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| 1 | Elabela-APJ axis contributes to embryonic development and prevents pre-eclampsia in pregnancy显示文摘 | Qionglin Zhou Kai Zhang Yu Guo Linxi Chen Lanfang Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 5 |
| 2 | Additive manufacturing technologies of porous metal implants显示文摘Biomedical metal materials with good corrosion resistance and mechanical properties are widely used in orthopedic surgery and dental implant materials,but they can easily cause stress shielding due to the significant difference in elastic modulus between the implant and human bones.The elastic modulus of porous metals is lower than that of dense metals.Therefore,it is possible to adjust the pore parameters to make the elastic modulus of porous metals match or be comparable with that of the bone tissue.At the same time,the open porous metals with pores connected to each other could provide the structural condition for bone ingrowth,which is helpful in strengthening the biological combination of bone tissue with the implants.Therefore,the preparation technologies of porous metal implants and related research have been drawing more and more attention due to the excellent features of porous metals.Selective laser melting(SLM)and electron beam melting technology(EBM)are important research fields of additive manufacturing.They have the advantages of directly forming arbitrarily complex shaped metal parts which are suitable for the preparation of porous metal implants with complex shape and fine structure.As new manufacturing technologies,the applications of SLM and EBM for porous metal implants have just begun.This paper aims to understand the technology status of SLM and EBM,the research progress of porous metal implants preparation by using SLM and EBM,and the biological compatibility of the materials,individual design and manufacturing requirements.The existing problems and future research directions for porous metal implants prepared by SLM and EBM methods are discussed in the last paragraph. | Zhou Linxi Yang Quanzhan Zhang Guirong Zhao Fangxin Shen Gang Yu Bo | 2014 | China Foundry2014，11，4： | 5 |
| 3 | Elabela-APJ axis: a novel therapy target !or cardiovascular diseases显示文摘 | Lanfang Li Qionglin Zhou Xiaoxiao Li Linxi Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 3 |
| 4 | Mitochondria-associated endoplasmic reticulum membranes (MAMs) involve in the regulation of mitochondrial dysfunction and heart failure显示文摘 | Kai Zhang Qionglin Zhou Yu Guo Linxi Chen Lanfang Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 2 |
| 5 | Variation at NoD2/CARDl5in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish population显示文摘 | Zhou Z LinXY Akolkar PN | 2002 | Am J Gastroenterol2002，97，12： | 1 |
| 6 | Iron-mediated lysosomal-mitochondrial crosstalk:a new direction in the treatment of aging and aging-related diseases显示文摘A recent study by Hughes et al.[1]showed that cysteine-mediated iron deficiency is the main cause of aging-related mitochondrial dysfunction.They also uncovered that aging-induced vacuolar/lysosomal de-acidification participates in the cysteine-mediated iron deficiency,implying that the de-acidifying lysosome triggers vacuolar/lysosomal dysfunction and iron deficiency,further leading to mitochondrial dysfunction.Previous studies showed that iron and lysosomal-mitochondrial crosstalk are the two important mechanisms that lysosome regulates aging,and it is well known that iron plays a pivotal role in various cell metabolic activities[2,3].Accumulating evidence shows that there is a close relationship between lysosome and mitochondria,yet little is known about the exact role of them.The discovery that iron deficiency mediates lysosomal-mitochondrial crosstalk has presented a new therapeutic avenue for managing aging and aging-related diseases. | Lingzhi Wang Qun Zhou Linxi Chen Jinyong Jiang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 1 |
| 7 | IRP2-Hif1α/Hif2αsignaling:a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation显示文摘Iron regulatory protein 2(IRP2),first separated from mouse in 1993,is a cytoplasmic iron-regulated RNA-binding protein.IRP2 is a subtype of iron regulatory proteins(IRPs).IRP2 binds to iron-responsive element(IRE)RNA sequence to maintain iron home-ostasis[1]. | Li Zhu Qionglin Zhou Lu He Linxi Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 0 |
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