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| 1 | Intelligent identification system of flow regime of oil-gas-water multiphase flow显示文摘 | WU Haojiang ZHOU Fangde WU Yuyuan | 2001 | International Journal of Multiphase Flow2001，27，3： | 1 |
| 2 | Grain boundary character and stress corrosion cracking behavior of Co-Cr alloy fabricated by selective laser melting显示文摘In this work,we used the selective laser melting(SLM)fabricated Co-Cr alloy with prominent residual strain,extremely non-equilibrium microstructures,and low stacking fault energy as a precursor to fabricate materials with the optimal grain boundary character distribution.The grain boundary engineering(GBE)of the Co-Cr alloy was achieved by a simple heat treatment of the SLM-fabricated Co-Cr alloy.The obtained GBE Co-Cr alloy exhibited 81.47%of special grain boundaries(∑3^(n)n=1,2,3),while it substantially disrupted the connectivity of the random high-angle boundaries,successfully reducing the propensity of intergranular degradation.Slow strain rate tests(SSRTs)showed that the GBE Co-Cr alloy possessed lower stress corrosion cracking(SCC)susceptibility and higher ductility in the corrosive environment(0.9%Na Cl solution)than in the air.The high fraction of special boundaries,coupled with the stress-induced martensitic transformation(SIMT)in the GBE Co-Cr alloy yielded these results,which unique and rarely simultaneously satisfied for common structural materials.The current'SLM induced GBE strategy'offers a novel approach towards customized GBE materials with high SCC resistance and ductility in the corrosive environment,shedding new light on developing high-performance structural materials. | Xin Dong Ning Li Yanan Zhou Huabei Peng Yuntao Qu Qi Sun Haojiang Shi Rui Li Sheng Xu Jiazhen Yan | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 3 | Intelligent Identification System of Flow Regime of Oil/gas/water Multiphase Flow显示文摘 | Wu Haojiang Zhou Fangde Wu Yuyuan | 2001 | International Journal of Multiphase Flow2001，27，： | 1 |
| 4 | Using BAC for HAA Removal,part 1: Batch study 显示文摘 | Zhou Haojiang Xie Yuefeng | 2002 | American Water Works Association Journal2002，94，4： | 1 |
| 5 | Use of BAC for HAA removal part 2, column study 显示文摘 | Xie Yuefeng Haojiang Zhou | 2002 | American Water Works Association Journal2002，92，5： | 1 |
| 6 | Intelligent identi- fication system of flow regime of oil-gas water multiphase flow显示文摘 | Wu Haojiang Zhou Fangde Wu Yuyuan | 2001 | International Journal of Multiphase Flow2001，27，3： | 1 |
| 7 | Use of BAC for HAA removal-Part 2,column study显示文摘 | Haojiang Zhou | 2002 | Jour AWWA2002，94，5： | 1 |
| 8 | Intelligent identification system of flow regiem of oil-gas-water multitiphasw flow显示文摘 | Wu Haojiang Zhou Fangde Wu Yuyuan | 2001 | International Journal of Multiphase Flow2001，27，3： | 1 |
| 9 | Intelligent identification system of flow regime of oil-gas-water multiphase flow 显示文摘 | WU Haojiang ZHOU Fangde WU Yuyuan | 2001 | International Journal of Muhiphase Flow2001，27，3： | 1 |
| 10 | Intelligent identification system of flow regime of oil-gas-water multiphase flow 显示文摘 | Wu Haojiang Zhou Fangde Wu yuyuan | 2001 | International Journal of Multiphase Flow2001，27，3： | 1 |
| 11 | Analytical modeling and free vibration piezoelectric bimorph 显示文摘 | Zhou Yanguo Chen Yunmin Ding Haojiang | 2005 | Journal of Zhejiang university SCIENCE2005，6，9： | 1 |
| 12 | Acidic methanol methylation for HAA analysis:Limitations and possible solutions 显示文摘 | Xie Yuefeng Rashid Inni Zhou Haojiang | 2002 | American Water Works Association2002，94，11： | 1 |
| 13 | Intelligent identification system of flow regime of oil-gas-water multi- phase flow显示文摘 | WU Haojiang ZHOU Fangde WU Yuyuan | 2001 | International Journal of Muhiphase Flow2001，27，3： | 1 |
| 14 | SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation显示文摘Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.Methods:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver can-cer.Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of patients.DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells.RNA sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis.Patient-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib.Results:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA methylation.SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer.SERPINE2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and angiogenesis.IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with EGFR.Mechanistically,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,c-Cbl.Additionally,EGFR was activated in liver cancer cells after sorafenib treatment,and SER-PINE2 knockdown-induced EGFR downregulation significantly enhanced the therapeutic efficacy of sorafenib against liver cancer.Furthermore,we found that SERPINE2 knockdown also had a sensitizing effect on lenvatinib treatment.Conclusions:SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c-Cbl-mediated ubiquitination,suggesting that inhibition of the SERPINE2-EGFR axis may be a potential target for liver cancer treatment. | Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song | 2024 | Cancer Communications2024，44，3： | 0 |
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