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您的检索式：作者名="Zhide Ding"
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| 1 | Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression显示文摘After leaving the testis,mammalian sperm undergo a sequential maturation process in the epididymis followed by capacitation during their movement through the female reproductive tract.These phenotypic changes are associated with modification of protein phosphorylation and membrane remodeling,which is requisite for sperm to acquire forward motility and induce fertilization.However,the molecular mechanisms underlying sperm maturation and capacitation are still not fully understood.Herein,we show that PPP3R2,a testis-specific regulatory subunit of protein phosphatase 3(an isoform of calcineurin in the testis),is essential for sperm maturation and capacitation.Knockout of Ppp3r2 in mice leads to male sterility due to sperm motility impairment and morphological defects.One very noteworthy change includes increases in sperm membrane stiffness.Moreover,PPP3R2 regulates sperm maturation and capacitation via(i)modulation of membrane diffusion barrier function at the annulus and(ii)facilitation of cholesterol efflux during sperm capacitation.Taken together,PPP3R2 plays a critical role in modulating cholesterol efflux and mediating the dynamic control of membrane remodeling during sperm maturation and capacitation. | Yue Liu Chujun Zhang Shiyao Wang Yanqin Hu Jia Jing Luyao Ye Ran Jing Zhide Ding | 2020 | Journal of Molecular Cell Biology2020，12，7： | 1 |
| 2 | Relief Program Sheds Light on the Needy显示文摘As the widening gap between the rich and poor has become a major byproduct of China’s nonstop economic growth over the past decades,the improvement of the disadvantaged group’s livelihood has become a top government concern.While numerous cities are working out their plans for'livelihood improvement projects,'local governments are making efforts to establish a sustainable mechanism that provides prompt,adequate relief to the needy.Licheng District in Jinan,capital of Shandong province,sets an example. | DING ZHIDE,is a professor with the Chinese Academy of Social Sciences | 2012 | The Journal of Human Rights2012，11，2： | 0 |
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