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2篇 您的检索式:作者名="Zihuang Li"
    题名 作者 年代 出处 被引量
1Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients’ prognosis显示文摘Yuhan Chen Xianming Li Shihai Wu Gang Xu Yayan Zhou Long Gong Zihuang Li Dong Yang 2014Medical Oncology2014,,12:1
2Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer显示文摘Aggregation-Induced Emission luminogen(AIEgen)possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety.Bacteria as a natural carrier have demonstrated great advantages in tumor targeted delivery and penetration to tumor.Herein,we construct a delivery platform that Salmonella VNP20009 act as an activated bacteria vector loaded the as-prepared novel AIEgen(TBTP-Au,VNP@TBTP-Au),which showed excellent radioimmunotherapy.VNP@TBTP-Au could target and retain AIEgen at the tumor site and deliver it into tumor cells specially,upon X-ray irradiation,much ROS was generated to induce immunogenic cell death via cGAS-STING signaling pathway to evoke immune response,thus achieving efficient radioimmunotherapy of the primary tumor with good biosafety.More importantly,the radioimmunotherapy with VNP@TBTP-Au formatted good abscopal effect that was able to suppress the growth of distant tumor.Our strategy pioneer a novel and simple strategy for the organic combination of bacteria and imaging-guided radiotherapy,and also pave the foundation for the combination with immunotherapy for better therapeutic effects.Yanhong Duo Zide Chen Zihuang Li Xing Li Yaoqiang Yao Tianzhao Xu Ge Gao Guanghong Luo 2023Bioactive Materials2023,,12:0
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