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| 1 | Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma显示文摘AIM To explore factors associated with persistent hepatitis B virus(HBV) infection in a cohort of hepatocellular carcinoma(HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen(HBsA g)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structuredquestionnaire. Demographics, relationship to index case, HBs Ag status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation(P = 0.0076), index generation(P = 0.0044), mothers positive for HBs Ag(P = 0.0007), and HBs Ag-positive index cases(P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBs Ag-positive relatives. Parent generation(P = 0.0359) and sex(P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBs Ag-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46(58.7%) families. Male offspring of HBsA gpositive mothers(P = 0.024) and older siblings were associated with high viral load.CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations. | Ai-Ru Hsieh Cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai | 2017 | World Journal of Gastroenterology2017，23，5： | 2 |
| 2 | Mechanisms for acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo 显示文摘 | Khoury SJ Gallon L Chen W | 1995 | J Exp Med1995，182，： | 2 |
| 3 | Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘 | Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | Visual acuity and contrast sensitivity in different types of posterior capsule opacification显示文摘 | Cheng CY YenMY Chen SJ | 2001 | J Cataract Refract Surg2001，27，7： | 1 |
| 5 | Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells显示文摘 | CHEN YH LIN SJ KU HH | 2001 | J Cell Biochem2001，82，： | 1 |
| 6 | Synthesis and characterization of a novel cationic chitosan-based ?occulant with a high water-solubility for pulp mill wastewater treatment 显示文摘 | Wang JP Chen YZ Yuan SJ | 2009 | Water Research2009，，43： | 1 |
| 7 | Aminoguanidine attenuates the delayedcirculatory failure and improves survival in rodent models of endotoxicshock显示文摘 | Wu CC Chen SJ Szabo C | 1995 | Br J Pharmacol1995，114，8： | 1 |
| 8 | Diurnal temperature rangeand daily mentality in Shanghai, China 显示文摘 | Kan HD London SJ Chen HL | 2007 | Environ Res2007，103，3： | 1 |
| 9 | Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment显示文摘 | Chen AC McDonald B Moss SJ | 1998 | Brain Res Mol Brain Res1998，54，1： | 1 |
| 10 | RP-HPLC法测定抗栓保心片中丹参酮ⅡA的含量显示文摘 | Tan SJ Chen PR | | Chin J Chin Mater Med0，，： | 1 |
| 11 | Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries显示文摘 | Li G Chen SJ Oparil S | 2000 | Circulation2000，101，12： | 1 |
| 12 | Humanization of an anti- vascularer endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders显示文摘 | Presta LG Chen H O'Connor SJ | 1997 | Cancer Res1997，57，20： | 1 |
| 13 | Reflection and critical thinking of humanistic care in medical education显示文摘 | Shiau SJ Chen CH | 2008 | Kaohsiung J Med Sci2008，24，7： | 1 |
| 14 | Netonatal adrenal hemorrhage presenting as a multiloculated cystic mass显示文摘 | Wang CH Chen SJ Yang LY | 2008 | J Chin Med Assoc2008，71，9： | 1 |
| 15 | Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in chinese patients 显示文摘 | Lau LI Chen SJ Cheng CY | 2006 | Invest Ophthalmol Vis Sci2006，47，8： | 1 |
| 16 | Prevalence and associated risk factors of age-related macular degeneration in an elderly chinese population in Taiwan: the shihpai eye study 显示文摘 | Chen SJ Cheng CY Peng KL | 2008 | Invest Ophthalmol Vis Sci2008，49，： | 1 |
| 17 | Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist显示文摘 | Tilton RG Munsch CL Sherwood SJ Chen YF Wu C | 2000 | Pulm Pharmacol Ther2000，13，： | 1 |
| 18 | Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis:comparison with restriction fragment length polymorphism analysis显示文摘 | Chen CY Shiesh SC Wu SJ | 2004 | Clin Chem2004，50，3： | 1 |
| 19 | A modified osmotic shock for periplasmic release of a recombinant creatinase from Eseherichia coli 显示文摘 | Chen YC Chen LA Chen SJ | 2004 | Biochem Eng J2004，19，3： | 1 |
| 20 | Evaluation of podocyte lesion in pa- tients with diabetic nephropathy:W ilms tumor-1 protein used as a podocyte marker 显示文摘 | Su J Li SJ Chen ZH | 2010 | Diabetes Res Clin Pract2010，87，2： | 1 |
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