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| 1 | Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment显示文摘 | Tianhua Xu Zitong Sheng Li Yao | 2017 | Frontiers of Medicine2017，11，3： | 23 |
| 2 | miR-503-3p promotes epithelialemesenchymal transition in breast cancer by directly targeting SMAD2 and E-cadherin显示文摘Although progress in clinical and basic research has significantly increased our understanding of breast cancer, little is known about the molecular mechanism underlying breast cancer metastasis. Identification of effective therapeutic targets to prevent breast cancer metastasis is urgently needed. The function of mi R-503-3p has been investigated in other cancers, but its role in breast cancer remains undefined.Here, we found that mi R-503-3p was overexpressed in breast cancer tissue and plasma compared with adjacent normal breast tissue and with plasma from healthy individuals. Moreover, we identified mi R-503-3p to be an oncogene of breast cancer cell proliferation, migration and invasion. Upregulation of mi R-503-3p in breast cancer cells inhibited expression of epithelialemesenchymal transition(EMT)-related protein SMAD2 and the epithelial marker protein E-cadherin by directly binding to their m RNA30 untranslated region, whereas increased expression of mesenchymal marker proteins, including vimentin and N-cadherin. Taken together, our findings support a critical role for mi R-503-3p in induction of breast cancer EMT and suggest that plasma mi R-503-3p may be a useful diagnostic biomarker for breast cancer. | Zitong Zhao Xinyi Fan Lanfang Jiang Zhongqiu Xu Liyan Xue Qimin Zhan Yongmei Song | 2017 | Journal of Genetics and Genomics2017，44，2： | 15 |
| 3 | Evaluating and Improving Wind Forecasts over South China: The Role of Orographic Parameterization in the GRAPES Model显示文摘Unresolved small-scale orographic(SSO) drags are parameterized in a regional model based on the Global/Regional Assimilation and Prediction System for the Tropical Mesoscale Model(GRAPES TMM). The SSO drags are represented by adding a sink term in the momentum equations. The maximum height of the mountain within the grid box is adopted in the SSO parameterization(SSOP) scheme as compensation for the drag. The effects of the unresolved topography are parameterized as the feedbacks to the momentum tendencies on the first model level in planetary boundary layer(PBL)parameterization. The SSOP scheme has been implemented and coupled with the PBL parameterization scheme within the model physics package. A monthly simulation is designed to examine the performance of the SSOP scheme over the complex terrain areas located in the southwest of Guangdong. The verification results show that the surface wind speed bias has been much alleviated by adopting the SSOP scheme, in addition to reduction of the wind bias in the lower troposphere. The target verification over Xinyi shows that the simulations with the SSOP scheme provide improved wind estimation over the complex regions in the southwest of Guangdong. | Shuixin ZHONG Zitong CHEN Daosheng XU Yanxia ZHANG | 2018 | Advances in Atmospheric Sciences2018，35，6： | 12 |
| 4 | The temporal and spatial distribution of ancient rice in China and its implications显示文摘The relics of ancient rice have been regarded as the most important objective evidence of the origina- tion and spread of rice cultivation.Based on the records of 280 rice relics sites and the rice cropping regionalization as well as the distribution map of paddy soils,the current study compiled the temporal and spatial distribution map of ancient rice distribution in China.The map shows that the distribution of ancient rice is spatially extensive and meantime comparatively concentrated,temporarily covering a long and relatively continuous time-span.The rice relics in the Central China double and single rice cropping regions are among the earliest and the most abundant ones,possessing continuity in time sequence.Combined with the discovery of ancient rice and paddy filed relics,soil micromorphology, pollen combination and element geochemistry,it is suggested that Central China was the origin center of rice cultivation in China.Rice had been spread to the rest part of China in three major waves,also to the East Asian part like Korea and Japan.The temporal and spatial distribution of ancient rice reflects the past environmental change,which is also meaningful to the current rice regionalization and plan- ning as well as food security in China. | GONG ZiTong CHEN HongZhao YUAN DaGang ZHAO YuGuo WU YunJin ZHANG GanLin | 2007 | Chinese Science Bulletin2007，52，8： | 11 |
| 5 | Improvement of the Surface Pressure Operator in GRAPES and Its Application in Precipitation Forecasting in South China显示文摘在这研究,我们调查了涉及在当前的全球、地区性的吸收和预言系统吸收表面压力的问题,葡萄。吸收表面压力的一个新计划被建议,包括一个新插值计划和使清醒的背景协变性。新计划考虑车站举起和模型地形学之间的差别,并且它特别处理在第一模型水平的下面在举起定位的车站。对比实验用原版和新吸收计划被进行。新插值计划和更新的背景协变性的影响被调查。我们的结果证明新插值计划利用了更多的观察并且改进了集体分析的质量。背景协变性用源于帕里什和 Derber 在 1992 建议的技术的统计被使清醒。当吸收表面压力时,实验证明更新的垂直协变性可以在空气的高水平在分析上有积极影响。如果在高水平的背景地的质量是差的,这影响可能是更重要的。一系列吸收实验被执行测试新计划的有效性。相应模拟实验作为起始的条件用两个计划的分析被进行。结果显示新计划导致在华南的海水平压力和降水的更好的预报,特别预报中等并且大雨。 | HUANG Yanyan XUE Jishan WAN Qilin CHEN Zitong DING Weiyu ZHANG Chengzhong | 2013 | Advances in Atmospheric Sciences2013，30，2： | 10 |
| 6 | Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2显示文摘Esophageal squamous cell carcinoma(ESCC) is one of the most common and deadly cancers in the world. Currently, clinical therapy of ESCC remains limited and the five-year survival rate is poor. The function of miR-425 has been reported in multiple human cancers.However, the tumorigenic role and clinical significance of miR-425 in ESCC remains unclear. We found that enhanced expression of miR-425 in ESCC cell lines not only promoted cell proliferation and colony formation, but also increased cellular metastasis. Furthermore, we revealed the mechanism that miR-425 inhibited the expression of SMAD2 by targeting the second binding site in the 30-untranslated region(30-UTR) in ESCC. This mode of action influenced not only SMAD2 mRNA expression but also protein expression. In addition, we detected the expression of miR-425 in ESCC tissues and plasma. Moreover, we analyzed the relationship between miR-425 expression and SMAD2 m RNA expression. We found that miR-425 was overexpressed in ESCC tissues and the plasma relative to adjacent normal tissues and plasma of healthy individuals. Furthermore, there was a negative correlation between miR-425 expression and SMAD2. Taken together, our results show that miR-425 functions as an oncogene by targeting the 30-UTR of SMAD2 and indicate the potential utility of plasma miR-425 as a novel biomarker for ESCC diagnosis. | Lingyan Liu Zitong Zhao Wei Zhou Xinyi Fan Qimin Zhan Yongmei Song | 2015 | Journal of Genetics and Genomics2015，42，11： | 10 |
| 7 | Land Use-Related Changes in Soils of Hainan Island During the Past Half Century显示文摘During the past half century, the land utilization of Hainan Island has undergone a rapid development,but in the meanwhile, soil degradation occurs. Analysis on some basic data of the soil series collected frommore than 100 soil profiles at the end of the 1990s and beginning of this century, in combination with dataavailable, showed that soils there suffered significant decline in organic matter, experienced P and K deficiencywith soil K going on losing and undergone acidification with continuing trend. The current situation calls forstrategies to build up Hainan into an important province of sound ecology by restoring forests, to improvefood quality by implementing K supplement projects, to combat soil acidification by ameliorating the soils andgrowing leguminous crops and to ensure health of the people by developing dairy production and increasingthe daily Ca uptake by the people. | GONG ZITONG, ZHANG GANLIN, ZHAO WENJUN, ZHAO YUGUO and CHEN ZHICHENGInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2003 | Pedosphere2003，13，1： | 9 |
| 8 | A 'Yellow Cap' on Quaternary Red Clay in Jiujiang,Jiangxi Province显示文摘A thin layer of yellow-brown-colored earth was generally found on Quaternary red clay in Jiujiang,Jiangxi Province. A typical profile was established. Both particle size distribution and REE (rare earthelements) characteristics of the yellow-brown-colored earth of the profile fully suggested its aeolian origin andclose similarity to Naming Xiashu loess. The study also implied aeolian origin of the underlying Quaternaryred clap Compared with the red clay, the yellow- brown- colored earth was less weathered because of its lowercontent of free iron and higher mole ratios of SiO2/A12O3 and SiO2/(Fe2O3+A12O3 ) as well as its lessdeveloped chemical microtextures of quartz grains.In order to study the aged of the two deposits comparatively, the thermoluminescent dating method wasused. As a result, the bottom of the yellow-brown-colored esrth was dated to 6015 ka B. P. and the upperpart of the red clay 38854 ka B. P. It was suggested that the yellow- browm- colored earth was formed inthe Late Pleistocene and was probably the aeolian deposit of the Last Glacial, which corresponded with theMalan loess in the Loess Plateau of the northwestern part of China; while the underlying red clay was formedin the Middle Pleistocene.A 'yellow cap' on Quaternary red clay in Jiujiang implied a great climatic and environmental varistionin the beginning of the Late Pleistocene in the southern pot of China, especially in the middle and lowerreaches of the Yangtze River. The eveal not only halted the rubification, once dominating the region, butalso produced a widespread covering of aeolian deposit, as only occurred in the cold and dry environment. | HU XUEFENG GONG ZITONG(1State Key Laboratory of Loess and Quaternary Geology, the Chinese Academy of Sciences, P. O. Box: 17,xi’an 710054 (China))(2Institute of Soil Science, the Chinese Acodemy of Sciences, P. O. Box 821, Nanjing 210008 (China)) | 1999 | Pedosphere1999，9，4： | 9 |
| 9 | TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer显示文摘Tumor necrosis factor receptor-associated protein 1(TRAP1), an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer(ESCC) remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast,silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC. | Yunwei Ou Lingyan Liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song Qimin Zhan | 2014 | Journal of Genetics and Genomics2014，41，10： | 8 |
| 10 | Probiotic effect of ferulic acid esterase-producing Lactobacillus plantarum inoculated alfalfa silage on digestion,antioxidant,and immunity status of lactating dairy goats显示文摘A feeding experiment was conducted to determine the effects of inoculating alfalfa silage with a ferulic acid esterase-producing inoculum on feed digestibility,rumen fermentation,antioxidant,and immunity status of lactating dairy goats.Twenty dairy goats were distributed into 2 experimental groups consisting of control diet(Lp MTD/1,including Lactobacillus plantarum MTD/1 inoculated silage)against diet containing silage treated with ferulic acid esterase-producing L.plantarum A1(Lp A1).Alfalfa silage inoculated with a ferulic acid esterase-producing Lp A1 had better fermentation quality than the Lp MTD/1inoculation.The application of Lp A1 improved silage antioxidant capacity as indicated by greater total antioxidant capacity(T-AOC),superoxide dismutase(SOD)and glutathion peroxidase(GSH-Px)activities in Lp A1 treated silage versus Lp MTD/1 treatment.Compared with Lp MTD/1 treated group,inoculation of silage with Lp A1 increased apparent total tract digestibility of dietary dry matter,organic matter and crude protein,and ruminal concentrations of total volatile fatty acids,acetate,propionate and isobutyrate as well.The results of current study also demonstrated improved antioxidant capacity and immune performance of dairy goats with Lp A1 inoculation.Feeding Lp A1-treated silage increased dairy goats’serum antioxidase activity,such as T-AOC,SOD,GSH-Px and catalase,and the serum concentration of immunoglobulin A,while decreased tumor necrosis factor a,interleukin(IL)-2 and IL-6.In addition,compared with Lp MTD/1,diet containing alfalfa silage inoculated with Lp A1 endowed dairy goats’milk with greater fat and protein contents,improved dairy goat milk quality without affecting feed efficiency. | Fuhou Li Baibing Zhang Yixin Zhang Xia Zhang Samaila Usman Zitong Ding Lizhuang Hao Xusheng Guo | 2022 | Animal Nutrition2022，，4： | 6 |
| 11 | Downregulation of miR-503 Promotes ESCC Cell Proliferation,Migration,and Invasion by Targeting Cyclin D1显示文摘Esophageal squamous cell carcinoma(ESCC) is one of the most aggressive cancers in China,but the underlying molecular mechanism of ESCC is still unclear.Involvement of microRNAs has been demonstrated in cancer initiation and progression.Despite the reported function of miR-503 in several human cancers,its detailed anti-oncogenic role and clinical significance in ESCC remain undefined.In this study,we examined miR-503 expression by q PCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues.Further investigation in the effect of miR-503 on ESCC cell proliferation,migration,and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpression of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype.Our study further identified CCND1 as the target gene of miR-503.Thus,miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. | Lanfang Jiang Zitong Zhao Leilei Zheng Liyan Xue Qimin Zhan Yongmei Song | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 5 |
| 12 | Classification of Ferrallitic Soils in Chinese Soil Taxonomy显示文摘The development of the classification of ferrallitic soils in China is reviewed and the classification ofFerralisols and Ferrisols in Chinese Soil Taxonomy is introduced in order to discuss the correlation betweenthe ferrallitic soil classification in the Chinese Soil Taxonomy and those of the other soil classification systems.In the former soil classification systems of China, the ferrallitic soils were classified into the soil groups ofLatosols, Latosolic red soils, Red soils, Yellow soils and Dry red soils, according to the combination of soilforming conditions, soil-forming processes, soil features and soil properties. In the Chinese Soil Taxonomy,most of ferrallitic soils are classified into the soil orders of Ferralisols and Ferrisols based on the diagnostichorizons and/or diagnostic characteristics with quantitatively defined properties. Ferralisols are the soilsthat have ferralic horizon, and they are merely subdivided into one suborder and two soil groups. Ferrisolsare the soils that have LAC-ferric horizon but do not have ferralic horizon, and they are subdivided intothree suborders and eleven soil groups. Ferralisols may correspond to part of Latosols and Latosolic red soils.Ferrisols may either correspond to part of Red soils, Yellow soils and Dry red soils, or correspond to part ofLatosols and Latosolic red soils. | GONG ZITONG CHEN ZHICHENG ZHAO WENJUN and SHI HUA(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Naroing 210008 China) | 2000 | Pedosphere2000，10，2： | 5 |
| 13 | Effect of Bacillus amyloliquefaciens and Bacillus subtilis on fermentation, dynamics of bacterial community and their functional shifts of whole-plant corn silage显示文摘Background:Bacillus amyloliquefaciens(BA)and Bacillus subtilis(BS)are usually used as feed supplements directly or bacterial inoculants in biological feeds for animals.However,few research have reported the effects of BA and BS on fermentation characteristics and bacterial community successions of whole-plant corn silage during ensiling.If the BA and BS inoculants have positive effects on silages,then they could not only improve fermentation characteristics,but also deliver BA or BS viable cells to ruminants,which would play its probiotic effect.Therefore,the objectives of this study were to investigate the effects of BA and BS on the fermentation,chemical characteristics,bacterial community and their metabolic pathway of whole-plant corn silage.Results:Freshly chopped whole-plant corn was inoculated without or with BA and BS,respectively,and ensiled for1,3,7,14 and 60 d.Results showed that BA and BS inoculations increased lactic acid concentrations of whole-plant corn silages compared with control,and BA inoculation decreased acetic acid concentrations,whereas BS inoculation decreased fiber contents and increased crude protein(CP)content.Higher water-soluble carbohydrate contents and lower starch contents were observed in BA-and BS-inoculated silages compared with that in control.The decreased CP content and increased non-protein nitrogen content were observed in BA-inoculated silage,which was consistent with the higher amino acid metabolism abundances observed in BA-inoculated silage.In addition,it was noteworthy that BA and BS inoculations increased the metabolism of cofactors and vitamins,and decreased the relative abundances of drug resistance:antimicrobial pathways.We also found that the bacterial metabolism pathways were clearly separated into three clusters based on the ensiling times of whole-plant corn silage in the present study.There were no significant differences in bacterial community compositions among the three groups during ensiling.However,BA and BS inoculations decreased the relative abundances of undesirable bacteria such as Acetobacter and Acinetobacter.Conclusion:Our findings suggested that the BS strain was more suitable as silage inoculants than the BA strain in whole-plant corn silage in this study. | Jie Bai Marcia Franco Zitong Ding Lin Hao Wencan Ke Musen Wang Dongmei Xie Ziqian Li Yixin Zhang Lin Ai Xusheng Guo | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 5 |
| 14 | Selenophene-Flanked Diketopyrrolopyrrole Based Conjugated Polymers for Ambipolar Field-Effect Transistors显示文摘Summary of main observation and conclusion The development of selenophene-flanked DPP(SeDPP)based copolymers,especially for the ambipolar ones,lags behind other aromatic group flanked DPP-based polymers.Herein,we report two new ambipolar SeDPP-based conjugated polymers.One is the alternating polymer PSeDPPFT with normal SeDPP and 3,4-difluorothiophene units.The other is PSeFDFT,in which the electron acceptor unit is replaced by a new SeDPP derivative,referred as to half-fused SeDPP.The more planar structure of half fused SeDPP endows the backbone of PSeFDFT with good rigidity and planarity.Both polymers exhibit ambipolar transporting properties in air.The PSeFDFT based fleld-effect transistors(FETs)display higher and more balanced ambipolar properties with μnave of 0.27 cm2·V-1·s-1,μe ave of 0.18 cm2·V-1·s-1,and μh ave/μeave of 1.5 than those of PSeDPPFT(μhave=0.11cm2·V-1·s-1,μeave=0.042cm2·V-1·s-1,and μh/μe=2.6).This is attributed to the more planar structure,lower LUMO level,higher HOMO level,and better interchain packing orientations of PSeFDFT by comparing with PSeDPPFT.Therefore,a new molecular design strategy to modulate the hole and electron transporting properties is proposed for conjugated D-A polymers. | Dandan Shi Xiaobo Yu Liangliang Chen Daoliang Chen Zitong Liu Xisha Zhang Guanxin Zhang Deqing Zhang | 2020 | Chinese Journal of Chemistry2020，38，10： | 4 |
| 15 | Magnetic resonance imaging tracing of transplanted bone marrow mesenchymal stem cells in a rat model of cardiac arrest-induced global brain ischemia显示文摘<正>BACKGROUND:Numerous studies have shown that magnetic resonance imaging(MRI) can detect survival and migration of super paramagnetic iron oxide-labeled stem cells in models of focal cerebral infarction. OBJECTIVE:To observe distribution of bone marrow mesenchymal stem cells(BMSCs) in a rat model of global brain ischemia following cardiac arrest and resuscitation,and to investigate the feasibility of tracing iron oxide-labeled BMSCs using non-invasive MRI. DESIGN,TIME AND SETTING:The randomized,controlled,molecular imaging study was performed at the Linbaixin Medical Research Center,Second Affiliated Hospital,Sun Yat-sen University,and the Institute of Cardiopulmonary Cerebral Resuscitation,Sun Yat-sen University, China from October 2006 to February 2009. MATERIALS:A total of 40 clean,Sprague Dawley rats,aged 6 weeks and of either gender,were supplied by the Experimental Animal Center,Sun Yat-sen University,China,for isolation of BMSCs. Feridex(iron oxide),Gyroscan Inetra 1.5T MRI system,and cardiopulmonary resuscitation device were used in this study. METHODS:A total of 30 healthy,male Sprague Dawley rats,aged 6 months,were used to induce ventricular fibrillation using alternating current.After 8 minutes,the rats underwent 6-minute chest compression and mechanical ventilation,followed by electric defibrillation,to establish rat models of global brain ischemia due to cardiac arrest and resuscitation.A total of 24 successful models were randomly assigned to Feridex-labeled and non-labeled groups(n=12 for each group).At 2 hours after resuscitation,5×10~6 Feridex-labeled BMSCs,with protamine sulfate as a carrier,and 5×10~6 non-labeled BMSCs were respectively transplanted into both groups of rats through the right carotid artery(cells were harvested in 1 mL phosphate buffered saline). MAIN OUTCOME MEASURES:Feridex-labeled BMSCs were observed by Prussian blue staining and electron microscopy.Signal intensity,celluar viability,and proliferative capacity of BMSCs were measured using MRI,Trypan blue test,and MTT assay,respectively.Distribution of transplanted cells was observed in rats utilizing MRI and Prussian blue staining prior to and 1,3,7,and 14 days after transplantation. RESULTS:Prussian blue staining displayed many blue granules in the Feridex-labeled BMSCs. High density of iron granules was observed in the cytoplasm under electron microscopy.According to MRI results,and compared with the non-labeled group,the signal intensity was decreased in the Feridex-labeled group(P<0.05).The decrease was most significant in the 50μg/mL Feridex-labeled group(P<0.01).There were no significant differences in celluar viability and proliferation of BMSCs between the Feridex-labeled and non-labeled groups after 1 week(P>0.05). Low-signal lesions were detected in the rat hippocampus and temporal cortex at 3 days after transplantation.The low-signal lesions were still detectable at 14 days,and positively stained cells were observed in the hippocampus and temporal cortex using Prussian blue staining.There were no significant differences in signal intensity in the non-labeled group. CONCLUSION:BMSC transplantation traversed the blood-brain barrier and distributed into vulnerable zones in a rat model of cardiac arrest-induced global brain ischemia.MRI provided a non-invasive method to in vivo dynamically and spatially trace Feridex-labeled BMSCs after transplantation. | Yue Fu Xiangshao Fang Tong Wang Jiwen Wang Jun Jiang Zhigang Luo Xiaohui Duan Jun Shen Zitong Huang | 2009 | Neural Regeneration Research2009，4，9： | 4 |
| 16 | Frequency-Hopping Frequency Reconnaissance and Prediction for Non-cooperative Communication Network显示文摘The continuous change of communica-tion frequency brings difficulties to the reconnaissance and prediction of non-cooperative communication net-works.Since the frequency-hopping(FH)sequence is usually generated by a certain model with certain regularity,the FH frequency is thus predictable.In this paper,we investigate the FH frequency reconnais-sance and prediction of a non-cooperative communi-cation network by effective FH signal detection,time-frequency(TF)analysis,wavelet detection and fre-quency estimation.With the intercepted massive FH signal data,long short-term memory(LSTM)neural network model is constructed for FH frequency pre-diction.Simulation results show that our parameter es-timation methods could estimate frequency accurately in the presence of certain noise.Moreover,the LSTM-based scheme can effectively predict FH frequency and frequency interval. | Gao Li Wei Wang Guoru Ding Qihui Wu Zitong Liu | 2021 | China Communications2021，18，12： | 4 |
| 17 | Effect of Perched Water Tables on Aluminosilicate Stability and Soil Genesis显示文摘The mineral stability and solute activities of soil solution extracted from selected horizons of seven studied pedons of Alfisols in Kentucky, USA, and the relationship between distribution of iron-manganese concretions and the restrictive layers were investigated. The results showed that the genesis and development of these soils and mineral weathering trends were strongly influenced by the depth of bedrock and the presence of perched water tables at lithic (limestone) interfaces due to the dissolution and buffering effect of limestone bedrock. The extractable Mg/Ca ratio as depth function and soil depth above bedrock could be used as indices of weathering and degree of soil development. Maximum iron-manganese concretion accumulation was found to occur in the horizon overlying clay horizon (>40% clay) with a sharp increase in clay content (>10%), which suggested that zones of Fe-Mn concretion accumulation in soils of the Inner Bluegrass Region appeared to be a sensitive genetic indicator of argillic horizons with restrictive permeability. | ZHANG MIN , GONG ZITONG and A. D. KARATHANASIS College of Resources and Environment, Shandong Agricultural University, Tai’an 271018 (China) Institute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) College of Agriculture, U | 2000 | Pedosphere2000，10，3： | 4 |
| 18 | Gap-free genome assembly and comparative analysis reveal the evolution and anthocyanin accumulation mechanism of Rhodomyrtus tomentosa显示文摘Rhodomyrtus tomentosa is an important f leshy-fruited tree and a well-known medicinal plant of the Myrtaceae family that is widely cultivated in tropical and subtropical areas of the world.However,studies on the evolution and genomic breeding of R.tomentosa were hindered by the lack of a reference genome.Here,we presented a chromosome-level gap-free T2T genome assembly of R.tomentosa using PacBio and ONT long read sequencing.We assembled the genome with size of 470.35 Mb and contig N50 of∼43.80 Mb with 11 pseudochromosomes.A total of 33382 genes and 239.31 Mb of repetitive sequences were annotated in this genome.Phylogenetic analysis elucidated the independent evolution of R.tomentosa starting from 14.37MYA and shared a recent WGD event with other Myrtaceae species.We identified four major compounds of anthocyanins and their synthetic pathways in R.tomentosa.Comparative genomic and gene expression analysis suggested the coloring and high anthocyanin accumulation in R.tomentosa tends to be determined by the activation of anthocyanin synthesis pathway.The positive selection and up-regulation of MYB transcription factors were the implicit factors in this process.The copy number increase of downstream anthocyanin transport-related OMT and GST gene were also detected in R.tomentosa.Expression analysis and pathway identification enriched the importance of starch degradation,response to stimuli,effect of hormones,and cell wall metabolism during the f leshy fruit development in Myrtaceae.Our genome assembly provided a foundation for investigating the origins and differentiation of Myrtaceae species and accelerated the genetic improvement of R.tomentosa. | angping Li Shiqiang Xu Zitong Xiao Jingming Wang Yu Mei Haifei Hu Jingyu Li Jieying Liu Zhuangwei Hou Junliang Zhao Shaohai Yang Jihua Wang | 2023 | Horticulture Research2023，10，3： | 3 |
| 19 | RASSF6-TRIM16 axis promotes cell proliferation,migration and invasion in esophageal squamous cell carcinoma显示文摘Ras-association(RA) domain family number 6(RASSF6) is a member of the Ras-association domain protein family.It is epigenetically inactive and negatively regulates the malignant progression of some tumors.However,its precise role in esophageal squamous cell carcinoma(ESCC) has not been reported.In this study,we performed immunohistochemistry(IHC) assay.The results show that RASSF6 is upregulated in ESCC and that the elevated expression level of RASSF6 is associated with lymph node metastasis and poor survival of ESCC patients.Consistent with the clinical obse rvations,the upregulation of RASSF6 greatly promotes ESCC cell proliferation,migration and invasion as well as the cell cycle transition to Gl/S phase in vitro.According to models in vivo,the downregulation of RASSF6 considerably inhibits ESCC tumor growth and lung metastasis.Mechanistically,RASSF6 negatively regulates the tumor suppressor tripartite-motif-containing protein 16(TRIM16) by promoting its ubiquitination-dependent degradation and eventually activates pathways associated with the cell cycle and epithelialmesenchymal transition(EMT).Together,these results indicate that the RASSF6-TRIM16 axis is a key effector in ESCC progression and that RASSF6 serves as a potential target for the treatment of ESCC. | Leilei Zheng Zitong Zhao Lulu Rong Liyan Xue Yongmei Song | 2019 | Journal of Genetics and Genomics2019，46，10： | 3 |
| 20 | Creep-Induced Phase Instability and Microstructure Evolution of a Nearly Lamellar Ti–45Al–8.5Nb–(W, B, Y) Alloy显示文摘Microstructure degradation and stress-induced transformation of a high Nb-containing TiAl alloy with nearly lamellar microstructure during creep were investigated.Tensile creep experiments were performed at 800,850 and 900℃ under 150 MPa in air.Microstructures before and after creep tests were examined using scanning and transmission electron microscopy(SEM and TEM).Dislocations within the lamellar structure andβo(ω)region and twin intersection in massiveγgrains were investigated.Dislocation sliding played a critical role in the deformation ofωo phase,which preferentially occurred on the(0002)ωo plane.Possible deformation mechanisms were revealed.A stress-inducedγ→α2 phase transformation took place during the creep test at 850 and 900℃.α2 lamella could directly decompose into theωo phase at 850℃.The instability of high-temperature microstructure can weaken the creep resistance and promote the plastic deformation of the lamellar matrix,thus could be detrimental to the creep properties.The correlations between creep properties and microstructure instability were discussed. | Xuyang Wang Jieren Yang Rui Hu Zitong Gao Jinguang Li Hengzhi Fu | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，12： | 3 |
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