yueqing Xia | 2022 | International Journal of Agricultural and Biological Engineering2022，15，3： | 0 |
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