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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | The influence of genetic polymor- phisms and interacting drugs on initial response to warfarin in Chi- nese patients with heart valve replacement显示文摘 | Zhong SL Liu Y Yu XY | 2011 | Eur J Clin Pharma- col2011，67，6： | 1 |
| 3 | Enhancement of ginseng saponin production in suspension cultures of Panax notoginseng: manipulation of medium sucrose 显示文摘 | Zhang Y H Zhong J J Yu J T | 1996 | J Biotechnol1996，51，： | 1 |
| 4 | Fabrication of twoweirstructure-based packed columns for on-chip solidphaseextraction of DNA显示文摘 | Zhong R T Liu D Y Yu L F | 2007 | Electrophoresis2007，28，： | 1 |
| 5 | Apelin modulates aor- tic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice显示文摘 | Zhong JC Yu XY Huang Y | 2007 | Cardiovasc Res2007，74，3： | 1 |
| 6 | Real-time seam tracking control technology during welding robot GTAW process based on passive vision sensor 显示文摘 | Xu Y L Yu H W Zhong J Y | 2012 | Journal of Materials Processing Technol- ogy2012，，： | 1 |
| 7 | Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer显示文摘 | Li Z Yu CP Zhong Y | 2012 | Ann Oncol2012，23，3： | 1 |
| 8 | Apelin modulates aorticvascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice显示文摘 | ZHONG J C YU X Y HUANG Y | 2007 | Cardiovasc Res2007，74，3： | 1 |
| 9 | The management of imdesirable cyanobacteria blooms in channel catfish pondsusing a constructed wetland : contribution to the control of of- flavor occurrences 显示文摘 | ZHONG F GA0 Y N YU T | 2011 | Water Research2011，45，19： | 1 |
| 10 | Compressive Behaviour of CFRP-Confined Rectangular Concrete Columns 显示文摘 | Tao Z Yu Q Zhong Y Z | 2008 | Magazine of Concrete Research2008，60，10： | 1 |
| 11 | Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients 显示文摘 | ZHONG S L YU X Y LIU Y | 2012 | Pharmaeogenet Genomies2012，22，3： | 1 |
| 12 | Development of novel qua- ntumdots as fluorescent sensors for application in highly sensitive spectrofluorimetrie determination of Cu^2+ 显示文摘 | Lai Y Yu Y Zhong P | 2006 | Analytical Letters2006，39，： | 1 |
| 13 | Impulsive control for TCS fuzzy model-based chaotic systems 显示文摘 | Zhong Q Bao J Yu Y | 2008 | Mathematics and Comput- ers in Simulation2008，79，3： | 1 |
| 14 | Full-length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half-smooth tongue sole Cynoglossus semilaevis 显示文摘 | Yu Y Zhong Q Zhang Q | 2009 | Internat J Immunog2009，36，3： | 1 |
| 15 | Exponential stabilization for discrete TakagiCSugeno fuzzy systems via impulsive control 显示文摘 | Zhong Q Bao J Yu Y | 2009 | Chaos Solitons and Fractals2009，41，4： | 1 |
| 16 | Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice显示文摘 | Yu XY Huang Y | 2007 | Cardiovasc Res2007，74，： | 1 |
| 17 | An automatic form er- ror evaluation method for characterizing micro- structured surfaces 显示文摘 | Yu D P Zhong X Wong Y S | 2011 | Measurement Science and Technology2011，22，01： | 1 |
| 18 | Design and Per- formance Study of the Active Magnetic Refrigerator for Room-Temperature Application 显示文摘 | Zheng Z G Yu H Y Zhong X C | 2009 | International Journal of Refrigeration2009，32，： | 1 |
| 19 | Casuarlna research and ap- plications in China 显示文摘 | Zhong C L Zhang Y Chen Yu | 2010 | Symbiosis2010，50，： | 1 |
| 20 | Study of metabolites from the degradation of polycyclic aromatic hydrocarbons(PAHs) by bacterial consortium enriched from mangrove sediments显示文摘 | Luan T G Keith S H Zhong Yu Y | 2006 | Chemosphere2006，65，11： | 1 |
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