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| 1 | Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats显示文摘Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain. However, few studies have systemically assessed its role in direct nerve injury-induced neuropathic pain and the underlying mechanism. Here, we determined that spared nerve injury(SNI)increased the expression of CXCL12 and its cognate receptor CXCR4 in lumbar 5 dorsal root ganglia(DRG)neurons and satellite glial cells. SNI also induced longlasting upregulation of CXCL12 and CXCR4 in the ipsilateral L4–5 spinal cord dorsal horn, characterized by CXCL12 expression in neurons and microglia, and CXCR4 expression in neurons and astrocytes. Moreover, SNIinduced a sustained increase in TNF-a expression in the DRG and spinal cord. Intraperitoneal injection(i.p.) of the TNF-a synthesis inhibitor thalidomide reduced the SNI-induced mechanical hypersensitivity and inhibited the expression of CXCL12 in the DRG and spinal cord.Intrathecal injection(i.t.) of the CXCR4 antagonist AMD3100, both 30 min before and 7 days after SNI,reduced the behavioral signs of allodynia. Rats given an i.t.or i.p. bolus of AMD3100 on day 8 of SNI exhibited attenuated abnormal pain behaviors. The neuropathic pain established following SNI was also impaired by i.t. administration of a CXCL12-neutralizing antibody. Moreover,repetitive i.t. AMD3100 administration prevented the activation of ERK in the spinal cord. The mechanical hypersensitivity induced in na?¨ve rats by i.t. CXCL12 was alleviated by pretreatment with the MEK inhibitor PD98059. Collectively, our results revealed that TNF-a might mediate the upregulation of CXCL12 in the DRG and spinal cord following SNI, and that CXCL12/CXCR4 signaling via ERK activation contributes to the development and maintenance of neuropathic pain. | Liying Bai Xinru Wang Zhisong Li Cunlong Kong Yonghui Zhao Jun-Liang Qian Quancheng Kan Wei Zhang Ji-Tian Xu | 2016 | Neuroscience Bulletin2016，32，1： | 20 |
| 2 | Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats显示文摘Nuclear factor kappa B(NF-κB) in the spinal cord is involved in pro-infl ammatory cytokine-mediated pain facilitation. However, the role of NF-κB activation in chronic morphine-induced analgesic tolerance and the underlying mechanisms remain unclear. In the present study, we found that the level of phosphorylated NF-κB p65(p-p65) was increased in the dorsal horn of the lumbar 4–6 segments after intrathecal administration of morphine for 7 consecutive days, and the p-p65 was co-localized with neurons and astrocytes. The expression of TNF-α and IL-1β was also increased in the same area. In addition, pretreatment with pyrrolidinedithiocarbamate(PDTC) or SN50, inhibitors of NF-κB, prevented the development of morphine analgesic tolerance and alleviated morphine withdrawal-induced allodynia and hyperalgesia. The increase in TNF-α and IL-1β expression induced by chronic morphine exposure was also partially blocked by PDTC pretreatment. In another experiment, rats receiving PDTC or SN50 beginning on day 7 of morphine injection showed partial recovery of the anti-nociceptive effects of morphine and attenuation of the withdrawal-induced abnormal pain. Meanwhile, intrathecal pretreatment with lipopolysaccharide from Rhodobacter sphae-roides, an antagonist of toll-like receptor 4(TLR4), blocked the activation of NF-κB, and prevented the development of morphine tolerance and withdrawal-induced abnormal pain. These data indicated that TLR4-mediated NF-κB activation in the spinal cord is involved in the development and maintenance of morphine analgesic tolerance and withdrawalinduced pain hypersensitivity. | Liying Bai Caihong Zhai Kun Han Zhisong Li Junliang Qian Ying Jing Wei Zhang Ji-Tian Xu | 2014 | Neuroscience Bulletin2014，30，6： | 10 |
| 3 | Efficacy of sunitinib in patients with metastatic renal cell carcinoma: initial experience in two Chinese centers显示文摘 | He Zhisong Guo Gang Zhang Cuijian Li Xuesong Fu Weijun Jin Jie Zhang Xu Zhou Liqun | 2014 | Chinese Medical Journal2014，，8： | 5 |
| 4 | Effects of Tidal Currents on Nonlinear Internal Solitary Waves in the South China Sea显示文摘The propagation and fission process of internal solitary waves (ISWs) with amplitudes of about 170 m are simulated in the northeast of the South China Sea (NSCS) by using the generalized Korteweg-de Vries (KdV) equation under continuous stratification. More attention is paid to the effects of the ebb and flood background currents on the fission process of ISWs. This kind of background current is provided by the composed results simulated in terms of monthly mean baroclinic circulation and barotropic tidal current. It is found that the obtained relation of the number of fission solitons to the water depth and stratification is roughly in accordance with the fission law derived by Djordjevic and Redekopp in 1978; however, there exists obvious difference between the effects of the ebb and flood background currents on the wave-lengths of fission solitons (defined as the distance between two neighboring peaks of ISWs). The difference in nonlinearity coefficient α between the ebb and flood background currents is a main cause for the different wave-lengths of fission solitons. | FAN Zhisong SHI Xingang Antony K. Liu LIU Hailong LI Peiliang | 2013 | Journal of Ocean University of China2013，12，1： | 3 |
| 5 | Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial显示文摘OBJECTIVE: To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold andclearing interior heat.METHODS: Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.RESULTS: Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group(P < 0.05) and the Chinese patent medicine group(P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group(P <0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group(P <0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.CONCLUSION: The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety. | Wu Zhisong Li Guodong Wei Wan Liu Zhaoheng Wang Wei Ma Ruihong Liu Wenhong Ma Jiaju Wang Yuguang Jiao Yang | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 3 |
| 6 | Riesz multiwavelet bases generated by vector refinement equation显示文摘In this paper, we investigate compactly supported Riesz multiwavelet sequences and Riesz multiwavelet bases for L2(Rs). Suppose ψ = (ψ1, . . . , ψr)T and ψ = ( ψ1, . . . , ψr)T are two compactly supported vectors of functions in the Sobolev space (Hμ(Rs))r for some μ > 0. We provide a characterization for the sequences {ψjk : = 1, . . . , r, j ∈ Z, k ∈ Zs} and {ψ jk : = 1, . . . , r, j ∈ Z, k ∈ Zs} to form two Riesz sequences for L2(Rs), where ψjk = mj/2ψ (M j ·k) and ψjk = mj/2 ψ (M j ·k), M is an s × s integer matrix such that limn→∞ Mn = 0 and m = |detM|. Furthermore, let = (1, . . . , r)T and = ( 1, . . . , r)T be a pair of compactly supported biorthogonal refinable vectors of functions associated with the refinement masks a, a and M, where a and a are finitely supported sequences of r × r matrices. We obtain a general principle for characterizing vectors of functions ψν = (ψν1, . . . , ψνr)T and ψν = ( ψν1, . . . , ψ?νr)T , ν = 1, . . . , m 1 such that two sequences {ψjνk : ν = 1, . . . , m 1, = 1, . . . , r, j ∈ Z, k ∈ Zs} and {ψ jνk : ν = 1, . . . , m 1, = 1, . . . , r, j ∈ Z, k ∈ Zs} form two Riesz multiwavelet bases for L2(Rs). The bracket product [f, g] of two vectors of functions f, g in (L2(Rs))r is an indispensable tool for our characterization. | LI Song LIU ZhiSong | 2009 | Science China Mathematics2009，52，3： | 3 |
| 7 | Mechanical property and microstructure of aluminum alloy-steel tubes joint by magnetic pulse welding显示文摘 | Haiping Yu Zhidan Xu Zhisong Fan Zhixue Zhao Chunfeng Li | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 8 | Time-delay- and time-reversal-based robust capon beamformers for ultrasound imaging 显示文摘 | Wang Zhisong Li Jian Wu Renbiao | 2005 | IEEE Transactions on Medical Imaging2005，24，10： | 1 |
| 9 | On robust capon beam- forming and diagonal loading显示文摘 | Li Jian Stoica P Wang Zhisong | 2003 | IEEE Transactions on Sig- nal Processing2003，51，7： | 1 |
| 10 | Robust Capon beamforming 显示文摘 | Stoica Petre Wang Zhisong Li Jian | 2003 | IEEE Signal Processing Letters:2003，10，6： | 1 |
| 11 | On robust Capon beamforming and diagonal loading 显示文摘 | Li Jian Petre Stoica and Wang Zhisong | 2003 | IEEE Signal Processing2003，51，7： | 1 |
| 12 | On robust capon beamforming and diagonal loading 显示文摘 | LI Jian STOICA P WANG Zhisong | 2003 | IEEE Transactions on Signal Processing2003，51，7： | 1 |
| 13 | New approaches for chirplet approximation 显示文摘 | Greenberg J M Zhisong Wang Jian Li | 2007 | IEEE Transactions on Signal Pro- cessing2007，55，2： | 1 |
| 14 | Robust capon beamforming 显示文摘 | STOICA P WANG Zhisong LI Jian | 2003 | IEEE Signal Processing Letters2003，10，6： | 1 |
| 15 | On robust Capon beamforming and diagonal loading 显示文摘 | LI Jian STOICA P WANG Zhisong | 2003 | IEEE Transactions on Signal Processing2003，51，7： | 1 |
| 16 | Robust capon beami'orming 显示文摘 | Stoica P Wang Zhisong Li Jian | 2003 | IEEE Signal Processing Letters2003，10，6： | 1 |
| 17 | Doubly constrained robust Capon beamformer 显示文摘 | LI Jian STOICA P WANG Zhisong | 2004 | IEEE Transactions on Signal Processing2004，52，9： | 1 |
| 18 | Time-delay- and time-reversal-based robust capon beamformers for ultrasound imaging 显示文摘 | Wang Zhisong Li Jian Wu Renbiao | 2005 | IEEE Transactions on Medical Imaging2005，24，10： | 1 |
| 19 | On robust Capon beam- former and diagonal loading显示文摘 | Jian Li Petre Stotica Zhisong Wang | 2003 | IEEE Trans Signal Processing2003，51，7： | 1 |
| 20 | Doubly constrained robust Capon beamformer显示文摘 | Li Jian Stoiea P Wang Zhisong | 2004 | IEEE Trans on Signal Processing2004，52，9： | 1 |
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