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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Biological activities of α-pinene and β-pinene enantiomers 显示文摘 | Rivas da Silva A C Lopes P M Barros de Azevedo MM | 2012 | Molecules2012，17，6： | 1 |
| 3 | The use of signal-analysis for the localization of an epileptogenic focus:a new approach显示文摘 | Pijn J P M Vijn P C M Lopes da Silva F H | | 0，，： | 1 |
| 4 | Para-metric analysis of the latera-l torsional buckling resistance ofsteel beams in case of fire显示文摘 | P M M Vila Real N Lopes L Sim es da Silva | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 5 | Superovulation of Mertolenga cows with two FSH preparations显示文摘 | Quaresma M A Lopes Da Costa L Robalo Silva J | 2003 | RPCV2003，98，546： | 1 |
| 6 | Kinetics and thermal behaviour of the structure formation process in HMP/ sucrose gelation显示文摘 | Lopes da Silva J A L Gonc Ё Alves M P | 1995 | Int J Biol Macromol1995，，17： | 1 |
| 7 | Structural Damage Detection by Fuzzy Clustering 显示文摘 | da Silva S Dias M Lopes V | 2008 | Me- chanical Systems and Signal Processing2008，22，7： | 1 |
| 8 | An XPS study of the fibre-matrix interface using sized carbon fibres as a model 显示文摘 | Reis M J Botelho Do Rego A M Lopes Da Silva J D | 1995 | J Mater Sci1995，30，1： | 1 |
| 9 | Parametric analysis of the lateral-torsional bucking resistance of steel beams in case of fire显示文摘 | Real P M M V Lopes N Simes da Silva L | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 10 | Dam- age detection in a benchmark structure using Ar-Arx models and statistical pattern recognition显示文摘 | Samuel da Silva Dias Jfinior M Lopes Junior V | 2007 | Journal of the Brazilian Socie- ty of Mechanical Sciences and Engineering2007，29，2： | 1 |
| 11 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 12 | A generalised fractional derivative approach to viscoelastic material properties measurement显示文摘 | De Espi'ndola J J Joao M da Silva Neto Eduardo Mo Lopes | 2005 | Applied Mathematics and Computation2005，164，： | 1 |
| 13 | Phylogenetic diversity of Brazilian Metarhizium associated with sugarcane agriculture显示文摘 | Rezende J M Zanardo A B R da Silva Lopes M | 2015 | BioControl2015，60，： | 1 |
| 14 | Parametric analysis of tbe lateral-torsional buckling resistance of steel beams in case of fire 显示文摘 | Real P M M Vila Lopes N Simes da Silva L | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 15 | Lateral-buckling of unstrained steel beams under fire conditions:improvement of EC3 proposal显示文摘 | Lopes N da Silva S L | 2004 | Computers and Structures2004，82，20： | 1 |
| 16 | Parametric analysis of the lateral-torsional buckling resistance of steel beams in case of fire显示文摘 | Lopes N da Silva S L | 2007 | Fire Safety Journal2007，42，6： | 1 |
| 17 | An XPS study of the fiber-matrix interface using sized carbon fibers as a model 显示文摘 | Reis M J Botelho Do Rego A M Lopes Da Silva J D | 1995 | Journal of Materials Science1995，30，： | 1 |
| 18 | The use of signal-analysis for the localization of an epileptogenic focus:a new approach显示文摘 | Pijn J P M Vijn P C M Lopes da Silva F H | 1989 | Adv Epileptol1989，17，： | 1 |
| 19 | Anthocyanin pigments in strawberry 显示文摘 | Lopes da Silva F Eseribano-bailon M T Perez Alonso J J | 2007 | LWT2007，40，： | 1 |
| 20 | Structural Dam- age Detection by Fuzzy Clustering显示文摘 | da Silva S Dias M Lopes V | 2008 | Mechanical Systems and Signal Processing2008，22，7： | 1 |
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