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| 1 | Five-year long-term outcomes of laparoscopic surgery for colon cancer显示文摘AIM:To perform a meta-analysis to answer whether long-term recurrence rates after laparoscopic-assisted surgery are comparable to those reported after open surgery.METHODS:A comprehensive literature search of the MEDLINE database,EMBASE database,and the Cochrane Central Register of Controlled Trials for the years 1991-2010 was performed.Prospective randomized clinical trials(RCTs)were eligible if they included patients with colon cancer treated by laparoscopic surgery vs open surgery and followed for more than five years.RESULTS:Three studies involving 2147 patients reported long-term outcomes based on five-year data and were included in the analysis.The overall mortality was similar in the two groups(24.9%,268/1075 in the laparoscopic group and 26.4%,283/1072 in open group).No significant differences between laparoscopic and open surgery were found in overall mortality during the follow-up period of these studies[OR(fixed) 0.92,95%confidence intervals(95%CI):0.76-1.12,P=0.41].No significant difference in the development of overall recurrence was found in colon cancer patients,when comparing laparoscopic and open surgery [2147 pts,19.3%vs 20.0%;OR(fixed)0.96,95% CI:0.78-1.19,P=0.71].CONCLUSION:This meta-analysis suggests that laparoscopic surgery was as efficacious and safe as open surgery for colon cancer,based on the five-year data of these included RCTs. | Bai HL Chen B Zhou Y Wu XT. | 2010 | World Journal of Gastroenterology2010，16，39： | 13 |
| 2 | The initial elevation of palaeokarst and planation surfaces on Tibet Plateau显示文摘THE formation periods,properties and initial elevations of Tibetan planation surfaces are keysto the issues ot the plateau uplift.Li et al.believed that the study on planation surfaces hasfar-reaching significance.Yang et al.indicated that the summit level and the basin level | Cui, ZJ Gao, QZ Liu, GN Pan, BT Chen, HL | 1997 | Chinese Science Bulletin1997，42，11： | 7 |
| 3 | Geological thermal events in Tarim Basin显示文摘TARIM Basin is the biggest sedimentary basin in China, and it is also an important area of | Chen, HL Yang, SF Dong, CW Zhu, GQ Jia, CA Wei, GQ Wang, ZG | 1997 | Chinese Science Bulletin1997，42，7： | 5 |
| 4 | Quantum chemical studies on antimalarial of artemisinin (qinghaosu) derivatives显示文摘In this paper theoretical studies were performed on artemisinin (qinghaosu) derivatives with semiempirical quantum chemical methods AMI and PM3. The antimalarial activity -logC has an obvious correlation with the net charge of C(16) and bond orders of bonds O(1)-C(10), O(2)-C(6), O(1)-O(2) and O(5)-C(16). According to the calculation results, we derived structure-activity relationship, presented the probable pharmacophore of qinghaosu derivatives and the interaction fashion between the drugs and the plasmodium receptor. | JIANG, HL CHEN, KX TANG, Y CHEN, JZ JI, RY | 1995 | Chinese Journal of Chemistry1995，13，2： | 5 |
| 5 | REAL-VALUED PERIODIC WAVELETS: CONSTRUCTION ANDRELATION WITH FOURIER SERIES显示文摘1.IntroductionWaveletshaverecentlyreceivedagreatdealofattentioninsuchareasassignalprocessingandimageprocessing([12],[8]).Variousmethodstoconstructwaveletshavebeengiven([14],[13],[9],[7]).Itiswellknownthatinmathematicsandmathematicphysicsmanyperiodicp... | Chen, HL Liang, XZ Peng, SL Xiao, SL | 1999 | Journal of Computational Mathematics1999，17，5： | 3 |
| 6 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 7 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 8 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 9 | Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells显示文摘 | Gabrilovich DI Chen HL Girgis KR | 1996 | Nature Med1996，2，10： | 1 |
| 10 | An eight-year study of epidemiologic features of enterovims 71 infection in Taiwan显示文摘 | Chen SO Chang HL Yan TB | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 11 | Independent prognostic value of elevated high-sensitivity C-reactive protein in chronic heart failure显示文摘 | Yin WH Chen JW Jen HL | 2004 | The American Heart Journal2004，147，5： | 1 |
| 12 | Intrahepatic cholangiocarcinoma in hepatolithiasis: a frequently overlooked disease显示文摘 | Sheen Chen Sm Chou FF Eng HL | 1991 | J Surg Oncol1991，47，： | 1 |
| 13 | Multi-Slice CT angiography in diagnosing total versus near occlusions of the internal carotid artery :comparison with catheter angiography 显示文摘 | Chen CJ Lee TH Hsu HL | 2004 | Stroke2004，35，1： | 1 |
| 14 | Effects of all- trans retinoic acid and epidermal growth factor on the expression of nm23 - H1 in human hepatocarcinoma cells显示文摘 | Liu F Qi HL Chen HL | 2000 | J Cancer Res Clin Oncol2000，126，2： | 1 |
| 15 | Hirayama flexion myelopathy:neural-position MR imaging findings-importance of loss of attachment显示文摘 | Chen CJ Hsu HL Tseng YC | 2004 | Radiology2004，231，1： | 1 |
| 16 | An eight-year study ofepidemiologic features of enterovirus 71 infection in Taiwan 显示文摘 | Chen SC Chang HL Yan TR | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 17 | Diurnal temperature rangeand daily mentality in Shanghai, China 显示文摘 | Kan HD London SJ Chen HL | 2007 | Environ Res2007，103，3： | 1 |
| 18 | An eight-year study of epi-demiologic features of enterovirus 71 infection in Taiwan显示文摘 | Chen SC Chang HL Yan TR | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 19 | Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis:crucial role of ERK-NRF2 signaling pathway显示文摘 | Wang X Chen HL Liu JZ | 2013 | J Biol Regul Homeost Agents2013，27，1： | 1 |
| 20 | Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan,1998-2005显示文摘 | CHEN KT CHANG HL WANG ST | | 0，，02： | 1 |
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