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| 1 | The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants显示文摘到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因,知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度,重金属的压力,和 Botrytis cinerea 感染。抵抗的线, overexpressing 在不同层次的真菌的 chitinases,是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力,尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些,揭示经常的起来规定(至少双重) 10 ,在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。 | Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein Lothar Willmitzer Ilan Chet Ada Viterbo | 2012 | Molecular Plant2012，5，5： | 5 |
| 2 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 3 | Gastric partitioning for the treatment of malignant gastric outlet obstruction显示文摘BACKGROUND Gastric outlet obstruction(GOO)is one of the main complications in stage IV gastric cancer patients.This condition is usually managed by gastrojejunostomy(GJ).However,gastric partitioning(GP)has been described as an alternative to overcoming possible drawbacks of GJ,such as delayed gastric emptying and tumor bleeding.AIM To compare the outcomes of patients who underwent GP and GJ for malignant GOO.METHODS We retrospectively analyzed 60 patients who underwent palliative gastric bypass for unresectable distal gastric cancer with GOO from 2009 to 2018.Baseline clinicopathological characteristics including age,nutritional status,body mass index,and performance status were evaluated.Obstructive symptoms were graded according to GOO score(GOOS).Surgical outcomes evaluated included duration of the procedure,surgical complications,mortality,and length of hospital stay.Acceptance of oral diet after the procedure,weight gain,and overall survival were the long-term outcomes evaluated.RESULTS GP was performed in 30 patients and conventional GJ in the other 30 patients.The mean follow-up was 9.2 mo.Forty-nine(81.6%)patients died during that period.All variables were similar between groups,with the exception of worse performance status in GP patients.The mean operative time was higher in the GP group(161.2 vs 85.2 min,P<0.001).There were no differences in postoperative complications and surgical mortality between groups.The median overall survival was 7 and 8.4 mo for the GP and GJ groups,respectively(P=0.610).The oral acceptance of soft solids(GOOS 2)and low residue or full diet(GOOS 3)were reached by 28(93.3%)GP patients and 22(75.9%)GJ patients(P=0.080).Multivariate analysis demonstrated that GOOS 2 and GOOS 3 were the main prognostic factors for survival(hazard ratio:8.90,95%confidence interval:3.38-23.43,P<0.001).CONCLUSION GP is a safe and effective procedure to treat GOO.Compared to GJ,it provides similar surgical outcomes with a trend to better solid diet acceptance by patients. | Marcus Fernando Kodama Pertille Ramos Leandro Cardoso Barchi Rodrigo Jose de Oliveira Marina Alessandra Pereira Donato Roberto Mucerino Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 2 |
| 4 | Noninvasive exclusion of fetal aneuploidy in an at risk couple with balanced translocation显示文摘 | Zhen ZK Zilberstein ME | 2000 | Mol Hum Reprod2000，6，2： | 1 |
| 5 | Eddy current sensor networks for aircraft fatigue monitoring显示文摘 | Goldfine N Zilberstein V Washabaugh A | 2003 | Materials Evaluation2003，61，7： | 1 |
| 6 | MWM Eddy Current Sensors for Monitoring of Crack Initiation and Growth During Fatigue Tests and in Service 显示文摘 | Vladimir Zilberstein Darrell Schlicker | 2001 | International Journal of Fatigue2001，23，： | 1 |
| 7 | Ketamine attenuates neutrophil activation after cardiopulmonary bypass 显示文摘 | Zilberstein G Levy R Rachinsky M | 2002 | Anesth Analg2002，95，3： | 1 |
| 8 | Decentralized control of cooperative systems: Categorization and complexity analysis 显示文摘 | Claudia Goldman Shlomo Zilberstein | 2004 | Journal of Artificial Intelligence Research2004，22，： | 1 |
| 9 | MWM Eddy-Current Arrays for Crack Initiation and Growth Monitoring 显示文摘 | Vladimir Zilberstein Karen Walrath | 2003 | International Journal of Fatigue2003，25，： | 1 |
| 10 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 11 | Decentralized control of cooperative systems:Categorization and complexity analysis显示文摘 | Goldman C V Zilberstein S | 2004 | Journal of AI Rcscarch2004，，： | 1 |
| 12 | Meandering winding magnetometer array eddy current sensors for detection of cracks in regions with fretting damage显示文摘 | Goldfine N Zilberstein V Cargill J S | 2002 | Materials Evaluation2002，60，7： | 1 |
| 13 | MWM-array sensors for in situ monitoring of high-temperature components in power plants显示文摘 | Sheiretov Y Grundy D Zilberstein V | | 0，，11： | 1 |
| 14 | MWM-array eddy current sensors for detection of cracks in regions with fretting damage显示文摘 | Goldfine N Zilberstein V Cargill S | | 0，，07： | 1 |
| 15 | Gastric cancer trends in ep- idemiology 显示文摘 | Zilberstein B Jacob CE Cecconello I | 2012 | Arq Gastroentero12012，49，3： | 1 |
| 16 | Lao*: a heuristic search algorithm that finds solutions with loops显示文摘 | HANSEN E ZILBERSTEIN S | 2001 | Artificial Intelligence2001，129，12： | 1 |
| 17 | Non-invasive exclusion of fetal aneuploidy in an at-risk couple with a bal- anced translocation显示文摘 | Wang J Y Zhen D K Zilberstein M E | 2000 | Mol Hum Rep rod2000，6，2： | 1 |
| 18 | Decentralized control of cooper- ative systems: Categorization and complexity analysis显示文摘 | GOLDMAN C V ZILBERSTEIN S | 2004 | Joumal of Artificial Intelligence Research2004，22，1： | 1 |
| 19 | LAO*:a heuristic search algorithm that finds solutions with loops显示文摘 | ZILBERSTEIN S | 2001 | Artificial Intelligence2001，129，12： | 1 |
| 20 | Ketamine attenuates neutrophil activation after cardiopulmonary bypass显示文摘 | LEVY R RACHINSKY M | 2002 | Anesth Analg2002，95，3： | 1 |
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