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| 1 | Upper mantle anisotropy in the Ordos Block and its margins显示文摘Based on the polarization analysis of teleseismic data,SKS (SKKS) fast-wave directions and delay times between fast and slow shear waves were determined for each of the 111 seismic stations from both permanent and temporary broadband seismograph networks deployed in the Ordos Block and its margins.Both the Silver and Chan and stacking analysis methods were used.In this way,an image of upper mantle anisotropy in the Ordos Block and its margins was acquired.In the western and northern margins of the Ordos Block,the fast-wave directions are consistently NW-SE.The fast-wave directions are mainly NWW-SEE and EW in the southern margin of the Ordos Block.In the eastern margin of the Ordos Block,the fast-wave directions are generally EW,although some run NEE-SWW or NWW-SEE.In the Ordos Block,the fast-wave directions trend near N-S in the north,but switch to near EW in the south.The delay time between fast and slow waves falls into the interval 0.48-1.50 s,and the average delay time at the stations in the Ordos Block is less than that in its margins.We suggest that the anisotropy of the stable Ordos Block is mainly caused by 'fossil' anisotropy frozen in the ancient North China Craton.The NE-trending push of the northeastern margin of the Tibetan Plateau has caused NW-SE-trending lithospheric extension in the western and northern margins of the Ordos Block,and made the upper mantle flow southeastwards.This in turn has resulted in the alignment of the upper mantle peridotite lattice with the direction of material deformation.In the southern margin of the Ordos Block,the collision between the North China and Yangtze blocks resulted in the fast-wave direction running parallel to the collision boundary and the Qinling Orogen.Combining this with the APM and velocity structure of the Qinling Orogen,we propose that eastward-directed asthenospheric-mantle channel flow may have occurred beneath the Qinling Orogen.In the eastern margin of the Ordos Block,the complex anisotropic characteristics of the Fenhe Graben and Taihang Orogen may be caused by the interaction of western Pacific Plate subduction,regional extensional tectonics,and the orogeny.For station YCI,the apparent splitting parameters (the fast-wave directions range from 45° to 106° and the delay times range from 0.6 to 1.5 s) exhibit systematic variations as a function of incoming polarization with a periodicity of π/2.This variation can be best explained by a two-layer anisotropic model (φlower=132°,δtlower=0.8 s,φupper=83°,δtupper=0.5 s).The upper layer anisotropy beneath station YCI can again be attributed to 'fossil' anisotropy frozen in the ancient North China Craton.The lower layer anisotropy is affected by the tectonic activity of the western Ordos Block.The NW-SE trending extension caused by the NE trending push of the northeastern margin of the Tibetan Plateau affected the deformation of the lower anisotropic layer beneath station YCI.By comparing the fast-wave directions with GPS velocity directions,we see that the crust and upper mantle possibly have vertically coherent deformation in the margins of the Ordos Block,whereas the internal deformation characteristics of the Ordos Block are complex and require further study. | CHANG LiJun WANG ChunYong DING ZhiFeng | 2011 | Science China Earth Sciences2011，54，6： | 25 |
| 2 | Seismic anisotropy of upper mantle in eastern China显示文摘Based on the polarization analysis of teleseismic SKS waveform data recorded at 65 seismic stations which respectively involved in the permanent and temporary broadband seismograph networks deployed in eastern China, the SKS fast-wave direction and the delay time between the fast and slow shear waves at each station were determined by use of SC method and the stacking analysis method, and then the image of upper mantle anisotropy in eastern China was acquired. In the study region, from south to north, the fast-wave polarization directions are basically EW in South China, gradually clockwise rotate to NWW-SEE in North China, then to NW-SE in Northeast China. The delay time falls into the interval [0.41 s, 1.52 s]. Anisotropic characteristics in eastern China indicate that the upper mantle anisotropy is possibly caused by both the collision between the Indian and Eurasian Plates and the subduction from the Pacific and Philippine Sea Plates to the Eurasian Plate. The collision between two plates made the crust of western China thickening and uplifting and the material eastwards extruding, and then caused the upper mantle flow eastwards and southeastwards. The subduction of Pacific Plate and Philippine Sea Plate has resulted in the lithosphere and the asthenosphere deformation in eastern China, and made the alignment of upper mantle peridotite lattice parallel to the deformation direction. The fast-wave polarization direction is consistent with the direction of lithosphere extension and the GPS velocity direction, implying that the crust-upper mantle deformation is possibly a vertically coherent deformation. | CHANG LiJun WANG ChunYong Ding ZhiFeng | 2009 | Science China Earth Sciences2009，52，6： | 21 |
| 3 | Crustal and uppermost mantle structure of SE Tibetan plateau from Rayleigh-wave group-velocity measurements显示文摘A shear-wave velocity model of the crust and uppermost mantle beneath the SE Tibetan plateau was derived by inverting Rayleigh-wave group-velocity measurements of periods between 10 and 70 s. Rayleigh-wave group-velocity dispersions along more than 3,000 interstation paths were measured based on analysis of teleseismic waveform data recorded by temporary seismic stations. These observations were then utilized to construct2 D group-velocity maps in the period range of 10–70 s.The new group-velocity maps have an enhanced resolution compared with previous global and regional group-velocity models in this region because of the denser and more uniform data coverage. The lateral resolution across the region is about 0.5° for the periods used in this study. Local dispersion curves were then inverted for a 3D shear-wave velocity model of the region by applying a linear inversion scheme. Our 3D shear-wave model confirms the presence of low-velocity zones(LVZs) in the crust beneath the northern part of this region. Our imaging shows that the upper-middle crustal LVZ beneath the Tengchong region is isolated from these LVZs beneath the eastern and northern part of this region. The upper–middle crustal LVZ may be regarded as evidence of a magma chamber in the crust beneath the Tengchong Volcanoes. Our model also reveals a slow lithospheric structure beneath Tengchong and a fast shield-like mantle beneath the stable Yangtze block. | Yonghua Li Jiatie Pan Qingju Wu Zhifeng Ding | 2014 | Earthquake Science2014，27，4： | 19 |
| 4 | Variations of shear wave splitting in the 2008 Wenchuan earthquake region显示文摘Through the analysis of S-wave particle motion of local events in the shear wave window, the polariza-tion directions of the faster shear wave and the delay times between the faster and the slower shear waves were derived from seismic recordings at the stations near the fault zones. The shear wave split-ting results of seven stations in the area of Longmenshan fault zone reveal spatial variation of the po-larization directions of the fast shear wave. The directions at stations in the southeastern side of the Longmenshan fault zone (in the Sichuan Basin area) are in the NE direction, whereas the direction at station PWU (in the Plateau), which is in the northwestern side of the faults, is in the EW direction. Systematic changes of the time delays between two split shear waves were also observed. At station L5501 in the southern end of the aftershock zone, the delay times of the slower shear wave decrease systematically after the main shock. After the main shock, the delay times at station PWU were longer than those before the earthquake. Seismic shear wave splitting is caused mostly by stress-aligned microcracks in the rock below the stations. The results demonstrate changes of local stress field dur-ing the main-shock and the aftershocks. The stress in the southern part of Wenchuan seismogenic zone was released by the main-shock and the aftershocks. The crustal stresses were transferred to the northeastern part of the zone, resulting in stress increase at station PWU after the main-shock. | DING ZhiFeng WU Yan WANG Hui ZHOU XiaoFeng LI GuiYin | 2008 | Science China Earth Sciences2008，51，12： | 18 |
| 5 | Upper mantle anisotropy and crust-mantle deformation pattern beneath the Chinese mainland显示文摘Over the past 10 years,the number of broadband seismic stations in China has increased significantly.The broadband seismic records contain information about shear-wave splitting which plays an important role in revealing the upper mantle anisotropy in the Chinese mainland.Based on teleseismic SKS and SKKS phases recorded in the seismic stations,we used the analytical method of minimum transverse energy to determine the fast wave polarization direction and delay time of shear-wave splitting.We also collected results of shear-wave splitting in China and the surrounding regions from previously published papers.From the combined dataset we formed a shear-wave splitting dataset containing 1020 parameter pairs.These splitting parameters reveal the complexity of the upper mantle anisotropy image.Our statistical analysis indicates stronger upper mantle anisotropy in the Chinese mainland,with an average shear-wave time delay of 0.95 s;the anisotropy in the western region is slightly larger(1.01 s)than in the eastern region(0.92 s).On a larger scale,the SKS splitting and surface deformation data in the Tibetan Plateau and the Tianshan region jointly support the lithospheric deformation mode,i.e.the crust-lithospheric mantle coherent deformation.In eastern China,the average fast-wave direction is approximately parallel to the direction of the absolute plate motion;thus,the upper mantle anisotropy can be attributed to the asthenospheric flow.The area from the Ordos block to the Sichuan Basin in central China is the transition zone of deformation modes between the east and the west regions,where the anisotropy images are more complicated,exhibiting'fossil'anisotropy and/or two-layer anisotropy.The collision between the Indian Plate and the Eurasian Plate is the main factor of upper mantle anisotropy in the western region of the Chinese mainland,while the upper mantle anisotropy in the eastern region is related to the subduction of the Pacific Plate and the Philippine Sea Plate beneath the Eurasian Plate. | WANG ChunYong CHANG LiJun DING ZhiFeng LIU QiongLin LIAO WuLin Lucy M FLESCH | 2014 | Science China Earth Sciences2014，57，1： | 18 |
| 6 | Seismic anisotropy of upper mantle in Sichuan and adjacent regions显示文摘Based on the polarization analysis of teleseismic SKS waveform data recorded at 94 broadband seis-mic stations in Sichuan and adjacent regions, the SKS fast-wave direction and the delay time between the fast and slow shear waves were determined at each station using the grid searching method of minimum transverse energy and the stacking analysis method, and the image of upper mantle anisot-ropy was acquired. The fast-wave polarization directions are mainly NW-SE in the study area, NWW-SEE to its northeast and NS to its west. The delay time falls into the interval [0.47 s, 1.68 s]. The spatial variation of the fast-wave directions is similar to the variation of GPS velocity directions. The anisotropic image indicates that the regional tectonic stress field has resulted in deformation and flow of upper mantle material, and made the alignment of upper mantle peridotite lattice parallel to the di-rection of material deformation. The crust-upper mantle deformation in Sichuan and adjacent regions accords with the mode of vertically coherent deformation. In the eastern Tibetan Plateau, the crustal material was extruded to east or southeast due to SE traction force of the upper mantle material. The extrusion might be obstructed by a rigid block under the Sichuan Basin and the crust has been de-formed. After a long-term accumulation of tectonic strain energy, the accumulative energy suddenly released in Yingxiu town of the Longmenshan region, and Wenchuan MS8.0 earthquake occurred. | CHANG LiJun WANG ChunYong DING ZhiFeng | 2008 | Science China Earth Sciences2008，51，12： | 16 |
| 7 | Upper mantle anisotropy of the eastern Himalayan syntaxis and surrounding regions from shear wave splitting analysis显示文摘Polarization analysis of teleseismic data has been used to determine the XKS(SKS,SKKS,and PKS)fast polarization directions and delay times between fast and slow shear waves for 59 seismic stations of both temporary and permanent broadband seismograph networks deployed in the eastern Himalayan syntaxis(EHS)and surrounding regions.The analysis employed both the grid searching method of the minimum tangential energy and stacking analysis methods to develop an image of upper mantle anisotropy in the EHS and surrounding regions using the newly obtained shear wave splitting parameters and previously published results.The fast polarization directions are oriented along a NE-SW azimuth in the EHS.However,within the surrounding regions,the fast directions show a clockwise rotation pattern around the EHS from NE-SW,to E-W,to NW-SE,and then to N-S.In the EHS and surrounding regions,the fast directions of seismic anisotropy determined using shear wave splitting analysis correlate with surficial geological features including major sutures and faults and with the surface deformation fields derived from global positioning system(GPS)data.The coincidence between structural features in the crust,surface deformation fields and mantle anisotropy suggests that the deformation in the crust and lithospheric mantle is mechanically coupled.In the EHS,the coherence between the fast directions and the NE direction of the subduction of the Indian Plate beneath the Tibetan Plateau suggests that the lithospheric deformation is caused mainly by subduction.In the regions surrounding the EHS,we speculate that a westward retreat of the Burma slab could contribute to the curved anisotropy pattern.The Tibetan Plateau is acted upon by a NE-trending force due to the subduction of the Indian Plate,and also affected by a westward drag force due to the westward retreat produced by the eastward subduction of the Burma slab.The two forces contribute to a curved lithospheric deformation that results in the alignment of the upper mantle peridotite lattice parallel to the deformation direction,and thus generates a curved pattern of fast directions around the EHS. | CHANG LiJun WANG ChunYong DING ZhiFeng YOU HuiChuan LOU Hai SHAO CuiRu | 2015 | Science China Earth Sciences2015，58，10： | 16 |
| 8 | Crustal stress field in Yunnan: implication for crust-mantle coupling显示文摘We applied the g CAP algorithm to determine239 focal mechanism solutions 3:0 M We 6:0T with records of dense Chin Array stations deployed in Yunnan,and then inverted 686 focal mechanisms(including 447 previous results) for the regional crustal stress field with a damped linear inversion. The results indicate dominantly strike-slip environment in Yunnan as both the maximum(r1) and minimum(r3) principal stress axes are sub-horizontal. We further calculated the horizontal stress orientations(i.e., maximum and minimum horizontal compressive stress axes: S H and S h, respectively) accordingly and found an abrupt change near *26°N. To the north, S H aligns NW-SE to nearly E-W while S h aligns nearly N-S. In contrast, to the south, both S H and S h rotate laterally and show dominantly fan-shaped patterns. The minimum horizontal stress(i.e., maximum strain axis) S h rotates from NW-SE to the west of Tengchong volcano gradually to nearly E-W in west Yunnan, and further toNE-SW in the South China block in the east. The crustal strain field is consistent with the upper mantle strain field indicated by shear-wave splitting observations in Yunnan but not in other regions. Therefore, the crust and upper mantle in Yunnan are coupled and suffering vertically coherent pure-shear deformation in the lithosphere. | Zhigang Xu Zhouchuan Huang Liangshu Wang Mingjie Xu Zhifeng Ding Pan Wang Ning Mi Dayong Yu Hua Li | 2016 | Earthquake Science2016，29，2： | 15 |
| 9 | Focal depths for moderate-sized aftershocks of the Wenchuan M_S8.0 earthquake and their implications显示文摘Sliding-window cross-correlation method is firstly adopted to identify sPn phase, and to constrain focal depth from regional seismograms, by measuring the time separation between sPn and Pn phases. We present the focal depths of the 17 moderate-sized aftershocks (MS≥5.0) of the Wenchuan MS8.0 earth-quake, using the data recorded by the regional seismic broadband networks of Shaanxi, Qinghai, Gansu, Yunnan and Sichuan. Our results show focal depths of aftershocks range from 8 to 20 km, and tend to cluster at two average depths, separate at 32.5°N, i.e., 11 km to the south and 17 km to the north, indicating that these aftershocks are origin of upper-to-middle crust. Combined with other results, we suggest that the Longmenshan fault is not a through-going crustal fault and the Pingwu-Qingchuan fault may be not the northward extension of the Longmenshan thrust fault. | ZHANG RuiQing WU QingJu LI YongHua DING ZhiFeng ZENG RongSheng | 2008 | Science China Earth Sciences2008，51，12： | 14 |
| 10 | Variations of shear wave splitting in the 2013 Lushan Ms7.0 earthquake region显示文摘In this paper, variations of shear wave splitting in the 2013 Lushan Ms7.0 earthquake sequence were studied. By analyzing shear wave particle motion of local events in the shear wave window, the fast polarization directions and the delay time between fast and slow shear waves were derived from seismic recordings at eight stations on the southern segment of the Longmenshan fault zone. In the study region, the fast polarization directions show partition characteristics from south to north. And the systematic changes of the time delays between two split shear waves were also observed. As for spatial distribution, the NE fast polarization directions are consistent with the Longmenshan fault strike in the south of focal region, whereas the NW fast direction is parallel to the direction of regional principal compressive stress in the north of focal region. Stations BAX and TQU are respectively located on the Central and Front-range faults, and because of the direct influence of these faults, the fast directions at both stations show particularity. In time domain, after the main shock, the delay times at stations increased rapidly, and decreased after a period of time. Shear-wave splitting was caused mostly by stress-aligned microcracks in rock below the stations. The results demonstrate changes of local stress field during the main shock and the aftershocks. The stress on the Lushan Ms7.0 earthquake region increased after the main shock, with the stress release caused by the aftershocks and the stress reduced in the late stage. | CHANG LiJun DING ZhiFeng WANG ChunYong | 2014 | Science China Earth Sciences2014，57，9： | 12 |
| 11 | Joint Inversion of the 3D P Wave Velocity Structure of the Crust and Upper Mantle under the Southeastern Margin of the Tibetan Plateau Using Regional Earthquake and Teleseismic Data显示文摘The special seismic tectonic environment and frequent seismicity in the southeastern margin of the Qinghai–Tibet Plateau show that this area is an ideal location to study the present tectonic movement and background of strong earthquakes in China's Mainland and to predict future strong earthquake risk zones. Studies of the structural environment and physical characteristics of the deep structure in this area are helpful to explore deep dynamic effects and deformation field characteristics, to strengthen our understanding of the roles of anisotropy and tectonic deformation and to study the deep tectonic background of the seismic origin of the block's interior. In this paper, the three-dimensional(3D) P-wave velocity structure of the crust and upper mantle under the southeastern margin of the Qinghai–Tibet Plateau is obtained via observational data from 224 permanent seismic stations in the regional digital seismic network of Yunnan and Sichuan Provinces and from 356 mobile China seismic arrays in the southern section of the north–south seismic belt using a joint inversion method of the regional earthquake and teleseismic data. The results indicate that the spatial distribution of the P-wave velocity anomalies in the shallow upper crust is closely related to the surface geological structure, terrain and lithology. Baoxing and Kangding, with their basic volcanic rocks and volcanic clastic rocks, present obvious high-velocity anomalies. The Chengdu Basin shows low-velocity anomalies associated with the Quaternary sediments. The Xichang Mesozoic Basin and the Butuo Basin are characterised by lowvelocity anomalies related to very thick sedimentary layers. The upper and middle crust beneath the Chuan–Dian and Songpan–Ganzi Blocks has apparent lateral heterogeneities, including low-velocity zones of different sizes. There is a large range of low-velocity layers in the Songpan–Ganzi Block and the sub–block northwest of Sichuan Province, showing that the middle and lower crust is relatively weak. The Sichuan Basin, which is located in the western margin of the Yangtze platform, shows high-velocity characteristics. The results also reveal that there are continuous low-velocity layer distributions in the middle and lower crust of the Daliangshan Block and that the distribution direction of the low-velocity anomaly is nearly SN, which is consistent with the trend of the Daliangshan fault. The existence of the low-velocity layer in the crust also provides a deep source for the deep dynamic deformation and seismic activity of the Daliangshan Block and its boundary faults. The results of the 3D P-wave velocity structure show that an anomalous distribution of high-density, strong-magnetic and high-wave velocity exists inside the crust in the Panxi region. This is likely related to late Paleozoic mantle plume activity that led to a large number of mafic and ultra-mafic intrusions into the crust. In the crustal doming process, the massive intrusion of mantle-derived material enhanced the mechanical strength of the crustal medium. The P-wave velocity structure also revealed that the upper mantle contains a low-velocity layer at a depth of 80–120 km in the Panxi region. The existence of deep faults in the Panxi region, which provide conditions for transporting mantle thermal material into the crust, is the deep tectonic background forthe area's strong earthquake activity. | LI Dahu LIAO Hua DING Zhifeng ZHAN Yan WU Pingping XU Xiaoming ZHENG Chen | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 12 |
| 12 | Tomographic imaging of P wave velocity structure beneath the region around Beijing显示文摘The three-dimension crustal and upper mantle structures in the region around Beijing were studied by seismic tomography. We used the P wave arrival times from local and teleseismic events. These events were recorded by 250 stations of the North China Seismic Array and 108 stations of the Beijing Telemetry Seismic Network. 118 869 P wave arrivals from 10 285 local events and 12 189 P wave arrivals from 107 teleseismic events were used in the inversion. We obtained the 3-D P wave velocity structure of the crust and upper mantle with the horizontal resolution of 0.3° in the studied region. The tomographic imaging shows the remarkably heterogeneous velocity variation. The velocity anomalies are in well agreement with the geological structure in the shallow crust. The different relationships between seismic activities and velocity anomalies may imply the different seismogenic structure and mechanism. Beneath the Moho under Taihangshan mountain and Yanshan mountain,we found the high velocity anomalies deep to 120 km and 200 km,respectively. The deep high velocity zone may be explained by the existence of the mountain root under Yanshan mountain. The high velocity anomalies in the upper mantle of North China basin may be the relics of the de-rooting from the former craton mantle lithosphere. | Zhifeng Ding Xiaofeng Zhou Yan Wu Guiyin Li Hong Zhang | 2009 | Earthquake Science2009，22，4： | 10 |
| 13 | Crustal velocity structures beneath North China revealed by ambient noise tomography显示文摘We collected continuous noise waveform data from January 2007 to February 2008 recorded by 190 broadband and 10 very broadband stations of the North China Seismic Array.The study region is divided into grid with interval 0.25°×0.25°,and group velocity distribution maps between 4 s and 30 s are obtained using ambient noise tomography method.The lateral resolution is estimated to be 20-50 km for most of the study area.We construct a 3-D S wave velocity model by inverting the pure path dispersion curve at each grid using a genetic algorithm with smoothing constraint.The crustal structure observed in the model includes sedimentary basins such as North China basin,Yanqing-Huailai basin and Datong basin.A well-defined low velocity zone is observed in the Beijing-Tianjin-Tangshan region in 22-30 km depth range,which may be related to the upwelling of hot mantle material.The high velocity zone near Datong,Shuozhou and Qingshuihe within the depth range of 1-23 km reveals stable characteristics of Ordos block.The Taihangshan front fault extends to 12 km depth at least. | Lihua Fang Jianping Wu Zhifeng Ding Weilai Wang Giuliano Francesco Panza | 2010 | Earthquake Science2010，23，5： | 7 |
| 14 | Upper-mantle velocity structures beneath the Tibetan Plateau and surrounding areas inferred from triplicated P waveforms显示文摘P-wave waveforms in the distance range between 12°and 30°were analyzed to investigate upper-mantle P velocity structures beneath the Tibetan Plateau and surrounding areas.The waveform data from 504 earthquakes with magnitudes larger than 5.0 between 1990 and 2005 that occurred within 30°from the center of the Plateau were modelled.We divided the study area into 6 regions and modeled upper-mantle-distance P waveforms with turning points beneath each region separately.The results show that the uppermantle P-wave velocity structures beneath India,the Himalayas,and the Lhasa Terrane are similar and contain a high-velocity lid about 250 km thick.The upper-mantle velocities down to 200 km beneath the Qiangtang Terrane,the Tarim Basin,and especially the Songpan-GarzêTerrane are lower than those in the south.The 410-km discontinuity beneath these two terranes is elevated by about 20 km.Highvelocity anomalies are found in the transition zone below 500 km under the Lhasa and Qiangtang Terranes.The results suggest that the Tibetan Plateau was generated by thrusting of the Indian mantle lithosphere under the southern part of Tibet.Portions of the thickened Eurasian mantle lithosphere were delaminated;they are now sitting in the transition zone beneath southern Tibet and atop of the 410-km discontinuity underneath northern Tibet. | RiSheng Chu LuPei Zhu ZhiFeng Ding | 2019 | Earth and Planetary Physics2019，3，5： | 6 |
| 15 | Suppression of murine breast cancer metastasis by selective inhibition of CXCR4 by synthetic polypeptide derived from viral macrophage inflammatory protein Ⅱ显示文摘Stromal cell-derived factor-1 and its receptor CXC chemokine receptor-4(CXCR4)have been implicated in breast cancer metastasis.A significant association between HER2 and CXCR4 expression has been observed in human breast tumor tissues,and overexpression of CXCR4 is essential for HER2-mediated tumor metastasis.Moreover,CXCR4 expression is low in normal breast tissues and high in malignant tumors,suggesting that a blockade of CXCR4 may limit tumor metastasis.The present study investigated the action of a synthetic antagonist 21-mer peptide derived from viral macrophage inflammatory protein Ⅱ against CXCR4(NT21MP)in inhibiting metastasis in vitro and in vivo.The results showed that chemotaxis of SKBR3 cells toward SDF-1αwas reduced by NT21MP in a dose-dependent manner(P<0.05).NT21MP inhibited tumor growth at 500μg/kg and in combination with Herceptin,the anti-HER2 antibody.The in vivo metastatic assay showed that NT21MP significantly inhibited pulmonary metastasis,and the number of metastatic tumor nodes on the surface of the lung was greatly decreased.Compared with the saline-treated control group,PCNA expression was dose-dependently decreased by NT21MP,the percentage of apoptotic cells was increased,and CXCR4 mRNA and protein expression were downregulated.In conclusion,NT21MP inhibits cellular proliferation,promotes apoptosis by downregulating CXCR4 expression,and suppresses the progression of primary and metastatic tumors.CXCR4 may be a useful therapeutic target for breast cancer,and NT21MP may serve as a potential target drug for the treatment of breast cancer metastasis. | YANG QingLin DING YongXing CHEN ChangJie TANG Jie ZHANG Ju YANG ZhiFeng | 2010 | Chinese Science Bulletin2010，55，20： | 6 |
| 16 | Upper crustal velocity and seismogenic environment of the M7.0 Jiuzhaigou earthquake region in Sichuan, China显示文摘On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone. | DaHu Li ZhiFeng Ding Yan Zhan PingPing Wu LiJun Chang XiangYu Sun | 2021 | Earth and Planetary Physics2021，5，4： | 4 |
| 17 | N-Type Mg_(3)Sb_(2-x)Bi_(x) Alloys as Promising Thermoelectric Materials显示文摘N-type Mg_(3)Sb_(2-x)Bi_(x) alloys have been extensively studied in recent years due to their significantly enhanced thermoelectric figure of merit(zT),thus promoting them as potential candidates for waste heat recovery and cooling applications.In this review,the effects resulting from alloying Mg_(3)Bi_(2) with Mg_(3)Sb_(2),including narrowed bandgap,decreased effective mass,and increased carrier mobility,are summarized.Subsequently,defect-controlled electrical properties in n-type Mg_(3)Sb_(2-x)Bi_(x) are revealed.On one hand,manipulation of intrinsic and extrinsic defects can achieve optimal carrier concentration.On the other hand,Mg vacancies dominate carrier-scattering mechanisms(ionized impurity scattering and grain boundary scattering).Both aspects are discussed for Mg_(3)Sb_(2-x)Bi_(x) thermoelectric materials.Finally,we review the present status of,and future outlook for,these materials in power generation and cooling applications. | Hongjing Shang Zhongxin Liang Congcong Xu Jun Mao Hongwei Gu Fazhu Ding Zhifeng Ren | 2020 | Research2020，，1： | 4 |
| 18 | Deep Seismogenic Environment in the Southern Section of the Longmenshan Fault Zone on the Eastern Margin of the Tibetan Plateau and Lushan M_s 7.0 Earthquake显示文摘The 2,026 earthquake events registered by the Sichuan regional digital seismic network and mobile seismic array after the April 20 th,2013 Lushan earthquake and 28,188 pieces of data were selected to determine direct P waves arrival times. We applied the tomographic method to inverse the characteristics of the velocity structure for the three-dimensional(3D) P wave in the mid-upper crust of the seismic source region of the Lushan earthquake. The imaging results were combined with the apparent magnetization inversion and magnetotelluric(MT) sounding retest data to comprehensively study the causes of the deep seismogenic environment in the southern section of the Longmenshan fault zone and explore the formation of the Lushan earthquake. Research has shown that there are obvious differences in velocity structure and magnetic distribution between the southern and northern sections of the Longmenshan fault zone. The epicenter of the Lushan earthquake is located near the boundary of the high and low-velocity anomalies and favorable for a high-velocity section. Moreover,at the epicenter of the Lushan earthquake located on the magnetic dome boundary of Ya'an,the development of high velocity and magnetic solid medium favors the accumulation and release of strain energy. Lowvelocity anomalies are distributed underneath the are of seismogenic origin,The inversion results of the MT retest data after the April 20 th Lushan earthquake also indicate that there a high-conductor anomaly occurs under the area of seismogenic origin of the Lushan earthquake,Therefore,we speculated that the presence of a high-conductivity anomaly and low-velocity anomaly underneath the seismogenic body of the Lushan earthquake could be related to the existence of fluids. The role of fluids caused the weakening of the seismogenic layer inside the mid-upper crust and resulted in a seismogenic fault that was prone to rupture and played a triggering role in the Lushan earthquake. | LI Dahu DING Zhifeng ZHAN Yan WU Pingping YE Qingdong | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 4 |
| 19 | Development and test of the Export Coefficient Model in the Upper Reach of the Yangtze River显示文摘 | Xiaowen Ding Zhenyao Shen Qian Hong Zhifeng Yang Xing Wu Ruimin Liu | 2009 | Journal of Hydrology2009，，3： | 3 |
| 20 | Upper crustal anisotropy observed around the Longmenshan fault in the 2013 M_S7.0 Lushan earthquake region显示文摘Based on the shear wave splitting analysis of the seismic recordings at 17 temporary stations and three permanent stations, we measured the shear wave splitting parameters(i.e., the polarization direction of fast shear wave and the time delay of slow wave) to perform a systematic analysis of the crustal seismic anisotropy around the Longmenshan fault in the 2013 M_S7.0 Lushan earthquake region. We observed apparent spatio-temporal characteristics in the shear wave splitting parameters. The spatial distribution of fast polarization directions showed a clear partitioning in the characteristics from northwest to southeast in the focal region,which changed from NW-SE to NE-SW. In the northwest of the focal region, the fast polarization direction was oriented to NW-SE, which was parallel to the maximum horizontal compressive stress direction. However, the NE-SW fast polarization direction in the southeast of the focal region was parallel to the Longmenshan fault strike. For station BAX on the Central fault in the middle of the focal region, the distribution of fast polarization directions showed a bimodal pattern, with one dominant in the NE-SW direction and the other in the NW-SE direction. With regard to the temporal variation, the time delays were large in the initial stage after the mainshock but then gradually decreased over time and tended to be stable in the later period. This indicated that stress in the focal region increased to a maximum when the main shock occurred, with the stress release caused by the mainshock and aftershock activity, and the stress gradually decreased after a period of time. The scatter of fast polarization directions was large after the main shock, but over time the scatter gradually decreased, indicating that the Lushan earthquake caused a large perturbation in the local stress field. As the stress gradually decreased and was adjusted by the aftershock activity, the perturbation gradually weakened. | Lijun Chang Zhifeng Ding Chunyong Wang | 2018 | Earthquake Science2018，31，4： | 2 |
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