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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Genome-wide atlas of transcription through maize development显示文摘 | Sekhon R S Lin H Childs K L Hirsch C N Buell C R de Leon N Kaeppler S M | 2011 | The Plant Journal2011，66，4： | 1 |
| 4 | Therapeutic antibody targeting of indi- vidual Notch receptors显示文摘 | Wu Y Cain-Hom C Choy L Hagenbeek T J de Leon G P Chen Y | 2010 | Nature2010，464，： | 1 |
| 5 | Novel binary expression vector for production of human IL-10 in Escherichia coli and Bifidobacterium longum 显示文摘 | REYES ESCOGIDOM L DE LEON | 2007 | Biotechnol Letter2007，29，8： | 1 |
| 6 | Coping strategies of latino women caring t'or a spouse recovering from a stroke: A grounded theory 显示文摘 | de Leon Arabit L | 2008 | The Journal of Theory Construction & Testing2008，12，2： | 1 |
| 7 | Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease显示文摘 | Mosconi L de Leon M Murray J | 2011 | J Alzheimers Dis2011，27，： | 1 |
| 8 | Darwin's fin- ches and their diet niches:the sympatric coexistence of imper- fect generalists显示文摘 | DE LEON L F PODOS J GARDEZI T | 2014 | Journal of Evolutionary Biology2014，27，6： | 1 |
| 9 | Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy显示文摘 | Shapiro BS Daneshmand ST De Leon L | 2012 | Fertil Steril2012，98，6： | 1 |
| 10 | Participation in cognitively stimulating activities and risk of incident Alzheimer disease显示文摘 | Robert S Wilson Carlos F Mendes De Leon Lisa L Barnes | 2002 | JAMA2002，287，6： | 1 |
| 11 | Mechanistic studies on Lewis acid catalyzed Biginelli reactions in ionic liquids: Evidence for the reac- tive intermediates and the role of the reagents 显示文摘 | Ramos L M Ponce de Leon Y Tobio A Y dos Santos M R | 2012 | Journal of Organic Chemistry2012，77，10： | 1 |
| 12 | The dosing of atypical antipsychotics 显示文摘 | de Leon J Armstrong S C Cozza K L | 2005 | Psychosomatics2005，46，3： | 1 |
| 13 | A novel binary expression vector for production of human IL-10 in Escherichia coli and Bifidobacterium longum 显示文摘 | REYES ESCOGIDOM L De LEON RODRIGUEZ A BARBADELA ROSAA P | 2007 | Biotechnol Lett2007，29，8： | 1 |
| 14 | Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy 显示文摘 | Shapiro BS Daneshmand ST De Leon L | 2012 | Fertil Steril2012，98，： | 1 |
| 15 | Expression of N-cadherin,NCAM,Fibronectin and Tenascin is Stimulated by TGF-β1,2,3 and β5 During the Formation of Precartilage Condensations显示文摘 | CHIMAL-Monroy J DIAZ de LEON L | 1999 | Int J Dev Biol1999，43，1： | 1 |
| 16 | Morphological bidirectional asso-ciative memories显示文摘 | Ritter G X Diaz de Leon J L Sussner P | 1999 | Neural Network1999，12，： | 1 |
| 17 | Miso- prostol preferable to ethacridine lactate for abortions at 13- 20 weeks of pregnancy: Cuban experience 显示文摘 | BOZA A V DE LEON R G CASTILLO L S | 2008 | Reprod Health Matters2008，16，31： | 1 |
| 18 | Clozapine and jaw dyskinesia:a case report显示文摘 | de Leon J Moral L Camu?as C | 1991 | J Clin Psychiatry1991，52，： | 1 |
| 19 | The origin of the spinal subdural space: ultrastructure findings显示文摘 | Reina MA De Leon Casasola O López A | 2002 | Anesth Analg2002，94，4： | 1 |
| 20 | Laparoscopic appendectomy in Italy : An appraisal of 26,863 cases 显示文摘 | Agresta F De Simone P Leone L | 2004 | Laparoendoscopic & Ad- vanced Surgical Techniques2004，14，1： | 1 |
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