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| 1 | Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine显示文摘Dear Editor,Urine passes through the entire kidney and urinary tract system starting from the glomerulus and ending to the urethra.Cells in the kidney and urinary tract could be exfoliated from the epithelium into the urine,while leukocyte could infiltrate from the local tissue into the urine,which makes the urine a useful subject for clinical evaluation of relevant diseases. | Yujia Wang Yu Zhao Zixian Zhao Dandan Li Hao Nie Yufen Sun Xiaobei Feng Ting Zhang Yu Ma Jing Nie Guangyan Cai Xiangmei Chen Wei Zuo | 2021 | Protein & Cell2021，12，4： | 2 |
| 2 | Single-cell transcriptome profiling of the vaginal epithelium reveals the heterogeneity of suprabasal cells显示文摘Dear Editor,The integrity of the vaginal epithelium is crucial for women’s reproductive health and for providing protection against HIV and sexually transmitted infections.1 The vagina is a tubular tract made of fibromuscular and elastic tissue that connects the cervix to the outer genitals.Its main function is to discharge uterine secretions.2 The vaginal epithelium(VE)is a keratinized,stratified squamous epithelium consisting of three layers:the basal layer,the suprabasal layer,and the apical cornified layer. | Chen Liang Zixian Zhao Sarah Liu Ting Zhang Wei Zuo | 2023 | Precision Clinical Medicine2023，6，1： | 0 |
| 3 | Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium显示文摘Information about the dynamic change and post-injury regeneration of cervical epithelium is relatively rare,even though it is tightly related to gynecologic malignancy.Here,using a feeder cell-based culturing system,we stably cloned mouse and human P63 and KRT5 expressing cells from the adult cervix as putative cervical stem/progenitor cells(CVSCs).When subjected to differentiation,the cultured cells gave rise to mature cervical epithelium by differentiating into squamous or glandular cells.The ability of endogenous mouse CVSCs to reconstitute cervical epithelium after injury was also evident from the genetic lineage tracing experiments.Single-cell transcriptomic analysis further classified the CVSCs into three subtypes and delineated their bi-lineage differentiation roadmap by pseudo-time analysis.We also tracked the real-time differentiation routes of two representing single CVSC lines in vitro and found that they recapitulated the predicted roadmap in pseudo-time analysis.Signaling pathways including Wnt,TGF-beta,Notch and EGFR were found to regulate the cervical epithelial hierarchy and implicated the different roles of distinct types of cells in tissue homeostasis and tumorigenesis.Collectively,the above data provide a cloning system to achieve stable in vitro culture of a bi-lineage stem/progenitor cell population in the cervix,which has profound implications for our understanding of the cervix stem/progenitor cell function in homeostasis,regeneration,and disease and could be helpful for developing stem cell-based therapies in future. | Zixian Zhao Yujia Wang Yingchuan Wu Dandan Li Ting Zhang Yu Ma Xiaoming Teng Wei Zuo | 2021 | Cell Regeneration2021，10，1： | 0 |
| 4 | Munabulake ophiolitic mélange:Implication for the evolution history of the north branch of the Proto-Tethys ocean显示文摘One of the ophiolites that record the Proto-Tethys Ocean’s episodic closure is the Munabulake ophiolitic mélange,which is situated in the middle of the Kunlun-Qaidam and Altun-Qilian blocks.Detailed field mapping revealed that the Munabulake ophiolitic mélange comprises local(ultramafic rocks,basalts,andesites,gabbros,diorites,and plagiogranites)and exotic(marble,gneiss,schist,and amphibolite)blocks,many of which are in the schist matrix(Qimantage Group).Based on geochronological,geochemical,and petrological observations,the mafic rocks in the Munabulake ophiolitic mélange can be categorized into three categories:498-Ma OIB-like gabbros,468-Ma Hawaiian alkaline basalt-like dolerite and pillow basaltic slices,and 428 Ma massive SSZ-like ultramafic rocks.The 501-452 Ma I-type granites exhibit arc affinities due to the oceanic crust subduction.These findings,along with spatial relationships,suggest that the Early Paleozoic ophiolite complex,island arc rocks,and accretionary complex generated as an intra-oceanic arc system as a result of obduction of the south Altun Ocean’s onto the Central Altun block within a north-directed subduction event.A dextral strike-slip was evident throughout the Early Paleozoic oceanic crust subduction based on the whole set of planar and linear structural data,and the subduction polarity was likely to the north.According to the ophiolitic mélange’s youngest rocks and the existence of 413 Ma granite dykes that are widely exposed in the Munabulake ophiolitic mélange,the Munabulake ophiolitic mélange was most likely emplaced during the Middle Silurian.This Munabulake ophiolitic mélange is similar in age and petrochemical characteristics to the other ophiolites in the South Altun subduction-collision belt,indicating that the Manabulak ophiolite mélange is a westward extension of the Apa-Mangya subduction-collision belt,which formed during the northward subduction of the South Altun Ocean slab during the Early Paleozoic.Thus,the final closing time of the South Altun Ocean is between 413 and 428 Ma. | Changfeng Liu Wencan Liu Baoying Ye Zixian Zhao He Su Xin Xu | 2024 | Geoscience Frontiers2024，15，1： | 0 |
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