| 2 | Circulating miR-221/222 reduces CD4^(+) T cells by inhibiting CD4 expression in colorectal cancer显示文摘Many patients with cancers have low levels of CD4+in their peripheral blood.However,the molecular mechanism is still unclear.Here,we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer(CRC),and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148,respectively.Transfection of either miR-221 or miR-222 resulted in the reduction of the surface CD4 antigen level but not the surface CD8 antigen level.The luciferase reporter assay showed that miR-221/222 directly regulated CD4 expression in human primary T cells.These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222.These findings provide a novel strategy for modulating the number of CD4+T cells in the blood and further adjusting the microenvironment suitable for immunotherapy. | Jiajia Hu Jiawei Zhang Meng Yu Zukai Liu Yan Zou Liwen Hong Tianyu Zhang Jing Sun Minhua Zheng Xuekai Zhu Zhengting Wang Sanhong Liu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
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