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| 1 | Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients显示文摘AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients.METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd.OMOM capsule endoscopy database.The patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and analyzed.RESULTS:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy procedures.One thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic diarrhea.The overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with OGIB.However,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 min.The overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER. | Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen | 2010 | World Journal of Gastroenterology2010，16，21： | 35 |
| 2 | Clinical application of magnetically controlled capsule gastroscopy in gastric disease diagnosis: recent advances显示文摘Magnetically controlled capsule gastroscopy(MCCG) is a novel system primarily used for the diagnosis of gastric disease. It consists of an endoscopic capsule with magnetic material inside, external guidance magnet equipment, data recorder and computer workstation. Several clinical trials have demonstrated that MCCG is comparable in accuracy in diagnosing gastric focal disease when compared to conventional gastroscopy. Further clinical studies are needed to test the diagnostic accuracy and improve the functioning of MCCG. This novel MCCG system could be a promising alternative for screening for gastric diseases,with the advantages of no anesthesia required, comfort and high acceptance across populations. | Zhuan Liao Wenbin Zou Zhao-Shen Li | 2018 | Science China(Life Sciences)2018，61，11： | 12 |
| 3 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015，25，2： | 12 |
| 4 | Audiovisual Sexual Stimulation and RigiScan Test for the Diagnosis of Erectile Dysfunction显示文摘 | Tao Wang Li Zhuan Zhuo Liu Ming-Chao Li Jun Yang Shao-Gang Wang Ji-Hong Liu Qing Ling Wei-Min Yang Zhang-Qun Ye | 2018 | Chinese Medical Journal2018，，12： | 10 |
| 5 | Study on chronic pancreatitis and pancreatic cancer using MRS and pancreatic juice samples显示文摘AIM:To investigate the markers of pancreatic diseases and provide basic data and experimental methods for the diagnosis of pancreatic diseases.METHODS:There were 15 patients in the present study,among whom 10 had pancreatic cancer and 5,chronic pancreatitis.In all patients,pancreatic cancer or chronic pancreatitis was located on the head of the p-a-ncrea-s.Pa-thology da-ta-of a-ll p-a-tients wa-s confirmed by biopsy and surgery.Among the 10 patients with pancreatic cancer,3 people had a medical history of longterm alcohol consumption.Of 5 patients with chronic pancreatitis,4 men suffered from alcoholic chronic pancreatitis.Pancreatic juice samples were obtained from patients by endoscopic retrograde cholangiopancreatography.Magnetic resonance spectroscopyn was performed on an 11.7-T scanner (Bruker DRX-500) using Call-Purcell-Meiboom-Gill pulse sequences.The parameters were as follows:spectral width,15 KHz;time domain,64 K;number of scans,512;and acquisition time,2.128 s.RESULTS:The main component of pancreatic juice included leucine,iso-leucine,valine,lactate,alanine,acetate,aspartate,lysine,glycine,threonine,tyrosine,histidine,tryptophan,and phenylalanine.On performing 1D 1H and 2D total correlation spectroscopy,we found a triplet peak at the chemical shift of 1.19 ppm,which only appeared in the spectra of pancreatic juice obtained from patients with alcoholic chronic pancreatitis.This triplet peak was considered the resonance of the methyl of ethoxy group,which may be associated with the metabolism of alcohol in the pancreas.CONCLUSION:The triplet peak,at the chemical shift of 1.19 ppm is likely to be the characteristic metabolite of alcoholic chronic pancreatitis. | Jian Wang Chao Ma Zhuan Liao Bing Tian Jian-Ping Lu | 2011 | World Journal of Gastroenterology2011，17，16： | 9 |
| 6 | Wireless esophageal pH capsule for patients with gastroesophageal reflux disease: A multicenter clinical study显示文摘AIM:To investigate the feasibility and safety of pH capsule to monitor pH in patients with gastroesophageal reflux disease(GERD).METHODS:Ninety-one patients with symptoms suggestive of GERD were enrolled in this study,46 of whom were randomized to the pH capsule group;the remaining 45 patients used the conventional catheter and pH capsule simultaneously.The pH data and traceswere recorded via automatic analysis,and capsule detachment was assessed using X-ray images.All of the patients were required to complete a questionnaire regarding tolerance with the capsule.RESULTS:The capsules were successfully attached on the first attempt,and no early detachment of the capsules was observed.Compared to the 24-h pH data recorded with the conventional catheter,the data collected with the pH capsule showed no significant differences in 24-h esophageal acid exposure.The measurements of esophageal acid exposure over 24 h collected with the two devices showed a significant correlation(r2=0.996,P<0.001).Capsule detachment occurred spontaneously in 89 patients,and 2 capsules required endoscopic removal due to chest pain.The capsule was associated with less interference with daily activity.CONCLUSION:The wireless pH capsule provides a feasible and safe method for monitoring gastroesophageal reflux and therefore may serve as an important tool for diagnosing GERD. | Xiao-Jun Yang Tian Gan Lei Wang Zhuan Liao Xiao-Hong Tao Wei Shen Xiao-Yan Zhao | 2014 | World Journal of Gastroenterology2014，20，40： | 9 |
| 7 | Preparation,Properties and Application of C/C-SiC Composites Fabricated by Warm Compacted-in situ Reaction显示文摘Carbon fibre reinforced carbon and SiC dual matrices composites (C/C-SiC) show superior tribological properties,high thermal shock resistance and good abrasive resistance,and they are promising candidates for advanced brake and clutch systems.The microstructure,mechanical properties,friction and wear properties,and application of the C/C-SiC composites fabricated by warm compacted-in situ reaction were introduced.The results indicated that the composites were composed of 50-60 wt pct carbon,2-10 wt pct residual silicon and 30-40 wt pct silicon carbide.The C/C-SiC brake composites exhibited good mechanical properties.The value of flexural strength and compressive strength could reach 160 and 112 MPa,respectively.The impact strength was about 2.5 kJ·m-2.The C/C-SiC brake composites showed excellent tribological performance,including high coefficient of friction (0.38),good abrasive resistance (1.10 μm/cycle) and brake steadily on dry condition.The tribological properties on wet condition could be mostly maintained.The silicon carbide matrix in C/C-SiC brake composites improved the wear resistance,and the graphite played the lubrication function,and right volume content of graphite was helpful to forming friction film to reduce the wear rate.These results showed that C/C-SiC composites fabricated by warm compacted-in situ reaction had excellent properties for use as brake materials. | Peng Xiao Zhuan Li Zibing Zhu Xiang Xiong | 2010 | Journal of Materials Science & Technology2010，26，3： | 8 |
| 8 | Diagnosis and treatment of autoimmune pancreatitis: experience with 100 patients显示文摘BACKGROUND: Autoimmune pancreatitis (AIP) is increasingly recognized as a unique subtype of pancreatitis. This study aimed to analyze the diagnosis and treatment of AIP patients from a tertiary care center in China.METHODS: One hundred patients with AIP who had been treated from January 2005 to December 2012 in our hospital were enrolled in this study. We retrospectively reviewed the data of clinical manifestations, laboratory tests, imaging examinations, pathological examinations, treatment and outcomes of the patients.RESULTS: The median age of the patients at onset was 57 years (range 23-82) with a male to female ratio of 8.1:1. The common manifestations of the patients included obstructive jaundice (49 patients, 49.0%), abdominal pain (30, 30.0%), and acute pancreatitis (11, 11.0%). Biliary involvement was one of the most extrapancreatic manifestations (64, 64.0%). Fifty-six (56.0%) and 43 (43.0%) patients were classified into focaltype and diffuse-type respectively according to the imaging examinations. The levels of serum Ig G and Ig G4 were elevated in 69.4% (43/62) and 92.0% (69/75) patients. Pathological analysis of specimens from 27 patients supported the diagnosis of lymphoplasmacytic sclerosing pancreatitis, and marked (>10 cells/HPF) Ig G4 positive cells were found in 20 (74.1%) patients.Steroid treatment and surgery as the main initial treatments were given to 41 (41.0%) and 28 (28.0%) patients, respectively. The remission rate after the initial treatment was 85.0%. Steroid was given as the treatment after relapse in most of the patients and the total remission rate at the end of follow-up was 96.0%.CONCLUSIONS: Clinical manifestations, laboratory tests, imaging and pathology examinations in combination could increase the diagnostic accuracy of AIP. Steroid treatment with an initial dose of 30 or 40 mg prednisone is effective and safe in most patients with AIP. | Lei Xin Yuan-Xiang He Xiao-Fei Zhu Qun-Hua Zhang Liang-Hao Hu Duo-Wu Zou Zhen-Dong Jin Xue-Jiao Chang Jian-Ming Zheng Changhai Hospital Second Military Medical University Chang-Jing Zuo Cheng-Wei Shao Gang Jin Zhuan Liao Zhao-Shen Li | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 6 |
| 9 | Guidelines for the diagnosis and treatment of chronic pancreatitis in China(2018 edition)显示文摘Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and functions.CP seriously affects the quality of life of patients and greatly increases the public medical burden of society.In recent years,the incidence of CP has increased worldwide.The concepts of etiology and therapies have been continuously updated. | Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang Xiao-Yan Chang Rong-Chun Zhang Xiao-Bin Li Yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese Medical Doctor Association | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 6 |
| 10 | Isolation of egg yolk IgY from hens immunized with S.mutans B29-33 and S.sobrinus 6715显示文摘目的 :从鸡蛋中提取特异性抗体 ,鉴定抗体性质并分析其蛋白质含量 ,以探索一种制备被动免疫防龋抗体的制备方法。方法 :变形链球菌GTF高表达株S .mutansB2 9- 33及茸毛链球菌S .sobrinus 6 715免疫母鸡 ,采用硫酸铵沉淀法提取鸡蛋黄抗体 ,SDS -PAGE凝胶扫描鉴定抗体性质 ,分析其纯度并用分光光度法测蛋白质含量。结果 :用硫酸铵沉淀法可提取出鸡蛋黄抗体 ,其性质为IgG ,蛋白质含量约为 7.0 0mg/ml。结论 :鸡蛋黄抗体含量高 ,作为被动免疫抗体的载体有较好的应用前景。 | FAN Ming-wen, JIANG Qian-zhou, BIAN Zhuan, ZHANG Ping, LIU Ning-hui, LIU Jian.College of Stomatology, Wuhan University, Wuhan 430079 | 2000 | 口腔医学纵横2000，16，3： | 6 |
| 11 | Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices显示文摘AIM:To review the literature on capsule endoscopy(CE) for detecting esophageal varices using conventional esophagogas troduodenoscopy(EGD)as the standard. METHODS:A strict literature search of studies comparing the yield of CE and EGD in patients diagnosed or suspected as having esophageal varices was conducted by both computer search and manual search.Data were extracted to estimate the pooled diagnostic sensitivity and specificity. RESULTS:There were seven studies appropriate for meta-analysis in our study,involving 446 patients. The pooled sensitivity and specificity of CE for detecting esophageal varices were 85.8%and 80.5%, respectively.In subgroup analysis,the pooled sensitivity and specificity were 82.7%and 54.8%in screened patients,and 87.3%and 84.7%in the screened/ patients under surveillance,respectively. CONCLUSION:CE appears to have acceptable sensitivity and specificity in detecting esophageal varices.However,data are insufficient to determine the accurate diagnostic value of CE in the screen/ surveillance of patients alone. | Yi Lu Rui Gao Zhuan Liao Liang-Hao Hu Zhao-Shen Li | 2009 | World Journal of Gastroenterology2009，15，10： | 5 |
| 12 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 13 | Transgene directionally integrated into C-genome of Brassica napus显示文摘Integration of a transgene into a C-genome chromosome plays an important role in reducing ecological risk of transgenic Brassica napus To obtain C-genome transgenic B. napus, herbi- cide-resistant bar gene was firstly transferred into B. oleracea var. alboglabra mediated by Agrobacterium tumefaciens strain LBA4404. Then using the trans- genic B. oleracea as paternal plants and 8 non- transgenic varieties of B. rapa as maternal plants, C- genome transgenic B. napus with bar gene was arti- ficially resynthesized by means of ovary culture and chromosome doubling. Among 67 lines of the resyn- thesized B. napus, 31 were positive, and 36 were negative according to PCR test for bar gene. At least 2 plants from each line were kept for PPT spray con- firmation. The result was in consistence with the PCR test. Genomic Southern blotting of three randomly chosen lines also showed that bar gene had been integrated into the genome of resynthesized B. napus lines. | LI Jun FANG Xiaoping WANG Zhuan LUO Lixia HU Qiong | 2006 | Chinese Science Bulletin2006，51，13： | 5 |
| 14 | Experiment on Hydraulic Fracturing in Rock and Induced Earthquake显示文摘Experiment on rock hydraulic fracturing strength under different confining pressures was conducted on a series of test specimens with various pre-cracks prepared from 7 types of rock. Combining the data of an actual reservoir-induced earthquake with the experimental results of the contemporary tectonic stress field according to the theory of rock strength and the principle and method of rock fracture mechanics, the authors tentatively investigated the earthquakes induced by pore-water pressure in rock and obtained the initial results as follows: (1) One type of induced earthquake may occur in the case of larger tectonic stress on such weak planes that strike in similar orientation of principle tectonic compressional stress in the shallows of the rock mass; the pore-water pressure σp may generate tensile fracture on them and induce small earthquakes; (2) Two types of induced earthquake may occur in the case of larger tectonic stress, i.e.,① on such weakness planes that strike in similar orientation of principle tectonic compressional stress, σ1, in the shallows of the rockmass, the pore-water pressure, σp, may generate tensile fracture on them and induce small earthquakes; ② When the tectonic stress approximates the shear strength of the fracture, the pore-water pressure σp may reduce the normal stress, σn, on the fracture face causing failure of the originally stable fracture, producing gliding fracture and thus inducing an earthquake. σp may also increase the fracture depth, leading to an induced earthquake with the magnitude larger than the previous potential magnitude; (3) There is a depth limit for each type of rock mass, and no induced earthquake will occur beyond this limit. | Yan Yuding Li Yalin Zhang Zhuan Ouyang Lisheng Xie Mingfu | 2005 | Earthquake Research in China2005，19，4： | 4 |
| 15 | Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/ cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1显示文摘我们的以前的研究证明了那可勃起的功能在怀有人的织物 kallikrein 的年老的转基因的老鼠(TGR ) 被保存 1 (hKLK1 ) ,当肉体的纤维变性上的 hKLK1 的分子的水平糟糕被理解禁止年龄相关的可勃起的机能障碍(编辑) 时。男野类型的 Sprague-Dawley 老鼠(WTR ) 和怀有 hKLK1 基因的 TGR 被喂到 4-month-old 或 18-month-old 并且把组划分了成三:年轻 WTR (yWTR ) 作为控制, WTR (aWTR ) ,并且 TGR (aTGR ) 。所有老鼠的可勃起的功能被多孔的神经 electrostimulation 方法估计。Massons 三色的染色被用来在阴茎海绵体评估肉体的纤维变性。我们发现在 aWTR 组的老鼠的可勃起的功能比另外的二个组的显著地低。Massons 三色的染色 yWTR 和 aTGR 组,与那些相比揭示了那 /collagen (C) 是的光滑的肌肉房间(SMC ) 的比率在 aWTR 组显著地更低。Immunohistochemistry 和西方的弄污分析被表现,并且结果示威了 α 的那表情; -SMA 更低,当时转变生长 factor-β 的表情;1 (TGF-β 1 ) , RhoA, ROCK1, p-MYPT1, p-LIMK2,和 p-cofilin 与在另外的二个组的那些相比在 aWTR 组是更高的。然而, LIMK2 和 cofilin 表情没在三个组之中不同。一起拿,这些结果显示 RhoA/ROCK1/LIMK/cofilin 小径可以涉及到先进年龄,和 hKLK1 引起的肉体的纤维变性可以由禁止这条小径的激活改善减少这肉体的纤维变性年龄相关的编辑。 | Kai Cui Yang Luan Tao Wang Li Zhuan Ke Rao Shao-Gang Wang Zhang-Qun Ye Ji-Hong Liu Dao-Wen Wang | 2017 | Asian Journal of Andrology2017，19，1： | 4 |
| 16 | Preparation and properties of C/C-SiC brake composites fabricated by warm compacted-in situ reaction显示文摘碳纤维增强了碳和硅碳化物双矩阵 compositesC/C-SiC 被温暖的压缩在里面的 situ reaction.The 微观结构制作,机械性质, tribological 性质,并且在速度是的不同刹车穿 C/C-SiC composites 的机制 investigated.The 结果显示 composites 由 58wt%C,37wt%SiC 组成,并且 5wt%Si .The 密度和开的孔是 2.0 g.cm^-3 并且10%, respectively.The C/C-SiC 刹车 composites 展览好机械 properties.The | Zhuan Li Peng Xiao Xiang Xiong | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，4： | 4 |
| 17 | Effects of land and building usage on population, land price and passengers in station areas: A case study in Fukuoka, Japan显示文摘 | Xinyu Zhuan Shichen Zhao | 2014 | Frontiers of Architectural Research2014，3，2： | 4 |
| 18 | Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review显示文摘 | Zhuan Liao Rui Gao Can Xu Zhao-Shen Li | 2010 | Gastrointestinal Endoscopy2010，，2： | 4 |
| 19 | Special Xenoliths in an Aegirine-Augite Syenite Porphyry in Liuhe,Yunnan,China:Discovery and Implications显示文摘捕虏体的三种特殊类型最近在 Liuhe 在 aegirine 辉石正长岩斑岩被发现了,云南,中国。 Petrographical ,石油化学,电子微探查,和扫描电子显微镜学研究显示那纯方解石 xenocrysts ,忍受石英的黄玉伟晶岩捕虏体源于在他们的迁居期间披风液体排除,并且黑微晶质的充满铁的硅酸盐融化捕虏体是伴随排除的披风液体的抽取的产品并且是,这石英主导地创作了,绿泥石,并且充满铁圆柱并且有典型矿物质的表硅酸盐矿物质例如本国的铁,磷灰石,和锆石。根据体积岩石化学药品和矿物质作文和结晶化国家,微晶质融化捕虏体不进一步是常规 magmatism,和特别本国的铁的存在的产品证明捕虏体是在减小或缺氧的条件下面的披风液体材料。特殊捕虏体的学习在学习区域在不同岩石和阶层中供应 polymetallic 矿化作用的一个重要深过程的 geochemical 背景。 | LIU Xianfan SONG Xiangfeng LU Qiuxia TAO Zhuan LONG Xunrong ZHAO Fufeng | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 3 |
| 20 | Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes显示文摘Type 1 diabetes(T1D)results from dysfunction of pancreatic isletsβcells.Recent studies supported that endoplasmic reticulum(ER)stress takes an important role in pancreaticβcell excessive loss,resulting in T1D.Here,we aimed to review the relationship between ER stress and T1D.Additionally,we also reviewed the potential mechanisms underlying ER stress mediated T1D.Studies have shown that severe ER stress is directly involved in the pancreaticβcells destruction and pathogenesis of T1D.ER stress plays a key part in pancreaticβcells and T1D,which will help in developing new effective therapeutics for T1D. | Zhao-Hui Cao Zhuan Wu Cong Hu Min Zhang Wu-Zhou Wang Xiao-Bo Hu | 2020 | Chinese Medical Journal2020，，1： | 3 |
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