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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Breaking strength of dry fermented sausages and their correlation with texture profile analysis (TPA) and physico-chemical characteristics显示文摘 | Herrero A M Ord6fiez J A de Avila R | 2007 | Meat Science2007，77，3： | 1 |
| 3 | The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response显示文摘 | de Los Santos T de Avila Botton S Weiblen R | 2006 | J Virol2006，80，4： | 1 |
| 4 | The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response显示文摘 | DE LOS SANTOS T DE AVILA BOTTON S WEIBLEN R | 2006 | J Virol2006，80，4： | 1 |
| 5 | Saccharomyces boulardii reduces infection intensi- ty of mice with toxocariasis显示文摘 | DE AVILA L F CONCEICAO F R TELMO PDE L | 2012 | Vet Parasitol2012，187，： | 1 |
| 6 | Pityriasis alba: a study of pathogenic factors 显示文摘 | Blessmann Weber M Sponchiado de Avila LG Albaneze R | 2002 | J Eur Acad Dermatol Venereol2002，16，5： | 1 |
| 7 | Conception rate, growth and lactation of dairy heifers treated with recombinant somatotropin显示文摘 | Grings E E Avila D M De Eggert R G | 1990 | Dairy Sci1990，73，： | 1 |
| 8 | Breakingstrength of dry fermented sausages and their correlation withtexture profile analysis(TPA) and physico-chemical characteristics显示文摘 | Herrero A M Oudonez J A DE Avila R | 2007 | Meat Science2007，77，： | 1 |
| 9 | Breaking strength of dry fermented sausages and their correlation with texture profile analy- sis (TPA) and physieo-chemieal characteristics显示文摘 | HERRERO A M ORDONEZ J A de AVILA R | 2007 | Meat Science2007，77，3： | 1 |
| 10 | Lipoprotein (a) and athero-thrombotic disease显示文摘 | DE LA PENA-DIAZ A IZAGUIRRE AVILA R ANGLES-CANO E | 2000 | Arch Med Res2000，31，： | 1 |
| 11 | Breaking strength of dry fermented sausages and their correlation with texture profile analysis (TPA) and physieo-chemieal char- acteristics显示文摘 | Herrero A M Oudonez J A DE Avila R | 2007 | Meat Science2007，77，： | 1 |
| 12 | Classification of Tospoviruses based on phylogeny of nu- cleoprotein gene sequence 显示文摘 | De Avila A C De Haan P Kormelink R | 1993 | Journal of General Virology1993，74，： | 1 |
| 13 | Estimation of zoo- plankton secondary production in estuarine waters: Comparison between the enzymatic (chitobiase) method and mathematical models using crus- taceans显示文摘 | Avila T R de Souza Machado A A Bianchini A | 2012 | Journal of Experimental Marine Biology and Ecology2012，，： | 1 |
| 14 | Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren 显示文摘 | Jardim-Botelho A Raft S R de Avila Rodrigues | 2008 | Trop Med Int Health2008，13，8： | 1 |
| 15 | The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response显示文摘 | De Los S De Avila B S Weiblen R | 2006 | J Virol2006，80，4： | 1 |
| 16 | Chitobiase of planktonic crustaceans from South Atlantic coast (Southern Brazil) : Characterization and influence of abiotic parameters on enzyme activity 显示文摘 | Avila T R de Souza Machado A A Bianchini A | 2011 | Journal of Experimental Marine Biology and Ecology2011，407，： | 1 |
| 17 | The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response显示文摘 | de Los Santos T de Avila Botton S Weiblen R | 2006 | J Virol2006，80，4： | 1 |
| 18 | Effect of fatty acid composition and positional distribution within the triglyceride on selected physical properties of dry-cured ham subcutaneous fat显示文摘 | SEGURA J ESCUDERO R ROMERO de AVILA M D | 2015 | Meat Science2015，103，： | 1 |
| 19 | Effect of antimicrobial peptides derived from human cathelicidin LL- 37 on Entamoeba histolytica trophozoites显示文摘 | Rico-Mata R De Leon-Rodriguez L M Avila E E | 2013 | Exp Parasitol2013，133，3： | 1 |
| 20 | Microbialtransglutaminase for cold-set binding of unsalted/salted pork modelsand restructured dry ham显示文摘 | de AVILA M D R ORD6NEZ J A de la HOZ L | 2010 | Meat Science2010，84，4： | 1 |
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