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| 1 | Retroperitoneal perivascular epithelioid cell tumours: A case report and review of literature显示文摘BACKGROUND The perivascular epithelioid cell tumour(PEComa)family of tumours mainly includes renal and hepatic angiomyolipomas,pulmonary lymphangioleiomyomatosis and clear cell“sugar”tumour of the lung.Several uncommon tumours with similar morphological and immunophenotypical characteristics arising at a variety of sites(abdominal cavity,digestive tract,retroperitoneum,skin,soft tissue and bones)are also included in the PEComa family and are referred to as PEComas not otherwise specified.CASE SUMMARY We present a 37-year-old female patient who underwent resection of an 8.5 cm×8 cm×4 cm retroperitoneal tumour,which eventually was diagnosed as PEComa of uncertain biological behaviour.Three years after the operation,the patient remains without any evidence of recurrence.A search was performed in the Medline and EMBASE databases for articles published between 1996 and 2018,and we identified 31 articles related to retroperitoneal and perinephric PEComas.We focused on sex,age,maximum dimension,histological and immunohistochemical characteristics of the tumour,follow-up and long-term outcome.Thirty-four retroperitoneal(including the present one)and ten perinephric PEComas were identified,carrying a malignant potential rate of 44%and 60%,respectively.Nearly half of the potentially malignant PEComas presented with or developed metastases during the course of the disease.CONCLUSION Retroperitoneal PEComas are not as indolent as they are supposed to be.Radical surgical resection constitutes the treatment of choice for localized disease,while mammalian target of the rapamycin(mTOR)inhibitors constitute the most promising therapy for disseminated disease.The role of mTOR inhibitors as adjuvant or neoadjuvant therapies needs to be evaluated in the future. | Zisis Touloumis Niki Giannakou Christos Sioros Argiro Trigka Maria Cheilakea Nikoletta Dimitriou John Griniatsos | 2019 | World Journal of Clinical Cases2019，7，21： | 4 |
| 2 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 3 | Clastic sedimentary features of beachrocks and their palaeo-environmental significance:comparison of past and modern coastal regimes显示文摘Clastic sedimentary features of beachrocks and unconsolidated deposits of parent beaches were investigated along the northern Aegean coastline(Greece) to assess their suitability in palaeo-environmental reconstruction.Twelve paired datasets were collected in the Thermaikos,Toroneos,Siggitikos and lerissos gulfs of the Chalkidiki Peninsula,the adjoining Kavala Gulf and Thassos Island,comprising beachrock cores and companion beach subsurface sediments.Particle size analyses based on univariate and bivariate statistics suggest that,during the time period of beachrock formation,depositional conditions differed distinctly from those of the modern parent beaches.The results imply difference of maturity level of beach evolution from the time of cementation(coarser materials-early stage of beach formation) to modern situation(finer materials-reworked and 'mature' beach sediments).Furthermore,the findings indicate increasing coastal protection due to beachrock exposure in the modern swash zone.In conclusion,it is suggested that textural analysis of beachrocks in comparison with unconsolidated sediments of the parent beach might provide information regarding differences of coastal depositional regimes and future research could focus on specific-layer analysis and comparison. | David PSOMIADIS Konstantinos ALBANAKIS Nikoleta ZISI Matthieu GHILARDI Elissavet DOTSIKA | 2014 | International Journal of Sediment Research2014，29，2： | 3 |
| 4 | Imaging of filtering blebs after implantation of the Ex-PRESS shunt with the use of the Visante optical coherence tomography显示文摘AIM: To analyze the features of the filtering blebs following implantation of the Ex-PRESS glaucoma device(model P-50) with the aid of the Visante anterior segment optical coherence tomography(AS-OCT)METHODS: Five patients with open angle glaucomas were included in the study. They all underwent implantation of the Ex-PRESS device under a scleral flap. The surgical procedure was augmented with the use of mitomycin C subconjunctivally. The filtering blebs were analyzed with the Visante AS-OCT with the scans taken along the axis of the implantation of the glaucoma device.RESULTS: All filtering blebs were graded as diffuse functioning. The morphological characteristics of the blebs were similar to those of the trabeculectomy.However the use of the Ex-PRESS implant tend to form a characteristic episcleral lake at the site of the plate of the implant. CONCLUSION: The use of the Ex-PRESS implant produces filtering blebs similar to those of the trabeculectomy with the formation of a characteristic episcleral lake at the site of the plate of the implant. | Aristeidis Konstantinidis Georgios D Panos Magdalini Triantafylla Georgios Labiris Efthimia Tsaragli Zisis Gatzioufas Vassilios Kozobolis | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 2 |
| 5 | Biosafety and biobanking: Current understanding and knowledge gaps显示文摘Infectious disease outbreaks,such as'Coronavirus disease 20190(COVID-19),can constitute major global health threats with far-reaching consequences.As outbreaks develop,the international scientific community must provide high-quality scientific research-ready biological samples to solve the existing clinical and epidemiological questions to better combat the pandemic.Such examples are provided by dedicated biobank facilities,the latter collecting increasingly high volumes of biological samples.However,the more significant concentrations of infectious or potentially infectious biological materials can create a safety risk.The current short report describes the first attempt to identify the published scientific works on biobanking and safety.Three broad thematic areas have been identified:the physical security relevant to staff and sample integrity,the data safety aspects,and the governance parameters relating to the previous two.While the current publications reflect a broad alignment with existing standards and best practices in the biobanking field,they also demonstrate an opportunity for further in-depth work on this field in the post-COVID-19 era. | Julie Roux Maissa Zeghidi Stephanie Villar Zisis Kozlakidis | 2021 | Biosafety and Health2021，3，5： | 2 |
| 6 | Stent placement in the mnagemnt of oesophageal leaks显示文摘 | Zisis C Guillin A Heyries L | 2008 | European Journal of Cardio-Thoracic Surgery2008，33，3： | 1 |
| 7 | Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects显示文摘Background Percutaneous left atrial appendage occlusion(LAAO)requires puncture of the interatrial septum.The immediate hemodynamic effects of iatrogenic atrial septal defects(iASD)after LAAO have not been examined so far.We aimed at evaluat-ing these effects through invasive measurements of pressure and oxygen saturation.Moreover,we assessed the incidence of per-sistent iASD at three months.METHODS Forty-eight patients scheduled for percutaneous LAAO were prospectively included in the study.Pressure and oxygen saturation were measured(1)in the right atrium(RA)before transseptal puncture,(2)in the left atrium(LA)through the transseptal sheath after transseptal puncture,(3)in the LA after removal of introducer sheath,and(4)in the RA after removal of introducer sheath.Transesophageal echocardiography was performed at three months to detect iASD.RESULTS Pressure in the RA increased significantly after removing the introducer sheath(P=0.034),whereas no difference was found in oxygen saturation in the RA(P=0.623).Pressure measurement in the LA showed no significant difference after re-moving the introducer sheath(P=0.718).Oxygen saturation in the LA also showed no significant difference(P=0.129).Follow-up transesophageal echocardiogram at 3 months revealed a persistent iASD in 4 patients(8.5%).CONCLUSIONS Our study suggests that iASD after percutaneous LAAO does not result in significant shunts directly after the procedure,although a significant increase of mean right atrial pressure can be observed.Persistent iASDs after percutaneous LAAO seem to be relatively rare at three months. | Ioannis Drosos Roberta De Rosa Philipp C.Seppelt Sebastian Cremer Silvia Mas-Peiro Katrin Hemmann Jana Oppermann Recha Blessing Mariuca Vasa-Nicotera Andreas M.Zeiher Zisis Dimitriadis | 2022 | Journal of Geriatric Cardiology2022，19，9： | 1 |
| 8 | Chest drainage systems in use 显示文摘 | Zisis C Tsirgogianni K Lazaridis G | 2015 | Ann Trans! Med2015，3，3： | 1 |
| 9 | Microwave-essisted extraction (MAE)-acid hydrolysis of dithiocarbamates for trace analysis in tobacco and peaches显示文摘 | Zisis V E Emmanouil N P Euphemia P M | 2002 | J Agric Food Chem2002，50，： | 1 |
| 10 | Correlative radiological, self-assessment and clinical analysis of evolution in instrumented dorsal and lateral fusion for degenerative lumbar spine disease. Autograft versus coralline hydroxyapatite显示文摘 | Panagiotis Korovessis Georgios Koureas Spyridon Zacharatos Zisis Papazisis Elias Lambiris | 2005 | European Spine Journal2005，，7： | 1 |
| 11 | Visco-plastic flow around a cylinder kept between parallel plates显示文摘 | ZISIS T MITSOULIS E | 2002 | J Non-Newtonian Fluid Mech2002，105，： | 1 |
| 12 | Local and overall wind pressure and force coefficients for solar panels 显示文摘 | Stathopoulos T Zisis I Xypnitou E | 2014 | Journal of Wind Engineering and Industrial Aerodynamics2014，125，： | 1 |
| 13 | Discrimination indices as screening tests for β-thalassemic trait显示文摘 | George Ntaios Anastasia Chatzinikolaou Zoi Saouli Fotios Girtovitis Maria Tsapanidou Georgia Kaiafa Zisis Kontoninas Androula Nikolaidou Christos Savopoulos Ifigenia Pidonia Stiliani Alexiou-Daniel | 2007 | Annals of Hematology2007，，7： | 1 |
| 14 | Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis显示文摘 | Georgios Labiris Leonie Troeber Zisis Gatzioufas Evangelos Stavridis Berthold Seitz | 2012 | Journal of Cataract & Refractive Surgery2012，，11： | 1 |
| 15 | Wind-induced cladding and structural loads on low-wood building 显示文摘 | Zisis I Stathopoulos T | 2009 | Journal of Structural Engineering ASCE2009，135，4： | 1 |
| 16 | Protocol for quality control in metabolic profiling of biological fluids by U(H)PLC-MS显示文摘 | Gika HG Zisi C Theodoridis G | 2016 | JChromatogr B Analyt Technol Biomed Life Sci2016，1008，： | 1 |
| 17 | Initial evaluation of a smoking cessation program incorporating physical activity promotion to Greek adults in antismoking clinics显示文摘 | Hassandra M Kofou G Zourbanos N Gratsani S Zisi V Theodorakis Y | | 0，，： | 1 |
| 18 | Thymoma and myasthenia gravis:clinical aspects and prognosis显示文摘 | Vachlas K Zisis C Rontogianni D | 2012 | Asian Cardiovasc Thorac Ann2012，20，1： | 1 |
| 19 | Bankruptcy Probability and Stock Prices: The Effect of Altman Z-Score Information on Stock Prices Through Panel Data显示文摘 | Nicholas Apergis John Sorros Panagiotis Artikis Vasilios Zisis | 2011 | Journal of Modern Accounting and Auditing2011，7，7： | 1 |
| 20 | Rigid, sem- irigid versus dynamic instrumentation for degenerative lumbar spinal stenosis: a correlative radiological and clinical analysis of short term results显示文摘 | PANAGIOTIS K ZISIS P GEORGIOS K | 2004 | Spine2004，29，7： | 1 |
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