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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Improved wet peroxide oxidation strategies for the treatment of chlorophenols显示文摘 | MUNOZ M DE PEDRO Z M CASAS J A | 2013 | Chemical Engineering Journal2013，228，： | 1 |
| 3 | NPY receptors and opioidergic system are in-volved in NPY-induced feeding in goldfish显示文摘 | DE PEDRO N LOPEZ-PATINO M A GUIJARRO AI | 2000 | Pep-tides2000，21，10： | 1 |
| 4 | Peptidoglycan struc- ture of Salmonella typhimurium growing within cultured mammalian cells 显示文摘 | Quintela J C de Pedro M A Zollner P | 1997 | Mol Microbiol1997，23，4： | 1 |
| 5 | Cavernomas in children with brain tumors: a late complication of radiotherapy 显示文摘 | Martínez-Lage J F de la Fuente I Ros de San Pedro J Fuster J L Pérez-Espejo M A Herrero M T | 2008 | Neurocirugia (Astur)2008，19，： | 1 |
| 6 | NPY receptors and opioidergic system are in- volved in NPY-induced feeding in goldfish 显示文摘 | DE PEDRO N LOPEZ-PATIiqO M A GUIJARRO A I | 2000 | Pep- tides2000，21，10： | 1 |
| 7 | Daily and seasonal variations in haematological and blood biochemical parameters in the tench,Tinca tinca Linnaeus,1758显示文摘 | De Pedro N Guijarro A I López-Patińo M A | | 0，，： | 1 |
| 8 | Food intake inhibition by melatonin in goldfish(Carassius auratus)显示文摘 | PINILLOS M L DE PEDRO N ALONSO-GóMEZ A L | 2001 | Physiology & Behavior2001，72，5： | 1 |
| 9 | Triclosan breakdown by Fenton-like oxidation显示文摘 | MUNOZ M DE PEDRO Z M CASAS J A | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 10 | Emerging knowledge of regulatory roles of D-amino acids in bacteria显示文摘 | CAVA F LAM H de PEDRO M A | 2011 | Cell Mol Life Sei2011，68，5： | 1 |
| 11 | Multi-residue analysis of pesticide residues in mangoes using solid-phase microextraction coupled to liquid chromatography and UV- Vis detection显示文摘 | Adalberto M Filho Fabio N dos Santos Pedro A de Paula Pereira | 2011 | J Sep Sci2011，34，21： | 1 |
| 12 | Chlorophenols breakdown by a sequential hydrodechlorination-oxidation treatment with a magnetic Pd-Fe/~,-A1203 catalyst 显示文摘 | MUNOZ M de PEDRO Z M CASAS J A | 2013 | Water Research2013，47，9： | 1 |
| 13 | Food intake inhibition by melatonin in goldfish (Carassius auratus)显示文摘 | Pinillos M L De Pedro N Alonso-Gomez A L | 2001 | Physiol Behav2001，72，： | 1 |
| 14 | Assessment of the generation of chlorinated by products upon Fenton-like oxidation of chlorophenols at different conditions显示文摘 | Munoz M de Pedro Z M Casas J A | 2011 | Journal of Hazardous Materials2011，190，123： | 1 |
| 15 | Associao de marcadores moleeulares SNP corn o contetado de tcido linolnico em sementes de soja显示文摘 | de Oliveira P M Pedro Ivo V G Maurflio A M et at | 2013 | Pesquisa Agropecuria Brasil- eira2013，48，3： | 1 |
| 16 | NPY receptors and opioidergic system are in- volved in NPY-induced feeding in goldfish 显示文摘 | DE PEDRO N L(3PEZ-PATI/IO M A GUIJARRO A I | 2000 | Pep- tides2000，21，10： | 1 |
| 17 | Food intake inhibition by melatonin in goldfish (Carassius auratus)显示文摘 | Pinillos M L De Pedro N Alonso-G6mez A L | 2001 | Physiol Behav2001，72，5： | 1 |
| 18 | Food intake inhibition by melatonin in goldfish ( Carassius auratus ) 显示文摘 | Pinillos M L De Pedro N Alonso-G6mez A L | 2001 | Physiology Behavior2001，72，5： | 1 |
| 19 | Food intake inhibition by melatonin in goldfish ( Carassius auratus) 显示文摘 | Pinillos M L De Pedro N Alonso-Gomez A L | 2001 | Physiology & Behaviour2001，72，5： | 1 |
| 20 | Daily and seasonal variations in hematological and blood biochemical parameters in the tench, Tinva tinca Linnaeus, 1758 显示文摘 | De Pedro N Guijarro A I Lpez-patio M A | 2005 | Aquaculture Research2005，36，12： | 1 |
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