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您的检索式：作者名="Zongyang Qiu"
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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Steric Hindrance Effect in High-Temperature Reactions显示文摘High-temperature reactions widely exist in nature.However,they are difficult to characterize either experimentally or computationally.The minimum energy path(MEP)model routinely used in computational modeling of chemical reactions is not justified to describe high-temperature reactions since high-energy structures are actively involved at high temperatures.In this study,we used methane(CH4)decomposition on Cu(111)surface as an example to compare systematically results obtained from the MEP model with those obtained from an explicit sampling of all relevant structures via ab initio molecular dynamics(AIMD)simulations at different temperatures.Interestingly,we found that,for reactions protected by strong steric hindrance effects,the MEP was still followed effectively even at a temperature close to the Cu melting point.In contrast,without such protection,the flexibility of the surface Cu atoms could lead to a significant reduction of the free-energy barrier at a high temperature.Accordingly,some earlier conclusions made about graphene growth mechanisms based on MEP calculations should be revisited.The physical insights provided by this study could deepen our understanding of high-temperature surface reactions. | Xiongzhi Zeng Zongyang Qiu Pai Li Zhenyu Li Jinlong Yang | 2020 | CCS Chemistry2020，2，6： | 0 |
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