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| 1 | Lens distortion correction based on one chessboard pattern image显示文摘这份报纸建议西洋象棋盘角落的一个察觉方法改正照相机 distortionsincluding 光线的失真, decentering 失真和棱柱失真。这个建议方法能完成高角落察觉率。然后,我们使用了反复的过程优化失真参数最小化失真剩余。首先,在这个方法,非失真点被四个点在图象中心附近评估;第二, Levenberg-Marquardt 非线性的优化算法被采用计算失真参数,然后由这些参数改正图象;第三,我们在改正的图象上计算了角落点,并且重复了以前的二步直到失真参数收敛。结果证明由反复的过程的建议方法能在可以忽略的图象中心和一根线的失真剩余的一般水准附近做细微失真的影响是几乎 0.3 个象素。 | Yubin WU Shixiong JIANG Zhenkun XU Song ZHU Danhua CAO | 2015 | Frontiers of Optoelectronics2015，8，3： | 3 |
| 2 | SARS-CoV-2 non-structural protein 13 (nspl3) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response显示文摘Dear Editor,COVID-19(Coronavirus Disease-2019),a respiratory disease caused by the novel virus strain,SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),an enveloped,positive-sense,single-stranded RNA betacoronavirus of the family Corona-viridae,has spread worldwide.1 Notably,SARS-CoV-2 infection led to poor induction of typeⅠ interferon response,and the impaired type Ⅰ IFN responses have been shown to be associated with severe COVID-19 disease.2 However,molecular mechanisms by which SARS-CoV-2 suppresses type Ⅰ IFN production,and how host cells respond to the inhibition of type Ⅰ IFN response during SARS-CoV-2 infection,remain largely unknown. | Guijie Guo Ming Gao Xiaochen Gao Bibo Zhu Jinzhou Huang Kuntian Luo Yong Zhang Jie Sun Min Deng Zhenkun Lou | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 3 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 4 | Clinical relevance of angiographic coronary collaterals during primary coronary intervention for acute ST-elevation myocardial infarction显示文摘 | Shen Ying Wu Feng Pan Chunzang Zhu Tianqi Zhang Qi Zhang Ruiyan Ding Fenghua Lu Lin Hu Jian Yang Zhenkun Shen Weifeng Wu Zonggui | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 5 | Digital Barcode Development for Single Nuclotide Polymorphism (SNP) Identification of Suzhong Swine Individuals显示文摘Suzhong swine is a hybrid breed derived from Taihu sows and Landrace boars. To identify Suzhong swine individuals and trace the source of pork products,single nucleotide polymorphisms( SNPs) identification of Suzhong swine individuals was studied. A total of 29 pairs of primers were designed and seven pairs of primers were used for identification of Suzhong swine individuals. The products amplified by seven pairs of primers could be directly sequenced,with clean sequencing map background and no ambiguity in sequence read. Totally 52 SNPs loci were amplified by seven pairs of primers,and 41 SNPs loci were reserved for identification of Suzhong swine individuals through correlation analysis and heterozygosity filtration( H≥0. 1). Meantime,the digital barcodes for SNP identification of 96 individuals of Suzhong swine derived from seven boars and 12 sows were developed,which well distinguished 96 individuals of Suzhong swine. Theoretically,41 SNPs amplified by seven pairs of primers could be used for identification of 5. 0 × 10~6 pig individuals. Therefore,digital barcode development method for SNP identification of Suzhong swine individuals can be used for individual identification of Suzhong swine in scale pig farm and meat product traceability. | Hu Yinong Ding Qian Ji Hongjun Wang Xiaoxiao Zhu Zhenkun Zhao Qingshun | 2016 | Animal Husbandry and Feed Science2016，8，6： | 0 |
| 6 | FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis显示文摘Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its use. Fibroblast growth factor (FGF) 10, a multifunctional paracrine growth factor, plays diverse roles in embryonic and postnatal heart development as well as in cardiac regeneration and repair. In this study we investigated the role of FGF10 as a potential modulator of doxorubicin-induced cardiac cytotoxicity and the underlying molecular mechanisms. Fgf10+/− mice and an inducible dominant negative FGFR2b transgenic mouse model (Rosa26rtTA;tet(O)sFgfr2b) were used to determine the effect of Fgf10 hypomorph or blocking of endogenous FGFR2b ligands activity on doxorubicin-induced myocardial injury. Acute myocardial injury was induced by a single injection of doxorubicin (25 mg/kg, i.p.). Then cardiac function was evaluated using echocardiography, and DNA damage, oxidative stress and apoptosis in cardiac tissue were assessed. We showed that doxorubicin treatment markedly decreased the expression of FGFR2b ligands including FGF10 in cardiac tissue of wild type mice, whereas Fgf10+/− mice exhibited a greater degree of oxidative stress, DNA damage and apoptosis as compared with the Fgf10+/+ control. Pre-treatment with recombinant FGF10 protein significantly attenuated doxorubicin-induced oxidative stress, DNA damage and apoptosis both in doxorubicin-treated mice and in doxorubicin-treated HL-1 cells and NRCMs. We demonstrated that FGF10 protected against doxorubicin-induced myocardial toxicity via activation of FGFR2/Pleckstrin homology-like domain family A member 1 (PHLDA1)/Akt axis. Overall, our results unveil a potent protective effect of FGF10 against doxorubicin-induced myocardial injury and identify FGFR2b/PHLDA1/Akt axis as a potential therapeutic target for patients receiving doxorubicin treatment. | De-pu Zhou Lian-cheng Deng Xiao Feng Hui-jing Xu Ye Tian Wei-wei Yang Ping-ping Zeng Li-hui Zou Xi-hua Yan Xia-yan Zhu Dan-hua Shu Qiang Guo Xiao-ying Huang Saverio Bellusci Zhenkun Lou Xiao-kun Li Jin-San Zhang | 2023 | Acta Pharmacologica Sinica2023，44，10： | 0 |
| 7 | A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus显示文摘T lymphocytes are crucial for antiviral responses and provide a promising repertoire for potential therapies of viral diseases such as cytomegalovirus(CMV)infection1 and the ongoing COVID-19 pandemic caused by SARS-CoV-2.^(2) CMV-related diseases occur once the host immune system is impaired or lacks a protective repertoire of virus-specific T lymphocytes.3 Adoptive transfer of T-cell receptor(TCR)-engineered T cells(TCR-Ts)provides an encouraging alternative treatment option for patients with CMV reactivation.^(4) However,generating TCR-Ts requires the identification of epitope-specific and functional TCR pairs.Modern single-cell sequencing techniques open up the ability to unravel TCR repertoires,^(5 )which offers a potential opportunity to screen functional TCR pairs for TCR-T therapy.Here,we report an efficient approach that combines ex vivo CD8+T-cell stimulation with single-cell RNA and TCR V(D)J sequencing to identify CMV-specific TCRs for generating TCR-Ts. | Fei Wang Qumiao Xu Zhenkun Zhuang Ziyi Li Qianqian Gao Yaling Huang Yonglun Luo Xiuqing Zhang Linnan Zhu Cheng-chi Chao | 2021 | Cellular & Molecular Immunology2021，18，5： | 0 |
| 8 | Facile Modification on Buried Interface for Highly Efficient and Stable FASn_(0.5)Pb_(0.5)I_(3) Perovskite Solar Cells with NiOx Hole-Transport layers显示文摘Formamidinium(FA)-based Sn-Pb perovskite solar cells(FAPb_(0.5)Sn_(0.5)I_(3) PSCs)with ideal bandgap and impressive thermal stability have caught enormous attention recently.However,it still suffers from the challenge of realizing high efficiency due to the surface imperfections of the transport materials and the energy-level mismatch between functional contacts.Herein,it is demonstrated that the modification on buried interface with alkali metal salts is a viable strategy to alleviate these issues.We systematically investigate the role of three alkali metal bromide salts(NaBr,KBr,CsBr)by burying them between the NiOx hole transport layer(HTL)and the perovskite light-absorbing layer,which can effectively passivate interface defects,improve energy-level matching and release the internal residual strain in perovskite layers.The device with CsBr buffer layer exhibits the best power conversion efficiency(PCE)approaching 20%,which is one of the highest efficiencies for FA-based Sn-Pb PSCs employing NiO_(x) HTLs.Impressively,the long-term storage stability of the unencapsulated device is also greatly boosted.Our work provides an efficient strategy to prepare desired FA-based ideal-bandgap Sn-Pb PSCs which could be applied in tandem solar cells. | Hui Zhang Yuan Zhou Tonghui Guo Xiang Zhang Zhenkun Zhu Junjun Jin Xiaxia Cui Dan Zhang Zhen Wang Lin Li Nai Wang Guanqi Tang Qidong Tai | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
| 9 | Dysregulation of PLOD2 Promotes Tumor Metastasis and Invasion in Hepatocellular Carcinoma显示文摘Background and Aims:Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma(HCC)patients while the underlying mechanism of metastasis remains elusive.In our study,procollagen-lysine,2-oxoglutarate 5-dioxygenase 2(PLOD2)was shown to be involved in the process of metastasis in HCC.Methods:The Cancer Genome Atlas(TCGA)database and HCC tissue microarrays were used to evaluate the expression of genes.In vitro migration,invasion,in vivo subcutaneous tumor model and in vivo lung metastasis assays were used to determine the role of PLOD2 in tumor growth and metastasis in HCC.RNA sequencing and gene set enrichment analysis were performed to uncover the downstream factor of PLOD2 in HCC cells.A luciferase reporter assay was performed to evaluate the interaction between PLOD2 and interferon regulatory factor 5(IRF5).Results:The expression of PLOD2 in HCC tissues was higher than that in adjacent tissues,and increased PLOD2 expression was often found in advanced tumors and was correlated with poor prognosis in HCC patients.In vitro experiments,knockdown of PLOD2 reduced the migration and invasion of human HCC cells.Loss of PLOD2 suppressed human HCC growth and metastasis in a subcutaneous tumor model and a lung metastasis model.Baculoviral IAP repeat containing 3(BIRC3)was proven to be the downstream factor of PLOD2 in human HCC cells.In addition,PLOD2 was transcriptionally regulated by IRF5 in HCC cells.Conclusions:High expression of PLOD2 was regulated by IRF5,which was correlated with the poor survival of HCC patients.PLOD2 enhanced HCC metastasis via BIRC3,suggesting that PLOD2 might be a valuable prognostic biomarker for HCC treatment. | Keren Li Yi Niu Kai Li Chengrui Zhong Zhiyu Qiu Yichuan Yuan Yunxing Shi Zhu Lin Zhenkun Huang Dinglan Zuo Yunfei Yuan Binkui Li | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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