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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan H Rourke K chinnaiyan AM | | 0，，： | 5 |
| 3 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 4 | 美国家族性高胆固醇血症或其他严重血脂异常患者的胆固醇筛查、疾病认知和他汀类药物治疗的情况与预测因子(1999-2014)显示文摘家族性高胆固醇血症(familial hypercholesterolemia,FH)和其他低密度脂蛋白胆固醇的极度升高显著增加动脉粥样硬化性心血管病风险;然而,最近的数据表明,他汀类药物的处方率在这些患者中仍然很低。FH或严重血脂异常者的筛查率、知晓率和他汀治疗率尚不清楚。 | 刘青 叶鹏 Bucholz EM Rodday AM Kolor K Khoury MJ de Ferranti SD | 2018 | 中华高血压杂志2018，26，5： | 5 |
| 5 | Human urotensinⅡis a potent vasoconstrictory and agonist for the orphan receptor GPR14 显示文摘 | Ames R S Sarau H M Chambers J K | 1999 | Nature1999，401，6750： | 3 |
| 6 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 7 | 在确诊并已接受治疗的原发性高血压患者中,炎症、内皮功能障碍和交感神经激活与血压之间的关系显示文摘研究结果表明,炎症、内皮功能紊乱、交感神经系统慢性激活在高血压发病机制中起重要作用。目前临床上关于血压与炎症、内皮功能紊乱以及交感神经系统激活之间的关系还不明确。该研究评估在确诊并已接受治疗的原发性高血压患者中,炎症[高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)]、内皮细胞功能紊乱(内皮素1)和交感神经慢性激活(血浆肾上腺素和去甲肾上腺素)的生物标记物水平是否与血压的测量值相关。研究者同时试图应用血压和上述标记物之间的关系诊断顽固性高血压,并探讨降压药物对上述生物标记物的影响。 | Tycinska AM Mroczko B Musial WJ Sawicki R Kaminski K Borowska H Sobkowicz B Szmitkowski M. 叶鹏 | 2011 | 中华高血压杂志2011，19，11： | 2 |
| 8 | Roles of TGF-beta in hepatic fibrosis 显示文摘 | Gressner AM Weiskirchen R Breitkopf K | 2002 | Front Biosci2002，7，： | 1 |
| 9 | Slow velsus fast shock wave lithotripsy rate for urolithiasis a prospective randomized study显示文摘 | Madbouly K EL-Tirafi AM Saida M | 2005 | J Urol2005，173，1： | 1 |
| 10 | Lovastatin and phenylacetate inhibit the induction ofnitric oxide synthase and eytokines in rat primary astrocytes, microglia and macrophages 显示文摘 | Pahan K Sheikh FG Namboodiri AM | 1997 | ] Clin Invest1997，100，11： | 1 |
| 11 | Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues 显示文摘 | Goodarzi K Goodarzi M Tager AM | 2003 | Nat Immunol2003，4，： | 1 |
| 12 | Endomet-rial CD56+ natural killer cells in women with recurrent miscarriage:a histomorphometric study显示文摘 | CLIFFORD K FLANAGAN AM REGAN L | 1999 | Hum Reprod1999，14，11： | 1 |
| 13 | 16-MDCT in the detection of occult wrist fractures:a comparison with skeletal scintigraphy显示文摘 | Groves AM Cheow H Balall K | 2005 | AJR2005，184，5： | 1 |
| 14 | Apolipopmtein(a):Structureand piolagy显示文摘 | Scow AM Naksjima K Edelstein C | 2001 | Front Biosci2001，6，： | 1 |
| 15 | Rotational injury of cervical facets: CT analysis of fracture patterns with implications for management and neurologic outcome 显示文摘 | Shanmuganathan K Mirvis SE Levine AM | 1994 | Am J Roentgenol1994，163，5： | 1 |
| 16 | LDL-Apheresis for the treatment of hyperchylomicronemia-induced pancreatitis 显示文摘 | Sattler AM Boek K Schmidt S | 2003 | Z Kardiol2003，92，3： | 1 |
| 17 | Risk factors for corneal graft failure and rejection in penetrating keratoplasty 显示文摘 | Inoue K Amano S Oshika T Ortiz BD Nelson PJ Krensky AM | 2001 | Acta Ophthalmol Scand2001，79，3： | 1 |
| 18 | FADD,a novel death domain-containing protein,interacts with the death domain of Fas and initiates apoptosis显示文摘 | Chinnaiyan Am O'Rourke K tewai M | 1995 | Cell1995，81，19： | 1 |
| 19 | The Free Radical Theory of Aging Matures 显示文摘 | BECKMAN K B AMES B N | 1998 | Physiol Reu1998，78，： | 1 |
| 20 | Growth of Chlamydia pneumoniae in cultured human peripheral blood mononuclear cells and induction of acytokine response显示文摘 | Kaukoranta-Tolvanen SS Teppo AM Laitinen K | 1996 | Microb Pathog1996，21，： | 1 |
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