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| 1 | Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-nave patients显示文摘AIM: To determine whether adding vitamin D, a potent immunomodulator, improves the hepatitis C virus (HCV) response to antiviral therapy. METHODS: Seventy-two consecutive patients with chronic HCV genotype 1 were randomized into two groups: the treatment group (n = 36, 50% male, mean age 47 ± 11 years) received Peg-α-2b interferon (1.5 μg/kg per week) plus ribavirin (1000-1200 mg/d) together with vitamin D3 (2000 IU/d, target serum level > 32 ng/mL), and the control group (n = 36, 60% male, mean age 49 ± 7 years) received identical therapy without vitamin D. HCV-RNA was assessed by realtime polymerase chain reaction (sensitivity, 10 IU/mL). The sustained virologic response (SVR) was defined as undetectable HCV-RNA at 24 wk post-treatment. RESULTS: Clinical characteristics were similar in both groups. The treatment group had a higher mean bodymass index (27 ± 4 kg/m2 vs 24 ± 3 kg/m2, P < 0.01), viral load (50% vs 42%, P < 0.01), and fibrosis score (> F2: 42% vs 19%, P < 0.001) than the controls. At week 4, 16 (44%) treated patients and 6 (17%) controls were HCV-RNA negative (P < 0.001). At week 12, 34 (94%) treated patients and 17 (48%) controls were HCV-RNA negative (P < 0.001). At 24 wk post-treatment (SVR), 31 (86%) treated patients and 15 (42%) controls were HCV-RNA negative (P < 0.001). Viral load, advanced fibrosis and vitamin D supplementation were strongly and independently associated with SVR (multivariate analysis). Adverse events were mild and typical of Peg-α-2b/ribavirin. CONCLUSION: Adding vitamin D to conventional Peg-α-2b/ribavirin therapy for treatment-na■ve patients with chronic HCV genotype 1 infection significantly improves the viral response. | Saif Abu-Mouch Zvi Fireman Jacob Jarchovsky Abdel-Rauf Zeina Nimer Assy Liver Unit | 2011 | World Journal of Gastroenterology2011，17，47： | 29 |
| 2 | Capsule endoscopy: Improving transit time and image view显示文摘AIM: To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa.METHODS: Ninety-five patients underwent capsule endoscopy (CE) by easily swallowing the capsule. They were divided into three study groups according to the preparation used: group A (n = 26) by polyethylene glycol (PEG) liter or with sodium phosphate (SP) 12 h prior to the CE study; group B (n = 29) by erythromycin 1 h prior to the CE study; and group C (n = 40) without any preparation. Visualization ranged from good to satisfactory to poor.RESULTS: The gastric emptying time in the group prepared with erythromycin was shorter but without statistical significance and the small bowel transit time was unaffected. In elderly subjects prepared by PEG or SP, the gastric emptying time was significantly longer (163.7 min, P = 0.05). The transit times of the three sub-groups were not affected by gender or pathology.The grade of cleaning of the entire study group was 3.27±1.1. The erythromycin group presented significantly the worst quality of images (P = 0.05) compared to the other sub-groups. Age, gender, and pathology had no effect on the quality of the cleaning of the small bowel in the sub-groups. One (1.05%) case had no natural excretion.CONCLUSION: Erythromycin markedly reduces gastric emptying time, but has a negative effect on the quality of the image in the small bowel. The preparation of elderly subjects with PEG or SP has a negative effect on the small bowel transit time. | Zvi Fireman D Paz Y Kopelman | 2005 | World Journal of Gastroenterology2005，11，37： | 25 |
| 3 | 雪藻高密度连续培养中生物量和花生四烯酸的高产率显示文摘以 1 .4cm和 2 .8cm光径的平板光生物反应器 ,恒定高光强 [2 4 0 0 μE/(m2 ·s) ],通气、无菌高密度连续培养雪地绿藻 (简称雪藻 )。连续采收并补充等量新鲜培养液 ,当藻体生物量(以去灰分干重表示 ,AFDW)达恒态时 ,研究雪藻比生长速率 (SGR)、藻体的生物产量、总脂肪酸 (TFA)和花生四烯酸 (AA)产率。结果表明 ,尽管随着比生长速率增加 ,雪藻高密度连续培养体系的AA/TFA、TFA/AFDW和AA/AFDW三个指标有不同程度的降低 ,但生物产量、总脂肪酸及其花生四烯酸产出都相当高。 2 .8cm光径的平板光生物反应器中 ,雪藻SGR为0 .2d- 1 时 ,每平方米光照面积日获 35 .3gAFDW的高产量 ;SGR 0 .1 35d- 1 时 ,TFA产率最大 ,为7.0g/(m2 ·d) ,此时AA产率也最高 ,达 2 .6g/(m2 ·d)。尽管 1 .4cm光径的反应器的培养体积比前者下降了 5 0 % ,但细胞浓度明显提高 ,单位光照面积的AFDW和TFA最大日产率只下降了37.3%和 1 0 % ,分别为 2 2 .1和 6.3g/(m2 ·d) ,而AA的最大日产率也是 2 .6g/(m2 ·d)。结果还表明 ,氮或磷营养亏缺能明显提高雪藻AA含量的各项指标 ,同时高光强也有利于雪藻累积AA。 | 刘建国 刘伟 Zvi Cohen Amos Richmond | 2002 | 海洋与湖沼2002，33，5： | 15 |
| 4 | Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study显示文摘AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B). Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). SB transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37). Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time. | Eva Niv Ido Bogner Olga Barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman | 2008 | World Journal of Gastroenterology2008，14，16： | 10 |
| 5 | 不同清洗方式对义齿白色假丝酵母菌生物膜清除效果的影响显示文摘目的比较不同清洁方式对义齿白色假丝酵母菌生物膜的清除能力。方法制作并消毒树脂片,在其表面培养白色假丝酵母菌生物膜,分别以化学(浸泡)、机械(刷洗)和复合(浸泡与刷洗并用)等方式处理覆有白色假丝酵母菌生物膜的树脂片,再将其浸入新鲜培养液进行残留生物膜的恢复培养,分别在0、6、24h后利用菌落计数进行效果评价。结果机械清除效果与牙膏种类密切相关,单纯的化学处理没有明显的清除作用,保丽净义齿清洁片复合处理清除白色假丝酵母菌生物膜的效果最佳,其处理后的树脂片培养24h仍未检出白色假丝酵母菌。结论不同的义齿清洗方法对附着在义齿表面的白色假丝酵母菌生物膜的清除能力有差异。其中,以保丽净义齿清洁片复合效果最好且能够持续地发挥抑菌作用。 | 李莉娜 Young Kim 舒毅 Renate Lux 田敏 Prasad Adusumilli Zvi Loewy 郭宏 Yu Shao 施文元 沈嵩 黄正蔚 田宇 朱昞 张恺 陈谦明 王敏 吴红崑 周学东 | 2010 | 国际口腔医学杂志2010，37，2： | 10 |
| 6 | Dual Resistance of Melon to Fusarium oxysporum Races 0 and 2 and to Papaya ring-spot virus is Controlled by a Pair of Head-to-Head-Oriented NB-LRR Genes of Unusual Architecture显示文摘Dear Editor, Potyviruses such as Papaya ring-spot virus (PRSV) cause important yield losses in cucurbits.Two distinct resistant alleles were identified in the Cucumis melo germplasm.Accession PI 414723 (Supplemental Table 1) possesses monogenic resistance,controlled by the Prv2 allele,and reacts to PRSV by systemic necrotic lesions;plants with the Prv1 allele,described in cultivar WMR-29,remain symptomless (Pitrat and Lecoq,1983).Fusarium oxysporum f.sp.melonis (FUS)exclusively attacks melon,causing severe wilt.Monogenic dominant resistance was described against races 0,1,and 2.The Fom-2 gene,controlling resistance to races 0 and 1,was cloned by Joobeur et al.(2004),and encodes a nucleotide binding domain (NB)-leucine rich repeat (LRR) protein.Our study focused on the Fom-1 gene,which confers resistance to races 0 and 2 (Risser et al.,1976),and on the Prv gene;the two are tightly linked on melon linkage group iX.Molecular markers were developed for the Fom-1/Prv locus,but no study has provided the resolution required for positional cloning. | Yariv Brotman Michael Normantovich Zachi Goldenberg Zvi Zvirin Irina Kovalski Nastacia Stovbun Tirza Doniger Anthony M. Bolqer Christelle Troadec Abdelhafid Bendahman~ RoniCohen Nurit Katzir Michel Pitrat Catherine Dogimont Rafael PerI-Treves | 2013 | Molecular Plant2013，6，1： | 9 |
| 7 | FATTY ACIDS PROFILE IN A HIGH CELL DENSITY CULTURE OF ARACHIDONIC ACID-RICH PARIETOCHLORIS INCISA (TREBOUXIOPHYCEAE,CHLOROPHYTA) EXPOSED TO HIGH PFD显示文摘The changes in arachidonic acid (AA) and fatty acids profiles along the growth curve of Parietochloris incisa, a coccoid snow green alga, were studied in a 2.8 cm light-path flat photobioreactor, exposed to strong photon flux density [PFD, 2400 μEmol/(m 2·s)]. Sixteen fatty acids were identified by gas chromatography showing that AA was the dominant fatty acid (33%-41%) followed by linoleic acid (17%-21%). AA content was closely investigated with respect to total fatty acids (TFA), ash free dry weight (AFDW) of cell mass as well as total culture content. These parameters were influenced significantly in a similar manner by culture growth phase, i.e., slightly decreasing in the lag period, gradually increasing in the logarithmic phase, becoming maximal at the early stationary phase, starting to decrease at the late stationary phase, sharply dropping at the decline phase. The increase in AA per culture volume during the logarithmic phase was not only associated with the increase in AFDW but also connected with a corresponding increase in AA/TFA, TFA/AFDW as well as AA/AFDW. The sharp decrease in AA content of the culture during the decline phase was mainly due to the decrease in AA/TFA, TFA/AFDW and AA/AFDW, although AFDW declined only a small extent. Maximal AA concentration, obtained at the early stationary phase, was 900 mg/L culture volume, and the average daily net increase of AA during 9 days logarithmic growth was 1.7 g/(m 2·day). Therefore, harvesting prior to the decline phase in a batch culture, or at steady state in continuous culture mode seems best for high AA production. The latter possibility was also further confirmed by continuous culture with 5 gradients of harvesting rate. | 刘建国 Zvi Cohen 等 | 2002 | Chinese Journal of Oceanology and Limnology2002，20，2： | 9 |
| 8 | Promoting metastasis: neutrophils and T cells join forces显示文摘 | Zvi G Fridlender Steven M Albelda Zvi Granot | 2015 | Cell Research2015，25，7： | 7 |
| 9 | PHYSIOLOGICAL INHIBITORY EFFECT OF OCS IN ARACHIDONIC ACID-RICH PARIETOCHLORIS INCISA (TREBOUXIOPHYCEAE, CHLOROPHYTA)显示文摘Parietochloris incisa is an arachidonic acid rich snow green alga. The main physiological profiles, such as ash free dry weight (AFDW), chlorophyll, carotenoid, protein and total fatty acids (TFA), in this alga exposed to old culture supernatant (OCS) at the decline phase or its crude ethyl acetate extracts (CEAE) were investigated by using tubular photobioreactors of different diameters. Results showed that both OCS and CEAE had strong inhibitory effect on the above physiological parameters. The longer the culture was exposed to OCS and the more CEAE were added into the algal culture, the more the above physiological properties were inhibited. Arachidonic acid (AA), the dominant component of fatty acids in this alga, was also seriously inhibited with respect to total TFA, AFDW of cell mass, or culture volume, due to a probable reduction of enzymes activities catalyzing chain elongation from C18:1ω9 to AA. These results incontestably evidenced that some CEAE dissolving substances existing in OCS, like auto inhibitors, inhibited P. incisa growth through feedback. Hence, any efficient removal of auto inhibitors from algal culture to decrease their bioactivity could be good for maximal production of desired products like AA. | 刘建国 张成武 Zvi Cohen Amos Richmond | 2002 | Chinese Journal of Oceanology and Limnology2002，20，3： | 7 |
| 10 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 11 | 俄罗斯的土地政策和农业土地市场显示文摘从1917年10月到1990年10月,俄罗斯在70多年的时间里不存在私有产权。土地国有化始于1917年布尔什维克革命,经过1929~1930年强制集体化后,到1930年末,98%的农业用地由为数不多的集体农场和国家农场(共约3万个)控制。然而,尽管集体化和国有化非常普遍和深入,私营(或者更合适的说法是“个体的”)农业仍在数百万小规模(不超过0.5公顷)的以生活为目的的家庭土地上存留了下来。 | Zvi Lerman Natalya Shagaida 张迪 | 2007 | 国土资源情报2007，，3： | 4 |
| 12 | 国际养老金互换显示文摘在过去的 2 0年间 ,互换 (SWAP,也称掉期 )合同已经成为联系分散的国家金融体系与国际金融网络之间关键的金融适配器。今天 ,世界各地的银行与投资公司广泛地应用互换来管理他们的货币、利率、权益市场风险 ,并以此降低交易成本。然而在过去 2 0年间同样快速增长的养老基金却没有使用互换。本文研究了养老基金如何使用互换来实现由广泛的国际分散化和套期保值带来的风险分担的利益 ,同时避免国内短缺的资本外逃至其他国家 ,还阐述了如何降低互换征收风险和跨国投资交易费用。 | 兹维.博迪(Zvi Bodi) 罗伯特.C.莫顿(Robert C.Merton) 杨林 | 2002 | 财贸经济2002，23，4： | 3 |
| 13 | 中东欧及前苏联国家农村土地改革的对比分析显示文摘 | Csaba Csaki Zvi Lerman | 2001 | 中国农村经济2001，，12： | 3 |
| 14 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 15 | Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN显示文摘 | Zvi G. Fridlender Jing Sun Samuel Kim Veena Kapoor Guanjun Cheng Leona Ling G. Scott Worthen Steven M. Albelda | 2009 | Cancer Cell2009，，： | 2 |
| 16 | Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage显示文摘 | Rene Olivares-Navarrete Sharon L. Hyzy Daphne L. Hutton Christopher P. Erdman Marco Wieland Barbara D. Boyan Zvi Schwartz | 2010 | Biomaterials2010，，10： | 2 |
| 17 | 中国金融创新和技术进步的前景展望——2001年中国金融国际论坛发言集萃显示文摘首先,我想谈谈金融在促进技术进步方面的历史地位.然后我想讲讲它在为新企业融资方面所起的作用及其形式.其中的主要观点是美国现代风险投资公司只是发挥为新企业创建初期提供资金的功能的一种组织形式.这种功能就是为新企业提供资金.有许多途径可以实现这种功能,从使用个人储蓄到使用家庭储蓄等等.所以在讨论金融体系改革和它与风险投资之间的联系时,我们必须考虑到为创业企业提供融资的所有的组织形式,并且考察一下风险投资公司是不是一种有用的补充.我相信它是,但是它只是许多有用形式中的一种. | Zvi Bodie | 2003 | 世界经济文汇2003，，2： | 2 |
| 18 | Cities and growth: Theory and evidence from France and Japan显示文摘 | Jonathan Eaton Zvi Eckstein | 1997 | Regional Science and Urban Economics1997，，4： | 2 |
| 19 | The search for R&D spillovers 显示文摘 | GRILICHES ZVI | 1991 | Scandinavian journal of Economics1991，94，： | 1 |
| 20 | Patent statistics as economic indicators:A survey显示文摘 | GRILIEHES ZVI | 1990 | Journal of Economic Literature1990，，28： | 1 |
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