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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | Skeletal muscle mitochondrial health and spinal cord injury显示文摘Mitochondria are the main source of cellular energy production and are dynamic organelles that undergo biogenesis, remodeling, and degradation. Mitochondrial dysfunction is observed in a number of disease states including acute and chronic central or peripheral nervous system injury by traumatic brain injury, spinal cord injury(SCI), and neurodegenerative disease as well as in metabolic disturbances such as insulin resistance, type Ⅱ diabetes and obesity. Mitochondrial dysfunction is most commonly observed in high energy requiring tissues like the brain and skeletal muscle. In persons with chronic SCI, changes to skeletal muscle may include remarkable atrophy and conversion of muscle fiber type from oxidative to fast glycolytic, combined with increased infiltration of intramuscular adipose tissue. These changes contribute to a proinflammatory environment, glucose intolerance and insulin resistance. The loss of metabolically active muscle combined with inactivity predisposes individuals with SCI to type Ⅱ diabetes and obesity. The contribution of skeletal muscle mitochondrial density and electron transport chain activity to the development of the aforementioned comorbidities following SCI is unclear. A better understanding of the mechanisms involved in skeletal muscle mitochondrial dynamics is imperative to designing and testing effective treatments for this growing population. The current editorial will review ways to study mitochondrial function and the importance of improving skeletal muscle mitochondrial health in clinical populations with a special focus on chronic SCI. | Laura C O'Brien Ashraf S Gorgey | 2016 | World Journal of Orthopedics2016，7，10： | 3 |
| 4 | 男性与女性急性心肌梗死住院后30d再入院率的比较显示文摘急性心肌梗死(acute myocardial infarction,AMI)出院后再次入院可显著增加医疗费用。AMI后的结局因性别而异,但性别与再入院的关系值得进一步探索。研究人员使用2013年美国再入院数据库,挑选出主要出院诊断为AMI的患者,并按性别和年龄对30d的再入院情况进行分层。结果显示,在214 824例AMI患者中,44%为年龄18-64岁,56%为≥65岁, | 刘莉 叶鹏 O'Brien C Valsdottir L Wasfy J Strom J Secemsky E Wang Y Yeh RW | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 5 | A rapid-response,high-sensitivity nanophase humidity sensor for respiratory monitoring 显示文摘 | Kalkan A K Li Handong O'Brien C J | 2004 | Electron Device Letters IEEE2004，25，8： | 1 |
| 6 | Polyimide materials based on pyromellitic dianhydride for the separation of carbon dioxide and methane gas mixtures显示文摘 | O' Brien K C Koros W J | 1988 | J Membr Sci1988，35，： | 1 |
| 7 | Total thyroiedctomy for climically benign disease of the thyroid gland显示文摘 | O' Brien C J | 2004 | Br J Surg2004，91，5： | 1 |
| 8 | Effect of varying the microencapsulationprocess on the functionality of hydrogenated vegetable fat insbortdough biscuits显示文摘 | O'Brien C M | 2003 | Food research international2003，36，： | 1 |
| 9 | Thermal self-sustainability of biochar production by pyrolysis显示文摘 | Berruti F Briens C | 2011 | Journal of Analytical and Applied Pyrolysis2011，91，1： | 1 |
| 10 | Production of antibodies to Staphylococcus aureus serotype 5,8 and 336 using poly(DL-lactide-co-glycoli-de)microspheres显示文摘 | O′Brien C N Guidry A J attom A F | 2000 | J Dairy Sci2000，83，： | 1 |
| 11 | Effect of antibodies to staphylococcal alpha and bcta toxins and Stuphylococcus aureus on the cytotoxicity for and adherence of the organism to bovine mammary epithelial cells显示文摘 | Cifrian E Guidry A J O'Brien C N | 1996 | Am J Vet Res1996，57，9： | 1 |
| 12 | C60:Buckminster- fullerene显示文摘 | Kroto H W Heath J R O'Brien S C | 1985 | Nature1985，318，： | 1 |
| 13 | A human colon cancer cell capable of initiating tumour growth in immunodeficient mice显示文摘 | OBRIEN C A POLLETT A GALLINGER S | 2007 | Nature2007，445，7123： | 1 |
| 14 | Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma 显示文摘 | O'BRIEN G C CAHILL R A BOUCHIER-HAYES D J | 2006 | Ir J Med Sci2006，175，1： | 1 |
| 15 | A human colon cancer cell capable of initiating tumour growth in immunodeficient mice显示文摘 | O'Brien C A Pollett A Gallinger S | 2007 | Nature2007，445，： | 1 |
| 16 | The Serrated Polyp Pathway To Colorectal Carcinoma 显示文摘 | O' Brien M J Yang S Huang C S | 2008 | Diagn Histopathol2008，1，4： | 1 |
| 17 | A decision support system for supplier selection using an integrated analytic hierarchy process and linear programming显示文摘 | GHODSYPOUR S H O'BRIEN C | 1998 | International Journal of Production Economics1998，5657，： | 1 |
| 18 | Signal transduction by cell adhesion receptors显示文摘 | Rosales C O'Brien V Kornberg L | 1995 | Biochim Biophys Acta1995，1242，1： | 1 |
| 19 | Molecular analysis of the stylar-expressed Solanum chacoense small asparagine-rich protein family reated to the HT modifier of gametophytic self-incompatibility in Nicotiana显示文摘 | O'Brien M Kapfer C Major G | 2002 | Plant J2002，32，： | 1 |
| 20 | Elastic Behavior of a Pseudo-fruit for Determining Bruise Damage to Fruit During Mechanized Handling显示文摘 | RIDER R C FRIDLEY R B BRIEN O M | 1973 | Transaction of the ASAE1973，16，2： | 1 |
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