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| 1 | MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation显示文摘然而,在绝经后的骨质疏松症的进步和发展的 miR-133a 的重要角色被报导了内在的机制还不是清楚的。在这研究, qRT-PCR 分析被执行在从绝经后的骨质疏松症病人(PMOP ) 和健康控制孤立的浆液估计 miR-133 表示。骨头矿物质密度(BMD ) 被双精力的 X 光检查 absorptiometry (DXA ) 在腰部的脊骨测量。结果证明 miR-133a 是显著地 upregulated 并且否定地在绝经后的 osteoporotic 女人的浆液与腰部的脊骨 BMD 相关。miR-133a 模仿, miR-133a 禁止者,和相应控制分别地是进 RAW264.7 和 THP-1 房间的 transfected。陷井积极的房间被数, NFATc1, c-Fos 和陷井的蛋白质表示被西方的污点分析检测。我们发现 MiR-133a 在 osteoclastogenesis 期间是 upregulated,并且 miR-133a 的 overexpression 支持了 RAW264.7 和 THP-1 房间的导致 RANKL 的区别进骨破折,而 miR-133a 击倒显示出颠倒的结果。在里面在 vivo 实验,老鼠是双边地 ovariectomized (OVX ) 并且与 antagomiR-133a 或 antagoNC 注射了,并且为分别地为 ELISA,微计算断层摄影术(CT ) 和骨头 histomorphology 分析收集浆液和腰部的脊骨被牺牲。它被发现那,在 OVX 老鼠, miR-133a 击倒在浆液改变了 osteoclastogenesis 相关的因素的层次并且增加了腰部的脊骨 BMD 并且改变了骨头 histomorphology。一起, miRNA-133a 通过支持骨破折区别涉及绝经后的骨质疏松症的规定。 | Zhongqi Li Wenzhi Zhang Yan Huang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 24 |
| 2 | Molecular Characterization of a Leaf Senescence-Related Transcription Factor BrWRKY75 of Chinese Flowering Cabbage显示文摘WRKY is a plant-specific transcription factor(TF) involved in the regulation of many biological processes; however, its role in leaf senescence of leafy vegetables remains unknown. In the present work, a WRKY TF, termed Br WRKY75 was isolated from Chinese flowering cabbage [Brassica rapa L. ssp. chinensis(L.) Mokino var. utilis Tsen et Lee]. Analysis of deduced amino acid sequence and the phylogenetic tree showed that Br WRKY75 has high homology with WRKY75 from Brassica oleracea and Arabidopsis thaliana, and belongs to the II c sub-group. Sub-cellular localization and transcriptional activity analysis revealed that Br WRKY75 is a nuclear protein with transcriptional repression activity, and was up-regulated during leaf senescence. Electrophoretic mobility shift assay confirmed that Br WRKY75 directly bound to the W-box(TTGAC) cis-element. Collectively,these results provide a basis for further investigation of the transcriptional regulation of Chinese flowering cabbage leaf senescence. | TAN Xiaoli FAN Zhongqi LI Lulu WU Ya KUANG Jianfei LU Wangjin CHEN Jianye | 2016 | Horticultural Plant Journal2016，2，5： | 11 |
| 3 | Additive manufacturing of thin electrolyte layers via inkjet printing of highly-stable ceramic inks显示文摘Inkjet printing is a promising alternative for the fabrication of thin film components for solid oxide fuel cells(SOFCs) due to its contactless, mask free, and controllable printing process. In order to obtain satisfying electrolyte thin layer structures in anode-supported SOFCs, the preparation of suitable electrolyte ceramic inks is a key. At present, such a kind of 8 mol% Y_(2)O_(3)-stabilized ZrO_(2)(8 YSZ) electrolyte ceramic ink with long-term stability and high solid loading(> 15 wt%) seems rare for precise inkjet printing, and a number of characterization and performance aspects of the inks, such as homogeneity, viscosity, and printability, should be studied. In this study, 8 YSZ ceramic inks of varied compositions were developed for inkjet printing of SOFC ceramic electrolyte layers. The dispersing effect of two types of dispersants, i.e., polyacrylic acid ammonium(PAANH4) and polyacrylic acid(PAA), were compared. The results show that ultrasonic dispersion treatment can help effectively disperse the ceramic particles in the inks. PAANH4 has a better dispersion effect for the inks developed in this study. The inks show excellent printable performance in the actual printing process. The stability of the ink can be maintained for a storage period of over 30 days with the help of initial ultrasonic dispersion. Finally, micron-size thin 8 YSZ electrolyte films were successfully fabricated through inkjet printing and sintering, based on the as-developed high solid loading 8 YSZ inks(20 wt%). The films show fully dense and intact structural morphology and smooth interfacial bonding, offering an improved structural quality of electrolyte for enhanced SOFC performance. | Zhongqi Zhu Zhiyuan Gong Piao Qu Ziyong Li Sefiu Abolaji Rasaki Zhiyuan Liu Pei Wang Changyong Liu Changshi Lao Zhangwei Chen | 2021 | Journal of Advanced Ceramics2021，10，2： | 7 |
| 4 | Experimental Study on Melting in a Rectangular Enclosure Heated Below with Discrete Heat Sources显示文摘The melting process of n-octadecane in a rectangular cavity with three discrete protruding heat sources on its bottom surface was studied experimentally. It was observed that the experimental process, for the geometric arrangement in this paper, is neither a fixed melting nor a contact melting, but one m which fixed melting and contact melting take place alternatively. The effects of Stefan number, initial subcooling and aspect ratio on the melting process are reported. The larger the Stefan number, the more frequently the contact melting may occur, so does the aspect ratio. The initial subcooling plays a role only in early stage. As the melting process proceeds, its effect on the melting process becomes less. | Jianhua Zhou Zhongqi Chen Dengying Liu Ji Li | 2001 | Journal of Thermal Science2001，10，3： | 6 |
| 5 | Flow Field and Heat Transfer Analysis of Local Structure for Regenerative Cooling Panel显示文摘Local structure of cooling panel has great effects on the heat transfer in the cooling channel for the scramjet. The problems of flow dead area and mass flow rate non-uniform distribution caused by the local structure effect the cooling effectiveness in the channel seriously. Numerical simulation to the flow field of scramjet cold panel with four different fuel injection island structures respectively has been carried out using the CFD commercial software-CFX in this research. The results reveal that flow dead area has been eliminated and flow field has been improved for the optimized structure. Furthermore, local resistance loss has been decreased and the mass flow rate non-uniform distribution in the channel has been reduced. Based on the optimized results, some suggestions about the local design of cooling panel have been proposed in this research. | Yu Feng Hongyan Huang Tao Li Duo Zhang Zhongqi Wang | 2012 | Journal of Thermal Science2012，21，2： | 5 |
| 6 | Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease显示文摘Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction. | Zhongqi Li Bonaventure Ip Vincent C.T.Mok Ho Ko | 2021 | Neural Regeneration Research2021，16，12： | 3 |
| 7 | A New Ductile Fracture Criterion and Its Application to the Prediction of Forming Limit in Deep Drawing显示文摘With considering the influence of equivalent plastic strain on void-damage and taking Lemaitre damage equivalent stress as plastic potential, based on continuous damage mechanics theory, a new criterion for ductile fracture is derived. The two key material constants in the criterion are determined by the combination of tension tests with FE (finite element) simulation. On the basis of the values of stress and strain calculated from commercial finite element software, the forming limit in cylindrical deep drawing of annealed aluminum alloy LY12(M) is predicted by means of the new ductile fracture criterion. Experiments verify that the predicted results are in agreement with the experimental ones. Hence, it is reliable to predict the forming limit in deep drawing by means of the new ductile fracture criterion. | Yuying YANG Zhongqi YU Xuechun LI Zhenzhong SUN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 3 |
| 8 | Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion显示文摘酸的微型环境,特别地酸察觉到的离子隧道 1a (ASIC1a ) ,被报导了象移植一样支持癌房间增长。在这研究,我们在胃的癌(GC ) 的移植和侵略上探索了 ASIC1a 的效果。ASIC1a 表示层次被 immunohistochemistry 从 16 个病人在配对的 GC 和邻近的正常纸巾检验。反向的抄写即时 PCR 和 immunoblotting 被进行与 ASIC1a 小发卡 RNA (shRNA ) 在 transfection 以后在 GC 房间线 AGS 估计 ASIC1a 表示层次。创伤愈合和 transwell 侵略试金被利用检测转移和侵略追随者 ASIC1a silencing。肿瘤形成被用来在 vivo 在 tumorigenicity 检测 ASIC1a 的角色。ASIC1a 表示水平在与非转移相比显示出手术后的转移的 GC 纸巾和非肿瘤纸巾是显著地更高的,这被发现。而且,有 shRNA 的 ASIC1a 的 silencing 显著地下面调整的 ASIC1a 表示和减少的 GC 房间移植和侵略。中等酸的细胞外的环境禁止了 GC 房间生存能力。而且, ASIC1a shRNA 在 vivo 引起了 tumorigenicity 的抑制。我们的学习是 attenuating 的第一份报告在 vitro 并且在由压制 ASIC1a 的 vivo 的 GC 的恶意的显型,并且建议一条新奇途径学习在 ASIC 和 GC 房间移植和侵略之间的关系。 | Xin Chen Xue Sun Zhe Wang Xiaojun Zhou Lu Xu Feng'e Li Xingding Zhang Ji'an Pan Lin Qi Haixin Qian Zhongqi Mao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 3 |
| 9 | Three decades of changes in water environment of a large freshwater Lake and its relationship with socio-economic indicators显示文摘Tai Lake(Ch: Taihu) has attracted international attention forcyanobacteria blooms.However, the drivers of cultural eutrophication, especially long-term socio-economic indicators have been little researched. The results of research demonstrate how socioeconomic development affected quality of water and how it has been improved by anthropogenic activities. This study described variability in indicators of water quality in Tai Lakeand investigated thedrivers. Significant relationships existed between concentrations of annual mean total nitrogen(TN), total phosphorous(TP), chemical oxygen demand(COD) and biological oxygen demand(BOD), and population, per capital gross domestic production(GDP) and sewage discharge(p < 0.05). However, mechanisms causing change varied among TN, TP, COD and BOD. Before 2000, the main contributors to increases in concentrations of TN were human population, GDP and volumes of domestic sewage discharges. After 2000, discharges of industrial sewage become the primary contributor. After 1998, the regressions of annual mean TN, TP and COD on per capital GDP, population and domestic sewage discharge were reversed compared to the former period. Since 1999, an apparent inverted U-shaped relationship between environmental pollution and economic development has developed, which indicated that actions taken by governments have markedly improved quality of water in Tai Lake. The statistical relationship between BOD and per capital GDP didn't conform to the Kuznet curve. The Ushaped Kuznet curve may offer hope for the future that with significant environmental investments a high GDP can be reached and maintained without degradation of the environment, especially through appropriate management of industrial sewage discharge. | Cuicui Li Weiying Feng Fanhao Song Zhongqi He Fengchang Wu Yuanrong Zhu John P.Giesy Yingchen Bai | 2019 | Journal of Environmental Sciences2019，31，3： | 3 |
| 10 | Isolation and Characterization of a Cinnamoyl CoA Reductase Gene(CCR) in Pear(Pyrus pyrifolia)显示文摘Pear is a popular and commercially important fresh fruit, and its texture is related to the presence of sclereid formatted by parenchyma cell with lignification in vascular plants. Previous studies have demonstrated that content of lignin may be regulated by cinnamoyl CoA reductase(CCR) in various plants. However, the function of CCR in pears remains very limited. In the present study, we isolated a cDNA encoding CCR(PpCCR, GenBank accession No. KF999958) and its promoter(proPpCCR) from Whangkeumbae pear to investigate the function of CCR in lignin biosynthesis. PpCCR-GFP expressed in rice mesophyll protoplast demonstrated that PpCCR-GFP was localized in the cytoplasm, indicating that CCR may function in cytoplasm without localization signals. In transgenic plants carrying PpCCR, we observed higher lignin content compared with that in wild type plants, further suggesting that PpCCR can affect the lignin contents through regulating lignin biosynthesis in Arabidopsis thaliana. More studies in other plants are needed to confirm our conclusion. | Meng HU Boya TAN Tao WU Xianming LI Junfan TU Fuchen YANG Hongyan ZHU Zhongqi QIN | 2014 | Agricultural Science & Technology2014，15，6： | 2 |
| 11 | Synthesis of nearly spherical AlN particles by an in-situ nitriding combustion route显示文摘Spherical AlN powders with micrometer size have attracted great attention owing to their good fluidity and dispersity. However, the industrial preparation methods usually require high temperature and long soaking time, which lead to the high cost and limit the wide application of the products. Herein, nearly spherical AlN particles with the average size of 2.5 μm were successfully synthesized via an in-situ combustion synthesis method. The effect of N_(2) pressure, NH_(4)Cl content, and Al particle size on the combustion reaction procedure, phase composition, and microstructure of the products was systematically investigated. The results showed that the decreased N_(2) pressure, increased NH_(4)Cl content, and Al particle size led to the decreasing of combustion temperature and speed, which further affected the morphology of the products. As a result, low N_(2) pressure(0.2 MPa), a small amount of NH4Cl(0.5 wt%), and fine Al particles(~2.5 μm) contributed to a moderate combustion temperature and facilitated the formation of nearly spherical AlN particles. In addition, based on the gas-releasing assisted quenching experiments and thermo-kinetic analysis, a two-step growth mechanism for the nearly spherical AlN particles was rationally proposed. The present method shows the advantages of low cost and high efficiency for preparing nearly spherical AlN particles, which can be used as raw materials for electronic substrates and fillers for packaging materials. | Zhilei Wei Kang Li Bangzhi Ge Chaowei Guo Hongyan Xia Yajie Guo Zhongqi Shi | 2021 | Journal of Advanced Ceramics2021，10，2： | 2 |
| 12 | Effect of reclamation on soil organic carbon pools in coastal areas of eastern China显示文摘The coastal wetlands of eastern China formone of the most important carbon sinks in the world.However, reclamation can significantly alter the soilcarbon pool dynamics in these areas. In this study, achronosequence was constructed for four reclamationzones in Rudong County, Jiangsu Province, easternChina (reclaimed in 1951, 1974, 1982, and 2007) and areference salt marsh to identify both the process of soilorganic carbon (SOC) evolution, as well as the effect ofcropping and soil properties on SOC with time afterreclamation. The results show that whereas soil nutrientelements and SOC increased after reclamation, theelectrical conductivity of the saturated soil extract (ECe),pH, and bulk density decreased within 62 years followingreclamation and agricultural amendment. In general, thesoil's chemical properties remarkably improved and SOCincreased significantly for approximately 30 years afterreclamation. Reclamation for agriculture (rice and cotton)significantly increased the soil organic carbon density(SOCD) in the top 60 cm, especially in the top 0-30 cm.However, whereas the highest concentration of SOCD inrice-growing areas was in the top 0-20 cm of the soilprofile, it was greater at a 20-60 cm depth in cotton-growing areas. Reclamation also significantly increasedheavy fraction organic carbon (HFOC) levels in the 0-30cm layer, thereby enhancing the stability of the soil carbonpool. SOC can thus increase significantly over a long timeperiod after coastal reclamation, especially in areas ofcultivation, where coastal SOC pools in eastern China tendto be more stable. | Jianguo LI Wenhui YANG Qiang LI Lijie PU Yan XU Zhongqi ZHANG Lili LIU | 2018 | Frontiers of Earth Science2018，12，2： | 2 |
| 13 | Research on the Soil Carbon Storage of Alpine Grassland under Different Land Uses in Qinghai-Tibet Plateau显示文摘 | Tao Li Lei Ji Tao Liu Zhongqi Song Shujing Yang Youmin Gan | 2013 | Journal of Agricultural Science and Technology(A)2013，3，2： | 2 |
| 14 | Experimental Study of Bowed-twisted Stators in an Axial Transonic Fan Stage显示文摘Bowed-twisted stators with large camber angles have been developed to replace the conventional tandem stators in an axial transonic fan stage working at high subsonic speeds.Experimental study is carried out on both stages with tandem stators and with bowed-twisted stators.Compared to the tandem stators,the bowed-twisted stators change the distribution of the low-energy fluid and the potential high-energy fluid at the compressor outlets,reduce the endwall loss significantly,improve the aerody-namic matching of rotors and stators,and eventually increase the fan stage performances.The aerodynamic performances of the fan stage at different operating points are compared and contrasted.The results show that the transonic fan stage with bowed-twisted stators has better aerodynamic performances.It is thus suggested that the bowed-twisted stators with large camber angles be popularized into the high-loaded transonic fan designs. | Chen Fu,Li Shaobin,Su Jiexian,Wang Zhongqi School of Energy Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2009 | Chinese Journal of Aeronautics2009，22，4： | 2 |
| 15 | circStrn3 is involved in bone cancer pain regulation in a rat model显示文摘Bone cancer pain(BCP)is a common chronic pain that is caused by a primary or metastatic bone tumor,More detailed molecular mechanisms of BCP are warranted.In this study,we established a BCP rat model.The von Frey hair test,body weight,and hematoxylin and eosin staining were employed.We screened differentilly expressed circRNAs(DECs)between the BCP group and sham group.The results revealed that 850 DECs were significantly up-regulated and 644 DECs were significantly down-regulated in the BCP group.Furthermore,we identified 1177 diffrentially expressed genes(DEGs)significantly up-regulated and 565 DEGs significantly down-regulated in the BCP group.Gene Ontology annotation of all 1742 DEGs revealed that biological regulation of metabolic processes,cellular processes,and binding were the top enriched terrms.For Kyoto Ency-clopedia of Genes and Genomes analysis,phagosome,HTLV-I infection,proteoglycans in cancer,and herpes simplex infection were significantly enriched in this study.In addition,we identified four selected circRNAs,chr6:72418120|72430205.chr20:756105717573740,chr18:69943105|69944476,and chr5:167516581|167558250,by quantitative real time PCR.chr6:72418120|72430205(circStrn3)was selected for further study based on expression level and the circRNA--miRNA--mRNA network table.Western blot analysis suggested that knockdown of circStrn3 could effectively induce Walker 256 cell apoptosis.In summary,our study provided a more in-depth understanding of the molecular mechanisms of BCP. | Yiwen Zhang Xiaoxia Zhang Zumin Xing Shuyi Tang Hanwen Chen Zhongqi Zhang Jiyuan Li Yalan Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 16 | Fault Detection in Reaction Wheel of a Satellite Using Observer-Based Dynamic 显示文摘 | Li Zhongqi Ma Liying KHASHAYAR KHORASANI | 2005 | Neural Networks2005，，： | 1 |
| 17 | Design and implementation of data-driven predictive cloud control system显示文摘The rapid increase of the scale and the complexity of the controlled plants bring new challenges such as computing power and storage for conventional control systems.Cloud computing is concerned as a powerful solution to handle complex large-scale control missions by using sufficient computing resources.However,the computing ability enables more complex devices and more data to be involved and most of the data have not been fully utilized.Meanwhile,it is even impossible to obtain an accurate model of each device in the complex control systems for the model-based control algorithms.Therefore,motivated by the above reasons,we propose a data-driven predictive cloud control system.To achieve the proposed system,a practical data-driven predictive cloud control testbed is established and together a cloud-edge communication scheme is developed.Finally,the simulations and experiments demonstrate the effectiveness of the proposed system. | GAO Runze XIA Yuanqing DAI Li SUN Zhongqi ZHAN Yufeng | 2022 | Journal of Systems Engineering and Electronics2022，33，6： | 1 |
| 18 | Numerical Study of the Air Bleeding Caused Non-Uniformity in Axial Compressor显示文摘Bleeding in the compressor is getting more and more attractive because the increasing demand of bleeding rate as the temperature of the first stage of turbine gets higher and needs more cooling air.Though plenty of work has been done about bleeding,however,most of the work is studied with a single passage or ignoring the real structure of the bleeding system.In the present study,multi-passage calculation was used through ANSYS CFX to consider the finite duct holes in the whole blade row,and the effect of the axial location of bleeding slot on the non-uniformity of the blade passage was investigated,and the non-uniform could maintain a low level when bleeding at the front part of the blade passage and the non-uniformity would become large when moving the bleeding slot much further downstream.Afterward,the air bleeding mass flow rate was studied.It’s found that the non-uniformity of air bleeding mass flow is small when bleeding at a low mass flow rate in each passage and results in relatively uniform flow field in the passage.However,the non-uniformity increases significantly as the bleeding mass flow rate increases.Some flow field details were also given to study how the flow field changes when bleeding non-uniformly. | CHEN Shaowen GONG Yun LI Weihang WANG Songtao WANG Zhongqi | 2020 | Journal of Thermal Science2020，29，1： | 1 |
| 19 | Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution显示文摘 | Rachael Mooney Yiming Weng Revathiswari Tirughana-Sambandan Valerie Valenzuela Soraya Aramburo Elizabeth Garcia Zhongqi Li Margarita Gutova Alexander J Annala Jacob M Berlin Karen S Aboody | 2014 | Future Oncology2014，，3： | 1 |
| 20 | Non-invasive microelectrode cadmium flux measurements reveal the spatial characteristics and real-time kinetics of cadmium transport in hyperaccumulator and nonhyperaccumulator ecotypes of Sedum alfredii显示文摘 | Jian Sun Ruigang Wang Zhongqi Liu Yongzhen Ding Tingqiang Li | 2012 | Journal of Plant Physiology2012，，： | 1 |
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