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| 1 | 脊髓型颈椎病后路手术术后椎间盘骨赘复合物的大小变化:椎板成形术和椎板切除融合术的比较研究显示文摘椎板切除融合术(laminectomy with fusion,LF)和椎板成形术是治疗脊髓型颈椎病(cervical spondylotic myelopathy,CSM)的两种后路术式。业界认为其术中减压效果主要与脊髓从腹侧致压结构(如椎间盘骨赘复合物)向背侧漂移的程度有关,但事实上LF术后脊髓减压的另一机制是腹侧椎间盘骨赘复合物自发性吸收、减小,融合节段运动范围发生改变。本研究的目的是为了明确腹侧椎间盘骨赘复合物在椎板成形术后是否缩小,同时比较其与LF的差异。 | Aliboye RM Zoller SD Ashana AA 白朝晖 王建华 | 2017 | 中国骨科临床与基础研究杂志2017，9，4： | 10 |
| 2 | Pancreatic cancer stem cell markers and exosomes-the incentive push显示文摘Pancreatic cancer(Pa Ca) has the highest death rate and incidence is increasing. Poor prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor population of so called cancer stem cells(CSC) within the mass of the primary tumor. CSC are defined by biological features, which they share with adult stem cells like longevity, rare cell division, the capacity for self renewal, differentiation, drug resistance and the requirement for a niche. CSC can also be identified by sets of markers, which for pancreatic CSC(Pa-CSC) include CD44v6, c-Met, Tspan8, alpha6beta4, CXCR4, CD133, Ep CAM and claudin7. The functional relevance of CSC markers is still disputed. We hypothesize that Pa-CSC markers play a decisive role in tumor progression. This is fostered by the location in glycolipid-enriched membrane domains, which function as signaling platform and support connectivity of the individual Pa-CSC markers. Outsidein signaling supports apoptosis resistance, stem cell gene expression and tumor suppressor gene repression as well as mi RNA transcription and silencing. Pa-CSC markers also contribute to motility and invasiveness. By ligand binding host cells are triggered towards creating a milieu supporting Pa-CSC maintenance. Furthermore, CSC markers contribute to the generation, loading and delivery of exosomes, whereby CSC gain the capacity for a cell-cell contact independent crosstalk with the host and neighboring non-CSC. This allows PaCSC exosomes(TEX) to reprogram neighboring nonCSC towards epithelial mesenchymal transition and to stimulate host cells towards preparing a niche for metastasizing tumor cells. Finally, TEX communicate with the matrix to support tumor cell motility, invasion and homing. We will discuss the possibility that CSC markers are the initial trigger for these processes and what is the special contribution of CSC-TEX. | Sarah Heiler Zhe Wang Margot Zoller | 2016 | World Journal of Gastroenterology2016，22，26： | 8 |
| 3 | 静脉血栓栓塞研究的既往与现今及未来显示文摘静脉血栓栓塞症(VTE)是继冠心病和中风后排名第三的最常见的心血管疾病。在过去的100年中,对于血液凝固过程及其调控机制的深入了解推进了VTE的诊断和治疗方法。1860年制定的魏尔肖三定律直今仍然是有效的,即VTE是由于血管壁受损、血液流动减慢和血液成分改变造成的。流行病学和临床科学现在也已经确定了V‘rE的多个后天获得性危险因素,如高龄、肿瘤、手术、外伤、固定、怀孕和使用口服避孕药等。随着遗传研究技术的快速发展,一些基因被确定与VTE的家族聚集性有关,与VTE相关的基因变异也逐渐被发现。遗传因素和后天获得性的危险因素在血栓的发展中相互作用。新型实验诊断项目能够帮助人们早期判断高凝状态。因此,为减少全球VTE负担,对VTE的预防,风险评估,诊断和治疗将更为重要。 | Bengt Zoller Pablo Garcia de Frutos Bjorn Dahlback 吴俊 | 2016 | 中华检验医学杂志2016，39，10： | 6 |
| 4 | Walking the thin line…ten years later:the dilemma of aboveversus below-ground features to support phylogenies in the Russulaceae(Basidiomycota)显示文摘For the very first time,morpho-anatomical features of both fruiting bodies as well as below-ground structures have been confronted with a newly produced multigene phylogeny of root symbiotic basidiomycetes using one of the most speciose genera of ectomycorrhizal fungi(Russula,Russulales)as an example.In this first of two papers,the authors focus more specifically on below-ground structures.Our five-gene phylogeny divides the genus in five main clades,here interpreted as representing seven subgenera,all significantly supported.Although more conserved than features of fruiting bodies,the anatomy of ectomycorrhiza does not allow for an unambiguous characterization of the main clades resolved by phylogenetic analysis,but the anatomy of ectomycorrhiza performs better to naturally classify the species of this genus.Features of fruiting bodies remain much more adequate for the delimitation of terminal clades and are irreplaceable for morphological species identification.Tropical taxa mostly nest in ancient lineages,but are also present in some terminal clades of otherwise temperate species groups.The shift from plectenchymatic to pseudoparenchymatic ECM outer mantle structures happened most likely already in the paleotropics,and is here hypothesized to have facilitated a major diversification of the genus with new hosts in the northern hemisphere.Available data as well as our own observations on below ground structures of several Lactifluus species suggests that this genus shares with Russula the absence of lactifers in ECM mantles and rhizomorphs,contrary to species of Lactarius where lactifers are always present.First observations on rhizomorphs of species in Multifurca confirm the presence of vessel-like and ladder-like hyphae,also found in the other agarioid genera of this family,while distinct lactifers are only present in the lactarioid,but not in russuloid members of this genus. | Bart Buyck Stefan Zoller Valerie Hofstetter | 2018 | Fungal Diversity2018，，2： | 3 |
| 5 | PNPLA3 rs738409-G in Recipients of Liver Transplants is a Risk Factor for Graft Steatosis显示文摘 | Armin Finkenstedt Claudia Auer Bernhard Glodny Ursula Posch Hansjoerg Steitzer Gerhard Lanzer Johann Pratschke Matthias Biebl Michael Steurer Ivo Graziadei Wolfgang Vogel Heinz Zoller | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 6 | CD44 splice variants confer metastatic behavior in rats:homologous sequences are expressed in humantumor cell lines显示文摘 | RUDY W ZOLLER M | 1991 | Cancer Res1991，51，： | 1 |
| 7 | Reduced quantum fluctuations in resonance fluorescence显示文摘 | Walls D F Zoller P | 1981 | Phys Rev Lett1981，47，10： | 1 |
| 8 | Identification of renal-cell-carcinoma-related cDNA clones by suppression subtractive hybridization显示文摘 | Pitzer C Stassar M Zoller M | 1999 | J Cancer Res Clin Oncol1999，125，89： | 1 |
| 9 | A major antigenic domain of hantaviruses is located on the aminoproximal site of the viral nucleocapsid protein 显示文摘 | Gott P L Zoller G Darai | 1997 | Virus Genes1997，14，： | 1 |
| 10 | Geometric manipula-tion of trapped ions for quantum computation 显示文摘 | Duan L M Cirac J I Zoller P | 2001 | Science2001，292，： | 1 |
| 11 | Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload 显示文摘 | Zoller H Koch RO Theurl I | 2001 | Gastroentorology2001，120，： | 1 |
| 12 | Hepcidin messenger RNA expression in human lymphocytes显示文摘 | Pinto JP Dias V Zoller H | | 0，，02： | 1 |
| 13 | Altered pharmacokinetics of voriconazole in a patient with liver cirrhosis显示文摘 | Weiler S Zoller H Graziadei I | 2007 | Antimicrob Agents Chemother2007，51，9： | 1 |
| 14 | CD44 splice variants: metastases meet lymphocytes显示文摘 | Herrlich P Zoller M Pals ST | 1993 | Immunol Today1993，14，： | 1 |
| 15 | Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3显示文摘 | Theurl I Zoller H Obrist P | 2004 | J Infect Dis2004，190，4： | 1 |
| 16 | Treatment of iatrogenic postoperative ureteral strictures with Acucise endoureterotomy显示文摘 | Seseke F Heuser M Zoller G | 2002 | Eur Urol2002，42，4： | 1 |
| 17 | Autoimmune diseases and venous thromboembolism: a review of the literature 显示文摘 | Zoller B Li X Sundquist J | 2012 | Am J Cardiovasc Dis2012，2，3： | 1 |
| 18 | CD44 in cancer progression: adhension, migrationand growth regulation显示文摘 | Marhaba R Zoller M | 2004 | J Mol Histol2004，35，3： | 1 |
| 19 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 20 | Alpha efficiency determination for OSL of quartz extracted from Chinese loess 显示文摘 | Lai Z P Zoller L Fuchs M | 2008 | Radiation Measurements2008，43，： | 1 |
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