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| 1 | Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration显示文摘AIM: To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fi ne-needle aspiration (EUS-FNA) for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions. METHODS: From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUS-FNA. The fi nal diagnosis was obtained either by surgery (356 cases) or after a mean clinical follow-up of 11.8 mo in the remaining patients. RESULTS: There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 (97.4/) cases. There were 352 (57.6/) malignancies and 259 (42.4/) benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67/ of the lesions. Overall, the sensitivity, specifi city, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4/, 99.2/, 99.3/, 77.2/ and 87.2/. Specif ically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8/ vs 82.4/, 100/ vs 98.4/, 100/ vs 99/, 54.8/ vs 74.1/ and 83.1/ vs 87.8/. For cystic lesions, the values were, respectively, 72.2/, 99.3/, 97.5/, 91/ and 92.2/. CONCLUSION: EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions canreveal the best negative predictive value and diagnostic accuracy, both higher than 90/. | José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo José Luiz Pimenta Módena | 2007 | World Journal of Gastroenterology2007，13，22： | 17 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 5 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 6 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 7 | Ultrasound guided core needle biopsy of breast masses: How many cores are necessary to diagnose cancer? 显示文摘 | De Lucena C E Dos Santos Junior J L De Lima Resende C A | 2007 | J Clin Ultrasound2007，35，7： | 1 |
| 8 | Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats显示文摘 | Pietá Dias C Martins de Lima MN Presti-Torres J | | 0，，04： | 1 |
| 9 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 10 | Identification of anovel antimicrobial peptide from Brazilian coast coral Phyllogorgiadilatata显示文摘 | de Lima LA Migliolo L Barreiro e Castro C | 2013 | Protein Pept Lett2013，20，10： | 1 |
| 11 | Prebiotic and diet/light chocolate dairy dessert:Chemical composition,sensory profiling and relationship with consumer expectation显示文摘 | De MORAIS E C LIMA G C De MORAIS A R | 2015 | LWT-Food Science and Technology2015，62，1： | 1 |
| 12 | Effect of hygroscopic expansion on the push-out resistance of glass ionomer-based cements used for the luting of glass fiber posts 显示文摘 | Cury AH Goracei C de Lima Navarro MF | 2006 | Endod2006，32，6： | 1 |
| 13 | The use of response surface methodology in optimization of lactic acid production: focus on medium supplementation, temperature and pH control显示文摘 | de LIMA C J B COELHO L F CONTIERO J | 2010 | Food Technology and Biotechnology2010，48，2： | 1 |
| 14 | Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and mieronueleus test 显示文摘 | Scolastici C Alves de Lima Barbisan F | 2008 | Toxicology in Vitro2008，，22： | 1 |
| 15 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 16 | Endoscopic treatment of cholangiocarcinoma and carcinoma of the duodenal papilla by intraductal high intensity US: results of a pilot study显示文摘 | Prat F Lafon C De Lima DM | 2002 | Gas trointest Endosc2002，56，6： | 1 |
| 17 | Knowledge about HPV and screening of cervical cancer among women from the metropolitan region of natal, brazil显示文摘 | Lima E G de Lima D B Miranda C A | 2013 | ISRN Obstet Gynecoh2013，2013，93： | 1 |
| 18 | MS222 does not induce primary DNA damage in fish显示文摘 | BARRETO R E GONTIJO A M M C ALVES - DE - LIMA R O | 2007 | Aquac2007，15，2： | 1 |
| 19 | Validity, reliability, feasibility and satisfaction of the mini-clinical evaluationexereise (mini-CEX) for cardiology residency training 显示文摘 | Alves de Lima A Barrero C Baratta S | 2007 | Med Teach2007，29，8： | 1 |
| 20 | lntestinal and pancreas enzyme activity of broilers exposed to thermal stress 显示文摘 | Routman K S l Yoshida L I Frizzas de Lima A C I et d | 2003 | Revista Brasileira de Ci-ncia Avlcola2003，5，1： | 1 |
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