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| 1 | Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China显示文摘The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (<500), Ce/Yb (<15) and SiO2 (43-55%), and relatively high Fe2O3T (6.4-11.5%); (2) the high-Ti/Y type situated in the western Tianshan area, which has high Ti/Y (>500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, εNd(t) ≈ +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick lithosphere and low geothermal gradient. | XIA Linqi, XU Xueyi, XIA Zuchun, LI Xiangmin, MA Zhongping and WANG Lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@pub.xaonline.com. Liu Shuchun and Liu Xinzhu | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 49 |
| 2 | Reassessment of petrogenesis of Carboniferous—Early Permian rift-related volcanic rocks in the Chinese Tianshan and its neighboring areas显示文摘The Carboniferous Early Permian rill-related volcanic successions.covering large areas in the Chinese Tianshan and its adjacent areas.make up a newly recognized important Phanerozoic large igneous province in the world.which can be further divided into two sub-provinces:Tianshan and Tarim. The regional unconformity of Lower Carboniferous upon basement or pre-Carboniferous rocks.the ages (360—351 Ma) of the youngest ophiolite and the peak of subduction metamorphism of high pressure-low temperature metamorphic belt and the occurrence of Ni-Cu-bearing mafic-ultramatic intrusion with age of—352 Ma and A-type granite with age of~358 Ma reveal that the final closure of the Paleo Asian Ocean might lake place in the Early Mississippian.Our summation shows that at least four criteria.being normally used to identify ancient asthenosphere upwelling(or mantle plumes),are met for this large igneous province:(1) surface uplift prior to magmatism:(2) being associated with continental ifting and breakup events:(3) chemical characteristics of asthenosphere(or plume) derived basalts;(4) close links to large-scale minerali/alion and the uncontaminaled basalts,being analogous to those of many 'ore-bearing' large igneous provinces.display Sr-Nd isotopic variations between plume and EMI geochemical signatures.These suggest that a Carboniferous asthenosphere upwelling and an Early Permian plume played the central role in the generation of the Tianshan—Tarim(central Asia) large igneous province. | Linqi Xia Xueyi Xu Xiangmin Li Zhongping Ma Zuchun Xia | 2012 | Geoscience Frontiers2012，3，4： | 30 |
| 3 | Mid—Late Neoproterozoic rift-related volcanic rocks in China:Geological records of rifting and break-up of Rodinia显示文摘Early Cambrian and Mid-Late Neoproterozoic volcanic rocks in China are widespread on several Precambrian continental blocks,which had aggregated to form part of the Rodinia supercontinent by ca.900 Ma.On the basis of petrogeochemical data,the basic lavas can be classified into two major magma types:HT(Ti/Y>500) and LT(Ti/Y<500) that can be further divided into HT1 (Nb/La>0.85) and HT2(Nb/La≤0.85),and LT1(Nb/La>0.85) and LT2(Nb/La≤0.85) subtypes, respectively.The geochemical variation of the HT2 and LT2 lavas can be accounted for by lithospheric contamination of asthenosphere-(or plume-) derived magmas,whereas the parental magmas of the HT1 and LT1 lavas did not undergo,during their ascent,pronounced lithospheric contamination.These volcanics exhibit at least three characteristics:(1) most have a compositional bimodality;(2) they were formed in an intracontinental rift setting;and(3) they are genetically linked with mantle plumes or a mantle surperplume.This rift-related volcanism at end of the MidNeoproterozoic and Early Cambrian coincided temporally with the separation between AustraliaEast Antarctica,South China and Laurentia and between Australia and Tarim,respectively. The Mid—Late Neoproterozoic volcanism in China is the geologic record of the rifting and break-up of the supercontinent Rodinia. | Linqi Xia Zuchun Xia Xueyi Xu Xiangmin Li Zhongping Ma | 2012 | Geoscience Frontiers2012，3，4： | 18 |
| 4 | Relationships between Basic and Silicic Magmatism in Continental Rift Settings:A Petrogeochemical Study of Carboniferous Post-collisional Rift Silicic Volcanics in Tianshan,NW China显示文摘Petrogeochemical data are reported for silicic volcanic rocks from the Tianshan Carboniferous rift, with the aim of discussing the petrogenesis of silicic magmas. Incompatible element vs. incompatible element diagrams display smooth positive trends for the Tianshan Carboniferous rift-related volcanic rocks; the isotope ratios of the silicic lavas [87Sr/86Sr(t)=0.69988–0.70532; εNd(t)=4.76–8.00; 206Pb/204Pb(t)=17.435–18.017; 207Pb/204Pb(t)=15.438–15.509; 208Pb/204Pb(t) = 37.075–37.723] encompass those of the basic lavas. These data suggest a genetic link between rhyolites and basalts, but are not definitive in establishing whether silicic rocks are related to basalts through fractional crystallization or partial melting. Geochemical modeling of incompatible vs. compatible elements excludes the possibility that silicic melts are generated by the melting of basaltic rocks, and indicates a derivation by fractional crystallization plus moderate assimilation of wall rocks (AFC) starting from intermediate rocks to silicic rocks. Continuous AFC from basalt to rhyolite, with small rates of crustal assimilation, best explains the geochemical data. The presence or absence of bimodal volcanism (the “Daly Gap”) might be related to cooling rates of magma chambers. In central and eastern Tianshan, the crust was thinner and the cooling rates of the magma chamber within the crust were greater. These conditions resulted in a rapid fall in temperature within the magma reservoir and caused a narrow temperature interval over which intermediate melts formed, effectively reducing the volume of the intermediate melts. | XIA Linqi XIA Zuchun XU Xueyi LI Xiangmin MA Zhongping WANG Lishe | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 14 |
| 5 | Co-occurrence of nitrite-dependent anaerobic methane oxidizing and anaerobic ammonia oxidizing bacteria in two Qinghai-Tibetan saline lakes显示文摘亚硝酸根依赖者厌氧氧化甲烷(n-damo ) 氧化的细菌和厌氧的氨(anammox ) 细菌是涉及全球碳并且氮骑车的二组微生物。为了测试 n-damo 和 anammox 细菌是否在自然盐的环境, DNA 和 cDNA 共同发生,样品从二个盐的湖的地表的沉积获得了(与 32 和 84 g/L 的咸度,分别地)与 anammox-damo-specific 和 n-damo-specific 教材集合的使用在西藏的高原上是 放大PCR 的,由克隆图书馆建设和种系发生的分析列在后面。DNA 和基于 cDNA 的克隆与 n-damo 结盟了, anammox 细菌成功地从二件样品被检索,显示这些二组细菌能象 84 g/L 一样高在有咸度的自然盐的环境共同发生。我们发现在自然为我们全球碳和氮周期的理解有大含意[出版摘要] | Jian YANG Hongchen JIANG Geng WU Weiguo HOU Yongjuan SUN Zhongping LAI Hailiang DONG | 2012 | Frontiers of Earth Science2012，6，4： | 12 |
| 6 | The altitude effect of ^(18)δO in precipitation and river water in the Southern Himalayas显示文摘The lapse rate of water isotopes is used in the study of the hydrologic cycle as well as in the estimation of uplift of the Tibetan Plateau.The greater elevation contrast in the Southern Himalayas allows for a detailed discussion about this lapse rate.We analyze variations of 18δO in precipitation and river water between 1320 m and 6700 m elevations in the Southern Himalayas,and calculate the specific lapse rate of water 18δO.The results show that the multi-year average lapse rate in precipitation over this region is 0.15‰/100 m.The one-year average lapse rate is 0.17‰/100 m from three sites along the Southern Himalayas.The two results agree,but are much lower than the global average of 0.28‰/100 m.This work also shows that there is a difference in precipitation 18δO lapse rate between the monsoon and non-monsoon seasons.The calculated precipitation lapse rate is much lower than that in surface water. | WEN Rong TIAN LiDe WENG YongBiao LIU ZhongFang ZHAO ZhongPing | 2012 | Chinese Science Bulletin2012，57，14： | 11 |
| 7 | Origin and evolution of oilfield brines from Tertiary strata in western Qaidam Basin:Constraints from ^(87)Sr/^(86)Sr,δD,δ^(18)O,δ^(34)S and water chemistry显示文摘Chemistry of major and minor elements,87Sr/86Sr,δD,δ18O and δ34S of brines were measured from Tertiary strata and Quaternary salt lakes in the western Qaidam Basin.The water chemistry data show that all oilfield brines are CaCl2 type.They were enriched in Ca2+,B3+,Li+,Sr2+,Br-,and were depleted in Mg2+,SO42-,which indicated that these brines had the characteristics of deeply circulated water.The relationship between δD and δ18O shows that all data of these brines decline towards the Global Meteoric Water Line(GWL) and Qaidam Meteoric Water Line(QWL),and that the intersection between oilfield brines and Meteoric Water Lines was close to the local spring and fresh water in the piedmont in the western Qaidam Basin.The results suggest that oilfield brines has initially originated from meteoric water,and then might be affected by water-rock metamorphose,because most oilfield brines distribute in the range of metamorphosing water.The 87Sr/86Sr values of most oilfield brines range from 0.71121 to 0.71194,and was less than that in salt lake water(>0.712),but close to that of halite in the study area.These imply that salt dissolution occurred in the process of migration.In addition,all oilfield brines have obviously much positive δ34S values(ranging from 26.46‰ to 54.57‰) than that of salt lake brines,which was caused by bacterial sulfate reduction resulting in positive shift of δ34S value and depleteed SO42-in oilfield brines.Combined with water chemical data and δD,δ18O,87Sr/86Sr,δ34S values,we concluded that oilfield brines mainly originate from the deeply circulated meteoric waters,and then are affected by salt dissolution,water-rock metamorphose,sulfate reduction and dolomitization during the process of migration.These processes alter the chemical compositions of oilfield brines and accumulate rich elements(such as B,Li,Sr,Br,K and so on) for sustainable utilization of salt lake resources in the Qaidam Basin. | FAN Qishun MA Haizhou LAI Zhongping TAN Hongbing LI Tingwei | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 10 |
| 8 | Process Control and Optimization for Heterologous Protein Production by Methylotrophic Pichia pastoris显示文摘The methylotrophic yeast Pichia pastoris is a highly successful system for production of a variety of heterologous proteins due to its unique features/abilities for effective protein expression, and tremendous efforts have been made to increase heterologous protein productivity by P. pastoris in recent years. When new engineered yeast strains are constructed and are ready to use for industrial protein production, process control and optimization techniques should be applied to improve the fermentation performance in the following aspects: (1) increase recombinant cell concentrations in fermentor to high density during growth phase; (2) effectively induce heterologous proteins by enhancing/stabilizing titers or concentrations of the proteins during induction phase; (3) decrease operation costs by relieving the working loads of heat-exchange and oxygen supply. This article reviews and discusses the key and commonly used techniques in heterologous protein production by P. pastoris, with the focus on optimizations of fermentation media and basic operation conditions, development of optimal glycerol feeding strategies for achieving high density cultivation of P. pastoris and effective heterologous protein induction methods by regulating specific growth rate, methanol concentration, temperatures, mixture ratio of multi-carbon substrates, etc. Metabolic analysis for recombinant protein production by P. pastoris is also introduced to interpret the mechanism of sub-optimal heterologous protein production and to explore further optimal expression methods. | GAO Minjie SHI Zhongping | 2013 | Chinese Journal of Chemical Engineering2013，21，2： | 10 |
| 9 | Micro-arc oxidation coatings on Mg-Li alloys显示文摘Micro-arc oxidation (MAO) method was used for the surface modification of an Mg-5wt.%Li alloy. Ceramic coatings were in-situ fabricated on the Mg-Li alloy. The morphology feature,phase composition,and corrosion-resistance of the formed ceramic coatings were studied by SEM,XRD,and electrochemical methods,respectively. The results showed that the coatings produced in a sodium silicate solution system were composed of MgO and Mg2SiO4. The ceramic coating became thicker and the content of Mg2SiO4 phase increased as the concentration of Na2SiO3 increased in the solution. The coating was loose at the low concentration of Na2SiO3 and was compact at the high concentration of Na2SiO3. The coated samples had a better corrosion resistance than the Mg-Li substrate in terms of the Tafel polarization curves and the cyclic voltammetry curves (CV). | Xu Yongjun Li Kang Yao Zhongping Jiang Zhaohua Zhang Milin | 2009 | Rare Metals2009，28，2： | 10 |
| 10 | 叶绿素浓度垂直不均一分布对于分层水体表观光学特性的影响显示文摘以往大部分海洋光学和海色研究都是以海洋光学有效成分及固有光学特性垂直均一分布的假设为基础进行的,然而海洋观测表明海水成分的垂直不均一性大量存在。文章通过Hydrolight辐射传输模拟研究了叶绿素浓度垂直不均一分布对海水表观光学特性的影响。叶绿素浓度垂直不均一分布由高斯模型来近似模拟,选择成熟的一类水体生物光学模型,利用Hydrolight辐射传输代码模拟表观光学特性,将垂直不均一廓线情况下模拟的表观光学特性值与具有本底值的均一廓线情况所模拟的相应值进行了比较。结果表明,水表面以下的叶绿素浓度最大值增加了蓝光波段的遥感反射率,减小了绿光波段的遥感反射率,而且改变了水体中辐射的方向分布,在叶绿素浓度最大值处,下行辐射漫衰减系数和平均余弦廓线分别出现峰值和谷值。 | 席颖 杜克平 张丽华 Zhongping Lee 李小文 | 2010 | 光谱学与光谱分析2010，30，2： | 10 |
| 11 | Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis显示文摘Triptolide(TP),a major active component of Tripterygium wilfordii Hook.F.(TWHF),is used to treat rheumatoid arthritis(RA).However,it has a narrow therapeutic window due to its serious toxicities.To increase the therapeutic index,a new triptolide-loaded transdermal delivery system,named triptolide-loaded liposome hydrogel patch(TP-LHP),has been developed.In this paper,we used a micro-needle array to deliver TP-LHP to promote transdermal absorption and evaluated this treatment on the pharmacokinetics and pharmacodynamics of TP-LHP in a rat model of collagen-induced arthritis(CIA).The pharmacokinetic results showed that transdermal delivery of microneedle TP-LHP yielded plasma drug levels which fit a onecompartment open model.The relationship equation between plasma concentration and time was C=303.59(e 0.064 t e 0.287t).The results of pharmacodynamic study demonstrated that TP-LHP treatment mitigated the degree of joint swelling and suppressed the expressions of fetal liver kinase-1,fetal liver tyrosine kinase-4 and hypoxia-inducible factor-1α in synovium.Other indicators were also reduced by TP-LHP,including hyperfunction of immune,interleukin-1β and interleukin-6 levels in serum.The therapeutic mechanism of TP-LHP might be regulation of the balance between Th1 and Th2,as well as inhibition of the expression and biological effects of vascular endothelial growth factor. | Gui Chen Baohua Hao Dahong Ju Meijie Liu Hongyan Zhao Zhongping Du Jizi Xia | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 10 |
| 12 | Seasonal variations of stable isotope in precipitation and moisture transport at Yushu,eastern Tibetan Plateau显示文摘Precipitation δ 18O at Yushu, eastern Tibetan Plateau, shows strong fluctuation and lack of clear seasonality. The seasonal pattern of precipitation stable isotope at Yushu is apparently different from either that of the southwest monsoon region to the south or that of the inland region to the north. This different seasonal pattern probably reflects the shift of different moisture sources. In this paper, we present the spatial comparison of the seasonal patterns of precipitation δ 18O, and calculate the moisture transport flux by using the NCAR/NCEP reanalysis data. This allows us to discuss the relation between moisture transport flux and precipitation δ 18O. This study shows that both the southwest monsoon from south and inland air mass transport from north affected the seasonal precipitation δ 18O at Yushu, eastern Tibetan Plateau. Southwest monsoon brings the main part of the moisture, but southwest transport flux is weaker than in the southern part of the Tibetan Plateau. However, contribution of the inland moisture from north or local evaporation moisture is enhanced. The combined effect is the strong fluctuation of summer precipitation δ 18O at Yushu and comparatively poor seasonality. | TIAN LiDe MA LingLong YU WuSheng LIU ZhongFang YIN ChangLiang ZHAO ZhongPing TANG Wei WANG Yu | 2008 | Science China Earth Sciences2008，51，8： | 9 |
| 13 | Chitinase-3 like-protein-1 function and its role in diseases显示文摘Non-enzymatic chitinase-3 like-protein-1(CHI3L1)belongs to glycoside hydrolase family 18.It binds to chitin,heparin,and hyaluronic acid,and is regulated by extracellular matrix changes,cytokines,growth factors,drugs,and stress.CHI3L1 is synthesized and secreted by a multitude of cells including macrophages,neutrophils,synoviocytes,chondrocytes,fibroblast-like cells,smooth muscle cells,and tumor cells.It plays a major role in tissue injury,inflammation,tissue repair,and remodeling responses.CHI3L1 has been strongly associated with diseases including asthma,arthritis,sepsis,diabetes,liver fibrosis,and coronary artery disease.Moreover,following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line,CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models.To date,interleukin-13 receptor subunit alpha-2,transmembrane protein 219,galectin-3,chemo-attractant receptor-homologous 2,and CD44 have been identified as CHI3L1 receptors.CHI3L1 signaling plays a critical role in cancer cell growth,proliferation,invasion,metastasis,angiogenesis,activation of tumor-associated macrophages,and Th2 polarization of CD4+T cells.Interestingly,CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis.This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis,then posits investigational strategies for targeted therapies. | Ting Zhao Zhongping Su Yingchang Li Xiaoren Zhang Qiang You | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 14 | Radiative forcing and global warming potential of perfluorocarbons and sulfur hexafluoride显示文摘We developed two radiation parameterizations with different resolutions(17-band and 998-band) for perfluorocarbons(PFCs) and sulfur hexafluoride(SF6) using the updated High-resolution Transmission Molecular Absorption(HITRAN) 2004 database and the correlated k-distribution method.We analyzed the impacts of the two radiation schemes on heating rates.Then we studied their instantaneous radiative efficiency,stratospheric adjusted radiative efficiency,global warming potential(GWP),and global temperature potential(GTP),for both clear-and all-sky conditions using a high-resolution radiation scheme.We found that the stratosphere-adjusted radiative efficiencies of C2F6,CF4,and SF6 for the whole sky were 0.346,0.098,and 0.680 W m-2 ppbv-1,respectively.Radiative forcing from the industrial revolution to 2005 was 0.001,0.007,and 0.004 W m-2,re-spectively;and was predicted to rise to 0.008,0.036,and 0.037 W m-2,respectively,by 2100,according to emission scenarios provided by the IPCC.The GWPs of C2F6,CF4,and SF6 are 17035,7597,and 31298,respectively,for a time horizon of 100 years relative to CO2.Their GTPs of pulse and sustained emissions,GTPP and GTPS,are 22468,10052,and 40935 and 16498,7355,and 30341,respectively,for a 100-year time horizon. | ZHANG Hua WU JinXiu SHEN ZhongPing | 2011 | Science China Earth Sciences2011，54，5： | 8 |
| 15 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 16 | Preparation of micro-arc oxidation coatings on magnesium alloy and its thermal shock resistance property显示文摘In the NaAlO2-Na2SiO3 compound system, the ceramic coatings were prepared on magnesium alloy by mi-cro-arc oxidation. The morphology, phase composition, and thermal shock resistance of the ceramic coatings were studied by scanning electron microscope, X-ray diffraction and thermal shock tests, respectively. The results showed that the ce-ramic coating contains MgO, MgAl2O4, as well as a little amount of Mg2SiO4. The thickness of the ceramic coatings in-creases with the current density increasing, when the current density is 12 A?dm?2, the thermal shock resistance of the produced ceramic coating is the best. The hardness of the ceramic coating is up to 10 GPa or so. | JIANG Zhaohua ZENG Xiaobin YAO Zhongping | 2006 | Rare Metals2006，25，3： | 7 |
| 17 | OSL chronology and paleoclimatic implications of paleodunes in the middle and southwestern Qaidam Basin, Qinghai-Tibetan Plateau显示文摘Aeolian sediments are widely distributed in the Qaidam Basin, northeastern Qinghai-Tibetan Plateau (QTP). The paleodunes are mainly located at the southeastern, middle and southwestern Qaidam Basin. However, ages of paleodunes in the middle and southwestern Qaidam Basin have not been well studied, although they are close to and might connect to the evolution of salt lakes in the central basin. In this study, we use single aliquot regeneration (SAR) protocol of Optically Stimulated Luminescence (OSL) to date the dune sand in these two regions. The results show that: (1) Sand accumulation in these regions started at ca. 4-3 ka and lasted to ca. 0.5 ka when they were stabilized, due to the arid climate in the late Holocene. (2) The underlying fluvial sand was formed during deglaciation at 12.6±0.8 ka. (3) The stabilization periods of the paleodunes correspond to stages of glacier advance in the northeastern QTP, during which lower temperatures caused the decrease of evaporation and increase of the effective moisture, leading to an increase of vegetation cover and stabilization of the dunes. | LuPeng Yu ZhongPing Lai Ping An | 2013 | Research in Cold and Arid Regions2013，5，2： | 7 |
| 18 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 19 | Preparation and structure of microarc oxidation ceramic coatings containing ZrO2 grown on LY12 Al alloy显示文摘Ceramic coatings containing ZrO2 were prepared in situ on LY12 aluminum alloy by microarc oxidation(MAO) in the mixed solution of zirconate and phosphate solution.The phase composition and morphology of the coatings were studied by XRD and SEM,respectively.The growing mechanism of ceramic coatings was discussed in a preliminary manner.The results show that with an increase in MAO time,the compactness of the coating improved and the thickness increased.From the inner layer to the coating surface,the content of Zr increased,while the content of Al decreased.In addition,the coating was composed of m-ZrO2,t-ZrO2,and a little amount of γ-Al2O3.With an increase in reaction time,the relative content of t-ZrO2 within the coating sharply decreased while the relative content of m-ZrO2 sharply increased,and then both generally kept at a constant level after 60 min. | WU Zhendong YAO Zhongping JIANG Zhaohua | 2008 | Rare Metals2008，27，1： | 6 |
| 20 | A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes显示文摘Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi's sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsv1-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral immediate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our discovery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and proliferation of HSV-1. | WU WenJuan GUO ZhongPing ZHANG XueMei GUO Lei LIU LongDing LIAO Yun WANG JingJing WANG LiChun LI QiHan | 2013 | Science China(Life Sciences)2013，56，4： | 6 |
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