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| 1 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 2 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 3 | Caspase Inhibitors Reduce Neuronal Injury After Focal but Not Global Cerebral Ischemia in Rats显示文摘 | Hui Li Frederick Colbourne Ping Sun Zonghang Zhao Alastair M. Buchan | 2000 | Stroke: Journal of the American Heart Association2000，，1： | 1 |
| 4 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 5 | PIC catalysis based on polyoxometalates promoting 5-HMF oxidation in H_(2)O/MIBK biphase显示文摘Novel polyoxometalate(POM)Pickering interfacial catalyst(PIC)was fabricated through loading(NH_(4))_(5)H_(6)PMo_(4)V_(8)O_(40)(PMo_(4)V_(8))on both alkyl and alkyl-amino groups functionalized silica nanoparticles.PMo_(4)V_(8)/SiO_(2)(C_(8)/C_(8)NH_(2)with molar ratio as 1:1)PIC system provided a new catalytic model for aerobic conversion of 5-hydroxymethylfurfural(5-HMF),as well as its recovery and product separation in H_(2)O/methyl isobutyl ketone(MIBK)biphase reaction.Balancing the ratio of PMo_(4)V_(8),C_(8)and C_(8)NH_(2)gave rise to variety in hydrophilicity and hydrophobicity for PMo_(4)V_(8)/SiO_(2)(C_(8)/C_(8)NH_(2)),which enhanced the transformation of 5-HMF to 2,5-diformylfuran(DFF)in H_(2)O/MIBK with 73.7%yield at 81.8%conversion than in H_(2)O or MIBK single phase. | Qiwen Wang Wenwen Bu Zonghang Li Yu Qi Xiaohong Wang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 6 | Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum显示文摘Diterpenoid alkaloids(DAs) have been often utilized in clinical practice due to their analgesic and anti-infammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathway responsible for DA production remains unknown.In this study, we successfully assembled a highquality, pseudochromosome-level genome of the DA-rich species Aconitum vilmorinianum(A.vilmorinianum)(5.76 Gb). An A. vilmorinianumspecific whole-genome duplication event was discovered using comparative genomic analysis,which may aid in the evolution of the DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent-kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origin of DAs in A.vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs. | Dake Zhao Ya Zhang Huanxing Ren Yana Shi Ding Dong Zonghang Li Guanghong Cui Yong Shen Zongmin Mou Edward JKennelly Luqi Huang Jue Ruan Suiyun Chen Diqiu Yu Yupeng Cun | 2023 | Journal of Integrative Plant Biology2023，65，10： | 0 |
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