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您的检索式：作者名="Zhongze Lin"
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| 1 | Enhanced electrical,mechanical and tribological properties of Cu-Cr-Zr alloys by continuous extrusion forming and subsequent aging treatment显示文摘As a promising material for the new generation of high-speed railway contact wires,the comprehensive optimization of the electrical conductivity,strength,hardness and wear resistance of the Cu-Cr-Zr alloy has received extensive attention.In this paper,a high-performance Cu-1Cr-0.1Zr alloy with an ultimate tensile strength of 599.1 MPa,a uniform elongation of 8.6%,a microhardness of 195.7 HV_(0.2) and an electrical conductivity of 80.07%IACS was achieved by the continuous extrusion forming(CEF)and subsequent peak-aging treatment.The grain refinement strengthening,dislocation strengthening and precipitation strengthening are identified to be responsible for the excellent electrical and mechanical properties of Cu-Cr-Zr alloy.The wear behavior of Cu-Cr-Zr alloy was investigated by examining the evolution of worn surface morphology and subsurface microstructure.The microhardness(H)and reduced elastic modulus(E_(r))of the subsurface below the worn surface measured by nanoindentation were calculated to gage the tribological performance of Cu-Cr-Zr alloy.Results show that the continuously extruded and subsequently peak-aged specimen has the best wear resistance,which indicates that the tribological properties of CuCr-Zr alloy strongly depend on its strength and hardness.It can be concluded that the CEF and subsequent aging treatment process provides a new and high-efficiency procedure for the continuous preparation of Cu-Cr-Zr alloys. | Zhe Shen Zhongze Lin Peijian Shi Jiale Zhu Tianxiang Zheng Biao Ding Yifeng Guo Yunbo Zhong | 2022 | Journal of Materials Science & Technology2022，，15： | 0 |
| 2 | Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury显示文摘Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon regeneration.Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal regenerative ability and disconnection of neural elements after injury,as well as the limited systemic drug delivery efficiency caused by blood spinal cord barrier.To develop an effective non-invasive treatment strategy for SCI in clinic,we generated an autologous plasma exosome(AP-EXO)based biological scaffold where AP-EXO was loaded with neuron targeting peptide(RVG)and growth-facilitating peptides(ILP and ISP).This scaffold can be targeted delivered to neurons in the injured area and elicit robust axon regrowth across the lesion core to the levels over 30-fold greater than naïve treatment,thus reestablish the intraspinal circuits and promote motor functional recovery after spinal cord injury in mice.More importantly,in ex vivo,human plasma exosomes(HP-EXO)loaded with combinatory peptides of RVG,ILP and ISP showed safety and no liver and kidney toxicity in the application to nude SCI mice.Combining the efficacy and safety,the AP-EXO-based personalized treatment confers functional recovery after SCI and showed immense promising in biomedical applications in treating SCI.It is helpful to expand the application of combinatory peptides and human plasma derived autologous exosomes in promoting regeneration and recovery upon SCI treatment. | Ning Ran Wenxiang Li Renjie Zhang Caorui Lin Jianping Zhang Zhijian Wei Zonghao Li Zhongze Yuan Min Wang Baoyou Fan Wenyuan Shen Xueying Li Hengxing Zhou Xue Yao Xiaohong Kong Shiqing Feng | 2023 | Bioactive Materials2023，，7： | 0 |
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