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| 1 | Antiparkinsonian treatment for depression in Parkinson's disease: Are selective serotonin reuptake inhibitors recommended?显示文摘Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the amelioration of the side-effects of antiparkinsonian therapy. The first-line treatment for depression in Parkinson's disease is the use of selective serotonin reuptake inhibitors(SSRIs). The clinical efficacy of these medications in patients with Parkinson's disease is questionable. In fact, based on their mechanism of action, which requires at least a functional serotonergic system, it is predicted that SSRIs will have lower efficacy in patients with Parkinson's disease. Here, we consider the mechanism of action of SSRIs in the context of Parkinson's disease by investigating the fall in the levels of serotonergic markers and the inhibitory outcomes of antiparkinsonian treatment on serotonergic nerve activity. Because certain classes of antidepressant drugs are widely available, it is necessary to perform translational research to address different strategies used to manage depression in Parkinson's disease. | Philippe De Deurwaerdère Yuqiang Ding | 2016 | Translational Neuroscience and Clinics2016，2，2： | 4 |
| 2 | Main outcomes from in situ thermo-hydro-mechanical experiments programme to demonstrate feasibility of radioactive high-level waste disposal in the Callovo-Oxfordian claystone显示文摘In the context of radioactive waste disposal,an underground research laboratory(URL)is a facility in which experiments are conducted to demonstrate the feasibility of constructing and operating a radioactive waste disposal facility within a geological formation.The Meuse/Haute-Marne URL is a sitespecific facility planned to study the feasibility of a radioactive waste disposal in the Callovo-Oxfordian(COx)claystone.The thermo-hydro-mechanical(THM)behaviour of the host rock is significant for the design of the underground nuclear waste disposal facility and for its long-term safety.The French National Radioactive Waste Management Agency(Andra)has begun a research programme aiming to demonstrate the relevancy of the French high-level waste(HLW)concept.This paper presents the programme implemented from small-scale(small diameter)boreholes to full-scale demonstration experiments to study the THM effects of the thermal transient on the COx claystone and the strategy implemented in this new programme to demonstrate and optimise current disposal facility components for HLW.It shows that the French high-level waste concept is feasible and working in the COx claystone.It also exhibits that,as for other plastic clay or claystone,heating-induced pore pressure increases and that the THM behaviour is anisotropic. | G. Armand F. Bumbieler N. Conil R. de la Vaissière J.-M. Bosgiraud M.-N. Vu | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 4 |
| 3 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 4 | Implications of safety requirements for the treatment of THMC processes in geological disposal systems for radioactive waste显示文摘The mission of nuclear safety authorities in national radioactive waste disposal programmes is to ensure that people and the environment are protected against the hazards of ionising radiations emitted by the waste.It implies the establishment of safety requirements and the oversight of the activities of the waste management organisation in charge of implementing the programme.In Belgium,the safety requirements for geological disposal rest on the following principles:defence-in-depth,demonstrability and the radiation protection principles elaborated by the International Commission on Radiological Protection(ICRP).Applying these principles requires notably an appropriate identification and characterisation of the processes upon which the safety functions fulfilled by the disposal system rely and of the processes that may affect the system performance.Therefore,research and development(R&D)on safety-relevant thermo-hydro-mechanical-chemical(THMC)issues is important to build confidence in the safety assessment.This paper points out the key THMC processes that might influence radionuclide transport in a disposal system and its surrounding environment,considering the dynamic nature of these processes.Their nature and significance are expected to change according to prevailing internal and external conditions,which evolve from the repository construction phase to the whole heatingecooling cycle of decaying waste after closure.As these processes have a potential impact on safety,it is essential to identify and to understand them properly when developing a disposal concept to ensure compliance with relevant safety requirements.In particular,the investigation of THMC processes is needed to manage uncertainties.This includes the identification and characterisation of uncertainties as well as for the understanding of their safety-relevance.R&D may also be necessary to reduce uncertainties of which the magnitude does not allow demonstrating the safety of the disposal system. | Frédéric Bernier Frank Lemy Pierre De Cannière Valéry Detilleux | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 3 |
| 5 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 6 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 7 | Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors显示文摘 | Alain Roche Baragur V. Girish Thierry de Baère Eric Baudin Valérie Boige Dominique Elias Philippe Lasser Martin Schlumberger Michel Ducreux | 2003 | European Radiology2003，，1： | 2 |
| 8 | Artificial neural network approach for multiphase segmentation of battery electrode nano-CT images显示文摘The segmentation of tomographic images of the battery electrode is a crucial processing step,which will have an additional impact on the results of material characterization and electrochemical simulation.However,manually labeling X-ray CT images(XCT)is time-consuming,and these XCT images are generally difficult to segment with histographical methods.We propose a deep learning approach with an asymmetrical depth encode-decoder convolutional neural network(CNN)for real-world battery material datasets.This network achieves high accuracy while requiring small amounts of labeled data and predicts a volume of billions voxel within few minutes.While applying supervised machine learning for segmenting real-world data,the ground truth is often absent.The results of segmentation are usually qualitatively justified by visual judgement.We try to unravel this fuzzy definition of segmentation quality by identifying the uncertainty due to the human bias diluted in the training data.Further CNN trainings using synthetic data show quantitative impact of such uncertainty on the determination of material’s properties.Nano-XCT datasets of various battery materials have been successfully segmented by training this neural network from scratch.We will also show that applying the transfer learning,which consists of reusing a well-trained network,can improve the accuracy of a similar dataset. | Zeliang Su Etienne Decencière Tuan-Tu Nguyen Kaoutar El-Amiry Vincent De Andrade Alejandro A.Franco Arnaud Demortière | 2022 | npj Computational Materials2022，，1： | 2 |
| 9 | Rho kinase blockade prevents inflammation via nuclear factor κB inhibition: evidence in Crohn’s disease and experimental colitis显示文摘 | Jean-Pierre Segain Diane Raingeard de la Blétière Vincent Sauzeau Arnaud Bourreille Gréory Hilaret Chrystelle Cario-Toumaniantz Pierre Pacaud Jean-Paul Galmiche Gervaise Loirand | 2003 | Gastroenterology2003，，5： | 2 |
| 10 | Use of the holmium: YAG laser in urology显示文摘 | Johnson DE Cromeens Dm Price RE | 1992 | Lasers Surg Med1992，12，： | 1 |
| 11 | Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast显示文摘 | De Villiers EM Sandstrom RE zur Hausen H | 2005 | Breast Cancer Res2005，7，1： | 1 |
| 12 | Engineering of vaginal tissue in vivo显示文摘 | De Filippo RE Yoo JJ Atala A | 2003 | Tissue Eng2003，9，2： | 1 |
| 13 | The ileal neo- bladder:complications and functional results in 363 patients af- ter 11 years of followup显示文摘 | Hautmann RE de Petriconi R Gottfried HW | 1999 | J Urol1999，161，2： | 1 |
| 14 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 15 | Fever of unknown origin in adults显示文摘 | Lambertuccil JR de Avilal RE | 2005 | Med Trop2005，38，6： | 1 |
| 16 | Transradial artery coronary angiography and intervention in patients with severe peripheral vascular disease 显示文摘 | De Belder AJ Smith RE Wainwright RJ | 1997 | Clin Radiol1997，52，2： | 1 |
| 17 | Serum bili-rubin concentration in patients with an established coronary arterydisease显示文摘 | Ghem C Sarmento-Leite RE de Quadros AS | 2010 | Int Heart J2010，51，2： | 1 |
| 18 | Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype显示文摘 | de Cremoux P de la Rochefordi e re A Savignoni A | 2009 | Int J Cancer2009，124，4： | 1 |
| 19 | Urethral replacement using cell seeded tubularized collagen matrices显示文摘 | De Filippo RE Yoo JJ Atala A | | 0，，： | 1 |
| 20 | Dietary fiber for the treatment of type 2 diabetes mellitus: a meta-analysis 显示文摘 | Post RE Mainous AG 3rd King DE | 2012 | J Am Board Fam Med2012，25，： | 1 |
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