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| 1 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014,5,11: | 14 |
| 2 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015,6,9: | 8 |
| 3 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021,6,2: | 8 |
| 4 | Different Expression Analysis in Fruit Softening and Ethylene Biosynthetic Pathways in Peaches of Different Flesh Textures显示文摘The aim of our study was to assess differences in the expression of genes involved in fruit softening and ethylene biosynthetic pathways under different temperature storage conditions. Different peach cultivars of ‘Xiacui' and ‘Yumyeong', which are stonyhard, ‘Yinhualu', which is softmelting, ‘Hujing Milu', which is hard-melting, and ‘Baby Gold 6', which is non-melting at 80% ripening, were collected as test materials. The results showed that only slight ethylene production was detected after harvesting of ‘Yumyeong' and ‘Xiacui' under either a room temperature(25 °C) or low temperature(4 °C). The fruit firmness of stonyhard cultivars was retained at a high level under room temperature over time, whereas a low temperature induced ‘Yumyeong' fruit to soften. Quantitative real-time PCR results indicated that the PpACS1 gene was highly expressed in soft-melting, hard-melting and non-melting cultivars; however, expression was extremely low in stonyhard peaches. PpACS2 or PpACS3, however,was not detected in all five cultivars. Interestingly, cold treatment significantly decreased firmness along with endo-PG expression obviously upregulated in ‘Yumyeong', but not in ‘Xiacui' peaches. In conclusion, this study revealed that fruit softening of peaches with different flesh textures was closely related to ethylene biosynthesis during the storage period, which was controlled via regulating relevant gene expression levels under different storage temperatures. | YANG Yong MA Ruijuan ZHANG Binbin SONG Zhizhong ZHANG Chunhua GUO Shaolei YU Mingliang | 2016 | Horticultural Plant Journal2016,2,2: | 7 |
| 5 | Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza显示文摘Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this winter.However,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear.Using a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following H1N1.We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets.Moreover,mortality was increased in sequentially infected mice compared with single-infection mice.Compared with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses.Combined immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 infection.Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter. | Linlin Bao Wei Deng Feifei Qi Qi Lv Zhiqi Song Jiangning Liu Hong Gao Qiang Wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021,6,6: | 4 |
| 6 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020,6,6: | 4 |
| 7 | Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-cancer silicon nanoparUcles显示文摘 | Xiaoyuan Ji Daoxia Guo Bin Song Sicong Wu Binbin Chu Yuanyuan Su Yao He | 2018 | Nano Research2018,11,10: | 3 |
| 8 | Radiation belt electron scattering by whistler-mode chorus in the Jovian magnetosphere: Importance of ambient and wave parameters显示文摘Whistler-mode chorus waves are regarded as an important acceleration mechanism contributing to the formation of relativistic and ultra-relativistic electrons in the Jovian radiation belts. Quantitative determination of the chorus wave driven electron scattering effect in the Jovian magnetosphere requires detailed information of both ambient magnetic field and plasma density and wave spectral property, which however cannot be always readily acquired from observations of existed missions to Jupiter. We therefore perform a comprehensive analysis of the sensitivity of chorus induced electron scattering rates to ambient magnetospheric and wave parameters in the Jovian radiation belts to elaborate to which extent the diffusion coefficients depend on a number of key input parameters. It is found that quasi-linear electron scattering rates by chorus can be strongly affected by the ambient magnetic field intensity, the wave latitudinal coverage, and the peak frequency and bandwidth of the wave spectral distribution in the Jovian magnetosphere, while they only rely slightly on the background plasma density profile and the peak wave normal angle, especially when the wave emissions are confined at lower latitudes. Given the chorus wave amplitude, chorus induced electron scattering rates strongly depend on Jovian L-shell to exhibit a tendency approximately proportional to L_J^3. Our comprehensive analysis explicitly demonstrates the importance of reliable information of both the ambient magnetospheric state and wave distribution property to understanding the dynamic electron evolution in the Jovian radiation belts and therefore has implications for future mission planning to explore the extreme particle radiation environment of Jupiter and its satellites. | BinBin Ni Jing Huang YaSong Ge Jun Cui Yong Wei XuDong Gu Song Fu Zheng Xiang ZhengYu Zhao | 2018 | Earth and Planetary Physics2018,2,1: | 3 |
| 9 | Geometric error analysis of an over-constrained parallel tracking mechanism using the screw theory显示文摘This paper deals with geometric error modeling and sensitivity analysis of an overconstrained parallel tracking mechanism. The main contribution is the consideration of overconstrained features that are usually ignored in previous research. The reciprocal property between a motion and a force is applied to tackle this problem in the framework of the screw theory. First of all, a nominal kinematic model of the parallel tracking mechanism is formulated. On this basis, the actual twist of the moving platform is computed through the superposition of the joint twist and geometric errors. The actuation and constrained wrenches of each limb are applied to exclude the joint displacement. After eliminating repeated errors brought by the multiplication of wrenches, a geometric error model of the parallel tracking mechanism is built. Furthermore,two sensitivity indices are defined to select essential geometric errors for future kinematic calibration. Finally, the geometric error model with minimum geometric errors is verified by simulation with SolidWorks software. Two typical poses of the parallel tracking mechanism are selected, and the differences between simulation and calculation results are very small. The results confirm the correctness and accuracy of the geometric error modeling method for over-constrained parallel mechanisms. | Jiateng ZHANG Binbin LIAN Yimin SONG | 2019 | Chinese Journal of Aeronautics2019,32,6: | 2 |
| 10 | Synthesis of cyclic carbonates and dimethyl carbonate using CO_(2) as a building block catalyzed by MOF-5/KI and MOF-5/KI/K_(2)CO_(3)显示文摘The synthesis of cyclic carbonates or dimethyl carbonate(DMC)using CO_(2) as a building block is a very interesting topic.In this work,we found that the metalorganic framework-5(MOF-5)/KI was an active and a selective catalytic system for the synthesis of cyclic carbonates from CO_(2) and epoxides,and MOF-5/KI/K_(2)CO_(3) was efficient for the preparation of DMC from CO_(2),propylene,and methanol by a sequential route.The impacts of temperature,pressure,and reaction time length on the reactions were investigated,and the mechanism of the reactions is proposed on the basis of the experimental results. | Jinliang SONG Binbin ZHANG Tao JIANG Guanying YANG Buxing HAN | 2011 | Frontiers of Chemistry in China2011,6,1: | 2 |
| 11 | An empirical model of the global distribution of plasmaspheric hiss based on Van Allen Probes EMFISIS measurements显示文摘Using wave measurements from the EMFISIS instrument onboard Van Allen Probes,we investigate statistically the spatial distributions of the intensity of plasmaspheric hiss waves.To reproduce these empirical results,we establish a fitting model that is a thirdorder polynomial function of L-shell,magnetic local time(MLT),magnetic latitude(MLAT),and AE*.Quantitative comparisons indicate that the model’s fitting functions can reflect favorably the major empirical features of the global distribution of hiss wave intensity,including substorm dependence and the MLT asymmetry.Our results therefore provide a useful analytic model that can be readily employed in future simulations of global radiation belt electron dynamics under the impact of plasmaspheric hiss waves in geospace. | JingZhi Wang Qi Zhu XuDong Gu Song Fu JianGuang Guo XiaoXin Zhang Juan Yi YingJie Guo BinBin Ni Zheng Xiang | 2020 | Earth and Planetary Physics2020,4,3: | 2 |
| 12 | On the loss mechanisms of radiation belt electron dropouts during the 12 September 2014 geomagnetic storm显示文摘Radiation belt electron dropouts indicate electron flux decay to the background level during geomagnetic storms,which is commonly attributed to the effects of wave-induced pitch angle scattering and magnetopause shadowing.To investigate the loss mechanisms of radiation belt electron dropouts triggered by a solar wind dynamic pressure pulse event on 12 September 2014,we comprehensively analyzed the particle and wave measurements from Van Allen Probes.The dropout event was divided into three periods:before the storm,the initial phase of the storm,and the main phase of the storm.The electron pitch angle distributions(PADs)and electron flux dropouts during the initial and main phases of this storm were investigated,and the evolution of the radial profile of electron phase space density(PSD)and the(μ,K)dependence of electron PSD dropouts(whereμ,K,and L^*are the three adiabatic invariants)were analyzed.The energy-independent decay of electrons at L>4.5 was accompanied by butterfly PADs,suggesting that the magnetopause shadowing process may be the major loss mechanism during the initial phase of the storm at L>4.5.The features of electron dropouts and 90°-peaked PADs were observed only for>1 MeV electrons at L<4,indicating that the wave-induced scattering effect may dominate the electron loss processes at the lower L-shell during the main phase of the storm.Evaluations of the(μ,K)dependence of electron PSD drops and calculations of the minimum electron resonant energies of H+-band electromagnetic ion cyclotron(EMIC)waves support the scenario that the observed PSD drop peaks around L^*=3.9 may be caused mainly by the scattering of EMIC waves,whereas the drop peaks around L^*=4.6 may result from a combination of EMIC wave scattering and outward radial diffusion. | Xin Ma Zheng Xiang BinBin Ni Song Fu Xing Cao Man Hua DeYu Guo YingJie Guo XuDong Gu ZeYuan Liu Qi Zhu | 2020 | Earth and Planetary Physics2020,4,6: | 2 |
| 13 | Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections显示文摘Human health is severely threatened by bacterial infections,which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections.To meet this goal,we synthesized a new kind of theranostic probes,made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).The new probes feature good selectivity for Gram-positive bacterial infections,favorable fluorescence,strong resistance to photobleaching (e.g.,12%loss of fluorescence intensity during 40min continuous laser excitation in the presence of Staphylococcus aureus (S.aureus)),and good biocompatibility (e.g.,cell viability >95%during 24h treatment).Because of these benefits,the probes were effective at prolonged (i.e.,8-day)fluorescence tracking of S.aureus infections in vivo,thus providing a visible and accurate way to evaluate treatment efficacy.Moreover,the resultant SiNPs-Van with a minimum inhibitory concentration (MIC)of ca.0.5μg/mL exhibited high antibacterial efficiency of 92.5%,superior to that (76.5%)of free Van with higher MIC of ca.1μg/mL. | Xia Zhai Bin Song Binbin Chu Yuanyuan Su Houyu Wang Yao He | 2018 | Nano Research2018,11,12: | 2 |
| 14 | Highly efficient synthesis of cyclic carbonates from CO 2 and epoxides catalyzed by KI/lecithin显示文摘 | Jinliang Song Binbin Zhang Peng Zhang Jun Ma Jinli Liu Honglei Fan Tao Jiang Buxing Han | 2011 | Catalysis Today2011,,1: | 1 |
| 15 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019,3,3: | 1 |
| 16 | A novel 5- DOF fully parallel manipulator and its kinematic optimi- zation 显示文摘 | Song Yimin Lian Binbin Sun Tao | 2014 | ASME Trans Journal of Mechanisms and Ro- botics2014,6,: | 1 |
| 17 | A Survey of Mathematical Tools in Topology and Performance Integrated Modeling and Design of Robotic Mechanism显示文摘Topology and performance are the two main topics dealt in the development of robotic mechanisms.However,it is still a challenge to connect them by integrating the modeling and design process of both parts in a unified frame.As the properties associated with topology and performance,finite motion and instantaneous motion of the robot play key roles in the procedure.On the purpose of providing a fundamental preparation for integrated modeling and design,this paper carries out a review on the existing unified mathematic frameworks for motion description and computation,involving matrix Lie group and Lie algebra,dual quaternion and pure dual quaternion,finite screw and instantaneous screw.Besides the application in robotics,the review of the work from these mathematicians concentrates on the description,composition and intersection operations of the finite and instantaneous motions,especially on the exponential-differential maps which connect the two sides.Furthermore,an in-depth discussion is worked out by investigating the algebraical relationship among these methods and their further progress in integrated robotic development.The presented review offers insightful investigation to the motion description and computation,and therefore would help designers to choose appropriate mathematical tool in the integrated design and modeling and design of mechanisms and robots. | Xinming Huo Shuofei Yang Binbin Lian Tao Sun Yimin Song | 2020 | Chinese Journal of Mechanical Engineering2020,33,4: | 1 |
| 18 | Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 http://gffzzd3cc09b8251d45dfo99vxoppcbuqn6oq6.ffgz.tsg.suse.edu.cn/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction. | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu Qifeng Wang Shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong Hua Zhaohui Huang | 2021 | Protein & Cell2021,12,8: | 1 |
| 19 | The identification of 'hotspots' of heavy metal polltion in soil- rice systems at a regional scale in eastern China 显示文摘 | Li Wanlu Xu Binbin Song Qiujin | 2014 | Science of the Total Environment2014,472,: | 1 |
| 20 | Importance of electron distribution profiles to chorus wave driven evolution of Jovian radiation belt electrons显示文摘Wave-particle interactions triggered by whistler-mode chorus waves are an important contributor to the Jovian radiation belt electron dynamics. While the sensitivity of chorus-driven electron scattering to the ambient magnetospheric and wave parameters has been investigated, there is rather limited understanding regarding the extent to which the dynamic evolution of Jovian radiation belt electrons, under the impact of chorus wave scattering, depends on the electron distribution profiles. We adopt a group of reasonable initial conditions based upon the available observations and models for quantitative analyses. We find that inclusion of pitch angle variation in initial conditions can result in increased electron losses at lower pitch angles and substantially modify the pitch angle evolution profiles of > ~500 keV electrons, while variations of electron energy spectrum tend to modify the evolution primarily of 1 MeV and 5 MeV electrons. Our results explicitly demonstrate the importance to the radiation belt electron dynamics in the Jovian magnetosphere of the initial shape of the electron phase space density, and indicate the extent to which variations in electron energy spectrum and pitch angle distribution can contribute to the evolution of Jovian radiation belt electrons caused by chorus wave scattering. | Jing Huang XuDong Gu BinBin Ni Qiong Luo Song Fu Zheng Xiang WenXun Zhang | 2018 | Earth and Planetary Physics2018,2,5: | 1 |