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| 1 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 2 | Diode-pumped power scalable Kerr-lens mode-locked Yb:CYA laser显示文摘Stable 68 fs pulses with the average power of 1.5 W is directly generated from a multimode diode-pumped Kerr-lens mode-locked Yb:CYA laser by separating the gain medium and Kerr medium. The repetition rate is about 50 MHz, resulting in a single pulse energy of 30 n J and a peak power of 0.44 MW. To the best of our knowledge, this is the highest single pulse energy ever produced from a mode-locked Yb:CYA oscillator. Our experimental results show that Yb:CYA crystal is an excellent candidate for multiwatt, sub-100 fs pulse generation in diode-pumped all-solid-state lasers. It is believed that the output power can be scalable to multi-W while the pulse duration is maintained with this simple method. | WENLONG TIAN YINGNAN PENG ZIYUE ZHANG ZIJIAO YU JIANGFENG ZHU XIAODONG XU ZHIYI WEI | 2018 | Photonics Research2018，6，2： | 8 |
| 3 | Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus显示文摘The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor(F_0) and then cleaved into a disulfide-linked F_1 and F_2 subunits during the process of protein maturation and secretion. To facilitate further investigation into the structure and function of F protein during virus infection, monoclonal antibodies(mAbs) against the F_2 subunit of Helicoverpa armigera nucleopolyhedrovirus(HearNPV)(Ha F) were generated. Two kinds of mAbs were obtained according to their different recognition epitopes: one kind of mAbs, as represented by 38F10,recognizes amino acid(aa) 85 to 123 of F_2 and the other kind, represented by 44D11, recognizes aa148 to 173 of F_2. Western blot and immunofluorescence assay confirmed that both of the mAbs recognized the F protein expressed in HearNPV infected cells, however, only 44D11 could neutralize HearNPV infection. The results further showed that 44D11 may not interact with a receptor binding epitope, rather it was demonstrated to inhibit syncytium formation in cells expressing the Ha F protein. The results imply that the monoclonal antibody 44D11 recognizes a region within HaF_2 that may be involved in the F-mediated membrane fusion process. | Zijiao Zou Jinliang Liu Zhiying Wang Fei Deng HuaUn Wang Zhihong Hu Manli Wang Tao Zhang | 2016 | Virologica Sinica2016，31，6： | 3 |
| 4 | Towards high-power, high-coherence, integrated photonic mm Wave platform with microcavity solitons显示文摘Millimetre-wave(mmWave)technology continues to draw great interest due to its broad applications in wireless communications,radar,and spectroscopy.Compared to pure electronic solutions,photonic-based mmWave generation provides wide bandwidth,low power dissipation,and remoting through low-loss fibres.However,at high frequencies,two major challenges exist for the photonic system:the power roll-off of the photodiode,and the large signal linewidth derived directly from the lasers.Here,we demonstrate a new photonic mmWave platform combining integrated microresonator solitons and high-speed photodiodes to address the challenges in both power and coherence.The solitons,being inherently mode-locked,are measured to provide 5.8 dB additional gain through constructive interference among mmWave beatnotes,and the absolute mmWave power approaches the theoretical limit of conventional heterodyne detection at 100 GHz.In our free-running system,the soliton is capable of reducing the mmWave linewidth by two orders of magnitude from that of the pump laser.Our work leverages microresonator solitons and high-speed modified uni-traveling carrier photodiodes to provide a viable path to chip-scale,high-power,low-noise,high-frequency sources for mmWave applications. | Beichen Wang Jesse SMorgan Keye Sun Mandana Jahanbozorgi Zijiao Yang Madison Woodson Steven Estrella Andreas Beling Xu Yi | 2021 | Light(Science & Applications)2021，10，1： | 3 |
| 5 | Optimization Method for Evaluating Wind Power Penetration Limit Constrained by Load Following Capacity显示文摘 | Zechun HU Zijiao HAN Fang ZHANG Xu XIE | 2013 | 电力系统自动化2013，37，19： | 3 |
| 6 | Hybrid System Level Modeling and Implementation of Configurable Processor for SoC显示文摘 | GUO Wei WEI Jizeng MA Zijiao WANG Zhenghua LIU Zhuangli | 2010 | Chinese Journal of Electronics2010，19，2： | 2 |
| 7 | Analysis of HCHs and DDTs in a sediment core from the Old Yellow River Estuary, China显示文摘 | Chunnian Da Guijian Liu Zijiao Yuan | 2013 | Ecotoxicology and Environmental Safety2013，，： | 2 |
| 8 | Synthesis of a conjugable hexasaccharide corresponding to the capsular polysaccharide of Campylobacter jejuni strain BH0142显示文摘The first assembly of a conjugation-ready hexasaccharide from the capsular glycan of C.jejuni.strain BH0142 has been accomplished.The synthesis features the efficient preparation of 6-deoxy-D-idoheptopyranosyl fluoride donors proceeding from allylα-D-C-glucopyranoside by a C1-to-C5 switch strategy with radical dehydroxymethylative fluorination as a key step,stereocontrolled construction of 1,2-trans-α-D-ido-heptopyranosidic bonds and of 1,2-cis-α-D-galactopyranosidic linkages.The obtained target oligosaccharide sets a solid foundation for making structurally-defined multivalent glycoconjugate vaccine candidates against C.jejuni.infections. | Zijiao Hou Jianjun Wang Xinxin Zhang Peng Wang Ni Song Ming Li | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 9 | An Inverse Kinematic Analysis Modeling on a 6-PSS Compliant Parallel Platform for Optoelectronic Packaging显示文摘Multiple degree of freedom motion platform is always one of the important components in optoelectronic packaging systems,its characteristics have a vital impact on the performances of optoelectronic packaging.This paper presents a 6-Prismatic-Spherical-Spherical compliant parallel platform for optoelectronic packaging.This platform is a kind of parallel layout structure,which uses the piezoelectric motors as active joints and the large-stroke flexure hinges are employed as passive joints.An inverse kinematic modeling based on elastokinematic analysis is analyzed and deduced.The elastokinematic analysis considers the elastic deformation of the large-stroke flexure hinges in movement process,and improves the positioning accuracy of the compliant parallel platform in applications.The finite element analysis model and the prototype of the compliant parallel platform are developed,and the validity of the proposed method is finally verified.This paper provides a theoretical reference and experimental data for the inverse kinematic analysis of six degrees of freedom motion compliant parallel platforms with large-stroke flexure hinges. | Fulong Hou Meizhu Luo Zijiao Zhang | 2019 | CES Transactions on Electrical Machines and Systems2019，3，1： | 0 |
| 10 | Molecular characterization and expression of the SiUCP2 gene in sea urchin Strongylocentrotus intermedius显示文摘Uncoupling protein 2 (UCP2) is a proton transporter located in the inner mitochondrial membrane, and inhibits the formation of adenosine triphosphate and reactive oxygen species by uncoupling oxidative phosphorylation. To provide a theoretical basis for the role of SiUCP2 in lipid metabolism, a 2 341-bp full-length cDNA of SiUCP2 from sea urchin Strongylocentrotus intermedius , which encodes 323 amino acids (predicted MW 36.11 kDa) was obtained, and the structure and function of the SiUCP2 gene and its expression at the mRNA and protein level were studied. SiUCP2 had high homology with UCP2 of other species. Expression of SiUCP2 was detected in the order of tube feet > gonads > coelomocytes > intestines. The expression level was the highest in prismatic larvae and lowest in the two-cell stage. Moreover, using in-situ hybridization, we found that SiUCP2 protein was expressed in the gonads and intestine. This study provided a theoretical basis for subsequent studies on the role of SiUCP2 and its regulatory mechanism in lipid metabolism, and for the improvement of gonad quality to obtain a higher economic value from sea urchins. | Lingshu HAN Zijiao QUAN Bing HAN Beichen DING Xiaofang HUANG Heng WANG Yaqing CHANG Jun DING | 2021 | Journal of Oceanology and Limnology2021，39，4： | 0 |
| 11 | Radio-frequency line-by-line Fourier synthesis based on optical soliton microcombs显示文摘Radio-frequency(RF) waveform synthesis has broad applications in ultrawide-bandwidth wireless communications, radar systems, and electronic testing. Photonic-based approaches offer key advantages in bandwidth and phase noise thanks to the ultrahigh optical carrier frequency. In this work, we demonstrate Fourier synthesis arbitrary waveform generation(AWG) with integrated optical microresonator solitons. The RF temporal waveform is synthesized through line-by-line amplitude and phase shaping of an optical soliton microcomb, which is down-converted to the RF domain through dual-comb optical coherent sampling. A variety of RF waveforms with tunable repetition cycles are shown in our demonstration. Our approach provides not only the possibility of precise Fourier synthesis at microwave and millimeter-wave frequencies, but also a viable path to fully integrated photonic-based RF AWG on a chip. | BEICHEN WANG ZIJIAO YANG SHUMAN SUN Xu Yi | 2022 | Photonics Research2022，10，4： | 0 |
| 12 | Molecular Cloning, Expression and Characterization of Peroxisome Proliferators-Activated Receptors Gamma in the Sea Urchin(Strongylocentrotus intermedius)显示文摘Peroxisome proliferators-activated receptor gamma(PPARγ) plays important regulatory roles in adipocyte differentiation. In this study, we cloned the full-length sequence of the PPARγ gene and analyzed its expression profile in different developmental stages and tissues of Strongylocentrotus intermedius. The full-length cDNA of PPARγ contains 2286 base pairs(bp) with a putative open reading frame of 1755 bp, and the gene encodes encoding a polypeptide of 584 amino acid residues. The predicted molecular mass of the protein is 67.27 kDa, and its theoretical isoelectric point(pI) is 10.07. The protein contains conserved motifs, including an RRM(RNA recognition motif) domain. PPARγ expression with the highest level was observed in the gonad, and the lowest was observed in the tube feet of S. intermedius. Time-course expression measurements at different developmental stages showed that the highest expression level of PPARγ is in the eggs and its weakest expression level is in the 32-cells stage. Knock-down of PPARγ by specific siRNA revealed that UCP2 expression is significantly decreased in the gonads and intestines 48 h post-transfection, indicating that the UCP2 is a downstream target gene of PPARγ.This finding suggests that PPARγ and UCP2 have positive regulatory effects in regulating adipocyte differentiation. Changes in fatty acid levels in the gonads before and after PPARγ interference were assessed, and decreased C18:2(trans, n-6) and C20:3(n-6) levels were observed 48 h after siRNA transfection. The results showed the function of PPARγ in fatty acid anabolism, The data are helpful to improve the current understanding of the fatty acid synthesis pathways and regulatory mechanisms in S. intermedius. They also provide an experimental basis for improving fatty acid synthesis in sea urchins, which is important for cultivating sea urchins with high nutritional value. | QUAN Zijiao HAN Lingshu CAO Yue GAO Pingping LIU Xiaoyu CHANG Yaqing DING Jun | 2021 | Journal of Ocean University of China2021，20，2： | 0 |
| 13 | Reflection on the cognitive differences between doctors and patients显示文摘As we all know, the doctor-patient relationship in China is in a very tense state. There are many reasons for this situation, an important factor among them is the cognitive differences between doctors and patients.Here we analyze the reasons for the cognitive differences between doctors and patients from the perspective of both doctors and patients cognition of diseases, the motives of both parties and the expectations of curing diseases.We will also discuss a: 'patient-centered' concept, strengthening effective communication between doctors and patients, as well as how they can respect each other's personality and rights. | XING Zengfang ZHANG Min WANG Zijiao LIU Shuang SUN Yingmei | 2018 | 中国研究型医院2018，5，5： | 0 |
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