|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘Cockayne syndrome(CS)is a rare autosomal recessive inherited disorder characterized by a variety of clinical features,including increased sensitivity to sunlight,progressive neurological abnormalities,and the appearance of premature aging.However,the pathogenesis of CS remains unclear due to the limitations of current disease models.Here,we generate integration-free induced pluripotent stem cells(iPSCs)from fibroblasts from a CS patient bearing mutations in CSB/ERCC6 gene and further derive isogenic genecorrected CS-iPSCs(GC-iPSCs)using the CRISPR/Cas9 system.CS-associated phenotypic defects are recapitulated in CS-iPSC-derived mesenchymal stem cells(MSCs)and neural stem cells(NSCs),both of which display increased susceptibility to DNA damage stress.Premature aging defects in CS-MSCs are rescued by the targeted correction of mutant ERCC6.We next map the transcriptomic landscapes in CS-iPSCs and GC-iPSCs and their somatic stem cell derivatives(MSCs and NSCs)in the absence or presence of ultraviolet(UV)and replicative stresses,revealing that defects in DNA repair account for CS pathologies.Moreover,we generate autologous GC-MSCs free of pathogenic mutation under a cGMP(Current Good Manufacturing Practice)-compliant condition,which hold potential for use as improved biomaterials for future stem cell replacement therapy for CS.Collectively,our models demonstrate novel disease features and molecular mechanisms and lay a foundation for the development of novel therapeutic strategies to treat CS. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2020 | Protein & Cell2020，11，1： | 7 |
| 2 | Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury:A Cohort Study显示文摘Background and Aims:Exertional heatstroke(EHS)is associated with strenuous physical activity in hot environments.The present study aimed to investigate dynamic changes of hepatic function indices in EHS patients and determine risk factors for death.Methods:This single-center retrospective cohort study considered all patients with EHS admitted to the intensive care unit at the General Hospital of Southern Theater Command of PLA from October 2008 to May 2019.Data on general characteristics,organ function parameters,and the 90-day outcome of enrolled patients were collected.Hepatic indices were collected dynamically,and patients with acute hepatic injury(AHI)were identified by plasma total bilirubin(TBIL)≥34.2μmol/L and an international normalized ratio≥1.5,or with any grade of hepatic encephalopathy.Results:In patients who survived,TBIL,alanine aminotransferase and aspartate aminotransferase were increased at 24 h,peaked at 2–3 days,and began to decrease at 5 days.In non-survivors,TBIL continuously increased post-admission.The area under the receiver operating characteristic curve for the prediction of mortality based on sequential organ failure assessment(SOFA)scores was 89.8%,and the optimal cutoff value was 7.5.Myocardial injury and infection were identified as independent risk factors for death in EHS patients with AHI.Conclusions:In EHS patients,hepatic dysfunction usually occurred within 24 h.Patients with AHI had more severe clinical conditions,and significantly increased 90-day mortality rates.SOFA scores over 7.5,complicated with myocardial injury or infection,were found to be risk factors for death in EHS patients with AHI. | Jingjing Ji Jinghua Gao Conglin Wang Leifang Ouyang Zheying Liu Zhifeng Liu | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 6 |
| 3 | Rambutan-like hierarchically heterostructured CeO2-CuO hollow microspheres: Facile hydrothermal synthesis and applications显示文摘层次地空范围具有为由于他们的唯一的结构的特征和性质的大量应用的大兴趣的 heterostructured。然而,有为大规模上的混合转变金属氧化物的高度特定的形态学的明确的空范围的制造仍然保持挑战性。在这个工作,一致像红毛丹的 heterostructured CeO 2-CuO 有积木经由一个灵巧的热水的方法被准备的界面的地点和 nanorods 和 nanoparticles 由锻烧跟随了的众多的 copper-ceria 的空 microspheres。重要地,这条途径能乐意地被扩大规模并且对各种各样的基于 CuO 的混合金属氧化物的合成适用复杂空范围。同样准备的 CeO 2-CuO 当主要由于小主要 nanoparticle 成分,为 supercapacitors 并且作为为 Rochow 反应的基于 Cu 的催化剂的电极材料高出现,空红毛丹两个都展出优异性能众多的内部 heterostructures 的区域,和形成。 | Yongjun Ji Zheying Jin Jing Li Yu Zhang Hezhi Liu Laishun Shi Ziyi Zhong Fabing Su | 2017 | Nano Research2017，10，2： | 4 |
| 4 | One-dimensional Cu-based catalysts with layered Cu-Cu20-CuO walls for the Rochow reaction显示文摘 | Jing Li Zailei Zhang Yongjun Ji Zheying Jin Shanying Zou Ziyi Zhong Fabing Su | 2016 | Nano Research2016，9，5： | 4 |
| 5 | Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women显示文摘Dear Editor, Polycystic ovary syn drome (PCOS) is a comm on female reproductive endocrinopathy that afflicts up to 10%-15% of women in reproductive age worldwide (Nestler, 2016). Women with PCOS exhibit hyperandrogenism, intermittent/ absent menstrual cycles, and polycystic ovaries on ultrasound (Rotterdam, 2004). The pathophysiology of PCOS extends beyond infertility and hirsutism to hypothalamic neuroendocrine dysfunotion (Goodarzi et al., 2011). Most wome n with PCOS exhibit in creased luteinizing horm one (LH) levels, resulting from high-frequency gonadotropin-releasing hormone (GnRH) secretion (Cimino et al., 2016). Pren ata I testostero ne (T) treatment in sheep results in disrupted steroid feedback on gonadotropin release, which in creases pituitary sen sitivity to GnRH and subseque ntly leads to LH hypersecretion (Sullivan and Moenter, 2004;Cardoso et al., 2016). A recent study shows that GnRHdependent LH pulsatility and secretion are elevated by anti- Mullerian hormone (AMH) in PCOS disease. The increased prenatal AMH reprograms fetus and induces PCOS in adults (Tata et al., 2018). Furthermore, the androgen receptor (AR) plays a role in hyperandrogenism and ovarian folliculoge esis in PCOS (Wang et al., 2015;Abbott, 2017). However, the disease mechanism behind PCOS remains unclear, and current management focuses on treating the symptoms but not the mechanism (Chen et al., 2016;Shi et al., 2018). A further understanding of this disease is necessary to uncover the pathology of PCOS and develop new potential therapeutic avenues and drugs. | Zheying Min Yue Zhao Jing Hang Yun Ren Tao Tan Yong Fan Yang Yu | 2019 | Protein & Cell2019，10，7： | 4 |
| 6 | Correction to: Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women显示文摘In the original publication the Fig.2 and the Supplementary Material 1 was incorrect.The correct version of Fig.2 and the Supplementary Material are provided in this correction article.NESTIN should be corrected to PAX6 in Fig.2C legend and at page 528 and Supplementary Material 1.NANOG should be corrected to PAX6 in Fig.2C picture. | Zheying Min Yue Zhao Jing Hang Yun Ren Tao Tan Yong Fan Yang Yu | 2020 | Protein & Cell2020，11，3： | 2 |
| 7 | Teaching Reform of“Automatic Control Theory Course for the Independent College Students”2010 international Conference on E-health Networking显示文摘 | xueling song zheying song chaoying liu | 2010 | Digital Ecosystems and Technologies2010，，： | 1 |
| 8 | IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1显示文摘 | Li Yuan Chang Zhou Yanxia Lu Min Hong Zuoyang Zhang Zheying Zhang Yaya Chang Chao Zhang Xuenong Li | 2015 | Cancer Letters2015，，： | 1 |
| 9 | γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells显示文摘 | Jide Tian Hoa Dang Zheying Chen Alice Guan Yingli Jin Mark A. Atkinson Daniel L. Kaufman | 2013 | Diabetes2013，，11： | 1 |
| 10 | Fabrication of hydroxyl group modified monodispersed hybrid silica particles band the h-SiO 2/TiO 2 core/shell microspheres as high performance photocatalyst for dye degradation显示文摘 | Shen Zheying Li Longyu Li Yat | | 0，，： | 1 |
| 11 | Research on Real-time Simulation and Control of Linear 1-stage Inverted Pendulum显示文摘 | Song Zheying Song Xueling Liu Chaoying | 2013 | Journal of Computers2013，8，4： | 1 |
| 12 | Correction to:Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction显示文摘CORRECTION TO:PROTEIN CELL http://gffzzd3cc09b8251d45dfoovcwuonu6vuo6c0v.ffgz.tsg.suse.edu.cn/10.1007/S13238-019-0623-2 In Fig.7C,we used the ERCC6mut.iPSCs(CS iPSCs)as NANOG positive control pluripotent cells in the upper pan-els.However,these cells were inadvertently labeled as ERCC6^(GC)-iPSCs.In the revised version of Fig.7C,we have updated the high-quality images along with the corrected mark.In addition,we have also made corresponding chan-ges in the figure legend. | Si Wang Zheying Min Qianzhao Ji Lingling Geng Yao Su Zunpeng Liu Huifang Hu Lixia Wang Weiqi Zhang Keiichiro Suzuiki Yu Huang Puyao Zhang Tie-Shan Tang Jing Qu Yang Yu Guang-Hui Liu Jie Qiao | 2022 | Protein & Cell2022，13，8： | 0 |
| 13 | 2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance显示文摘The overexpression of heat shock proteins(HSPs)in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments,inducing thermoresistance and thus diminishing the treatment efficacy.Here,we report a distinct“non-inhibitor involvement”strategy to address this issue through engineering a calcium-based nanocatalyst(G/A@CaCO_(3)-PEG).The constructed nanocatalyst consists of calcium carbonate(CaCO_(3))-supported glucose oxidase(GOD)and 2D antimonene quantum dots(AQDs),with further surface modification by lipid bilayers and polyethylene glycol(PEG).The engineered G/A@CaCO_(3)-PEG nanocatalyst features prolonged blood circulation,which is stable at neutral pH but rapidly degrades under mildly acidic tumor microenvironment,resulting in rapid release of drug cargo in the tumor microenvironment.The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate(ATP)and subsequent down-regulation of HSP expression.This effect then augments the therapeutic efficacy of photothermal hyperthermia induced by 2D AQDs upon irradiation with near-infrared light as assisted by reversing the cancer cells’thermoresistance.Consequently,synergistic antineoplastic effects can be achieved via low-temperature photothermal therapy.Systematic in vitro and in vivo evaluations have demonstrated that G/A@CaCO_(3)-PEG nanocatalysts feature potent antitumor activity with a high tumor-inhibition rate(83.92%).This work thus paves an effective way for augmenting the hyperthermia-based tumor treatments via restriction of the ATP supply. | Jianrong Wu Xiaojun Cai Gareth R.Williams Zheying Meng Weijuan Zou Li Yao Bing Hu Yu Chen Yuanyi Zheng | 2022 | Bioactive Materials2022，7，4： | 0 |
| 14 | Molecular glues modulate protein functions by inducing protein aggregation:A promising therapeutic strategy of small molecules for disease treatment显示文摘Molecular glues can specifically induce aggregation between two or more proteins to modulate biological functions.In recent years,molecular glues have been widely used as protein degraders.In addition,however,molecular glues play a variety of vital roles,such as complex stabilization,interactome modulation and transporter inhibition,enabling challenging therapeutic targets to be druggable and offering an exciting novel approach for drug discovery.Since most molecular glues are identified serendipitously,exploration of their systematic discovery and rational design are important.In this review,representative examples of molecular glues with various physiological functions are divided into those mediating homo-dimerization,homo-polymerization and hetero-dimerization according to their aggregation modes,and we attempt to elucidate their mechanisms of action.In particular,we aim to highlight some biochemical techniques typically exploited within these representative studies and classify them in terms of three stages of molecular glue development:starting point,optimization and identification. | Hongyu Wu Hong Yao Chen He Yilin Jia Zheying Zhu Shengtao Xu Dahong Li Jinyi Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 0 |
| 15 | Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1显示文摘Many circular RNAs(circRNAs)are reported to be abnormally expressed during the progression of various tumors,and these circRNAs can be used as anti-tumor targets.Therefore,it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer(CRC).Here,we report that hsa_Circ_0000826(Circ_0000826),a circ RNA with significantly reduced expression level in CRC tissues,is associated with a poor prognosis in patients.The silencing of Circ_0000826 promotes the proliferation of CRC cells.Conversely,the overexpression of Circ_0000826 restricted CRC cell proliferation both in vitro and in vivo.Furthermore,Circ_0000826 could target AU-rich element RNA-binding protein 1(AUF1).AUF1,known as heterogeneous nuclear ribonucleoprotein D(hnRNP D),could bind to the c-MYC 3’-UTR and promote c-MYC expression.When Circ_0000826 binds to AUF1,it competitively inhibits the binding of AUF1 to the c-MYC 3’-UTR,which inhibits the c-MYC expression and cell proliferation.These results provide novel insights into the functional mechanism of Circ_0000826 action in CRC progression and indicate its potential use as a therapeutic target in CRC. | Zheying Zhang Wenyan Fan Qingzu Gao Yifei Han Jingyu Ma Wuji Gao Yuhan Hu Huifang Zhu Rui Yang Haijun Wang Baoshun Du Zuoyang Zhang Jiateng Zhong | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 16 | A novel MEMS-based focal plane array for infrared imaging显示文摘On the basis of opto-mechanical effect and micro electromechanical system(MEMS)technology,a novel substrate-free focal plane array(FPA)with the thermal isolated structure for uncooled infrared imaging is developed,even as alternate evaporated Au on SiN cantilever is used for thermal isolation.A human thermal image is obtained successfully by using the infrared imaging system composed of the FPA and optical detecting system.The experiment results show that the realization of thermal isolation structure in substrate-free FPA increases the temperature rise of the deflecting leg effectively,whereas the noise equivalent temperature difference(NETD)is about 200 mK. | LI Chaobo JIAO Binbin SHI Shali YE Tianchun CHEN Dapeng ZHANG Qingchuan GUO Zheying DONG Fengliang WU Xiaoping | 2007 | Frontiers of Electrical and Electronic Engineering in China2007，2，1： | 0 |
| 17 | Current development of bicyclic peptides显示文摘Bicyclic peptides,a class of polypeptides with two loops within their structure,have emerged as powerful tools in the development of new peptide drugs.They have the potential to bind to challenged drug targets,with antibody-like affinity and selectivity.Meanwhile,bicyclic peptides possess small molecule-like access to chemical synthesis,which is conducive to large-scale synthesis and screening.In the last five years,bicyclic peptide technology has been increasingly developed,and researchers have carried out a variety of studies to elucidate the potential functions of bicyclic peptides.With the continuous development of synthetic methods and the advances of new technology to build bicyclic peptide libraries,bicyclic peptides are now becoming widely used in the development of new drugs for various diseases.This perspective provides an overview of the structure types,synthesis and applications of bicyclic peptides in current drug development,and our own views on future challenges of bicyclic peptides. | Dazhi Feng Lihua Liu Yuqi Shi Pian Du Shengtao Xu Zheying Zhu Jinyi Xu Hong Yao | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 18 | VIS Atlas:A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns显示文摘Integration of oncogenic DNA viruses into the human genome is a key step in most virusinduced carcinogenesis.Here,we constructed a virus integration site(VIS)Atlas database,an extensive collection of integration breakpoints for three most prevalent oncoviruses,human papillomavirus,hepatitis B virus,and Epstein-Barr virus based on the next-generation sequencing(NGS)data,literature,and experimental data.There are 63,179 breakpoints and 47,411 junctional sequences with full annotations deposited in the VIS Atlas database,comprising 47 virus genotypes and 17 disease types.The VIS Atlas database provides(1)a genome browser for NGS breakpoint quality check,visualization of VISs,and the local genomic context;(2)a novel platform to discover integration patterns;and(3)a statistics interface for a comprehensive investigation of genotypespecific integration features.Data collected in the VIS Atlas aid to provide insights into virus pathogenic mechanisms and the development of novel antitumor drugs. | Ye Chen Yuyan Wang Ping Zhou Hao Huang Rui Li Zhen Zeng Zifeng Cui Rui Tian Zhuang Jin Jiashuo Liu Zhaoyue Huang Lifang Li Zheying Huang Xun Tian Meiying Yu Zheng Hu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
| 19 | Ascl1 represses the mesendoderm induction in Xenopus显示文摘 | ZheYing Min Hao Lin Xuechen Zhu Li Gao Aftab A. Khand Qinghua Tao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 0 |
| 20 | Further studies on thickness vibrations of piezoelectric plate excited by parallel field显示文摘In this paper, the thickness vibrations of the piezoclectric plate excited by a parallel field are further analysed. The new formula of resonant frequency equation and electromechanical coupling factor of the coupling modes are obtained. The characteristics of piezoelectrically-tunable frequency for the pure and coupling modes are investigated and ap plied to two examples. | ZHAO Zheying (Institute of Acoustics, Academia Sinica. Beijing 100080) | 1995 | Chinese Journal of Acoustics1995，14，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员