3篇
您的检索式：作者名="Zhong Hejiang"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 2 | Submental tracheal intubation for resection of recurrent giant pituitary tumor:a case report显示文摘在为巨大的垂体肿瘤的切除术收到 transmaxillary 途径的病人的航线管理介绍临床的挑战给麻醉学者。为气管的 intubation 的口头或鼻的线路能防碍外科的过程。这份报告描述 submental 为在经由 transmaxillary 经历了周期性的巨大的垂体肿瘤的切除术的一个病人的航线管理的气管的 intubation 途径。Submental 气管的 intubation 在操作期间是为航线管理的一种能适应、安全的其他的技术。 | Zhong Hejiang Wang Yunling Yang Tiande | 2011 | Journal of Medical Colleges of PLA(China)2011，26，1： | 0 |
| 3 | Perioperative anesthetic management of interrupted aortic arch associated with severe pulmonary hypertension in a young adult: case report and review of the literature显示文摘The interrupted aortic arch (IAA) is rare congential heart defect and entails a very poor prognosis without surgical treatment. We describe a young adult patient with IAA associated with severe pulmonary hypertension and discuss the perioperative anesthetic management of single-stage surgical correction in this patient. Preoperative anesthetic preparation with better understanding of the malformation, intraoperative hemodynamic monitoring, and adequate alveolar ventilation in the perioperative period were all important factors contributing to a successful outcome. | Zhong Hejiang Huang Jing Yang Tiande Qi Yueyong | 2011 | Journal of Medical Colleges of PLA(China)2011，26，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员